Career Opportunities

Position:

Anti-Bribery and Anti-Corruption Consultant (PT)

Function:

Business Operations

Location:

Remote

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

Responsible for assessing third parties to identify and mitigate bribery and corruption risk. Collaborate with cross functional business partners regarding bribery and corruption risks and controls.

Roles and Responsibilities of the Position:

• Assists more senior compliance professionals and business operations in evaluating bribery and corruption risks related to third party engagements, including reviewing third parties' responses to due diligence questionnaires, identifying and escalating relevant bribery and corruption risks, and working with the business and third party to mitigate such risks.
• Maintains a high level of awareness and knowledge of Anti-Bribery/Anti-Corruption (ABAC) regulations and requirements.

Required Qualifications and Preferred Background:

• Bachelor’s Degree in Finance or related field
• 5+ years of experience in Compliance, Audit, Law, or Risk Management
• ABAC compliance experience 
• Risk management certification - TRACE Anti-Bribery Specialist or similar certification - is a plus
• Collaborative problem-solver
• Experience with conducting ABAC due diligence on third parties

Physical Demands/Travel:

The physical demands of this job are consistent with light office duties. 

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is a remote office setting  

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Associate Director, Data Management

Function:

Clinical Data Management

Location:

Remote

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Associate Director, Clinical Data Management is responsible for leading and overseeing data management tasks for one (or more) clinical programs from study start-up through database lock for clinical trials.  The Associate Director, Data Management will manage a team within the Data Management Group and work collaboratively across multiple cross functional groups including Clinical Operations, Biostatistics and Clinical Science.  The Associate Director will also be responsible for DM vendor management, contracts and relationships to ensure database development, data review/cleaning, database auditing, database lock, and receipt of final database deliverables are in compliance with standard operating procedures and regulatory agency guidelines. The Associate Director, Data Management ensures all Data Management activities stay within full compliance of Loxo regulatory and legal policies.

Roles and Responsibilities of the Position:

• Represents Data Management for one (or more) clinical programs from a strategic planning and execution capacity in program team meetings and development strategy meetings
• Oversees the creation and execution of data management timelines used to coordinate and synchronize deliverables with the overall study timelines
• Evaluate and design DM processes for study execution, data delivery management as well as for initiatives which require cross functional collaboration
• Manage team within DM group for specific program including day to day operations, resource allocation for study, and career track development
• Participate in study vendor FRP/bid process for all vendors as required
• Evaluate and engage CRO/service providers for all studies and relationships as required
• Monitors the progress of all data management activities on all studies to ensure project timelines are met
• Proactively identifies potential program and delivery issues/risks and recommends/ implements solutions
• Collaborate with Statisticians and Statistical Programmers in production of clinical trial reports and other deliverables
• Performs any and all other tasks and activities as requested by CDO

Required Qualifications and Preferred Background:

• Bachelor’s degree in life sciences, math, computer science or related field required. Master’s degree in life sciences, math, computer science or related field preferred
• Minimum of 12+ years’ clinical data management experience
• Demonstrated leadership, line management and project management skills
• Oncology/Hematology experience strongly preferred
• Prior experience with biostatistics and SAS programming preferred
• Thorough and broad knowledge of data management processes, including EDC and interactive voice response system (IVRS)experience.
• Knowledge of regulatory guidelines such as GCP, 21 CFR Part 11 etc.
• Knowledge of study data tabulation model (SDTM)
• Must have excellent verbal, written and communication skills
• Ability to work independently as well as in a team environment
• Excellent time management skills and a proven ability to work on multiple projects at any given time in a fast-paced environment.
• Demonstrated ability to stay abreast of trends and new information in the profession

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Associate Director level position could range from between $135,300 to $198,516 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.

Available locations for this role:

• South San Francisco, CA
• Stamford, CT
• US Remote-Based

Physical Demands/ Travel:

The physical demands of this job are consistent with light office duties. This position will travel occasionally; the average travel for this position is 15-20% with some variation based upon the demands of the business imperatives.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in an office setting.  

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Associate Director/Director, Biostatistics and Statistical Programming Process and Infrastructure (BSPPI)

Function:

Biostatistics

Location:

Remote

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Associate Director/Director, Biostatistics and Statistical Programming Process and Infrastructure (BSPPI) will play a key role in modernizing the Biostatistics Department by assessing, improving, and managing its standards, infrastructure, and processes. The Associate Director/Director, BSPPI will work closely with the Loxo@Lilly Biostatistics leadership team, Lilly biostatistics and data management to establish best practices, processes and efficient integrated handoffs from data and analysis perspective. The Associate Director/Director, BSPPI will have an opportunity to influence best practices and innovative processes cross functionally to enable agile drug development in the context of an exciting and growing oncology portfolio.  

Roles and Responsibilities of the Position:

• Processes: Collaboratively lead assessment, implementation, and management of lean process development and associated documentation for biostatistics and statistical programming
• Infrastructure: Partner with leads from interfacing cross functions such as Data Management and IT across Loxo@Lilly and Lilly to analyze and continuously improve the computing infrastructure that includes statistical computing environment and standard software utilities 
• People: Develop collaborative relationships with relevant functions within Loxo@Lilly and Lilly by leading/participating in cross functional initiatives to bridge the differences in standards, processes, and infrastructure.
• Standards: Lead the development, improvement, and adaption of standards for statistical analysis documents, SAS and R programs, TFLs, and SDTM and ADaM datasets. Keep abreast with industry and regulatory trends related to biostatistics and statistical programming.
• Technology: Introduce/develop breakthrough and incrementally innovative technical capabilities to ensure optimal operation of Biostatistics department.

Required Qualifications and Preferred Background:

• Bachelor/Master’s/PhD Degree in Computer Science, Statistics, Mathematics, Life Sciences or other relevant scientific fields with a minimum 7-10 years Pharmaceutical/Biotech data science, programming and/or statistics experience is required
• Experience in analyzing, designing, developing, and managing the change of implementing innovative solutions is required
• Knowledge of SAS programming language and familiarity with macro development is required
• Knowledge of programming languages in addition to SAS such as R and Python, and programming tools used in clinical research and drug development is preferred.
• Solid knowledge of the drug development process, interaction of statisticians and statistical programmers, and experience in complex technical projects is required.
• Familiarity with regulatory guidelines, CDISC standards, biostatistics and statistical programming submission deliverables, and validation processes is required.
• Excellent verbal/written and interpersonal skills including the ability to communicate and collaborate effectively in a cross-functional setting 

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position level could range from between $135,300 to $ 198,516 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Physical Demands/Travel:

The physical demands of this job are consistent with light office duties. 

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Associate Manager / Senior Associate Manager, Business Operations

Function:

Business Operations

Location:

Remote

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Associate Manager / Senior Associate Manager of Business Operations is responsible for negotiating complex contracts to support drug development and related discovery pipeline needs including custom scientific engagements with external partners and CROs, material and data license agreements, sponsored research agreements, and associated amendments.

Roles and Responsibilities of the Position:

• Work with discovery primarily focusing on biology, translational medicine, biologics, biomarker, legal, and finance teams to help draft, negotiate and manage contract amendments in support of drug development and related discovery pipeline needs
• Identify and mitigate business risks throughout the contracting process
• Help manage projects resulting from these contracts, including working with project managers and finance to track results as well as financial and resource obligations

Required Qualifications and Background:

• Bachelor’s Degree in Science related discipline required
• 3+yearsof business development/vendor management experience, preferably in a biotechnology or pharmaceutical setting, with significant experience negotiating and managing molecular biology and exploratory research engagements
• Strong contract drafting, review and analysis skills with an emphasis on intellectual property
• Ability to communicate efficiently and effectively
• Ability to manage and meet strict deadlines, work independently, and multi-task
• Excellent attention to detail and critical thinking skills
• Experience optimizing the tracking and sharing of information, including establishing new processes and/or systems
• MS Office skills (Outlook, Word, Excel, PowerPoint)

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Associate Manager level position could range from between $78,000 to $114,498 and at the Senior Associate Manager level from between $89,750 to $131,672 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.

Physical Demands/Travel:

The physical demands of this job are consistent with light office duties

.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in an office setting.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Associate Manager, IT Contracts Manager (Contractor)

Function:

Business Operations

Location:

Remote

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Associate Manager of Business Operations is responsible for negotiating contracts to support IT related to drug discovery and development projects. 

Roles and Responsibilities of the Position:

• Work with information technology, discovery, legal, and finance teams to help draft, negotiate and manage contracts and amendments to support the business needs
• Identify and mitigate business risks throughout the contracting process
• Provides guidance to Loxo’s discovery project managers related to ongoing IT/discovery engagements
• Potential to support third party risk management process for IT vendors

Required Qualifications and Preferred Background:

• Bachelor’s degree
• 3+ years of contract management experience, including the drafting and negotiation of software licenses and professional services agreements
• Experience negotiating software to support drug discovery and bioinformatics is a plus
• IT vendor management experience
• Strong contract drafting, review and analysis skills
• Ability to communicate and collaborate efficiently and effectively in a dynamic environment
• Ability to manage and meet strict deadlines, work independently, and multi-task
• Excellent attention to detail
• MS Office skills (Outlook, Word, Excel, PowerPoint)

Physical Demands/ Travel:

 The physical demands of this job are consistent with light office duties.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in an office.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Associate Manager/Manager – GMP Audits

Function:

Quality Assurance

Location:

Remote

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

Loxo Oncology at Lilly is seeking a highly motivated QA Audit Associate Manager/Manager who is an excellent influencer and enjoys a fast paced, dynamic work environment. The ideal candidate has demonstrated strong knowledge in GXPs for small and large molecule pharmaceuticals in both clinical trials and product manufacturing. The candidate will manage the GxP audit program for third party qualifications as well as the internal audit program.  The candidate will lead a team of auditors as well as execute GxP audits. The Manager QA Audits will collaborate both internally and externally to oversee the planning and execution of all audits. 

Roles and Responsibilities of the Position:

• ·       Conducts Audits for which L@L is responsible
• ·       Key activities include, but are not limited to: 
• o   Plan, execute, and monitor L@L qualification audits
• o   Plan and execute internal audits
• o   Support development of an audit schedule
• o   Support audits conducted of L@L by outside auditors
• o   Partner with L@L functional areas to support Health Authority audits
• o   Partner with L@L Third Party Risk Management Team to determine required audits
• o   Partner with parent company to support strategic auditing initiatives
• ·       Provide input in Quality Management review, which includes metric generation and data analysis.
• ·       Support process improvement projects
• ·       Perform other duties as assigned. 

Required Qualifications and Background:

• Bachelor's Degree is required in science, health or related field 5-7 years experience in the Biotech/Pharmaceutical industry
• Working knowledge of Microsoft 365 suite, Veeva, etc.
• Comprehensive working knowledge of global GMPs requirements
• Strong working knowledge of global regulations and guidelines (e.g., FDA/EU and ICH) for early phase pharmaceutical development in both clinical trials execution and drug substance/drug product manufacturing (small and large molecule)
• Ability to adapt quickly to shifting needs and/or priorities.
• Strong Project Management skills in order to manage projects at various stages and effectively multi-task
• Able to interface well with all levels of personnel.
• Capacity to produce high quality results across multiple projects and demands, through effective prioritization, while working under short deadlines associated with a fast-paced dynamic scientific environment.
• Excellent communications skills, both written and verbal.
• Excellent teamwork, interpersonal skills and negotiation skills, both internally and externally.
• Strategic thinker, open-minded and flexible to adopting new ideas.
• Motivated, committed and self-managed.
• Willingness to work in a dynamic and changing corporate environment
• Requires a flexible work schedule to accommodate program priorities and international activities as needed.
• Exceptional attention to detail

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Associate Manager level position could range from between $78,000 to $114,498 and $103,200 to $151,423 for the Manager position, and will depend in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Physical Demands:

No physical demands.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

Ability to travel to travel 50%No specific work demands.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Associate Manager/Manager – QA Audits

Function:

Quality Assurance

Location:

Remote

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

Loxo@Lilly is seeking a highly motivated QA Associate Audit Manager who is an excellent influencer and enjoys a fast paced, dynamic work environment. The ideal candidate has demonstrated strong knowledge in GXPs for small and large molecule pharmaceuticals in both clinical trials and product manufacturing. The candidate will be responsible for working the third party risk management team as well as managing assigned audits (scheduling, conducting, following up and closing).

Roles and Responsibilities of the Position:

• Conducts audits for which Loxo@Lilly is responsible.
• Key activities include, but are not limited to: 
• o   Plan, execute, and monitor Loxo@Lilly qualification audits
• o   Plan and execute internal audits
• o   Support development of an audit schedule
• o   Support audits conducted of Loxo@Lilly by outside auditors
• o   Partner with Loxo@Lilly functional areas to support Health Authority audits
• o   Partner with Loxo@Lilly Third Party Risk Management Team to determine required audits
• o   Partner with parent company to support strategic auditing initiatives
• Provide input in Quality Management review, which includes metric generation and data analysis.
• Drive the inspection readiness program for clinical programs.
• Support process improvement projects.
• Perform other duties as assigned. 

Required Qualifications and Preferred Background:

• Bachelor's Degree is required in science, health or related field 5-7 years experience in the Biotech/Pharmaceutical industry 
• Working knowledge of Microsoft 365 suite, Veeva, etc.
• Comprehensive working knowledge of GCPs, GCLPs, CAP and CLIA requirements.
• Strong working knowledge of global regulations and guidelines (e.g., FDA/EU and ICH) for early phase pharmaceutical development in both clinical trials execution and drug substance/drug product manufacturing (small and large molecule). 
• Ability to adapt quickly to shifting needs and/or priorities.
• Strong Project Management skills in order to manage projects at various stages and effectively multi-task. 
• Able to interface well with all levels of personnel. 
• Capacity to produce high quality results across multiple projects and demands, through effective prioritization, while working under short deadlines associated with a fast-paced dynamic scientific environment.
• Excellent communications skills, both written and verbal.
• Excellent teamwork, interpersonal skills and negotiation skills, both internally and externally.
• Strategic thinker, open-minded and flexible to adopting new ideas.
• Motivated, committed and self-managed.
• Willingness to work in a dynamic and changing corporate environment.
• Requires a flexible work schedule to accommodate program priorities and international activities as needed.
• Exceptional attention to detail.

Additional Locations for this Role:

• Louisville, CO
• South San Francisco, CA
• Stamford, CT

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Associate Manager level position could range from between $78,000 to $114,498 and $103,200 to $151,423 for the Manager position, and will depend in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Physical Demands:

No physical demands. 

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

Ability to travel to travel 50%No specific work demands.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Associate Manager/Specialist, Quality Assurance - GMP

Function:

Quality Assurance

Location:

Remote

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Associate Manager/Specialist, Quality Assurance - GMP will work closely with Loxo@Lilly Regulatory, Drug Supply, CMC, and the associated contract organizations in support of activities associated with GMP manufacturing and release. The Associate Manager/Specialist, Quality Assurance – GMP will additionally provide Quality Systems support, as required.

Roles and Responsibilities of the Position:

• Work closely with Loxo@Lilly QA, CMC, Regulatory, Drug Supply, and CMO colleagues through all phases of drug development, particularly early phase to ensure compliance and timeliness of GMP work, including:
• Batch record review (Executed and Master) for all phases of manufacturing (drug substance, drug product, packaging, labeling, and associated intermediates)
• Final disposition of finished product for clinical use, including country-specific release and collaboration with Qualified Persons (QPs)
• Authoring and review of deviations, CAPAs, and change controls
• Investigation of product complaints
• Quality review of analytical documentation including: analytical methods; validation protocols and reports; specifications; and stability protocols, reports, and expiry extensions
• QC of IMPD/IND CMC sections
• Review and approval of clinical product labels
• Authoring/ revision of SOPs
• Implementation of process improvements
• Ensuring that GMP work at Loxo and contract organizations is done in compliance with applicable laws, regulations, guidelines, and SOPs.
• Participation on project teams and sub-teams as needed and assigned
• Additional tasks as required.

Required Qualifications and Preferred Background:

• BA/BS in science or engineering 
• A minimum of 5 years of experience in Quality Assurance in an FDA regulated Biotech or Pharmaceutical setting at the Specialist level, 8 + years at the Associate Manager level
• Experience in Batch Review and Release for clinical phase products
• Experience authoring and reviewing Deviations, CAPAs, and Change Controls
• Experience working with solid oral dosage products and/or Biologics
• Working knowledge of cGMP’s (CFR/ICH) and applicable international regulations/guidelines
• Experience working with Contract Manufacturing Organizations
• Strong understanding of GMP requirements for early phase drug development
• Attention to detail and accuracy of work
• Ability to work in a fast-paced environment to meet tight deadlines
• Ability to problem solve and implement process improvements
• Ability to serve as an active participant and contributor in cross-functional meetings
• Ability to escalate issues when necessary
• Ability to work in a cross-functional environment
• Ability to work in a virtual manufacturing environment
• Demonstrated ability to work well with other accomplished professionals
• Willing collaborator
• Strong communication skills, both written and oral

Additional locations for this role:

• Louisville, CO
• Stamford, CT
• South San Francisco, CA

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Specialist level position could range from between $67,850 to $99,563 and $78,000 to $114,498 at the Associate Manager level and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.

Physical Demands/ Travel:

The physical demands of this job are consistent with light office duties

.

Domestic and International Travel 10-15%

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

 Work Environment:

This position’s work environment is in an office, manufacturing facility.

The work environment characteristics described here are representative of those an employee encounters while performing the

essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Associate Scientist/Senior Associate Scientist/Scientist Cell Line Generation

Function:

Large Molecule Biology & Discovery Technologies

Location:

New York, NY

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

We are looking for a highly capable and motivated laboratory-based scientist experienced in cell line generation and characterization. This individual will be a part of the cell line generation/cell biology team that generates engineered cell lines for our preclinical programs in oncology. The primary responsibilities will include engineering cell lines for use in

in vitro

mechanistic assays and studies. The right candidate is expected to work within a collaborative team environment, while being able to work independently to design, execute, and optimize experiments. Beyond performing experiments, the scientist will analyze the data from experiments, present the data in meetings and work with the rest of the team to determine the next steps. Position level will be commensurate with applicant’s experience.

Roles and Responsibilities of the Position:

• Construct knockout and expression vectors using mammalian plasmid and lentiviral, adenoviral, or retroviral systems. Viral titer measurement, and viral stock maintenance.
• Generate engineered stable cell lines using transfection, CRISPR/Cas9 tools, lentiviral transduction, etc.
• Optimize cell line development platforms to improve speed and reproducibility of cell line development
• Perform routine molecular and cell biology techniques like DNA/RNA/protein extraction, qPCR analysis, western blot analysis, fluorescent microscopy and so on.
• Maintain cultures of frequently used suspension and adherent cell lines.
• Deposit and archive cell lines in the company’s repository cell line bank.
• Keep detailed and accurate laboratory records, present results at group meetings and project team meetings

Required Qualifications and Preferred :

• BA/BS/MS/PhD in biology, cell biology, molecular biology or a related field and 2+ years recent experience working with mammalian cell culture in industry, academic or research setting
• Basic tissue culture techniques such as cell propagation, cryo- preservation, maintenance and so on
• Prior cell culture experience with immortalized cell lines, cancer cell lines and/or primary cells
• Experience creating stable cell lines, transient transfections, viral transductions
• Experience with performing qPCR, ELISA, western blot, flow cytometry, and cell sorting, all in the context of mammalian cells. Fluorescent microscopy experience would be a plus.
• Experience in RNAi, CRISPR, and chemical inhibition of cellular pathways
• Prior experience with various analytical reagents such as Calcein AM, Cell Titer Glo, Alamar Blue, Annexin, PI/7AAD, and immunofluorescent antibodies
• A high level of proficiency with many kinds of scientific software used to operate lab equipment and/or the ability to quickly master new software
• Experience and proficiency with data analysis using statistical software such as Excel, Prism, Spotfire or others
• Must be organized and efficient and able to work according to timelines.
• Pharma/biotech drug discovery experience a plus    

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Associate Scientist level position could range from between $59,00 to $86,577 and that the base salary for the Senior Associate Scientist level position could range from between $67,850 to to $99,563 and that the base salary for the Scientist level position could range from between $78,000 to $114,498 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.

Physical Demands/ Travel:

The physical demands of this job are consistent with laboratory bench setting and light office duties.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in a laboratory-based setting.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Bioinformatics Engineer/Sr Bioinformatics Engineer

Function:

Target Discovery

Location:

Remote

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

We are seeking a talented and highly motivated Bioinformatics Engineer to join our Discovery Bioinformatics group. The successful candidate will build informatics solutions using high-performance computing and cloud technology multidimensional clinical and preclinical -omics data. They will provide the engineering leadership to build creative solutions to challenging data problems.

Roles and Responsibilities for the Position

• The successful candidate will have a flexible, learning mindset to design and work in a highly dynamic team, creating workflows to process and analyze high-dimensional data. This will include development of self-service analytics tools to enable and facilitate the real-time analysis of scientific data within our research community.

Required Qualifications and Preferred Background

• Bachelor’s/Master’s/PhD in computer science, bioinformatics, or equivalent experience
• 2+ years of software development experience, including experience in computer science, bioinformatics or other applied science
• Documented track record delivering and deploying large-scale informatics production solutions in the cloud using AWS/Azure and Docker
• Experience implementing bioinformatics pipelines using scalable cloud solutions. Familiarity with Nextflow is a plus.
• A strong knack for creating visually appealing UX/UI, and ability to abide by clear design rules.
• Understanding of NGS technology, and downstream -omics data analysis (RNAseq, ATACseq, ChIPseq, etc.).
• Familiarity with designing, maintaining and implementing relational databases. Experience with NoSQL databases a plus
• Proficiency in working within a Linux/Unix environment

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Scientist level position could range from between $78,000 to $114,498 and the Senior Scientist level position could range from between $89,750 to $131,672 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Computational Biologist (Multiple Locations)

Function:

Target Discovery

Location:

South San Francisco, CA

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

We are seeking a talented and highly motivated Computational Biologist to join our Discovery Bioinformatics group. The successful candidate will work closely with a multi-disciplinary team to rapidly advance small molecule drug development efforts. This position is expected to develop and validate data-driven hypotheses to advance transformative medicines.

Roles and Responsibilities of the Position:

• The successful candidate will work in a face-paced and highly collaborative environment to tackle important questions in oncology drug development. They will employ the latest genomics and statistical approaches to interrogate these questions. Success critically depends on an ability to effectively present complex analyses and results in a clear and concise manner to a diverse audience of scientists.

Required Qualifications and Preferred Background:

• MS/PhD in Bioinformatics, Biostatistics, Computational Biology, or similar area of study. Alternatively, post-graduate training in high-dimensional data analyses, supported by scientific achievements (eg., publications, patents, etc), would also be considered equivalent
• Relevant experience must be supported by scientific accomplishments such as publications, scientific presentations, patents, etc.
• Strong understanding of relevant concepts in cancer biology and molecular biology
• Hands-on experience with data analysis involving high-throughput molecular assays such as DNA/RNA-Seq, ATAC/ChIP-Seq, single-cell technologies, etc.
• Understanding of current best-practices for high-throughput genomics/molecular data analyses and their underlying statistical principles
• Experience using programming languages such as R, Python, or similar for statistical analysis

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position could range from between $78,000 to $114,497 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Available Locations for this role:

• South South Francisco, CA
• New York City, NY
• US Based- Remote

Physical Demands / Travel:

The physical demands of this job are consistent with light office duties.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in an office.  

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Director, Discovery Bioinformatics

Function:

Target Discovery

Location:

South San Francisco, CA

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

We are seeking a talented and experienced scientist to join our growing Discovery Bioinformatics team, operating in an interdisciplinary and tightly integrated research community at Loxo@Lilly. The successful candidate will be responsible for developing a vision with Oncology Leadership and oversee the strategy to guide computational biology efforts for target discovery in support of oncology drug development and translational research. This leadership position leads a team of diverse and talented computational scientists contributing to projects across multiple departments in Discovery, Research, and Clinical Development.

Roles and Responsibilities for the Position:

• The successful candidate will join a dynamic team and oversee computational biology efforts at the intersection of discovery, translational, and clinical research.
• They will lead a team, develop scientists, and help build a research strategy that leverages deep cancer biology knowledge and high-dimensional data.
• Success critically depends on the ability to foster a team to execute and communicate the broader computational biology vision and strategy.

Required Qualifications and Preferred Background:

• PhD in Bioinformatics, Biostatistics, Computational Biology, or similar area of study required with a minimum of 8 years of experience in computational biology, bioinformatics, and/or cancer biology
• Demonstrated track record of strategic scientific leadership leveraging computational biology to drive discovery in the clinical and pre-clinical settings
• Strong understanding of relevant concepts in cancer biology, drug development, and current therapeutic landscape in oncology
• Knowledge of current best-practices for high-throughput genomics/molecular data analyses and familiarity of their underlying statistical principles
• Excellent communication and interpersonal skills 

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position level could range from between $135,300 to $198,516 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Additional Locations for the Position:

• South San Francisco, CA
• Alexandria Center, NY

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Manager/Senior Manager, Data Management (Multiple Locations)

Function:

Clinical Data Management

Location:

Remote

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Manager/Senior Manager, Data Management is responsible for leading and overseeing data management tasks from study start-up through database lock for clinical trials.  This individual works collaboratively across multiple cross functional groups including Clinical Trial Managers (CTM’s), Biostatistics and Clinical Data Management vendors to ensure database development, data review/cleaning, database auditing, database lock, and receipt of final database deliverables are in compliance with standard operating procedures and regulatory agency guidelines. The Lead Clinical Data Manager ensures all Clinical Operations activities stay within full compliance of Loxo standard operating procedures (SOP) and regulatory agency guidelines.

Roles and Responsibilities of the Position:

• Represents Clinical Data Management at study team meetings with responsibility for operational execution of CDM activities.
• Executes and manages data management timelines to coordinate and synchronize deliverables with the overall study timelines.
• Generates and/or reviews/approves study documents (e.g. Data Management Plans, Case Report Forms, data transfer specifications, SAE and/or external data reconciliation plans, coding conventions, study protocols, UAT execution).
• Executes and/or distributes data management metrics, listings, and reports, as required.
• Escalate resource need to PL to meet the current study needs.
• Effectively apply knowledge of applicable internal, external and regulatory requirements/expectations (MHRA, FDA, ICH, GCP, PhRMA, Privacy, etc) to data collection and DM plans.
• Collaborate and oversee CRO/service providers on assigned studies.
• Executes/manages all data management activities on assigned studies to ensure project timelines are met.
• Continually seek means of improving processes to reduce cycle time and decrease work effort.
• Provides training on the CRF completion guidelines and EDC system at Investigator meetings and to internal or external team members, as needed.
• Proactively identifies potential study issues/risks and recommends/ implements solutions.
• Responsible for the accuracy and completeness of the clinical data collected during a clinical trial for all data deliverables.
• Provide DM support to Statisticians and Statistical Programmers in production of clinical trial reports and other deliverables.
• Work with partners to increase vendor/partner efficiencies.
• Performs any and all other tasks and activities as requested.

Required Qualifications and Preferred Background:

• Bachelor’s degree in life sciences, math, computer science or related field required.
• Minimum of 6+ years’ clinical data management experience.
• A minimum of 1+ years of direct sponsor experience required.
• Demonstrated leadership and project management skills.
• Thorough and broad knowledge of data management processes, including EDC and interactive voice response system (IVRS)experience.
• Demonstrated proficiency in MS Office (Outlook, MS Word, Excel, PowerPoint).
• Experience with web-based Electronic Data Capture (EDC), clinical data management systems and industry wide thesauri, such as MedDRA and WHO Drug.
• Good working knowledge of regulatory guidelines such as GCP, 21 CFR Part 11 etc.
• Knowledge of industry standards (CDISC, SDTM, ADaM, CDASH).
• Excellent verbal, written and interpersonal skills required for working successfully in a cross-functional team environment.
• Able to communicate and collaborate effectively with cross-functional teams in face-to-face conversation, by telephone and by email.
• Proven ability to work independently as well as in a team environment.
• Excellent time management skills and a proven ability to work on multiple projects at any given time in a fast-paced environment.
• Demonstrated ability to stay abreast of trends and new information in the profession.
• Excellent verbal/written and interpersonal skills required for working successfully in a cross-functional team environment.
• Able to communicate and collaborate effectively with cross-functional teams in face-to-face conversation, by telephone, and by email.

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Manager position level could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.

Additional Preferred Qualifications:

• 5+ years prior oncology/hematology experience highly desirable.
• Recent Phase 3 registration study and submission experience preferred.

Available locations for this role:

• Stamford, CT
• South San Francisco, CA
• US Based-Remote

Physical Demands / Travel

The physical demands of this job are consistent with light office duties

. 

This position will travel occasionally; the average travel for this position is 15-20% with some variation based upon the demands of the business imperatives.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in a home-based office setting.  

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Manager/Senior Manager, Project Management, Oncology Research

Function:

Program and Alliance Management

Location:

Remote

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Manager/Sr. Manager will play a critical role in establishing program strategic goals and implementing them through project execution as a part of the Loxo Oncology Research, specifically focusing on Target Discovery and Translational Sciences portfolio. Loxo Oncology Research focuses on early discovery research, translational, preclinical, and early development within Loxo Oncology at Lilly. The role will be responsible for facilitating program strategic goals, planning and execution of deliverables within scope, budget and timeline, in a cross-functional, dynamic environment. The role will work closely with Target Discovery and Translational Sciences team members as well as project team leads to create and implement project strategic plans for programs from early discovery to translational (supporting early and late phase clinical assets). This includes assessment of external outsourcing needs in the form of actively engaging, identifying, establishing, and managing external collaborators and vendors to meet any outsourcing needs. 

Roles and Responsibilities for the Position

• Facilitate and support project teams in establishing and translating strategic program goals into project plan(s) with clearly outlining deliverables, milestones, and go/no-go decisions.
• Engage with team members of discovery biology, discovery bioinformatics, discovery signaling, and translational sciences to track project activities ensuring alignment of project deliverables with strategic goals.
• Actively facilitate project meetings with internal and external stakeholders (create agendas, minutes, and track action items).
• Drive day-to-day operational activities by coordinating with stakeholders from different functional departments – business operations (third party contracts initiation and tracking), procurement, finance, and other relevant functional areas as needed.
• Excellent in adaptive communications; effectively manage communications vertically and horizontally in a cross-functional environment involving external and internal stakeholders.
• Contribute to project communications and identifying gaps and ambiguities in communication channels and addressing them to maintain alignment across the team.
• Actively contribute to create project updates, reports, presentations, and memos and maintain project document repository.
• Identify and assess the needs for outsourcing, establish relationships with external collaborators, and manage alliances on an ongoing basis.
• Drive day-to-day operational activities by coordinating with stakeholders from different functional departments - legal/Business operations, procurement, finance, and other relevant functional areas.
• Adaptive to change in priorities and able to drive project outcomes ensuring re-alignment with program deliverables in changing landscape.
• Contribute to building positive, collaborative teams across various scientific disciplines, and encouraging sharing of new ideas, and creative ways to solve problems often needed in discovery research.
• Support the creation of an organizational project framework for different functional groups and build operational guidelines and processes. 

Required Qualifications and Preferred Background

• BS degree with 5+ years project management experience in relevant scientific fields (e.g., Biology) or Master’s degree with 3+ years project management experience in within Biotech, pharmaceutical, or healthcare research setting.
• Prior experience is in program management in early drug discovery or translational research setting will be preferable.
• Excellent verbal, written communication, and interpersonal skills.
• Excellent organizational skills, efficient, with strong attention to detail

Additional Preferences:  
• PMP certification is desirable
• Experience in managing external suppliers, vendors, and other external alliances and seasoned in navigating through ambiguities associated with early-stage discovery research
• Ability to anticipate key challenges and proactively propose solutions
• Adaptive to changes and apply creative problem-solving skills to meet project and other operational needs
• Proficient in identifying and applying tools to effectively manage and track projects - MS Office suite, MS Project, other Project Management tools
• Create and implement new tools and work towards creating and implementing processes customized for furthering discovery research

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Manager level position could range from between $103,200 to $151,423 and anticipates that the base salary for the Senior Manager level position could range from between $118,700 to $174,137 but will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.

PhysicalDemands/ Travel:

The physical demands of this job are consistent with light office duties.  Travel - up to 25%

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Principal Scientist, Bioassay, Mass Spectroscopist

Function:

Bioassay

Location:

Louisville, CO

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Bioassay Principal Scientist, Mass Spectroscopist will be responsible for performing analyses of covalent interactions between enzymes and irreversible inhibitors to support drug discovery in a team environment. The scientist fulfilling this position will be responsible for characterizing adducts formed between enzyme and irreversible inhibitor and determining the kinetics of this interaction.  A strong background in experimental curve-fitting, statistics, and mass spectroscopic method develop and execution is required.

Roles and Responsibilities of the Position

• Design, develop, and execute mass spectroscopic analyses of the covalent interactions between enzymes and irreversible inhibitors.
• Actively engage in advancing small molecule drug discovery oncology programs.
• Perform comprehensive data analysis
• Communicate experimental findings to team members
• Actively engaged in advancing drug discovery programs 
• This is a “hands-on” laboratory, based position.

Required Qualifications and Preferred Background

• BS/MS/Ph.D. in biochemistry, biophysics, analytical chemistry, or related fields
• Ph.D. with >5 years’ experience in industry and/or academia, or BS or MS with >10 years industrial experience.
• Experience with instrumentation and data analyses for quadropole time of flight mass spectroscopy
• Covalent small molecule screening experience
• Experience in determining intact mass of protein adducts
• Excellent oral and written communication skills including experimental documentation.
• Strong enzymology background with experience in data analysis of irreversible inhibition (i.e., determining Ki and kinact values).
• Works well with team members across functional areas.
• Ability to multi-task and shift priorities rapidly to meet tight deadlines.
• Highly organized with exceptional attention to detail.
• Good and thoughtful listener.
• Enthusiastic, self-motivated and a continuous learner
• Proficient in Microsoft Office suite and applications

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Principal Scientist level position could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Principal Scientist, Bioassay, SPR Specialist

Function:

Bioassay

Location:

Louisville, CO

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Bioassay Principal Scientist, SPR-Specialist will be responsible for developing and performing binding assays to support drug discovery in a team environment. The scientist fulfilling this position will be responsible for developing screening assays and characterization of small molecule binding affinities and on and off rates.   A strong background in experimental curve-fitting, statistics, and assay optimization and execution is required.

Roles and Responsibilities of the Position

• Design, develop, and execute Surface Plasmon Resonance (SPR) assays.
• Conduct high-throughput fragment screens to identify starting points for Small Molecule Discovery
• Develop robust SPR assays to drive target potency
• Collect data to measure KD values and on and off rates of small molecules
• Actively engage in advancing small molecule drug discovery oncology programs.
• Screen small molecule inhibitors to drive internal structure-based drug design.
• Perform comprehensive data analysis
• Communicate experimental findings to team members
• Actively engaged in advancing drug discovery programs 
• This is a “hands-on” laboratory, based position.

Required Qualifications and Preferred Background

• BS/MS/Ph.D. in biochemistry, biophysics, or related fields
• PhD with >5 years’ experience in industry and/or academia, or BS or MS with >10 years industrial experience.
• The successful candidate is expected to have expertise in biochemistry and assay development.
• Experience with Biacore Instrumentation is a requirement.
• Experience with Biacore 8K+ is a plus.
• Strong background in curve-fitting
• Excellent oral and written communication skills including experimental documentation.
• Works well with team members across functional areas.
• Ability to multi-task and shift priorities rapidly to meet tight deadlines.
• Highly organized with exceptional attention to detail.
• Good and thoughtful listener.
• Enthusiastic, self-motivated and a continuous learner
• Proficient in Microsoft Office suite and applications

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Principal Scientist level position could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.

Physical Demands/ Travel:

The physical demands of this job are consistent with laboratory bench setting and light office duties.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in a laboratory-based setting.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Principal Scientist, Translational Sciences

Function:

Translational Sciences

Location:

Indianapolis, IN

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Principal Scientist, will be part of the Loxo@Lilly’s Translational Sciences group in Indianapolis, IN. The Translational Sciences group is responsible for developing and executing strategies for precision medicine including identifying and validating biomarkers, establishing combination strategies and understanding drug resistance. The Principal Scientist, will have a strong understanding of cell cycle and signal transduction pathways. This is a hands-on position for an experienced scientist who enjoys working in the lab. The successful candidate must have excellent people skills and be able to work with a positive, “can-do” attitude in a dynamic, fast-paced, team environment focused on high quality science to deliver innovative cancer drugs. 

Roles and Responsibilities of the Position:

• Design and execute key experiments to evaluate compounds, identify combination partners and investigate drug resistance.
• Translate preclinical findings to biomarker and combination strategies to advance programs to clinical development
• Work closely with clinical team to develop and test hypotheses that could determine the clinical response and define the patient populations.  
• Engage in cross-functional collaborations across the company.
• Identify, evaluate, and manage vendors for outsourced services and studies.
• Prepare reports for internal and external purposes including regulatory submissions.
• Participate and lead project-based and technical team meetings to identify and solve problems, guide work towards project goals, communicate on-going work and progress, and plan forward thinking strategies. 

Required Qualifications and Background:

• PhD in Molecular/Cellular Biology or Biochemistry, or related field with either:
• 6+ years hands-on molecular and cell biology experience AND 2+ years work experience in a biotech/pharma setting or
• 10+ years hands-on molecular and cell biology experience
• OR a BS/MS in Molecular/Cellular Biology or Biochemistry with either
• 10+ hands-on molecular and cell biology experience AND 4+ years work experience in a biotech/pharma setting or
• 15+ years hands-on molecular and cell biology experience

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Principal Scientist level position could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.

Physical Demands/ Travel:

The physical demands of this job are consistent with working in a laboratory/ bench environment. Some light lifting, and maneuvering may be required.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in a lab/bench environment.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Principal/Senior Principal Scientist, DMPK (multiple locations)

Function:

Small Molecule Discovery

Location:

Remote

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

Loxo@Lilly’s Drug Discovery team has an immediate opening for an experienced drug metabolism scientist. The Loxo@Lilly team’s mission is to invent life-changing targeted therapies for cancer patient populations that are poorly treated by existing therapies. To that end, we have built a multi-disciplinary team of dedicated drug discovery scientists who are passionate about driving the science forward to create highly selective drugs for known oncogenic drivers. We are currently looking for accomplished DMPK program representative with a proven track records of success in small molecule drug discovery. The ideal candidate will be passionate about solving complex DMPK challenges and will excel at working closely with scientists across disciplines. The position requires excellent people skills, a positive can-do attitude, and the ability to thrive in a highly interactive, fast-paced, team environment.

Roles and Responsibilities for this Position:

• Design and execute in vitro and in vivo preclinical studies to understand the pharmacokinetics (PK) and absorption, metabolism, distribution, and excretion (ADME) of new chemical entities (NCE)
• Provide management and oversight of CROs in the conduct of in vitro and in vivo ADME studies
• Advise medicinal chemistry teams on complex DMPK issues
• Perform non-compartmental pharmacokinetic analysis on data
• Review in vivo protocols and study reports
• Collate data and present to program teams
• Contribute to authoring and review of regulatory reports and documents
• Maintain accurate and timely electronic lab notebook

Required Qualifications and Preferred Background:

• BS, MS or Ph.D. in medicinal chemistry, biochemistry or related discipline
• BS with 10+, MS with 8+ or Ph.D. with 5+ years of DMPK experience
• Experience managing and overseeing CROs
• Experience managing Bioanalytical and Pharmacokinetic studies strongly preferred
• Must have pharmacokinetic modeling experience
• Experience with bioanalysis method and assay development
• Good written and oral presentation capabilities

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Principal Scientist position level could range from between $103,200 to $151,423 and that the base salary for the Senior Principal Scientist position level could range from between $118,700 to $174,137 will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Available Locations for this role:

• New York, NY
• US Based-Remote

Physical Demands/ Travel:

The physical demands of this job are consistent with light office duties. 

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in an office.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Principal/Senior Principal Scientist, Mass Spec, Large Molecule Discovery

Function:

Large Molecule Discovery

Location:

South San Francisco, CA

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Principal/Senior Principal Scientist, Mass Spec, Large Molecule Discovery will play an important role in the discovery and development of transformative therapeutics in the Loxo@Lilly Large Molecule Discovery team. The role requires a clear understanding of Large Molecule Discovery strategy. This role will potentially lead a team that will  address challenges in characterization of antibodies, reagent proteins and ADCs with mass-spectrometry. This includes conducting and overseeing experiments for protein/ antibody peptide mapping, intact mass analysis, post-translational modification (PTM) analysis, ADC characterization,  developability assessment, and pre-clinical in-vivo/pharmacokinetic studies utilizing bioanalytical techniques, mass-spectrometry, and other analytical characterization. 

Roles and Responsibilities of the Position:

• Lead a team that will specialize in characterization of therapeutic proteins that include ADCs, bispecific and other format antibodies, with mass-spectrometry and analytical techniques
• Responsible for developing strategies that include identification of above listed therapeutic proteins and protein reagents by peptide mapping, intact mass analysis, and post-translational modification (PTM) analysis
• This role will be tasked with ADC characterization, and developability assessment, and pre-clinical in-vivo/pharmacokinetic studies utilizing bioanalytical techniques
• Present data at meetings that may include representatives from other departments and/or outside parties and participates in brainstorming and troubleshooting within team, offering, and implementing solutions to problems.
• Participate in designing, overseeing, and executing key experiments for analytical and mass-spectrometry based characterization of these large molecules from early discovery to early development stage.
• Interact and collaborate with other teams across the company to provide analytical and mass-spec solutions; analyze, collate, and disseminate data to teams in a timely manner
• Work cross-functionally as part of internal multi-disciplinary teams, as well as working with external partners and CROs.

Required Qualifications and Background:

• PhD degree in Chemistry or Biological Science with 6 years’ experience at the Principal Scientist level and 8+ years at the Senior Principal Scientist level or MS/BSc degree in Life or analytical sciences or equivalent fields with at least 12 years of relevant job experience in the biopharma industry with good understanding of drug development process with emphasis on antibody-drug conjugates.
• Experienced in setting up and maintaining mass-spectrometry and analytical research lab.
• Demonstrated proven expertise in protein mass-spectrometry for antibodies including LC-MS intact protein analysis, peptide mapping, conjugate analysis, PTMs, de-novo sequencing, and chemical modifications
• Experienced in small molecule and protein mass-spectrometry of antibody drug-conjugates (ADC) for characterization of conjugation site analysis, positional isomers, free drug, drug stability, and metabolite analysis
• Experienced in setting up studies for assessment of antibodies and ADCs for developability/CMC and assist in writing of technical reports, SOPs, and regulatory documents for IND
• Prior experience in participation of team efforts for antibody lead panel generation, lead optimization, and IND enabling studies
• Demonstrated can-do attitude and brings innovative ideas in challenging projects set up in a collaborative, cross-functional organization
• Excellent communication skills and with strong organizational abilities

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Principal Scientist position level could range from between $103,200 to $151,423 and the Senior Principal Scientist position level could range from between $118,700 to $174,137 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Physical Demands/ Travel:

The physical demands of this job are consistent with laboratory bench setting.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in a lab.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Project Manager, Third Party Management, Consultant

Function:

Business Operations

Location:

Remote

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

Loxo@Lilly is seeking a Project Manager to support third party management. The ideal candidate has an understanding of the various risk domains that are relevant for third party management and is able to multi-task and remain extremely organized to manage risk assessments for many vendors simultaneously. The candidate will work collaboratively with both internal colleagues and external third parties to manage assessments from the initial request to completion as well as monitoring thereafter

.

Roles and Responsibilities of the Position:

• Oversees and acts as Business Operations point person for the third party management process and works closely with Quality and contracting team. Key activities include, but are not limited to: 
• Checking and communicating the status of third party vendors.
• Maintaining a third party qualification list.
• Facilitating qualification reviews by subject matter experts for various risk domains.
• Managing the third party management IT system.
• Working with internal and external business partners to facilitate timely completion of assessments and periodic reviews.
• Collaborating with stakeholders for continuous process improvement improvement of processes.
• Ensuring seamless communication between Loxo@Lilly and Lilly.

Required Qualifications and Preferred Background:

• Bachelor's Degree is required with 3+ years experience in the Biotech/Pharmaceutical industry.
• Understanding of key risk areas to be assessed (e.g., privacy, anti-corruption, etc.).
• Ability to adapt quickly to shifting needs and/or priorities.
• Strong project management skills in order to manage projects at various stages and effectively multi-task.
• Working knowledge of a comprehensive enterprise risk management process.
• Effective communication skills.
• Enjoys fast-paced, dynamic environment.
• Exceptional attention to detail.

Physical Demands/ Travel:

The physical demands of this job are consistent with light office duties

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in an office or remote based

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Research Associate, Proteomics

Function:

Molecular & Cellular Biology

Location:

South San Francisco, CA

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

This position is an opportunity to learn and grow within a dynamic discovery biology team dedicated to creating specific targeted therapeutics for genetically defined oncology targets. The ideal candidate is someone who enjoys technical challenges, has the protein handling and cell culture skills needed to drive basic oncology research forward, and will excel in a collaborative environment.  Experience with cell culture and biochemical techniques will be critical.  Direct experience with sample preparation and method development for mass spectrometry are desirable.  The ideal candidate will be enthusiastic about cancer research and is not afraid to get their hands dirty by helping with core lab functions including cell culture, protein characterization, mass spectrometry, and laboratory automation. The qualified candidate will have experience with basic chemistry/biology laboratory practices and is passionate to learn additional techniques working in a growing and dynamic group focused on discovery research. The candidate will work as part of a collaborative team of scientists with expertise in protein characterization, cell culture, chemistry, biochemistry, structure, and biophysics, supporting hit-to-lead and lead-ID phases of our oncology drug programs. The candidate will have opportunities to learn cutting edge techniques and to learn and develop technical expertise in proteomics.

Required Qualifications and Preferred Background:

• BA/BS, MS in Chemistry, Biology, Biochemistry, or related field
• Ideal candidate will have hands-on experience with cell culture, sample preparation, and sample handling.
• Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels.
• Highly organized with excellent analytical, documentation and multi-tasking skills.
• Familiarity with Thermo Orbitrap and/or Bruker timsTOF Pro instrumentation is ideal.
• Experience in cell line generation is a plus.
• Experience with mass spectrometry/proteomics is a plus.
• Expertise in other methods of enzymology or biophysical characterization and structural biology is a plus.

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Research Associate level position could range from between $50,000 to $63,250 and the Senior Research Associate level position will range from $58,000 to $85,109, and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.

Physical Demands/ Travel:

The physical demands of this job are consistent with laboratory setting. 

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in a lab. 

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Research Associate/Associate Scientist, Biophysics

Function:

Biophysics

Location:

Louisville, CO

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

Loxo@Lilly's newly formed Drug Discovery group in Louisville, Colorado has an immediate opening for a researcher in Biophysics. The Loxo Drug Discovery group’s mission is to invent life-changing targeted therapies for cancer patient populations that are poorly treated by existing therapies. To that end, we are building a multi-disciplinary team of dedicated drug discovery scientists who are passionate about driving the science forward to create highly selective drugs for known oncogenic drivers.

The ideal candidate is self-motivated, responsible, and a productive scientist who enjoys collaborating with biologists, chemists, and assay scientists.  In this role, he/she will utilize a variety of assay technologies including mass spectrometry, fluorescence spectroscopy, surface plasmon resonance, and isothermal titration calorimetry to evaluate protein/ligand interactions.  Experience in protein purification and characterization is a plus. This position requires excellent people skills, a positive can-do attitude, passion for lab work, attention to detail, and the ability to thrive in a highly interactive, fast-paced, team environment. 

Roles and Responsibilities of the Position:

• Prosecute biophysical assays to identify and characterize small-molecule modulators using a variety of techniques and detection methods, including chromogenic, MS, SPR, ITC, FP, FRET and TR-FRET
• Continuously expand our biochemical characterization repertoire by exploring and developing additional assay and technological instrumentation
• Calculate and report assay results to the project teams
• Document experiments and results in electronic notebook, and results database

Required Qualifications and Preferred Background:

• A BS or MS with 0-3+ years relevant work experience. Level commensurate with education and experience
• Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels
• Highly organized and detail oriented with excellent analytical, documentation, and multi-tasking skills
• Committed continual learner, who is accustomed to staying current with the latest scientific breakthroughs in structure-based drug design and biophysics
• Expertise in other methods of enzymology or biophysical characterization and structural biology is a plus
• Protein Purification and characterization a plus

Loxo Oncology, Inc. currently anticipates that the base salary for the Research Associate level position could range from between $50,000 to $73,370 and that the base salary for the Associate Scientist could range from between $59,000 to $86,577 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.

Physical Demands/Travel:

The physical demands of this position are consistent with working in a laboratory/ bench environment. Some lifting, and maneuvering of equipment may be required.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is based in a laboratory/ bench environment.

The work environment characteristics described here are representative of those an employee encounters while preforming the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Scientist, Organoid Team, Discovery Technologies

Function:

Large Molecule Biology & Discovery Technologies

Location:

New York, NY

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Scientist in the Discovery Technologies, Organoid Group, will be joining a large and dynamic group focused on executing experiments on the cutting edge of pharmaceutical sciences. The candidate will execute experiments to support various research programs for identified targets and will be expected to demonstrate expertise with various organoid and patient-derived models, to be able to troubleshoot technical difficulties encountered in organoid growth, and to interrogate the work of third parties and collaborators. The candidate will also be encouraged to develop their own ideas, contribute these to the broader organoid group as well as project teams, and is expected to be a dynamic and motivated scientist who can drive their own experiments and research activities, while collaborating extensively with the rest of the organization to execute on various research programs. The candidate will collaborate with project teams in NYC, Indianapolis, SSF, and Boulder for design and execution of studies, and will work closely with multi-disciplinary teams, providing expertise throughout all stages of the lifecycle of target modulation and validation to advance our portfolio. 

Roles and Responsibilities of the Position:

• Scientific roles and responsibilities:
• Develop key capabilities for the generation of necessary patient-derived organoid models for detailed functional characterization
• Design and execute studies to profile candidate molecules in organoid systems
• Troubleshoot technical difficulties encountered in organoid establishment, growth and testing
• Test biologics or small molecules in organoid tumor models (dose response experiments, profiling, comparing to control compounds)
• Grow organoids of various types; have extensive knowledge of media and growth factors on organoid development
• Perform experiments that modulate target expression in organoid systems
• Interrogate experimental conduct of third parties/vendors
• Additional responsibilities:
• Communicate results at project team meetings, be involved in the coordination and preparation of presentations
• Discuss results with technical as well as non-technical personnel
• Lead, and work collaboratively across multiple laboratory-based functions to establish the mechanisms, phenotypes, and biology of new targets using modern approaches in molecular and cellular biology and biochemistry
• Work in cross functional environments via extensive collaboration with other parts of the organization
• Direct leadership of a junior scientist may be required

Required Qualifications and Preferred Background:

• BS degree in biological sciences with 5 years of experience or MS/PhD in biological sciences with 2-3 years of experience required
• Extensive expertise working with organoid models
• Deep expertise in cancer disease states (indications, mutational status, tumor cell drivers)
• Demonstrated experience in working collaboratively across various scientific disciplines to meet end goals of business
• Excellent communication and interpersonal skills
• Demonstrated ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines
• Excellent written and verbal communication skills

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the {insert position} level position could range from between $78,000 to $ $114,498

and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.

Physical Demands/ Travel:

The physical demands of this job are consistent with laboratory setting.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in a lab. 

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Scientist, Structural Biology

Function:

Structural Biology

Location:

Louisville, CO

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

This position offers the opportunity to be part of Loxo’s discovery teams focused on creating novel, highly specific and selective drugs for genetically identified targets.  The Structural Biologist will offer structural and mechanistic insights to a multi-disciplinary discovery team by providing high-resolution protein-ligand crystal structures.  This role also provides the opportunity to work on larger, collaborative structural biology projects involving cryo-EM.

Roles and Responsibilities for the Position:

• Generate protein-small molecule complex x-ray crystal structures with hands-on lab involvement throughout the entire gene to structure process including protein expression, purification, crystallization, and structure determination
• Coordinate protein construct design, expression, and purification with the project team to support biochemical and biophysical assays.
• Rapidly communicate scientific results and insights to the team
• Identify, evaluate, and manage vendors for outsourced services and studies
• Collaborate with colleagues throughout the company to ensure structural work meets the program needs and results are appropriately interpreted
• Participate and lead project-based and technical team meetings to identify and solve problems, guide work towards project goals, communicate on-going work and progress, and plan forward thinking strategies
• Develop and continually advance one’s knowledge base on genetically targeted drugs and structure-based drug design
• Proactively investigate new or different technologies, methods, and service providers to ensure our work is being done in a scientifically sound, efficient, and reasonable way
• In the future, this position’s responsibilities may include supervision of scientists and associates

Required Qualifications and Preferred Background:

• PhD in Biochemistry, Biophysics, Chemistry, or related field
• Ideal candidate will have with 5+ years hands-on gene to structure protein-small molecule crystallography experience in a biotech/pharma setting
• Experienced in crystallization of protein-small molecule complexes and high-resolution x-ray structure determination
• Extensive experience in protein construct design, expression, purification, and characterization
• Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels
• Highly organized with excellent analytical, documentation and multi-tasking skills
• Committed to staying current with the latest scientific breakthroughs in structure-based drug design and structural biology.
• Experience in other methods of biophysical and structural biology, such as Cryo-EM, is a plus
• A learners mindset

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Scientist level position could range from between $78,000 to $114,498 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Physical Demands/ Travel:

The physical demands of this job are consistent with laboratory setting.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in a lab.  

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Scientist/Senior Scientist Chemistry/Bioconjugation, Large Molecule Discovery

Function:

Large Molecule Discovery

Location:

South San Francisco, CA

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

Loxo@Lilly’s Large Molecule Discovery team is looking for a Scientist/Senior Scientist, in Chemistry/Biochemistry to support our growing biologics portfolio. This role will support Antibody-drug conjugates (ADCs) linker and payload design, conjugation chemistry, and downstream biochemical assays to enhance ADC biological and pharmacologic properties. We are looking for a strong scientist with good knowledge and hands-on experience in designing, preparing, and characterizing ADCs. This individual will be a self-motivated, responsible, and productive scientist who enjoys collaborating. He/she will be responsible for rigorous experimental design, data analysis, and data interpretation. This position requires excellent people skills, a positive can-do attitude, and the ability to thrive in a highly interactive, fast-paced, team environment.

Roles and Responsibilities of the Position:

• Work with the bioconjugate chemistry and cross-functional teams to prepare, analyze, and optimize the linker-payload and its bioconjugation chemistry.
• Apply organic and medicinal chemistry skills to explore new ADC payload and linker designs to enhance ADC biological and pharmacologic properties.
• Work on the ADCs-related structure-activity relationships (SAR) study design and development.
• Perform enzyme kinetic analyses and MOA studies to characterize biological enzymes in the lysosomal and subcellular fractions.
• Oversee outsourcing linker-payload and bioconjugation chemistry to external CROs and monitor results.
• Maintain scientific and technical expertise through familiarity with scientific literature and attending conferences.
• Document experiments and results in electronic notebook or database. 

Required Qualifications and Background:

• Ph.D. in Chemistry/Biochemistry discipline (>0-5 years for Ph.D., either in the industrial or academic environment), with a record of lab-based independent research experience.
• Strong foundation in chemical biology research and development.
• Hands-on experience with classic conjugation techniques for therapeutic proteins.
• Experience with protein purification systems is preferred
• Must be highly collaborative and able to effectively engage small-molecule research project teams to make rapid progress.
• Demonstrated ability to work well with other accomplished professionals within and across functions/teams.
• Ability to multi-task and shift priorities rapidly to meet tight deadlines.
• Excellent written and verbal communicator.
• Detail oriented and well organized.
• Enthusiastic, self-motivated, and keen to improve processes. 

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Scientist level could range from between $78,000 to $114,498 and that the base salary for the Senior Scientist could range from between $89,750 and $131,672 but will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Physical Demands/Travel:

The physical demands of this position are consistent with working in a laboratory/ bench environment. Some light lifting, and maneuvering may be required.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

  Work Environment:

 This position’s work environment is based in a laboratory/ bench environment.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Scientist/Senior Scientist, Biophysics

Function:

Biophysics

Location:

Louisville, CO

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

Loxo's newly formed Drug Discovery group in Louisville, Colorado has an immediate opening for a researcher in Biophysics. The Loxo Drug Discovery group’s mission is to invent life-changing targeted therapies for cancer patient populations that are poorly treated by existing therapies. To that end, we are building a multi-disciplinary team of dedicated drug discovery scientists who are passionate about driving the science forward to create highly selective drugs for known oncogenic drivers.

The ideal candidate is self-motivated, responsible, and a productive scientist who enjoys collaborating with biologists, chemists, and assay scientists.  In this role, he/she will utilize a variety of assay technologies including mass spectrometry, fluorescence spectroscopy, surface plasmon resonance, and isothermal titration calorimetry to evaluate protein/ligand interactions.  Successful candidate will have a demonstratable history of developing, and executing, creative biophysical assays.  Some experience in coding is a plus, including but not limited to Python, R, Go, and SAS. This position requires excellent people skills, a positive can-do attitude, passion for lab work, attention to detail, and the ability to thrive in a highly interactive, fast-paced, team environment. 

Roles and Responsibilities of the Position:

• Design and develop novel biophysical assays to identify and characterize small-molecule or biological modulators using a variety of techniques and detection methods including chromogenic, MS, SPR, ITC, FP, FRET and TR-FRET
• Experimentally explore biological consequence of mechanism of inhibition by coordinating experiments with our cell biology team.
• Creatively address biologic/biophysical questions across a wide variety of techniques and technologies
• Continuously expand our biochemical characterization repertoire by exploring and developing additional assay and technological instrumentation
• Calculate and report assay results to the project teams
• Document experiments and results in electronic notebook, and results database
• Software coding experience is a plus

Required Qualifications and Preferred Background:

• A BS, MS, or PhD in a Life Sciences discipline, with training in molecular biology, enzymology or biochemistry, and a record of lab based independent research experience, minimum of 10 years for BS, >5 years for MS and >0-3 years for PhD, either in industrial or academic environment
• Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels
• Highly organized and detail oriented with excellent analytical, documentation, and multi-tasking skills
• Committed continual learner, who is accustomed to staying current with the latest scientific breakthroughs in structure-based drug design and biophysics

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Scientist level position could range from between $78,000 to $114,498 and the base salary at the Sr. Scientist level could range between $89,750 and $131,672 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.

Physical Demands/Travel:

The physical demands of this position are consistent with working in a laboratory/ bench environment. Some lifting, and maneuvering of equipment may be required.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is based in a laboratory/ bench environment.

The work environment characteristics described here are representative of those an employee encounters while preforming the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Scientist/Senior Scientist, Enzymology

Function:

Small Molecule Discovery

Location:

San Diego, CA

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Enzymology Scientist or Sr. Scientist will be responsible for developing and performing enzyme and binding assays to support drug discovery and development in a team environment. The scientist fulfilling this position will be responsible for characterizing the effects of small molecules on specific protein targets and will provide enzymology expertise to the project teams.  A strong background in experimental curve-fitting, statistics, and assay optimization and execution is required.

Roles and Responsibilities of the Position:

• Design, develop, and execute enzyme and binding assays in multiple formats
• Screen small molecule inhibitors in plate-based assays formats to drive internal structure-based drug design
• Operate, implement, and troubleshoot laboratory automation
• Actively engage in advancing small molecule drug discovery oncology programs
• Perform comprehensive data analysis 
• Communicate experimental findings to team members
• Operate, implement, and troubleshoot laboratory automation
• Actively engaged in advancing drug discovery programs  
• This is a “hands-on” laboratory, based position

Required Qualifications and Preferred Background:

• BS/MS/Ph.D. in biochemistry, biophysics, or related fields
• Ph.D. with >2 years’ experience in industry or academia, or BS or MS with >5 years industrial experience
• The successful candidate is expected to have expertise in biochemistry, enzymology, and assay development
• Experience with general biochemical and kinetic-based assay technologies (e.g. TR-FRET, AlphaLISA® FP, Luminescence)
• Experience with laboratory instrumentation and automation for medium to high-throughput screening
• Excellent oral and written communication skills including experimental documentation
• Works well with team members across functional areas
• Ability to multi-task and shift priorities rapidly to meet tight deadlines
• Highly organized with exceptional attention to detail.
• Good and thoughtful listener
• Enthusiastic, self-motivated and a continuous learner
• Proficient in Microsoft Office suite and applications

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Scientist level position could range from between $78,000 to $114,498 and the Senior Scientist level position could range from between $89,750 to $131,672 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Physical Demands / Travel

The physical demands of this job are consistent with a lab.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in a lab.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Scientist/Senior Scientist, Proteomics

Function:

Molecular & Cellular Biology

Location:

South San Francisco, CA

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Scientist will be responsible for design and execution of mass spectrometry experiments  to explore protein interactions that drive cancer’s progression. The candidate will work on multiple drug discovery project teams to provide rapid and rigorous mechanistic characterizations to understand the activities of small molecule compounds, advance novel drug targeting strategies, develop novel assays for drug discovery project teams, understand drug resistance, and evaluate new targets. The candidate will work closely with other project team members across disciplines including structural biology, cell biology, in vitro pharmacology, and medicinal chemistry.This position is based in our South San Francisco site. 

Roles and Responsibilities for the Position

• Collaborate with colleagues throughout the company to ensure timely delivery of data.
• Adapt to highly dynamic project priorities, with diligent and rapid communication of scientific results and insights to the team.
• Develop and continually advance one’s knowledge base on genetically targeted drugs and structure-based drug design. 
• Enthusiasm for laboratory research, with demonstrated experience independently generating precise, reliable data
• Driven by a fundamental interest to learn, develop new technologies and contribute to drug discovery
• Experience with cell biology and/or biochemical methods used for expressing, detecting, enriching & characterizing proteins (e.g. sample preparation methods for bottom-up proteomics workflows)

Required Background and Preferred Qualifications

• PhD in Biochemistry, Chemistry, Molecular/Cellular Biology or related field
• Familiarity with Thermo Orbitrap and/or Bruker instrumentation preferred
• Experience with large, complex data set analysis
• Expertise in analytical mass spectrometry
• Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels.
• Committed to staying current with the latest scientific breakthroughs in the targeted oncology field from target identification through human clinical trials.
• Good and thoughtful listener who values collaboration

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Scientist level position could range from between $78,000 to $114,498 and the base salary at the Sr. Scientist level could range between $89,750 and $131,672 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Senior Associate Scientist/Scientist, Biology, Target Discovery

Function:

Target Discovery

Location:

South San Francisco, CA

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

We are seeking a highly motivated and experienced individual to join a dynamic and fast-paced biology team in Target Discovery. The successful candidate will support lab-based research projects to identify and validate novel druggable targets. The ideal candidate is a team player familiar with routine molecular and cellular biology techniques, and has demonstrated organizational skills. This individual learn various cutting-edge techniques and thrive in a team-oriented environment with career growth opportunity.  

Roles and Responsibilities of the Position:

• Maintain and establish various mammalian cell lines used to credential novel targets.
• Perform cellular and biochemical assays to evaluate the outcome of various genetic or chemical perturbations.    
• Analyze, interpret, and present the data to the team and/or organization.
• Troubleshoot experiments in a timely manner.
• Learn and apply new techniques to support ongoing efforts.
• Actively participate in group discussions and collaborate with colleagues throughout the organization.
• Contribute to a safe and efficient workplace. 

Required Qualifications and Preferred Background:

• BS or MS in biology, cancer, molecular biology, cell biology, biochemistry, or related discipline, with 3+ years lab-based experience.
• Expertise in routine molecular and cellular techniques.
• Experience in gene editing (CRISPR, TALEN, etc.) and/or high-throughput screening is a plus.
• Excellent collaborative and interpersonal skills.
• Highly organized, detail-oriented, self-motivated and strong documentation skills.
• Outstanding communication, writing, and presentation skills are a must.

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Senior Associate Scientist position level could range from between $67,850 to $99,563 and the Scientist position level could range between $78,000 and $114,498 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Physical Demands:

The physical demands of this job are consistent with working in a laboratory/ bench environment. Some light lifting, and maneuvering may be required.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in a laboratory/bench environment.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Senior Associate Scientist/Scientist, Cell Biology

Function:

Discovery Signaling

Location:

New York, NY

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Senior Associate Scientist/Scientist, Cell Biology will be part of the Loxo@Lilly’s Discovery Signaling group in Alexandria Center, NY. The Discovery Signaling group is responsible for identifying molecular targets for life-changing oncology drugs, establishing the cellular reporters for onco-pathways and investigating the mechanism of actions of novel drug candidates with a focus on small molecule drugs, and providing forward-thinking approaches to advance our clinical portfolio.  The Senior Associate Scientist/Scientist, Cell Biology will be responsible for creating and evaluating cellular models, assays, execution strategies to quantitatively determine the potency and selectivity of small molecule compounds and interrogate signaling pathways.  This is a hands-on position for an experienced lab scientist who enjoys working in the lab. This scientist must have excellent people skills and be able to work with a positive, “can-do” attitude in a dynamic, fast-paced, team environment focused on high quality science to deliver innovative cancer drugs. 

Roles and Responsibilities of the Position:

• Create, develop and validate quantitative mammalian cellular assays to address the project team’s mechanistic and functional needs. 
• Establish engineered cell models to determine the actions of drugs on the specific oncogenic signaling. 
• Collaborate with colleagues throughout the company to ensure assays meet the program needs and results are appropriately interpreted.
• Prepare reports for internal and external purposes including regulatory submissions.
• Participate and lead project-based and technical team meetings to identify and solve problems, guide work towards project goals, communicate on-going work and progress, and plan forward thinking strategies. 
• Develop and continually advance one’s knowledge base on the molecular pathways being targeted by our clinical and research programs.
• Proactively investigate new or different technologies, methods, and service providers to ensure our work is being done in a scientifically sound, efficient, and reasonable way.

Required Qualifications and Preferred Background:

• BS degree with 5+ years experience, MS degree with 3+ years experience or PhD with 1+ years experience in Molecular/Cellular Biology, Biochemistry, or related field with 2+ years hands-on molecular biology and cell assay experience in a biotech/pharma setting or BS/MS in Molecular/Cellular Biology or Biochemistry with 3+years hands-on molecular biology and cell assay experience in a biotech/pharma setting.

Ideal candidate will also have:
• Experience in culture cancer cell lines and/or patients-derived primary tumor cells, in both 2D and 3D system.
• Demonstrated hands-on experience in flow cytometry-based cell analysis and cell sorting.  
• Experience in creating, developing, and running cellular assays; engineering cell lines to express or knock-down genes of interest, interrogating cellular signal transduction pathways, and characterizing kinase activity.
• Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels.
• Highly organized with excellent analytical, documentation and multi-tasking skills. Proficient in Microsoft Office suite and applications. 
• Good and thoughtful listener who values collaboration. 
• Enthusiastic, self-motivated and keen to improve processes and overcome inefficiencies. 

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Associate Scientist level could range from between $59,000 to $86,577 and that the base salary for the Scientist level could range from between $78,000 to $114,498 will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

This position’s work environment is in a lab/bench environment.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Senior Associate Scientist/Scientist, Target Discovery (Functional Genomics)

Function:

Target Discovery

Location:

South San Francisco, CA

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

We are seeking a highly motivated and experienced individual to join a dynamic and fast-paced biology team in Target Discovery. The Senior Associate Scientist/Scientist will be responsible for creating and executing strategies toward discovery and credentialing of oncology targets through close collaboration with other discovery and translational functions. The ideal candidate will have a strong understanding of oncogenic pathways and experience in designing experiments to evaluate molecular interactions and cellular pathways. The Senior Associate Scientist/Scientist Target Discovery will be part of a multi-disciplinary effort focused on bringing forward innovative cancer drug therapy.

Roles and Responsibilities of the Position:

• Conceive and execute functional genomics screens for target discovery, interrogating MOA of therapeutic modalities, and understanding mechanisms of resistance and/or sensitivity.
• Design and perform screen follow-up studies using a repertoire of gene editing and cellular/molecular biological tools.
• Analyze, interpret, and present the data to the team and/or organization.
• Troubleshoot experiments in a timely manner.
• Learn and apply new techniques to support ongoing efforts.
• Actively participate in group discussions and collaborate with colleagues throughout the organization.
• Contribute to a safe and efficient workplace.

Required Qualifications and Preferred Background:

• BS or MS in biology, cancer, molecular biology, cell biology, biochemistry, or related discipline, with 3+ years lab-based experience
• Proficiency in mammalian cell culture
• Experience with gene editing platforms (i.e. CRISPR, TALEN, etc)
• Experience with functional genomics (i.e. CRISPR screen) is a plus
• Experience with general molecular biological techniques including PCR, cloning, and Western Blot, etc
• Highly organized, detail-oriented, self-motivated, and strong presentation/documentation skills
• Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, scientific advisors, and staff at all levels and problem-solving skills

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Senior Associate Scientist level could range from between $67,850,000 to $99,563, and that the base salary for the Scientist level could range from between $78,000 to $114,498 will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Physical Demands/ Travel:

The physical demands of this job are consistent with working in a laboratory/ bench environment. Some light lifting, and maneuvering may be required.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in a lab/bench environment.The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Senior Principal Scientist, Large Molecule Biology Target Strategy

Function:

Large Molecule Biology & Discovery Technologies

Location:

New York, NY

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The role of Sr. Principal Scientist, Large Molecule Biology (LMB) Target Strategy, will be an essential member of the LMB team with responsibility for overall target strategy for new large molecules in the pipeline.  The candidate is expected to have a strong background in drug discovery including preclinical and early clinical research.  The role will be fully computer/literature/congress based research (no lab work) and will include involvement in internal strategy for novel target identification.  The candidate will work very closely with LMB leadership and the project leaders to lead identification of targets that fit the existing and future platforms for the LM team.  The role will similarly collaborate across the Loxo clinical group and the external space in order to identify and vet potential targets of interest. This is a highly visible role, expected to be highly independent and deliverable focused but also highly collaborative.  

Roles and Responsibilities of the Position:

• Lead the Large Molecule target identification strategy including but not limited to ADC’s and T cell engagers (note: this is not a laboratory-based position)
• Propose new targets for consideration in the portfolio after synthesizing clinical, preclinical and translational data.  Incorporate aspects of the Loxo portfolio interest, platform needed and feasibility, and unmet medical need.
• Attend conferences and work sessions to gain extensive clinical knowledge of the landscapes and targets of interest. Combine this emerging clinical data landscape and synthesize into actionable ideas
• Establish and expand depth of knowledge in areas of scientific, clinical, and strategic interest to the company via scientific/medical conference attendance, market research, cross functional KOL interactions, and literature reviews.
• Assess competitive landscape and identify areas of unmet medical need
• Collaborate with and collect feedback across functional areas (R&D, Medical Affairs, Medical, Clinical Science) to integrate cross-functional input and incorporate writing due diligence summaries and recommendations for new target proposals.
• Work closely with leadership in LMB to review progress, discuss findings and generate reports (frequent meetings, discussions, and exchanges in real-time).  Also work with peers in LMB in a collaborative manner on projects.
• With a deep understanding of cancer biology, review translational information, understand dose limiting toxicities, and Phase 1-3 clinical trial data including control groups to share ideas and influence strategy of programs
• Report strategies, summaries and target data in memos, presentations, and detailed summaries.
• Work closely with project management group as needed
• Organize and lead meetings with external collaborators

Required Qualifications and Preferred Background:

• 8+ years of Biotech/Pharmaceutical industry experience and an advanced doctoral degree in relevant scientific fields (e.g., biology) or 15+ years’ experience and a BS/MS degree
• Deep understanding of cancer biology and translational science
• Demonstrated understanding of clinical development (including trial design, assessing safety)
• Strong collaboration skills working with both internal and external parties
• Good verbal, written communication, and interpersonal skills
• Excellent organizational skills, efficient, with strong attention to detail
• Demonstrates consistent delivery of tasks with moderate supervision
• Ability to anticipate problems and proactively propose solutions
• Highly motivated, organized and detail oriented
• Proficient in MS Office suite

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Senior Principal Scientist position level could range from between $118,700 to $174,137 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion

Physical Demands/ Travel:

The physical demands of this job are consistent with an office. This role requires the ability to travel to travel 10-20 %.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in an office.  

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Senior Project Manager, Small Molecule Discovery

Function:

Program and Alliance Management

Location:

Louisville, CO

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Senior Project Manager will establish and implement project-specific strategic goals from early-stage discovery, lead identification, lead optimization through candidate seeking and advancement as a part of the Loxo Small Molecule Discovery portfolio, in a cross-functional, dynamic environment. The role will work closely with team leaders and Loxo's Small Molecule Discovery leadership to create and implement project’s strategic plans. The Project Manager is expected to support 2-4 projects depending upon the project’s requirements. 

Roles and Responsibilities for the Position:

• Establish strategic project goals and translate goals into project plan(s) with clear deliverables, milestones, and go/ no-go decisions
• Establish project strategic objectives by collaborating with Loxo Small Molecule- Discovery leadership team
• Engage with functional team leads of medicinal chemistry, biology, DMPK, CMC, and toxicology (and other key stakeholders) to plan, execute, and track project activities, ensuring alignment of project deliverables with strategic goals
• Actively manage assays and studies conducted at external collaborators and vendors to meet outsourcing needs as needed.
• Actively facilitate project meetings: create agendas, minutes, and track action items
• Create and maintain organizational documents and tools, e.g., screening cascades, data summaries, project timelines, Spotfire dashboards, compound demand-supply forecasts, and various other trackers to ensure clear, effective, transparent, and efficient implementation of projects
• Create project updates, reports, presentations, and memos and maintain project document repository in collaboration with team members
• Proficient in adaptive communications; effectively manage communications vertically and horizontally in a cross-functional environment
• Proactively contribute to and manage project communications. Identify gaps and ambiguities in communication channels and address them to maintain alignment across the team
• Drive day-to-day operational activities by coordinating with stakeholders from different functional departments – legal, business operations, procurement, finance, and other relevant functional areas as needed
• Proactively identify gaps in processes and actively create processes to meet project needs
• Adaptive to change in priorities and able to drive project outcomes ensuring re-alignment with project deliverables in changing landscape
• Contribute to building positive, collaborative teams across scientific disciplines, and encourage sharing of new ideas and creative ways to solve problems often needed in drug discovery research

Required Qualifications and Preferred Background:

• BS, MS, or PhD  in chemistry, biology, or related sciences
• Small molecule drug discovery experience: BS with 7 years, MS with 4 years, or PhD  with 2 years. Part of the experience could come from project management/ alliance management responsibilities in pharmaceutical research & development
• Must be self-motivated and have excellent time management skills
• Excellent verbal, written communication and interpersonal skills.
• Excellent organizational skills, efficient, with strong attention to detail

Additional Preferences:  
• PMP certification is preferred, but not required
• Proficient in identifying and applying tools to effectively manage and track projects - MS Office suite, MS Project
• Experience with data visualization software, such as Spotfire
• Create and implement new tools and processes customized for furthering discovery research

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Senior Manager level position could range from between $118,700 to $174,137 but will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.

Physical Demands/ Travel:

The physical demands of this job are consistent with laboratory setting. 

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in a lab. 

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Senior Scientist, Bio-Analytical Chemistry, Large Molecule Discovery

Function:

Large Molecule Discovery

Location:

South San Francisco, CA

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

Loxo@Lilly’s Large Molecule Discovery team is looking for a Senior Scientist, Analytical Sciences to support our growing biologics portfolio. This role will support enzymology studies on ADCs and to carry out mass-spec based quantitation of small molecules and ADCs, distributed across various tissues and biological matrices, for ADC Discovery Research.  This individual will be a self-motivated, responsible, and productive scientist who enjoys collaborating. He/she will be responsible for rigorous experimental design, data analysis and data interpretation. This position requires excellent people skills, a positive can-do attitude, and the ability to thrive in a highly interactive, fast-paced, team environment.

Roles and Responsibilities of the Position:

• Design and develop novel biochemical assays to identify and characterize small-molecule modulators using a variety of techniques and detection methods, including chromogenic, FP, FRET, TR-FRET, BRET, and ALPHA.
• Perform enzyme kinetic analyses and MOA studies to characterize the effect of biological enzyme systems on ADCs.
• Prepare lysosomal and subcellular fractions from various cancer cell-lines
• Extraction of small molecules and ADCs from a variety of tissue samples and biological matrices for mass-spec quantitation
• Mass-spec based quantitation of small and large molecules extracted from various biological matrices
• LC method development for various characterization and bioanalytical applications
• Continuously expand on biochemical repertoire by exploring and developing additional assay and technological instrumentation.
• Oversee outsourcing of enzyme assays to external CROs and monitor results.
• Operate automated platforms for liquid handling.
• Calculate and report assay results to the project teams.
• Document experiments and results in electronic notebook or database.
• This position is a hands-on lab-based role

Required Qualifications and Preferred Background:

• A BS, MS, or PhD in a Life Sciences discipline, with training in chemistry, analytical chemistry, biochemistry or related fields, and a record of lab based independent research experience, minimum of 10 years for BS, >8 years for MS and >5 years for PhD, either in industrial or academic environment.
• Hands-on experience in characterizing small molecules, antibodies and ADCs using  state-of-the-art AB Sciex/Thermo/ Waters TOFs and Triple Quads.
• Hands-on experience in analyzing mass-spec data using various vendor provided software for small molecule and protein analysis
• Hands-on experience in running various analytical techniques including, and not limited, to HPLCs and UPLCs for characterization and quantitation of small/large molecules
• Familiarity with routine maintenance and troubleshooting of analytical and mass-spec instrumentation
• Must be highly collaborative and able to effectively engage small-molecule research project teams to make rapid progress.
• Demonstrated ability to work well with other accomplished professionals within and across functions/teams. Willing collaborator.
• Strong written and oral communication skills.
• Ability to multi-task and shift priorities rapidly to meet tight deadlines.
• Excellent written and verbal communicator.
• Detail oriented and well organized.
• Good and thoughtful listener.
• Enthusiastic, self-motivated, and keen to improve processes.
• Proficient in Microsoft Office suite and applications. 

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Senior Scientist position level could range from between $89,750 to $131,672 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Physical Demands/Travel:

The physical demands of this position are consistent with working in a laboratory/ bench environment. Some light lifting, and maneuvering may be required.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

  Work Environment:

 This position’s work environment is based in a laboratory/ bench environment.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Senior Scientist/Principal Scientist, Protein Sciences

Function:

Protein Sciences

Location:

Louisville, CO

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

This position offers the opportunity to be part of Loxo@Lilly's discovery teams focused on creating novel, highly specific and selective drugs for genetically identified targets. The Protein Purification Scientist will support the internal and external discovery research efforts across multiple projects and project teams. This is an extremely important role where the right person will be able to have a real impact on cutting-edge science, making a real difference in patient’s lives. 

Roles and Responsibilities of the Position:

• Provide recombinant protein expression and protein purification expertise to deliver proteins central to research activities for small molecule discovery
• Understand the quality of proteins required for functional and biophysical assays, and develop protocols to deliver well characterized proteins accordingly
• Execute projects in an efficient manner, working with aggressive timelines
• Values quality over quantity, with the ability to prioritize
• Rapidly communicate scientific results and insights to the team
• Prepare reports for internal and external purposes including regulatory submissions
• Participate and lead project-based and technical team meetings to identify and solve problems, guide work towards project goals, communicate on-going work and progress, and plan forward thinking strategies
• Continually advance your understanding of current methodology and emerging technologies by reading scientific literature
• Proactively investigate new or different technologies, methods, and service providers to ensure our work is being done in a scientifically sound, efficient, and reasonable way

Required Qualifications and Preferred Background:

• BA/BS/MS/PhD in protein sciences, biology, biochemistry, molecular biology, or a related field along with hands-on experience, working in a laboratory in a biotechnology/pharmaceutical setting
• (3+ years’ experience with a PhD; 5+ years’ experience with an MS degree; 8+ years’ experience with BS/BA degree); may also consider experience out of an academic/research setting
• Strong team player who inspires colleagues to solve difficult problems and develop efficient workflows
• Experience designing expression constructions for functional assays and crystallography
• Proficient with molecular biology techniques including cloning
• Expertise with a variety of protein expression systems including E. coli and Baculovirus infected insect cells
• Expertise with protein purification techniques such as IMAC, SEC, IEX and affinity chromatography is required, ideally utilizing the AKTA FPLC systems
• Expertise with protein characterization techniques such as LCMS, western blotting, and thermal stability assays, is desirable.
• Familiarity with biophysical and functional techniques such as SPR, ASMS, fluorescent binding assays, and enzyme kinetic assays is beneficial
• The candidate must be self-motivated but always maintain focus on why we are here and who is important i.e. the patients and their families/caregivers
• Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels
• Desire and ability to flex between protein expression/purification/characterization is a must
• Highly organized with excellent analytical, documentation and multi-tasking skills

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Senior Scientist position level could range from between $89,750 to $131,672 and that the base salary for the Principal Scientist position level could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Physical Demands/ Travel:

The physical demands of this job are consistent with light office duties.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

 Work Environment:

This position’s work environment is in an office and the lab. 

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Senior/Principal Computational Biologist, Team Lead (multiple locations)

Function:

Target Discovery

Location:

South San Francisco, CA

Position Summary

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

We are seeking a talented and highly motivated experienced Computational Biologist to join our Discovery Bioinformatics group. The candidate will lead bioinformatics efforts across multi-disciplinary teams to rapidly advance small molecule drug development efforts. This position is expected to lead and oversee broader strategic involvement in shaping the next generation of cancer therapies through data-driven approaches.

Roles and Responsibilities of the Position:

• The successful candidate will join a dynamic team and oversee computational biology efforts across multiple functions. They will be expected to lead a team, supervise and develop scientists, and help build a research strategy that leverages deep cancer biology knowledge and high-dimensional data. Success critically depends on the ability to effectively present complex analyses and results in a clear and concise manner to a diverse audience of scientists.

Required Qualifications and Preferred Background:

• PhD in Bioinformatics, Biostatistics, Computational Biology, or similar area of study required. Post-doctoral training or equivalent prior work experience (3-5+ years)
• Substantial publication record and/or similar achievements
• Demonstrated track record of strategic scientific leadership in the computational biology field with leading and developing scientists.
• Strong understanding of relevant concepts in cancer biology and molecular biology
• Experience in large-scale data analyses involving high-throughput molecular assays such as DNA/RNA-Seq, ATAC/CHiP-Seq, single-cell technologies, etc.
• Understanding of current best-practices for high-throughput genomics/molecular data analyses and familiarity of their underlying statistical principles
• Experience using programming languages such as R, Python, or similar for statistical analysis

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Senior Scientist position level could range from between $89,750 to $131,672 and that the base salary for the Principal Scientist position level could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Available Locations for this role

• South South Francisco, CA
• New York City, NY
• US Based-Remote

Physical Demands / Travel:

The physical demands of this job are consistent with light office duties.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in an office.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email

loxoaccommodation@loxooncology.com

for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Position:

Outstanding Team Member

Reporting To:

Dedicated, Knowledgeable Supervisor

Location:

United States and Beyond

Position Summary

Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by that goal. We pursue this goal with a tenacity, focus and commitment to excellence that defines who we are and how we work.

We seek dedicated, passionate, hardworking intelligent, thoughtful and authentic individuals who thrive within a collaborative and fast-paced environment and will bring their experiences, unique perspectives and problem-solving skills to the team. In return, we cultivate an environment that rewards and recognizes hard work and provides opportunities for learning and growth as part of a team making a meaningful difference in the field of medicine and for individual patients.

If you share our passion, please let us know how you could contribute to our team. We don't want to pass up an opportunity for the right candidate to join us just because you found us before we found you.

Connect With Us

Submit your resume and your "Who", "What" and "Why" (see below) to careers@loxooncology.com.

Your "Who", "What" and "Why":

• Who are you?
• What will you bring to Loxo?
• Why do we need you on the team?

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

For more information about Loxo Oncology’s privacy practice, please view the Privacy Statement.