Career Opportunities

Career Opportunities


Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by our goal of improving the lives of people living with cancer. We pursue this goal with a tenacity, focus, and commitment to excellence that defines who we are and how we work.

We seek dedicated, passionate, hardworking, intelligent, thoughtful, and authentic individuals who thrive within a collaborative and fast-paced environment and will bring their experiences, unique perspectives and problem-solving skills to the team. In return, we cultivate an environment that rewards and recognizes hard work and provides opportunities for learning and growth as part of a team making a meaningful difference in the lives of patients.


Reports To:

TBD

Position Summary

Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by that goal. We pursue this goal with a tenacity, focus and commitment to excellence that defines who we are and how we work.

We are seeking an experienced Administrative Assistant/Receptionist for our South San Francisco office. The right candidate will be a positive, proactive individual who enjoys working with and supporting our internal team as well as guests and external vendors visiting our South San Francisco office. We seek a detail-oriented professional excited to contribute to our mission, learn and grow within the role, and act as the face and voice of Loxo at our South San Francisco location.

Roles and Responsibilities of the Position*

This position interacts with internal contacts at all levels of the organization as well as a diverse group of important external callers and visitors. Independent judgment is required to plan, prioritize and organize a diversified workload and recommend improvements in office practices or procedures. Responsibilities include:

  • Provide administrative support including typing, filing, calendar management, booking travel, reconciling expenses, meeting coordination and other administrative tasks.
  • Answer non-routine correspondence and assemble highly confidential and sensitive information.
  • Assist with other special projects as needed, including assisting with offsite meetings, events, large print/copy jobs, projects, coordinating external vendors, etc.
  • Coordinate and facilitate the use of all conference rooms.
  • Greet visitors, and work closely with the team to ensure interviews and meetings remain on schedule.
  • Assist with ordering, set-up/cleanup of office lunches (and dinners when necessary).
  • Restock kitchen supplies daily (or more frequently depending on need).
  • Clean and restock the coffee machine weekly (or more frequently depending on need).
  • Send and receive packages via USPS, UPS and FedEx.
  • Collect and distribute the mail daily (or more frequently depending on need).
  • Maintain copy rooms and printers/copiers in coordination with the IT team.

Required Qualifications and Background

  • Minimum of 3+ years in a comparable Administrative/Office Coordinator/ Assistant/Receptionist role.
  • Positive, eager and helpful attitude.
  • Professional demeanor and excellent written and verbal communication skills.
  • Able to work within a fast-paced environment, adept at juggling multiple tasks and priorities and prioritizing independently.
  • Enthusiastic, self-motivated and keen to improve processes and overcome inefficiencies.
  • Effective collaborator with a variety of stakeholders, thoughtful listener and team player.
  • Able to maintain a calm, patient and “can-do” approach.
  • Conscientious, detail-oriented, well-organized and takes initiative to anticipate and address needs.
  • Able to bring a proactive and creative approach to problem solving.
  • Proficient in Microsoft Office suite and applications.
  • ***Please note: this role requires an on-site presence from 8:30am-5pm, Monday to Friday (and additional hours if/as needed).***

Physical Demands / Travel

The physical demands of this job are consistent with light office duties; candidate should have the capability to lift up to 10lbs.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in an office.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each roles and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.


Reports To:

Senior Director, Bioassay Screening

Position Summary

Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by that goal. We pursue this goal with a tenacity, focus and commitment to excellence that defines who we are and how we work.

The Bioassay Screening Scientist will be responsible for identifying, developing, and performing robust, reproducible biological assays to support drug discovery and development in a team environment.  The Bioassay Screening Scientist will provide hands-on compound screening efforts in support of Loxo’s small molecule drug discovery pipeline in Oncology.   The scientist fulfilling this position will be responsible for characterizing the effects of small molecule compounds on specific protein targets in enzymes and cells using multiple plate-based assay formats including HTRF, ELISA, In-Cell Western, and proliferation.  A strong background in experimental curve-fitting, statistics, and assay optimization and execution is required.The Bioassay Screening Scientist will be responsible for identifying, developing, and performing robust, reproducible biological assays to support drug discovery and development in a team environment.  The Bioassay Screening Scientist will provide hands-on compound screening efforts in support of Loxo’s small molecule drug discovery pipeline in Oncology.   The scientist fulfilling this position will be responsible for characterizing the effects of small molecule compounds on specific protein targets in enzymes and cells using multiple plate-based assay formats including HTRF, ELISA, In-Cell Western, and proliferation.  A strong background in experimental curve-fitting, statistics, and assay optimization and execution is required.

Roles and Responsibilities of the Position*

  • Design, execute, and trouble-shoot experiments utilizing fluorescence, ELISA, In-Cell Western, and proliferation readouts
  • Perform comprehensive data analysis while communicating experimental findings to team members.
  • Operate, implement and troubleshoot laboratory automation.
  • Interact on work projects with CROs.
  • Support regulatory filings and be actively engaged in advancing drug discovery programs. 
  • This is a “hands-on” laboratory, based position.

Required Qualifications and Background

  • BA/BS/MS in biology, biochemistry or related field.
  • 2-8 years of highly relevant hands-on lab experience in biotech or pharma environment including 1+ years culturing cells and performing cell assays.
  • A scientific foundation in the understanding and implementation of a wide range of biochemical and cell-based screening assays and readouts.
  • Excellent oral and written communication skills including experimental documentation.
  • Works well with team members daily across functional areas.
  • Continual learner who works independently and possesses a can-do attitude.
  • Ability to multi-task and shift priorities rapidly to meet tight deadlines.
  • Highly organized with exceptional attention to detail.
  • Proficient in Microsoft Office suite and applications.

Physical Demands / Travel

The physical demands of this job are consistent with a lab.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in a lab.  

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each roles and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.


Reports To:

Senior Manager, Clinical Data Management

Position Summary

Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by that goal. We pursue this goal with a tenacity, focus and commitment to excellence that defines who we are and how we work.

The Contract Clinical Data Manager is responsible for overseeing data management tasks from study start-up through database lock for clinical trials.  This individual collaborates with the Clinical Trial Managers (CTMs), Biostatistics team, and data management vendors to ensure database development, data review/cleaning, database auditing, database lock, and receipt of final database deliverables are in compliance with standard operating procedures and regulatory agency guidelines. The Clinical Data Manager ensures all Clinical Operations activities stay within full compliance of Loxo regulatory and legal policies.The Contract Clinical Data Manager is responsible for overseeing data management tasks from study start-up through database lock for clinical trials.  This individual collaborates with the Clinical Trial Managers (CTMs), Biostatistics team, and data management vendors to ensure database development, data review/cleaning, database auditing, database lock, and receipt of final database deliverables are in compliance with standard operating procedures and regulatory agency guidelines. The Clinical Data Manager ensures all Clinical Operations activities stay within full compliance of Loxo regulatory and legal policies.

Roles and Responsibilities of the Position*

  • Represents data management in study team meetings.
  • Manages data management timelines to coordinate and synchronize deliverables with the overall study timelines.
  • Generates and/or reviews/approves study documents (e.g. Data Management Plans, Case Report Forms, data transfer specifications, SAE and/or external data reconciliation plans, coding conventions, study protocols, UAT execution).
  • Executes and/or distributes data management metrics, listings, and reports, as required.
  • Oversight of data management CRO/service providers on assigned studies.
  • Monitors the progress of all data management activities on assigned studies to ensure project timelines are met.
  • Provides training on the CRF completion guidelines and EDC system at Investigator meetings and to internal or external team members, as needed.
  • Proactively identifies potential study issues/risks and recommends/implements solutions.
  • Responsible for the accuracy and completeness of the clinical data collected during a clinical trial, able to work independently towards the assigned goal.
  • Provide DM support to Statisticians and Statistical Programmers in production of clinical trial reports and other deliverables.

Required Qualifications and Background

  • Bachelors’ degree in Life Sciences, Computer Sciences, Mathematics, health related field or equivalent experience.
  • 6+ years of CDM experience in the pharmaceutical or biotechnology industry
  • CRO management experience a plus.
  • Prior oncology/hematology experience highly desirable.
  • Requires solid knowledge of clinical data management principles, clinical trials process and regulatory requirements.
  • Excellent verbal/written and interpersonal skills required for working successfully in a cross-functional team environment.
  • Able to communicate and collaborate effectively with cross-functional teams in face-to-face conversation, by telephone, and by email.
  • Good working knowledge of ICH, FDA, and GCP regulations and guidelines
  • Strong well-rounded technical skills (EDC systems, MS Word, Excel, PowerPoint).
  • Knowledge of industry standards (CDISC, SDTM, CDASH).
  • Experience with web-based Electronic Data Capture (EDC), clinical data management systems and industry wide thesauri, such as MedDRA and WHO Drug.
  • Proven ability to work both independently or in a team setting.

Physical Demands / Travel

This position will travel occasionally; the average travel for this position is 10-15% with some variation based upon the demands of the business imperatives.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

The position’s work environment is based in a typical office setting with occasional travel required.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each roles and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.


Reports To:

Senior Clinical Trial Manager

Position Summary

Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by that goal. We pursue this goal with a tenacity, focus and commitment to excellence that defines who we are and how we work.

CRA/Field Site Monitor will coordinate clinical studies and be responsible for all major stages of study development, execution, monitoring, and close-out. This individual will also be responsible for clinical study site maintenance, data and source documentation collection, as well as field monitoring of clinical trials. Duties will include ensuring compliance to the study protocol, and Monitoring Plan by ensuring completeness and accuracy of data as well as compliance with domestic and international regulations, Good Clinical Practices, applicable regulatory standards, and Standard Operating Procedures.

Roles and Responsibilities of the Position*

  • Drafts materials including informed consents, case report forms (CRFs), CRF completion guidelines, and technical instructions.
  • Carries out clinical site qualification, IRB/ethical committee submissions, protocol initiation, site monitoring, and site close-out
  • Coordinates and manages the activities of investigative sites to ensure compliance with study protocol requirements
  • Ensures preparation, collection and distribution of trial master file (TMF) documents and maintenance of regulatory files at investigative site
  • Conducts clinical site and data monitoring and completes monitoring visit reports
  • Evaluates clinical data and coordinates data query resolutions
  • Supports internal departmental quality compliance
  • Prepares progress reports and performance metrics

Required Qualifications and Background

  • Minimum of 2 years field monitoring experience
  • Oncology experience highly preferred
  • Understands and can apply knowledge of clinical trial designs to trial execution
  • Advanced knowledge and experience with GCP/ICH and local regulations
  • Experience in web-based data collection applications, knowledge of key areas of Compliance
  • Strong communication skills as single point of contact for investigator
  • Strong skills in building and maintaining relationships with investigative sites
  • Excellent organizational skills with high attention to detail is required
  • Strong computer skills (spreadsheets, word processing, etc.) is required
  • Ability to manage, prioritize, and routinely report progress on multiple projects and tasks
  • Strong presentation skills to internal professionals and external collaborators
  •  

Physical Demands / Travel

Physical Demands:

The physical demands of this job are consistent with light office duties

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

This role can require up to 40% domestic and international travel

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

Work Environment:

This position’s work environment is in an office.   

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

No specific work demands.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each roles and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.


Reports To:

Senior Director, Medical Affairs

Position Summary

Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by that goal. We pursue this goal with a tenacity, focus and commitment to excellence that defines who we are and how we work.

The Diagnostics Medical Science Liaison (DxMSL) is responsible for the identification and engagement of targeted groups of regional thought leaders within the pathology, laboratory, and oncology communities with specific responsibility for providing consistent delivery of educational and compliant scientific information surrounding clinical/scientific aspects of cancer diagnosis and biomarker/genomic testing.

Roles and Responsibilities of the Position*

  • Identify and develop relationships with clinical/community/academic thought leaders on a local and regional level.
  • Serve as Loxo Oncology’s scientific representative to the Pathology, Diagnostic and Medical communities and facilitate the appropriate exchange of scientific information.
  • Utilize approved resources to address inquiries, ensuring they are in compliance with all guidelines and regulations.
  • Communicate diagnostic and therapeutic market trends which may impact biomarker/genomic testing.  
  • Participate and support advisory boards and steering committees.
  • Lead and/or participate on committee/project teams which support Diagnostic MSL strategies as delegated by MSL leadership. 
  • Attend identified relevant national/regional/local education meetings and conferences, maximizing opportunities at these events.
  • Develop and implement educational speaker programs for the pathology/lab audience.
  • Educate on high quality comprehensive testing for relevant biomarkers in precision oncology and make ties to Loxo pipeline assets.

Required Qualifications and Background

  • Advanced doctoral degree strongly preferred (e.g. PharmD, MD, DO, or PhD). Candidates with a diagnostic laboratory and or clinical pathology background (e.g. MSN, PA) and extensive hematology/oncology MSL experience will also be considered.
  • 0-3+years’ MSL experience in Oncology or Oncology Diagnostics required
  • Ability to establish and maintain relationships with influential thought leaders.
  • Product launch experience a plus; Laboratory or Clinical Diagnostics experience beneficial.
  • Exceptional interpersonal skills.
  • Ability to excel in dynamic settings with short timelines.
  • Strong written/verbal communication and presentation skills.
  • Proficient in Microsoft Office suite and applications.

Physical Demands / Travel

Please note this role will require up to 50% travel, primarily within assigned region but also nationally and globally as required.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is remote based, with significant travel on a regional basis to various sites.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each roles and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.


Reports To:

Senior Medical Director, Medical Affairs

Position Summary

Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by that goal. We pursue this goal with a tenacity, focus and commitment to excellence that defines who we are and how we work.

The Diagnostics Medical Science Liaison (DxMSL) is responsible for the identification and engagement of targeted groups of regional thought leaders within the pathology, laboratory, and oncology communities with specific responsibility for providing consistent delivery of educational and compliant scientific information surrounding clinical/scientific aspects of cancer diagnosis and biomarker/genomic testing.

Roles and Responsibilities of the Position*

  • Identify and develop relationships with clinical/community/academic thought leaders on a local and regional level.
  • Serve as Loxo Oncology’s scientific representative to the Pathology, Diagnostic and Medical communities and facilitate the appropriate exchange of scientific information.
  • Utilize approved resources to address inquiries, ensuring they are in compliance with all guidelines and regulations.
  • Communicate diagnostic and therapeutic market trends which may impact biomarker/genomic testing.  
  • Participate and support advisory boards and steering committees.
  • Lead and/or participate on committee/project teams which support Diagnostic MSL strategies as delegated by MSL leadership. 
  • Attend identified relevant national/regional/local education meetings and conferences, maximizing opportunities at these events.
  • Develop and implement educational speaker programs for the pathology/lab audience.
  • Educate on high quality comprehensive testing for relevant biomarkers in precision oncology and make ties to Loxo pipeline assets.

Required Qualifications and Background

  • Advanced doctoral degree strongly preferred (e.g. PharmD, MD, DO, or PhD). Candidates with a diagnostic laboratory and or clinical pathology background (e.g. MSN, PA) and extensive hematology/oncology MSL experience will also be considered.
  • 0-3+years’ MSL experience in Oncology or Oncology Diagnostics required
  • Ability to establish and maintain relationships with influential thought leaders.
  • Product launch experience a plus; Laboratory or Clinical Diagnostics experience beneficial.
  • Exceptional interpersonal skills.
  • Ability to excel in dynamic settings with short timelines.
  • Strong written/verbal communication and presentation skills.
  • Proficient in Microsoft Office suite and applications.

Physical Demands / Travel

Please note this role will require up to 50% travel, primarily within assigned region but also nationally and globally as required.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is remote based, with significant travel on a regional basis to various sites.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each roles and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.


Reports To:

Senior Director, Drug Safety

Position Summary

Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by that goal. We pursue this goal with a tenacity, focus and commitment to excellence that defines who we are and how we work.

The Drug Safety Specialist will be responsible for providing Drug Safety/Pharmacovigilance support for new and ongoing clinical trials including the collection, processing, and reporting of adverse events/endpoints while adhering to International Council for Harmonization (ICH) guidelines, Good Clinical Practices (GCP), applicable regulatory guidelines, data protection guidelines and study procedures. 

Required Qualifications and Background

  • Perform triage of incoming Serious Adverse Event (SAE) reports and consider assessments of seriousness, listedness, and causality; coordinate triage review with medical monitor.   
  • Review case narratives, including identifying relevant information from source documents and write/review queries when additional information needed 
  • Review data entry of SAEs in safety database including MedDRA coding
  • Coordinate medical monitor case review
  • Assist with the management of case processing deadlines
  • Assist in reconciliation between the safety and clinical databases for serious adverse events.
  • Compile safety information for aggregate safety reports and other safety related reports.
  • Assist with ongoing safety surveillance
  • Assist with compilation and updating of safety related spreadsheets including metrics and SUSAR submissions
  • Review and update existing standard operating procedures (SOPs) and assist with creation of new SOPs for safety department as indicated  
  • May oversee work performed by a safety Contract Research Organization (CRO)

Physical Demands / Travel

The physical demands of this job are consistent with light office duties.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in an office.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each roles and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.


Reports To:

Office Manager

Position Summary

Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by that goal. We pursue this goal with a tenacity, focus and commitment to excellence that defines who we are and how we work.

The Laboratory/Administrative Assistant will provide critical support in a robust Discovery Lab environment.  This role will be broken down into two areas: 1. Lab support consisting primarily of safety maintenance, sample management and tracking, and data entry.  2. Administrative support consisting of visitor management, overseeing deliveries, provide expense reporting, assisting with coordination of meetings and conferences, ordering and organizing supplies, planning team lunches/dinners, and working on special projects as needed.

Roles and Responsibilities of the Position*

Lab Support:

  • Prepare samples for testing, manage organized storage of samples, provide samples to assay scientists for internal assays, and ship samples to external vendors for testing.
  • Maintain complete, accurate and organized systems; file addition/correction sheets, requisitions and scientific/date results according to internal SOPs and guidelines.
  • Entry of data into electronic lab notebooks
  • Assist with obtaining quotes for external assays and the coordination of delivery of samples between lab and external vendors, both US and international. 
  • Contribute to the upkeep and safety of the laboratory and ensure a clean, safe, adequately supplied work area.

Administrative Support:

  • Schedule key meetings and calls for team members and process expense reports.
  • Organize complex activities such as travel, conferences and department activities.
  • Coordinate team lunches and dinners and facilitate weekly GrubHub lunch orders.  
  • Welcome outside visitors.
  • Receive and organize multiple deliveries per week, requiring some lifting and moving of boxes on a regular basis.
  • Process both US and international outgoing shipments.
  • Coordinate office maintenance and support and work closely with our IT vendor.
  • Stock and maintain kitchen and shared office areas as well as order office supplies.
  • Act as a point of contact for the team, field questions and inquiries, and proactively problem solve.
  • Assist with the coordination and facilitation of onsite candidate interviews and employee onboarding.
  • Assist with special projects as needed.

Required Qualifications and Background

  • Bachelor’s degree in the Life Sciences preferred;  
  • 1-2 years’ experience as a Lab Assistant or an Administrative Assistant supporting a Discovery Lab Environment.  Excellent opportunity for a recent college graduate with a Biology or Chemistry degree in search of their  first industry job.
  • Proficient in Microsoft Office suite and applications including proficient use of Excel.
  • Strong attention to detail and communication skills.
  • Collaborative, enthusiastic and self-motivated; driven to improve processes and eliminate inefficiencies

Physical Demands / Travel

The physical demands of this job are consistent with working in a wet-laboratory setting.  Requires ability to lift 15lbs.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in a wet-laboratory setting.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each roles and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.


Reports To:

Senior Director, Clinical Development

Position Summary

Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by that goal. We pursue this goal with a tenacity, focus and commitment to excellence that defines who we are and how we work.

This position offers the opportunity to participate in the entire spectrum of the drug development process. We design our drugs “from the ground up”, starting with the selection of a target we hypothesize is critical for cancer survival and producing a highly potent and specific inhibitor of that single target.  As the Senior Clinical Scientist, you will have the opportunity to not only move this drug “from the bench to the bedside”, from initial planning of the first-in-human clinical trial to the pivotal studies necessary to prove its clinical efficacy and gain regulatory approval but also lead a team of Clinical Scientists. You will participate directly in improving the lives of people fighting their cancers.

Roles and Responsibilities of the Position*

In your role, you will team with the medical monitor and other team members to design, implement execute and analyze results for Phase 1, 2 and 3 clinical trials for ultimate culmination in clinical study reports and NDA/MAA submissions. Excellent communication skills are important, as you will interact with a variety of collaborators, including colleagues, outside consultants, clinical research sites, and key opinion leaders.

We are a small company, but we are highly focused on clinical and regulatory execution. As a key member of our team, you will have the opportunity to work and learn in a fast-paced, team-oriented and exciting work environment that will literally change the lives of cancer patients for the better.

The Senior Clinical Scientist will help translate preclinical discoveries into developing the next generation of cancer therapies and will be responsible for the design, implementation, and monitoring of clinical development programs. These programs include early proof of concept through registration in a variety of targets and may involve collaborations with corporate development partners. Responsibilities encompass strategic planning to ensure optimized clinical development plans for assigned projects. This person must be interested in working in a fast-paced, team-oriented environment and be adaptable to rapidly changing priorities. 

  • Serve as the lead clinical science representative on global and regional clinical execution teams.
  • Create and foster strong strategic partnerships with colleagues that include Clinical Operations/Development, Global Regulatory Affairs, Clinical Pharmacology, Statistics, Medical Affairs, Data Management and pre-Clinical Development. 
  • Lead the design and interpretation of clinical trials. 
  • Assist in the writing and/or development of protocols, informed consent forms, case report forms, Statistical Analysis Plans, Data Management plans, clinical study reports and regulatory-related documents.
  • Assistance in the development of abstracts, manuscripts, study/program design and presentations; collaborate with external consultants as needed.
  • Review, interpret, and present clinical data from development program and the relevant literature at relevant scientific meetings.
  • Support the writing of subsequent regulatory briefing documents.
  • Lead and accountable for interpretation of interim data analyses, clinical data review, and preparation of dose escalation meetings.  
  •  Demonstrate substantial and relevant knowledge of scientific and medical literature in oncology and its application to strategic design and operational achievements.
  • Along with Clinical Operations, work closely and liaise regularly with clinical sites and investigators to oversee study enrollment and success in clinical trials
  • Apply scientific and operational knowledge to identify and analyze problems and information of considerable complexity and implement effective plans and solutions.
  • Ability to prioritize effectively and meet multiple deadlines successfully with attention to detail, setting high performance standards.
  • Proactively generate ideas for improvements and take action to solve problems and achieve goals beyond what is required.

Required Qualifications and Background

  • PharmD, PhD or MD or MSN in Nursing.
  • The ideal candidate will have 7 years of biopharma experience in an academic or industry setting and at least 2+ years’ medical/clinical scientist experience in oncology. At least 7 years’ clinical research experience preferred, particularly in drug development in oncology.
  • Clinical trial expertise along with experience in oncology with drug development highly desirable. Must possess a strong background in clinical trials in an academic or industry setting.
  • Extensive academic/industry experience in laboratory-based cancer research or clinical trials is preferred.
  • The skills required for success in the job include scientific and analytic ability, ability to think strategically and tactically, an interest in applied clinical research, an ability to work effectively in multifunctional teams and excellent organizational and communication skills.
  • The candidate must demonstrate proven ability to evaluate, interpret and present complex scientific data to both technical and non-technical audiences.
  • Demonstrated ability to work well with other accomplished professionals within and across functions/teams. Willing collaborator.
  • Strong communication skills both written and oral.
  • Ability to multi-task and shift priorities rapidly to meet tight deadlines.
  • Professional demeanor and appearance and an excellent written and verbal communicator.
  • Detail oriented and well organized.
  • Good and thoughtful listener.
  • Enthusiastic, self-motivated and keen to improve processes and overcome inefficiencies.
  • Proficient in Microsoft Office suite and applications.

Physical Demands / Travel

The physical demands of this job are consistent with light office duties.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in an office.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each roles and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.


Reports To:

Vice President, Discovery Biology

Position Summary

Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by that goal. We pursue this goal with a tenacity, focus and commitment to excellence that defines who we are and how we work.

This position offers the opportunity to be part of Loxo’s discovery teams focused on creating novel, highly specific and selective drugs for genetically identified targets.  The Senior Structural Biologist will offer structural and mechanistic insights to a multi-disciplinary discovery team by providing high-resolution protein-ligand crystal structures.

Roles and Responsibilities of the Position*

  • Generate protein-small molecule complex x-ray crystal structures with hands-on lab involvement throughout the entire gene to structure process including protein expression, purification, crystallization, and structure determination.
  • Coordinate protein construct design, expression, and purification with the project team to support biochemical and biophysical assays.
  • Rapidly communicate scientific results and insights to the team.
  • Identify, evaluate, and manage vendors for outsourced services and studies.
  • Collaborate with colleagues throughout the company to ensure structural work meets the program needs and results are appropriately interpreted.
  • Prepare reports for internal and external purposes including regulatory submissions.
  • Participate and lead project-based and technical team meetings to identify and solve problems, guide work towards project goals, communicate on-going work and progress, and plan forward thinking strategies. 
  • Develop and continually advance one’s knowledge base on genetically targeted drugs and structure-based drug design.
  • Proactively investigate new or different technologies, methods, and service providers to ensure our work is being done in a scientifically sound, efficient, and reasonable way.
  • In the future, this position’s responsibilities may include supervision of scientists and associates.

Required Qualifications and Background

  • PhD in Biochemistry, Chemistry, or related field
  • Ideal candidate will have with 5+ years hands-on gene to structure protein-small molecule crystallography experience in a biotech/pharma setting.
  • Highly skilled in crystallization of protein-small molecule complexes and high-resolution x-ray structure determination
  • Extensive experience in protein construct design, expression, purification, and characterization
  • Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels.
  • Highly organized with excellent analytical, documentation and multi-tasking skills
  • Committed to staying current with the latest scientific breakthroughs in structure-based drug design and structural biology.
  • Expertise in other methods of biophysical and structural biology is a plus

Physical Demands / Travel

The physical demands of this job are consistent with light office duties.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in an office and the lab.  

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each roles and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.


Position

Outstanding Team Member

Location

Stamford, CT, South San Francisco, CA, or Boulder, CO (or another location to be determined)

Position Summary

Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by that goal. We pursue this goal with a tenacity, focus and commitment to excellence that defines who we are and how we work.

We seek dedicated, passionate, hardworking intelligent, thoughtful and authentic individuals who thrive within a collaborative and fast-paced environment and will bring their experiences, unique perspectives and problem-solving skills to the team. In return, we cultivate an environment that rewards and recognizes hard work and provides opportunities for learning and growth as part of a team making a meaningful difference in the field of medicine and for individual patients.

If you share our passion, please let us know how you could contribute to our team. We don't want to pass up an opportunity for the right candidate to join us just because you found us before we found you.

Connect With Us

Submit your resume and your "Who", "What" and "Why" (see below) to careers@loxooncology.com.

Your "Who", "What" and "Why":

  • Who are you?
  • What will you bring to Loxo?
  • Why do we need you on the team?