Career Opportunities

Career Opportunities


Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by our goal of improving the lives of people living with cancer. We pursue this goal with a tenacity, focus, and commitment to excellence that defines who we are and how we work.

We seek dedicated, passionate, hardworking, intelligent, thoughtful, and authentic individuals who thrive within a collaborative and fast-paced environment and will bring their experiences, unique perspectives and problem-solving skills to the team. In return, we cultivate an environment that rewards and recognizes hard work and provides opportunities for learning and growth as part of a team making a meaningful difference in the lives of patients.

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Position:
ADME/DMPK Associate Scientist/Scientist
Function:
Discovery Small Molecule
Location:
Boulder, CO
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

Loxo Oncology at Lilly’s Drug Discovery team has an immediate opening for an ADME/DMPK Scientist.  The Loxo Oncology at Lilly team’s mission is to invent life-changing targeted therapies for cancer patient populations that are poorly treated by existing therapies. To that end, we have built a multi-disciplinary team of dedicated drug discovery scientists who are passionate about driving the science forward to create highly selective drugs for known oncogenic drivers.
Role and Responsibilities for the Position
  • Design and execute preclinical and absorption, metabolism, distribution, and excretion (ADME) studies to understand the pharmacokinetics (PK) of drug candidates
  • Run weekly ADME assay to guide chemistry structure activity relationships (SAR)
  • Participate in the management of CROs in the conduct of in vitro ADME studies
  • Analyze in vitro sample utilizing LC-MS/MS
  • QC in vivo protocols and study reports
  • Collate data and present to program team
  • Contribute to authoring and review of regulatory reports and documents
  • Maintain accurate and timely electronic lab notebook
  • Work effectively both independently and in a team environment
Required Qualifications and Background
  • BS or MS degree in chemistry, biochemistry or related discipline
  • 2-6 years of laboratory experience
  • 1+ year LC-MS/MS experience (Sciex systems preferred)
  • Experience with bioanalysis method and assay development
  • Good written and oral presentation capabilities
  • Must have experience with pharmacokinetic modeling
  •  
    Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Associate Scientist level could range from between $59,000 to $86,577 and that the base salary for the Scientist level could range from between $78,000 to $114,498 will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands:
 
The physical demands of this position are consistent with working in a laboratory/ bench environment. Some light lifting and maneuvering may be required.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 Work Environment:
 
This position’s work environment is based in a laboratory/ bench environment.
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Associate Director, Diagnostic Medical Affairs
Function:
Diagnostic Medical Affairs
Location:
Remote
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Associate Director, Diagnostic Medical Affairs will provide input to diagnostic strategy and support execution of that strategy for assigned precision medicine product launches. This role has specific focus on identifying unmet medical needs and barriers to adoption of clinical biomarker testing for the program disease states. Strategic planning and execution will include but is not limited to planning educational needs, publication planning, thought leader engagement, and internal cross functional alignment with business unit teams. As part of the Loxo Oncology at Lilly global medical affairs team, the Associate Director will focus on understanding the diagnostic testing environment and building plans to address identified gaps which may impact adoption or utilization of biomarker tests. The Associate Director Medical Affairs may help to inform diagnostic development strategy as well as support launch strategy for biomarker testing. The Associate Medical Director provides expertise to a variety of diagnostic focused tasks and utilizes their expertise in clinical diagnostics and companion diagnostics to establish strong partnerships with internal and external stakeholders. Additionally, the Associate Director will provide cross functional support to address business needs of the development, clinical and commercial teams as it relates to diagnostic testing.
Roles and Responsibilities of the Position
  • Support the development and implementation of the diagnostic Medical Affairs launch strategy for assigned programs.
  • Work closely and in synergy with diagnostic development teams as well as therapeutic medical affairs team.
  • Communicate diagnostic and therapeutic market trends which may impact biomarker testing.
  • Support companion diagnostic development timelines associated with assigned programs.
  • Serve as Loxo Oncology’s scientific representative to the pathology, diagnostic and medical communities; facilitate the appropriate exchange of scientific information.
  • Participate and support advisory boards and steering committees.
  • Provide support through development and/or review of field based diagnostic educational and promotional materials for scientific accuracy.
Required Qualifications and Background
  • MD with formal Training in Anatomic Pathology, American Board of Pathology – Anatomic Pathology eligible or certified; OR PhD with 3+ years’ pathology, in vitro diagnostic development or clinical diagnostic laboratory experience in oncology. 
  • Strong knowledge of pathology laboratory clinical diagnostic testing processes, regulatory oversight, technologies and methods used.
  • Ability to apply diagnostic medical experience and knowledge to business needs.
  • Excellent verbal and written communications. Proficient with evaluating and reporting complex scientific and clinical data and translating them into simple messages. Quick understanding of a disease landscape. 
  • Must have proven experience working in a matrixed environment and be an effective collaborator. 
  • Self-directed and proactive individual with ability to thrive in a fast-paced, entrepreneurial, dynamic environment with high performing colleagues 
  • Comfortable executing on multiple projects independently. 
  • Ability to build strong relationships with co-workers of various backgrounds and expertise.  
  • Ability to function at a high level in a team setting whether leading the group or acting as an individual contributor 
  • Excellent interpersonal skills, with the ability to gain respect and influence and to build lasting relationships with internal colleagues as well as external thought leaders within the diagnostics community.
  • Ability to critically review current Dx literature, providing relevance to our products and markets.
  • Planning and organizational ability as well as budget management.
  • Proficient in Microsoft Office suite and applications.
Additional Preferred Qualifications
  • Experience in Hematologic cancer diagnostic tests in pathology
  • Experience with both anatomic and molecular pathology laboratories and test methods
  • Experience and knowledge of IVD and CDx market, regulatory processes and reimbursement
  • Prior direct management experience
  • Experience interacting with pathologists and pathology laboratories
Physical Demands/ Travel:
 
The physical demands of this job are consistent with light office dutiesThis role requires up to 40% travel primarily to US offices but also with global travel for international business meetings several times per year.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
Work Environment:
 
This position’s work environment is in a home office.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position could range from between $135,300 to $198,516 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Associate Director, Discovery Biology
Function:
Target Discovery
Location:
South San Francisco, CA
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Discovery Biology team will be part of a multi-disciplinary effort focused on bringing forward innovative cancer drug therapies. The Discovery Biology Associate Director will be responsible for leading a research team to identify the next generation of molecular targets for cancer therapeutics. Experience in either functional genomics or chemical biology is required. The Associate Director will lead the discovery and early validation of oncology targets through close collaborations with other discovery and translational functions. 
Roles and Responsibilities of the Position
  • Lead cross-functional teams that will be responsible for novel target discovery and validation including Discovery Biology team members in SSF and NYC
  • Supervise and mentor PhD and non-PhD scientists engaged in target identification and validation to think deeply and work creatively while delivering excellent scientific results and insights to the project teams and their colleagues
  • Develop and implement strategies that will enable Discovery Biology team members to continually advance internal drug development efforts through our discovery, clinical and research programs
  • Innovate technologies and methods to advance our discovery projects particularly in the area of gene editing/functional genomics and or chemical biology
  • Engage leaders across Loxo Oncology at Lilly to identify, credential, and advance new targets and serve as a liaison for the Discovery Biology team and the company at large
  • Contribute to due diligence evaluation of external opportunities
  • Mentor post-doctoral fellows
Required Qualifications and Background
  • PhD in systems biology, molecular & cellular biology, chemical biology, or related field
  • Minimum of 5-10 years research experience following post-doctoral training with prior experience in target discovery/credentialing and cancer biology in the biotech or pharma setting
  • Extensive experience in the areas of cancer biology and cancer genomics
  • Demonstrated track record of success in leveraging functional genomics or chemical biology platforms
  • Demonstrated evidence for the ability to partner with computational biologists to leverage systems-scale datasets
  • Expertise in designing and commissioning studies using a variety of research tools in cancer cell lines and murine models of cancer
  • Experience in leading PhD level scientists
  • Outstanding communication, writing, and presentation skills is a must
  • Highly organized with excellent analytical, documentation and multi-tasking skills
  • Provide strategic input to target identification and validation strategy to leadership team
  • Ability to collaborate, lead, and influence others
Additional Preferred Qualifications
  • Hands on experience executing functional genomics screens or deploying chemical biology tools
  • Experience working with external CROs to optimize internal/external resources
Physical Demands/ Travel:
 
The physical demands of this job are consistent with light office duties and some laboratory work. Some light lifting, and maneuvering may be required.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in an office and laboratory environment.
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Associate Director, Discovery Biology
Function:
Target Discovery
Location:
New York, NY
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Discovery Biology team will be part of a multi-disciplinary effort focused on bringing forward innovative cancer drug therapies. The Discovery Biology Associate Director will be responsible for leading a research team to identify the next generation of molecular targets for cancer therapeutics. Experience in either functional genomics or chemical biology is required. The Associate Director will lead the discovery and early validation of oncology targets through close collaborations with other discovery and translational functions. 
Roles and Responsibilities of the Position
  • Lead cross-functional teams that will be responsible for novel target discovery and validation including Discovery Biology team members in SSF and NYC
  • Supervise and mentor PhD and non-PhD scientists engaged in target identification and validation to think deeply and work creatively while delivering excellent scientific results and insights to the project teams and their colleagues
  • Develop and implement strategies that will enable Discovery Biology team members to continually advance internal drug development efforts through our discovery, clinical and research programs
  • Innovate technologies and methods to advance our discovery projects particularly in the area of gene editing/functional genomics and or chemical biology
  • Engage leaders across Loxo Oncology at Lilly to identify, credential, and advance new targets and serve as a liaison for the Discovery Biology team and the company at large
  • Contribute to due diligence evaluation of external opportunities
  • Mentor post-doctoral fellows
Required Qualifications and Background
  • PhD in systems biology, molecular & cellular biology, chemical biology, or related field
  • Minimum of 5-10 years research experience following post-doctoral training with prior experience in target discovery/credentialing and cancer biology in the biotech or pharma setting
  • Extensive experience in the areas of cancer biology and cancer genomics
  • Demonstrated track record of success in leveraging functional genomics or chemical biology platforms
  • Demonstrated evidence for the ability to partner with computational biologists to leverage systems-scale datasets
  • Expertise in designing and commissioning studies using a variety of research tools in cancer cell lines and murine models of cancer
  • Experience in leading PhD level scientists
  • Outstanding communication, writing, and presentation skills is a must
  • Highly organized with excellent analytical, documentation and multi-tasking skills
  • Provide strategic input to target identification and validation strategy to leadership team
  • Ability to collaborate, lead, and influence others
Additional Preferred Qualifications
  • Hands on experience executing functional genomics screens or deploying chemical biology tools
  • Experience working with external CROs to optimize internal/external resources
Physical Demands/ Travel:
 
The physical demands of this job are consistent with light office duties and some laboratory work. Some light lifting, and maneuvering may be required.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in an office and laboratory environment.
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Associate Director, GxP Systems
Function:
Information Technology
Location:
Remote
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Associate Director, GxP Systems will partner with business leaders to align IT GxP efforts with business requirements. Engage with business leaders and IT to build out a robust and scalable GxP environment, ensuring that all technology, architecture, and governance are aligned to strategic business initiatives. This position will act as the IT GxP SME for all interactions with the FDA.
Roles and Responsibilities of the Position
  • Build out GxP environment using a strong understanding of business core functions and GxP compliance needs while considering LO@LLY’s short and long-term organizational goals and initiatives.
  • Provides guidance and counsel on technology, enhancements and upgrades available that drives delivery of compliance solutions consistent with business direction.
  • Builds and leads a team comprised of FTEs and contractors who specialize in IT GxP systems.
  • Manage technology investments to align with IT compliance architecture and roadmap in partnership with the business.
  • Regularly assesses company’s GxP systems and identifies any potential Part 11 or Annex 11 gaps.
  • Drives all GxP system projects throughout entire life cycle including implementation, training, deployment, adoption, change control, upgrades and retirement of all GxP systems in partnership with business.
  • Initiates and manages corrective actions resulting from audit or inspection findings or other quality events pertaining to GxP deliverables or activities and determines solutions or recommendations for changes and/or improvements.
  • Works cross functionally with business areas to maintain and upgrade GxP systems
  • Provides input into GxP system change controls 
Required Qualifications and Background
  • Minimum BS/BA in Engineering, IT, or Computer Science (may consider relevant experience in lieu of education
  • 8+ years of related experience within IT GxP within pharmaceutical or biotechnology setting).
  • 3+ years of experience leading an IT GxP team or equivalent leadership experience within life sciences industry.
  • Expert working knowledge of global Health Authority requirements and expectations (e.g. EU, FDA, etc.) for computerized systems in the pharmaceutical industry. 
  • Experience in a regulated pharmaceutical environment required.
  • Demonstrated ability to work well with other accomplished professionals within and across functions/teams. Willing collaborator.
  • Strong written and oral communication skills.
  • Ability to multi-task and shift priorities rapidly to meet tight deadlines.
  • Enthusiastic, self-motivated and keen to improve processes and overcome inefficiencies.
  • Proficient in Microsoft Office suite and applications.
  • Veeva experience preferred
Available locations for this position
  • Remote- US Based
  • Stamford, CT
  • South San Francisco, CA
Physical Demands/ Travel:
 
The physical demands of this job are consistent with light office duties.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
Work Environment:
 
This position’s work environment is in an office.
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Associate Director, Large Molecule Biology
Function:
Discovery Biologics
Location:
New York, NY
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Associate Director, Large Molecule Biology will lead a dynamic group of scientists (internal team as well as external CRO) conducting various research projects to identify large molecule/biologics which can effectively treat various forms of cancer.  This is a hands-on role where you will lead from the bench.  The Associate Director, Large Molecule Biology will design and perform experiments that determine the efficacy of pipeline agents through a variety of techniques such as in vitro and ex vivo assays, target validation, and functional screening. Collaboration across functional areas within Loxo Oncology at Lilly is required including Large Molecule and Oncology Biologics senior leadership.  The Associate Director, Large Molecule Biology will be a key member of the large molecule organization, where you will be responsible for maintaining the scientific quality and efficiency of your organization, as well as assist and contribute to the strategic direction of large molecule discovery.
Roles and Responsibilities of the Position
  • Design and oversee the execution of key mechanistic and discovery biology experiments involving diverse oncogenic mechanisms (i.e., tumor indications, signaling, cancer targets, biologic mechanisms of tumor inhibitions).
  • Design and execute a scientific research discovery program from idea development to IND filing.
  • Maintain focus on project deliverables and prioritize experiments and efforts accordingly.
  • Oversee/perform assays to identify the drug candidate evaluate the candidate for clinical testing.
  • Liaise with CROs and vendors to outsource activities, provide input to management team on vendor selection.
  • Provide scientific expertise when determining organizations to strategically partner with.
  • Interrogate experimental conduct of third parties/vendors.
  • Participate in target identification in collaboration with leadership.
  • Build, lead, and manage team of Scientists at various levels.  
  • Indirectly oversee work of third parties/vendors (e.g., CROs).
  • Manage resource allocation effectively.
  • Build roadmaps to execute on specific targets, and overall strategic projects.
Required Qualifications and Background
  • PhD in cellular biology, immunology, or allied disciplines with minimum 3+ years’ industry experience OR BS/MS with 10+ years of direct pharmaceutical/biotechnology experience.
  • Laboratory experience with ADC and TCE platforms highly preferred
  • Knowledge of immunology and/or cancer signaling biology experience
  • Strong attention to detail and highly goal oriented with demonstrated critical thinking capabilities.
  • Ability to trouble shoot effectively and think outside of the box.
  • Ability to collaborate with translational biology functions (PK/PD, toxicology, Ab discovery).
  • Proven success leading, managing, and coaching others (either directly or indirectly).
  • Demonstrated ability and track record in managing work overseen by third parties/vendors/strategic partners.
  • Demonstrated experience in working collaboratively across various scientific disciplines to meet end goals of business.
  • Demonstrated excellence in making key strategic decisions in support of broader business goals.
  • Excellent written and verbal communication skills.
Physical Demands/ Travel:
 
The physical demands of this job are consistent with laboratory/bench setting
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in a lab.  
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Associate Director/Director, Data Management - Clinical Pharmacology (Multiple Locations)
Function:
Clinical Data Management
Location:
Remote
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

This role is responsible for oversight of all Clinical Pharmacology healthy subject studies conducted by or on behalf of Loxo Oncology at Lilly.  This will include, but not limited to the following responsibilities: direct report supervision, DM mentorship, data collection strategy, data flow management, transfer management, maintaining a high degree of data quality and integrity and any other activities pursuant to study execution per policy and protocol. 
 
This individual will manage and mentor study level lead data managers.  This role will also work closely with program leads from cross functional groups including, but limited too, Clinical Trial Managers, Biostatistics, medical monitors.  This role is also responsible for DM vendor management, contract reviews and relationships to ensure vendor tasks and responsibilities are in compliance with standard operating procedures and regulatory agency guidelines. This role ensures all Data Management activities stay within full compliance of Loxo regulatory and legal policies.
Roles and Responsibilities of the Position
  • Represents CDM from a strategic planning and execution capacity in development team meetings.
  • Lead and implement process development for Clin Pharm study execution activities.
  • Provide oversight of CRO and associated activities and responsibilities for study start-up, conduct and close-out.
  • Participate in Request for Proposal engagements with vendors in cooperation with cross-functional representatives.
  • Contribute to the evaluation of RFPs, subsequent bid defenses and the eventual selection of vendor partners.
  • Proactively identifies potential program and delivery issues/risks and recommends/ implements solutions.
  • Creation of data management timelines used to coordinate and synchronize deliverables with the overall program and efficacy study timelines.
  • Manage a team within the CDM Clin Pharm group including day to day operations, resource and study allocation, and career development.
  • Understand and influence CDM resourcing strategies to meet the current program/study needs.
  • Develop and ensure that deep knowledge of internal, external and regulatory requirements/expectations are understood, well communicated and applied to data deliverables.
  • Effectively apply knowledge of applicable internal, external and regulatory requirements/expectations (MHRA, FDA, ICH, GCP, PhRMA, Privacy, etc) to data collection, validation and CDM documents.
  • Continually seek and implement means of improving processes to reduce cycle time, study costs as well as a decrease work effort.
  • Lead/Sponsor CDM department-level improvement initiatives.
  • Evaluate and engage CRO/service providers for all studies and relationships, as needed.
  • Work with partners to increase vendor/partner efficiencies.
  • Monitors the progress of all data management activities on all studies to ensure project timelines are met.
  • Performs any and all other tasks and activities as requested.
Required Qualifications and Background
  • Bachelor’s degree in life sciences, math, computer science or related field required. Master’s degree in life sciences, math, computer science or related field preferred.
  • Minimum of 10+ years’ clinical data management experience. 
  • Minimum of 3 years’ Oncology/Hematology experience.
  • Minimum of 3 years’ direct report experience.
  • Demonstrated knowledge of drug development processes.
  • Demonstrated leadership and project management skills.
  • Demonstrated ability to effectively partner/influence cross functionally to deliver results.
  • Thorough and broad knowledge of data management processes, including EDC and interactive voice response system (IVRS)experience.
  • Knowledge of regulatory guidelines such as GCP, 21 CFR Part 11 etc.
  • Knowledge of study data tabulation model (SDTM, ADaM, CDISC).
  • Must have excellent verbal, written and communication skills.
  • Ability to work independently as well as in a team environment.
  • Excellent time management skills and a proven ability to work on multiple projects at any given time in a fast-paced environment.
  • Demonstrated ability to stay abreast of trends and new information in the profession.
Additional Preferences
  • Managing or Oversight of healthy subject clinical pharmacology studies.
  • Sponsor experience preferred.
  • Recent submission experience preferred (FDA, EMA, PMDA, etc).
Available locations for this role
  • South San Francisco, CA
  • Remote- US based
Physical Demands/ Travel:
 
The physical demands of this job are consistent with light office duties. This position will travel occasionally; up to 20% with some variation based upon the demands of the business imperatives.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
Work Environment:
 
This position’s work environment is in an office setting.  
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Associate Director/Director, Regulatory Affairs (Multiple Locations)
Function:
Regulatory Affairs
Location:
Remote
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Associate Director/Director, Regulatory Affairs will contribute to the formulation of regulatory strategy, serve as the regulatory lead on relevant project teams, and act as the regulatory contact for US/Global health authorities as required.  This individual will oversee the planning and execution of major submissions and responses to regulatory authorities related to IND/NDA submissions, Annual Reports, Investigator Brochures, IND amendments, briefing book for FDA meetings, as well as responses to requests.
Roles and Responsibilities for the Position
  • Responsible for developing and implementing the regulatory strategy for assigned projects and programs for projects in all stages of development (IND through NDA/BLA approval)
  • Applies global regulatory knowledge governing responsible products to contribute to the overall development strategy
  • Provide regulatory leadership & guidance to project teams
  • Lead and support FDA meetings; develops briefing packages for meetings with FDA and other global health authorities
  • Responsible for coordinating all aspects of regulatory submissions relevant to assigned projects or programs
  • Develop response strategies and submissions to regulators
  • Develop regulatory submission documents. Manage or delegate the management of the completion of documents and other assigned tasks within established timelines and with high quality – in terms of scientific content, organization, clarity, accuracy, format, consistency and adherence to regulatory guidelines, styles and processes
  • Develop strategies and drafts and/or review responses and other documents intended for submission to FDA and other global health authorities
  • Identify and assess regulatory risks for assigned projects or programs
  • Prepare and deliver effective presentations for internal audiences
  • Monitor newly published FDA guidelines and international guidance documents in the context of new and ongoing development programs
  • Primary point of contact to regulatory agencies relevant to assigned projects or programs, as appropriate
Required Qualifications and Background
  • 8+ years pharmaceutical/drug development experience and 6+ years in Regulatory Affairs.  Advanced degree in a scientific discipline preferred.
  • Experience in successful submission of INDs/CTAs required, NDA/BLA/MAA submission experience preferred.
  • Proven experience navigating successful submissions in the oncology space is preferred
  • Strong scientific foundation, including a good understanding of oncology, is preferred.
  • Knowledge and understanding of US regulatory requirements
  • Self-motivated in accelerating work to meet challenging timelines
  • Ability to work both independently with minimal direction and within project teams, committees, corporate partners, etc. to attain group goals
  • Demonstrate excellent communication skills
  • Ability to represent the group in project teams
  • Ability to work both independently with minimal direction and within project teams, committees, corporate partners, etc. to attain group goals
  • Demonstrate good communication skills
  • Experience in interfacing with relevant regulatory authorities
  • Experience and knowledge in the preparation of major regulatory submissions and supportive amendments or supplements
  • Experience in interpretation and application of regulations, guidelines, policy statements, etc.
Available Locations for This Role
  • Stamford, CT
  • South San Francisco, CA
  • Indianapolis, IN
  • US Based-Remote
The physical demands of this job are consistent with light office duties.
 
Travel < 10%.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Associate Manager, Maintenance
Function:
Facilities/EHS
Location:
Boulder, CO
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

Loxo Oncology at Lilly is seeking a highly motivated, self-starting individual to join the team as a Associate Manager, Maintenance.  This position supports facilities and laboratory equipment maintenance and repair in oncology research and development facilities in a safe, efficient manner.   
Roles and Responsibilities of the Position:
  • Repair and maintain plant equipment and facilities.
  • Outfit and set-up maintenance shop in new research facility.
  • Assist in the start-up and commissioning of new research facility.
  • Support operations in existing Boulder lab facilities with emergency response and equipment repair.
  • Schedule and perform routine PM maintenance and lubrications.
  • Repair, calibrate and test plant and laboratory equipment as required.
  • Complete work requests in a timely and professional manner.
  • Organize and maintain new facility turnover documentation and drawings.
  • Schedule, coordinate and work with vendors and contractors when on-site.
  • Development and maintain electronic records for calibration and maintenance work performed.
  • Operate and maintain maintenance equipment and tools.
  • Follow safe work practices to maintain safe working conditions.
  • Clean building exteriors and grounds, assist in snow and ice removal.
  • Order and inventory all necessary supplies and parts to perform required duties.
  • Maintain and adhere to annual departmental budget.
  • Perform routine audits for maintenance and safety.
  • Perform work in confined space.
  • Perform duties while using a ladder.
  • Complete all required documentation.
  • Execute other responsibilities and projects as required.
Required Qualifications and Preferred Background:
  • Use of hand and power tools. Electrical troubleshooting and use of electrical test equipment. Perform mechanical repairs.
  • Minimum of 5 years electrical and mechanical maintenance in a research environment. Instrumentation, PLC and building management system experience a plus.
  • Project management experience including oversight and coordination of contractors.
  • Familiarity with asset management software and experience utilizing electronic records for facilities maintenance activities.
  • Familiarity with laboratory equipment and support systems including hoods, incubators, glass washers, autoclaves, refrigerators, freezers, centrifuges, material handling and waste collection.
Available Locations for this
  • Boulder/Louisville, CO
Physical Demands/ Travel:
 
The physical demands of this job are consistent with a maintenance shop environment.
       On-call emergency response required.
       Must be able to operate a forklift.
       Must be able to lift 50 pounds.
       Must be able to wear a respirator.
       Must be able to walk and stand for several hours per day.
       Must be able to climb ladders and work at elevated heights.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in a maintenance shop and laboratory environment.  
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position could range from between $78,000 to $114,497 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
 


*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Associate Manager/Senior Associate Manager, Publications
Function:
Communications
Location:
Remote
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Associate Manager, Publications supports the efficient planning, tracking and dissemination of key scientific data including but not limited to abstracts, oral and poster presentations, and manuscripts. Additionally, he/she will have operational responsibilities for all aspects of medical communications and publications.
Roles and Responsibilities of the Position
  • Plans, writes, edits and finalizes manuscripts, abstracts, posters, slide presentations, and other documents to ensure appropriate evaluation and presentation of data, methodology, and interpretation aligned with the objectives of Loxo Oncology at Lilly.
  • Provides support to the preclinical, medical, health-outcomes, and other relevant teams for the submission of scientific publications to target journals, congresses, and other venues.
  • Develops content for and reviews publications for clarity, accuracy of content, consistency, and interpretation.
  • Develops high quality deliverables.
  • Gains a progressively deepening understanding of disease state and current medical issues related to the Loxo Oncology at Lilly portfolio, and serves as a technical resource on molecule and/or disease state; uses this expertise to interpret and present scientific and statistical data in publications.
Required Qualifications and Preferred Background
  • Bachelor’s degree requires; advanced degree in a science field (Pharm D, PhD, DO, MD, MS or RN) strongly preferred along with 2+ years of Medical Communications/ Publications experience. Experience in the Oncology/targeted therapy drug market desired.
  • Excellent verbal and written communications. Proficient with evaluating and reporting complex scientific and clinical data and translating them into simple messages. Quick understanding of a disease landscape.
  • Experience with medical and scientific communication to expert and lay audiences
  • Self-directed and proactive individual with ability to thrive in a fast-paced, entrepreneurial, dynamic environment with high performing colleagues.
  • Comfortable executing on multiple projects independently.
  • Possesses strong integrity as well as the ability to build strong relationships with co-workers of various backgrounds and expertise
  • Ability to function at a high level in a team setting whether leading the group or acting as an individual contributor
  • Demonstrated flexibility as well as planning and organizational ability
Available locations for this role
  • Remote- US Based
  • Stamford, CT
  • Indianapolis, IN
  • South San Francisco, CA
Physical Demands/ Travel:
 
The physical demands of this job are consistent with light office duties.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in an office or remote based.
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Associate Scientist/Scientist, Medicinal Chemistry
Function:
Discovery Small Molecule
Location:
Boulder, CO
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

Loxo Oncology at Lilly’s Drug Discovery team has an immediate opening for a Medicinal Chemist.  The Loxo Oncology at Lilly team’s mission is to invent life-changing targeted therapies for cancer patient populations that are poorly treated by existing therapies. To that end, we have built a multi-disciplinary team of dedicated drug discovery scientists who are passionate about driving the science forward to create highly selective drugs for known oncogenic drivers. We are currently looking for medicinal chemists with a proven track records of success in synthetic organic chemistry. The ideal candidate will be passionate about using synthetic chemistry and data analysis skills to solve medicinal chemistry challenges and will excel at working closely with scientists across disciplines.  The position requires excellent people skills, a positive can-do attitude, and the ability to thrive in a highly interactive, fast-paced, team environment.
Roles and Responsibilities for the Position
  • Drive the team forward with new medicinal chemistry analogs that consistently move the project toward the next breakthrough drug candidate.
  • Optimize lead series for potency, selectivity, physiochemical properties, in vitro ADME, and PK by coupling multivariate SAR analysis with hypothesis-driven medicinal chemistry design principles.
  • Work closely with structural biology and computational chemistry colleagues to design novel compounds and hypotheses that address key drug optimization goals.
  • Reduce ideas to practice in the lab quickly by effectively employing a broad range of modern organic chemistry transformations, synthetic methods, purification and characterization techniques.
  • Synergize with the broader team by communicating results, sharing insights, making plans, and setting goals in an open, honest way.
Required Qualifications and Background
  • B.S. with 5+ years, M.S. with 3+ years, or Ph.D. with 0-1 years’ experience with a focus on synthetic organic chemistry or experience in small molecule organic synthesis and/or drug discovery experience in a biotechnology or pharmaceutical setting.
  • Proficiency in modern synthetic methodology and variable reaction scales.
  • Ability to design feasible synthetic routes to target molecules and choose appropriate reaction conditions.
  • Skilled user of synthetic chemistry instrumentation: HPLC, LC-MS, NMR, and purification systems.
  • Experience in lead compound optimization for potency, selectivity, ADME and PK is preferred but not required.
  • Experience in using common synthetic chemistry software: electronic notebook, ChemDraw, Excel, literature search engines.
  • An excellent team player with ability to communicate synergistically with a multidisciplinary team. Highly organized with excellent analytical, documentation, time management, and multi-tasking skills.
  •  
    Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Associate Scientist level could range from between $59,000 to $86,577 and that the base salary for the Scientist level could range from between $78,000 to $114,498 will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
The physical demands of this position are consistent with working in a laboratory/ bench environment. Some light lifting and maneuvering may be required.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Associate Scientist/Scientist, Medicinal Chemistry (San Diego, CA)
Function:
Discovery Small Molecule
Location:
San Diego, CA
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

Loxo Oncology at Lilly’s Drug Discovery team has an immediate opening for a Medicinal Chemist.  The Loxo Oncology at Lilly team’s mission is to invent life-changing targeted therapies for cancer patient populations that are poorly treated by existing therapies. To that end, we have built a multi-disciplinary team of dedicated drug discovery scientists who are passionate about driving the science forward to create highly selective drugs for known oncogenic drivers. We are currently looking for medicinal chemists with a proven track records of success in synthetic organic chemistry. The ideal candidate will be passionate about using synthetic chemistry and data analysis skills to solve medicinal chemistry challenges and will excel at working closely with scientists across disciplines.  The position requires excellent people skills, a positive can-do attitude, and the ability to thrive in a highly interactive, fast-paced, team environment.
Roles and Responsibilities for the Position
  • Drive the team forward with new medicinal chemistry analogs that consistently move the project toward the next breakthrough drug candidate.
  • Optimize lead series for potency, selectivity, physiochemical properties, in vitro ADME, and PK by coupling multivariate SAR analysis with hypothesis-driven medicinal chemistry design principles.
  • Work closely with structural biology and computational chemistry colleagues to design novel compounds and hypotheses that address key drug optimization goals.
  • Reduce ideas to practice in the lab quickly by effectively employing a broad range of modern organic chemistry transformations, synthetic methods, purification and characterization techniques.
  • Synergize with the broader team by communicating results, sharing insights, making plans, and setting goals in an open, honest way.
Required Qualifications and Background
  • B.S. with 5+ years, M.S. with 3+ years, or Ph.D. with 0-1 years’ experience with a focus on synthetic organic chemistry or experience in small molecule organic synthesis and/or drug discovery experience in a biotechnology or pharmaceutical setting.
  • Proficiency in modern synthetic methodology and variable reaction scales.
  • Ability to design feasible synthetic routes to target molecules and choose appropriate reaction conditions.
  • Skilled user of synthetic chemistry instrumentation: HPLC, LC-MS, NMR, and purification systems.
  • Experience in lead compound optimization for potency, selectivity, ADME and PK is preferred but not required.
  • Experience in using common synthetic chemistry software: electronic notebook, ChemDraw, Excel, literature search engines.
  • An excellent team player with ability to communicate synergistically with a multidisciplinary team. Highly organized with excellent analytical, documentation, time management, and multi-tasking skills. 
The physical demands of this position are consistent with working in a laboratory/ bench environment. Some light lifting and maneuvering may be required.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Bioinformatics Engineer/Senior Bioinformatics Engineer (Multiple Locations)
Function:
Discovery Bioinformatics
Location:
South San Francisco, CA
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

We are seeking a talented and highly motivated Bioinformatics Engineer to join our Discovery Bioinformatics group. The successful candidate will build informatics solutions using high-performance computing and cloud technology multidimensional clinical and preclinical -omics data. They will provide the engineering leadership to build creative solutions to challenging data problems.

Roles and Responsibilities of the Position
  • The successful candidate will have a flexible, learning mindset to design and deliver scientific databases, create workflows to process and analyze high-dimensional data. This will include development of self-service analytics tools to enable and facilitate the real-time analysis of scientific data within our research community. This position will lead local and off-shore engineering teams to deliver informatics solutions focused on data accessibility, quality, and reproducibility.
Required Qualifications and Background
  • Bachelor’s/Master’s/PhD in computer science, bioinformatics, or equivalent experience
  • 2+ years of software development experience, including experience in computer science, bioinformatics or other applied science
  • Documented track record delivering and deploying large-scale informatics production solutions in the cloud using AWS/Azure and Docker
  • Experience implementing bioinformatics pipelines using scalable cloud solutions. Familiarity with Nextflow, Snakemake, or WDL/Cromwell a plus.
  • Understanding of NGS technology, and downstream -omics data analysis (RNAseq, ATACseq, ChIPseq, etc.).
  • Familiarity with designing, maintaining and implementing relational databases. Experience with NoSQL databases a plus
  • Proficiency in working within a Linux/Unix environment
  • High-level understanding of full-stack web development including implementing RESTful web services with Javascript and related languages
  • Strong scripting abilities using Python, Perl, Go, Javascript or any other related programming language
Available Locations for this role
  • South San Francisco, CA
  • New York City, NY
  • US Based- Remote

Physical Demands/ Travel:
 
The physical demands of this job are consistent with light office duties.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
Work Environment:
 
This position’s work environment is in an office.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position could range from between $89,750 to $131672 for a senior scientist and $103,200 to $151,423 for a Principal Scientist and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Clinical Contracts Manager (Multiple Locations)
Function:
Clinical Operations
Location:
South San Francisco, CA
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Clinical Contracts Manager is responsible for managing all aspects of vendor selection / contracting, site contracting, and negotiation / execution of other required agreements (e.g. LOIs) in support of the clinical development plan. This role requires the ability to solve complex problems that require ingenuity, innovation, and creativity as well as experience working with clinical research phases I-IV.  The ability to collaborate with other clinical contracts team members, clinical trial teams, investigational sites and vendors is imperative. 

Roles and Responsibilities of the Position
  • Collaborate with clinical trial teams and other internal stakeholders, vendors and investigational sites to support timely study start-up to meet departmental and organizational goals.
  • Key vendor selection and contracting responsibilities include:
  • Develop study level budget based on CRO benchmark data
  • Manage the formulation of request for information (RFI) and request for proposals (RFP) for clinical services including bidding process
  • Contract and budget negotiation
  • Manage the development and execution of Vendor Master Agreements and Scope of Work (SOWs)
  • PO generation and management
  • Ongoing contract management (e.g. spend, change orders)
  • Key site contracting responsibilities include:
  • Develop patient/site level budget templates based on benchmark data
  • Manage the development and execution of Master Clinical Trial Agreements (MCTAs) and Clinical Trial Agreements (CTAs)
  • Ongoing contract management (e.g. amendments) 
  • Manage the development and execution of other agreements as needed.
  • When required, act as liaison between clinical service groups (SMO, CRO), legal and clinical trial teams for outsourced trials.
  • Manage the negotiation efforts to resolve complex and “deal breaker” issues with external parties.
  • Develop contract concepts and techniques and solve complex contractual problems that require ingenuity, innovation, and creativity.  
Required Qualifications and Background
  • BS degree in business administration, finance, science or related field or equivalent on the job experience may be considered; advanced degree a plus.
  • Minimum 3-5 years of experience in pharmaceutical services with 2+ years of contract management and/or study start-up activities including contract negotiations and management
  • High degree of organizational, analytical, and team management skills.
  • Ability to handle complex budgets.
  • Computer literacy with document and spreadsheet applications.
  • Ability to work on complex, multi-faceted projects.
  • Proven negotiation skills and vast knowledge of clinical trial agreements. 
  • Demonstrated ability to work well with other accomplished professionals within and across functions/teams; Strong collaborator.
  • Strong communication skills both written and oral.
  • Ability to multi-task and shift priorities rapidly to meet tight deadlines.
  • Professional demeanor.
  • Detail oriented and well organized.
  • Good and thoughtful listener.
  • Enthusiastic, self-motivated and keen to improve processes and overcome any inefficiencies.
  • Proficient in Microsoft Office suite and applications.
Available locations for this role
  • Stamford, CT
  • South San Francisco, CA
  • US Based-Remote
Physical Demands/ Travel:
 
The physical demands of this job are consistent with light office duties.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in an office.  
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Clinical Data Specialist/Senior Clinical Data Specialist (Multiple Locations)
Function:
Clinical Data Management
Location:
Remote
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Data Management Support position is responsible for performing clinical data management tasks from study start-up through eTMF archiving as directed by the study Lead Data Manager (LDM). This individual collaborates with the cross-functional study team to develop Sponsor clinical data review listings,  perform Sponsor Data Manager data review/cleaning, post and QC data transfers to and from Loxo, generate and report on study data metrics, and draft the Sponsor Data Management Plans for LDM review. The Data Management Support position ensures all actions are in full compliance with Loxo standard operating procedures (SOP) and regulatory agency guidelines. 
Roles and Responsibilities of the Position
  • Assists the Sponsor LDM to provide day to day support of Data Management (DM) services, including but not limited to the following tasks.
  • Partners with Contract Research Organization (CRO) DM for tracking and reporting on vendor data completeness and cleanliness.
  • Generates and distributes study data metric reports and data review listings which may include Excel pivot tables, algorithms, or VLOOKUP.
  • May be requested to perform oversight of vendor data including timeline development, PowerPoint slide development and presentation, and data trends reporting.
  • Communicate complex issues clearly through multiple media methods including email, instant message, text, telephone, and video phone.
  • May develop low-complexity data listings from Electronic Data Capture (EDC), JReview, or other reporting tool.
  • Drafts specifications for medium to high-complexity listings and reports.
  • Performs data review as directed by the LDM.
  • Vendor data transfer management
  • Drafts Sponsor DM documents such as Data Transfer Specifications (DTS), Data Management Plan (DMP), EDC design specifications, edit check specifications (ECS), Data Snapshot Requirements Plan, et al.
  • Performs Sponsor DM review of CRO generated Data Management documents such as:  CRF completion guidelines, DMP, data reconciliation plans, ECS or any other document as assigned by the LDM.
  • Performs Sponsor user acceptance testing (UAT) of EDC, reports, listings, data integrations, et al.
  • Works in partnership with CRO and DM Vendor representatives to ensure DM services timelines are transparent and on-track.
  • Attends internal, vendor, and CRO meetings as directed by the LDM.
  • Performs any and all other tasks and activities as requested.
Required Qualifications and Background
  • Bachelor’s degree in life sciences, math, computer science or related field required.
  • Minimum of two years’ clinical data management experience. 
  • Oncology research experience is preferred.
  • Proficiency in MS Office (Outlook, Word, Excel, PowerPoint)
  • Experience in MS Project is preferred.
  • Experience with web-based EDC, clinical data management systems and industry wide thesauri, such as MedDRA and WHO Drug.
  • Experience with Veeva EDC is preferred.
  • Excellent time management skills and a proven ability to work on multiple projects at any given time in a fast-paced environment.
  • Available to assist the study team to achieve important data deliverables across Pacific and Eastern Time Zone.
  • Self-driven and high achieving while maintaining a focus on quality in all aspects of work.
Available locations for this role
  • Stamford, CT
  • South San Francisco, CA
  • US Based-Remote
Physical Demands / Travel

The physical demands of this job are consistent with light office duties. This position will travel occasionally; the average travel for this position is infrequent (<10%) with some variation based upon the demands of the business imperatives.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in the employee’s home office.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Clinical Research Associate/Sr. Clinical Research Associate (Multiple Locations)
Function:
Clinical Operations
Location:
Remote
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Clinical Research Associate / Senior CRA in collaboration with the Clinical Trial Manager and/or other operational leadership, contributes to the operational execution of clinical studies to ensure delivery on time, within budget, and of high quality in compliance with ICH/GCP, Regulatory Authorities’ regulations/guidelines, and applicable SOPs/WPs.  Responsibilities may include participation on one or more cross-functional study team(s) and/or performance and quality oversight of Contract Research Organization (CRO) teams and other vendors.
 
 
Roles and Responsibilities of the Position
  • Provide operational input on development, management and maintenance of study deliverables [i.e. timelines, study plans, documents, etc.] through collaboration with internal and external stakeholders.
  • Contribute to deliverables within study, drive to solutions across a multi-functional study team.
  • Anticipate and resolve key technical operational problems with multi-functional study team; evaluate and determine issues that require escalation.
  • Use performance metrics and quality indicators to assist with driving study execution.
  • Manage the monitoring visit report review process in order to maintain oversight of clinical monitoring quality and adherence to protocol and established processes and plans.
  • Support Health Authority inspections and CQA audits as required. 
  • Ensure completeness & accuracy of the required data in study management tools including clinical trial management systems, patient enrollment forecasting, etc.
  • Provide proactive identification of potential risks and development/implementation of actions to avoid or mitigate.
  • Develop and maintain collaborative relationships with internal and external partners/stakeholders including both vendors and investigational sites.
  • Collaborate with vendors and other study team members regarding study specific issues and follow through to resolution.
  • Assist in the creation and review of study documents, including but not limited to the Protocol, Informed Consent Form (ICF) and other patient facing materials and assist in updating these study documents as needed.  The CRA may have opportunities to lead creation/updates/review of study documents, as agreed upon with assigned Clinical Trial Manager or Clinical Operations leadership.
  • Participate in vendor specification development and management/oversight.  Vendor oversight activities may include responsibility for specific tasks associated with oversight (ie, review of monitoring visit reports generated by CRO) or may opportunities to lead the overall management of a specific vendor (ie, travel vendor), as agreed upon with assigned Clinical Trial Manager or Clinical Operations leadership.
  • Management of TMF set-up, ongoing quality review, and final reconciliation.
  • In conjunction with Drug Supply Management, manage shipment and reconciliation of Investigational Product (IP) at study and site level as needed.
  • Liaise as needed with CRO and investigative sites to ensure clinical trial data is captured and resolved as required.
  • Contribute to data review/cleaning of clinical data as needed and as defined by study plans.
  • Actively contribute during study meetings including presenting as a subject matter expert as well as generating and distributing study team agendas and meeting minutes.
  • Contribute to development / coordination of study training and study training materials for study team, investigational sites, and vendors. 
  • Contribute to oversight of the required country regulatory (e.g. CTA, MoH) and country/site IRB/IEC submissions/approvals/notifications.
  • Assist with the collection of various study documents such as country/site insurance, CSR appendices, etc.
  • Assist with Investigator Meeting coordination and planning.
  • In addition to all activities listed, Senior CRAs must be able to manage larger, more complex deliverables within a clinical trial with minimal oversight.
Required Qualifications and Background
  • BA/BS Degree in a relevant discipline with 2-4 years’ experience in the clinical trial environment required (inclusive of site level or other relevant experience) for Clinical Research Associate level; direct sponsor and/or CRO experience or 5+ years relevant non-sponsor or CRO experience required for Senior CRA level.
  • Knowledge of ICH/GCP and regulatory guidelines/directives.
  • Demonstrates analytical approach and anticipation of problems.
  • Identifies gaps and provides constructive feedback and solutions.
  • Ability to multi-task effectively and prioritize assignments from multiple sources.
  • Excellent organizational skills.
  • Strong communication skills, both written and oral; proficiency in English.
  • Strong knowledge of MS applications including (but not limited to) MS Project, Word, Excel, PowerPoint.
  • Knowledge of study tools including electronic system skills such as CTMS/ EDC/ IRT/ eTMF.
  • Knowledge of drug development process. Proactively shares information, ideas, input, and/or expertise with team members. Demonstrates concern for high quality outcomes.
  • Responds flexibly to changing business demands and opportunities, proactively looking for ways to contribute.
Available locations for this role
  • Stamford, CT
  • South San Francisco, CA
  • US Based-Remote
Physical Demands/ Travel:
 
The physical demands of this job are consistent with light office duties. Up to 25% travel may be required.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in an office.
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position could range from between $78,000 to $114,498 for a Clinical Research Associate and $89,750 to $131,672 for a Sr. Clinical Research Associate and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
 



*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Clinical Trial Manager/Senior Clinical Trial Manager (Multiple Locations)
Function:
Clinical Operations
Location:
South San Francisco, CA
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Clinical Trial Manager / Senior Clinical Trial Manager will manage one (or more) clinical studies including leading the planning, organization, and coordination of all operational aspects of the clinical study from protocol development through database lock / study closure;  ensure delivery on time, within budget, and of high quality in compliance with ICH/GCP, Regulatory Authorities’ regulations/guidelines, and applicable SOPs/WPs; Provide operational leadership on cross-functional study team(s) and performance and quality oversight of Contract Research Organization (CRO) teams and other vendors.
Roles and Responsibilities of the Position
  • Provide operational leadership on development, management and maintenance of study deliverables [i.e. timelines, study plans, documents, etc.] through collaboration with internal and external stakeholders.
  • Lead and manage the execution of clinical trials, drive to solutions across a multi-functional study team.
  • Anticipate and resolve complex and key technical, operational or business problems with multi-functional study team; evaluate and determine issues that require escalation.
  • Use performance metrics and quality indicators to drive study execution.
  • Support Health Authority inspections and CQA audits as required, including driving inspection/audit readiness through life of study. 
  • Manage study team and/or CRO to ensure completeness & accuracy of the required data in study management tools including clinical trial management systems, patient enrollment forecasting, etc.
  • Proactively identify potential risks and lead the development/implementation of actions to avoid or mitigate; identify points for escalation.
  • Develop and maintain collaborative relationships with internal and external partners/stakeholders including both vendors and investigational sites.
  • Collaborate with vendors and other study team members regarding study specific issues; drive team through issue resolution.
  • Lead and/or collaborate in the creation and review of study documents, including but not limited to the Protocol, Informed Consent Form (ICF) and other patient facing materials, case report forms, and clinical study reports. Manage completion of these deliverables to ensure timelines are upheld. Ensure study documents are updated as needed throughout the trial.
  • Partner with internal contracts management to ensure review, finalization, and escalation as needed of site contracts and budgets.
  • Plan site and country identification and selection in collaboration with internal partners.
  • As appropriate per vendor/scope of work, manage and/or participate in vendor selection, specification development and management/oversight. 
  • Ensure management of the TMF set-up, ongoing quality review, and final reconciliation.
  • Liaise as needed with CRO and investigative sites to ensure clinical trial data is captured and resolved as required.
  • Contribute to data review/cleaning of clinical data as needed and as defined by study plans.
  • Lead study meetings including presenting as a subject matter expert as needed, ensuring agenda and meeting minutes are generated and distributed as needed.
  • Manage the development/coordination of study training and study training materials for study team, investigational sites, and vendors. 
  • Contribute to oversight of the required country regulatory (e.g. CTA, MoH) and country/site IRB/IEC submissions/approvals/notifications.
  • Ensure the collection of various study documents such as country/site insurance, CSR appendices, etc. is completed as needed.
  • Manage Investigator Meeting coordination and planning.
  • Lead and assist in training other Clinical Operations roles (e.g. CRAs).
  • In addition to all activities listed, Senior Clinical Trial Managers must be able to manage large, complex trials and/or manage multiple ongoing studies simultaneously with minimal oversight.
Required Qualifications and Background
  • BA/BS degree in a relevant discipline with 5+ years’ experience in clinical drug development required at Clinical Trial Manager level; 6+ years’ experience required for Senior Clinical Trial Manager level.
  • For oncology studies: Oncology and/or Hematology experience preferred; for clinical pharmacology studies: Clinical Pharmacology/Healthy Volunteer experience preferred
  • Experience in managing global clinical trials preferred.
  • Experience with managing clinical research budgets.
  • Knowledge of ICH/GCP and regulatory guidelines/directives.
  • Experience with managing a multi-functional team, including leadership skills and driving deliverables.
  • Demonstrates analytical approach and anticipation of problems.
  • Identifies gaps and provides constructive feedback and solutions.
  • Follows issues to resolution and escalates as appropriate.
  • Ability to multi-task effectively and prioritize assignments from multiple sources.
  • Excellent organizational skills.
  • Strong communication skills, both written and oral; proficiency in English.
  • Strong knowledge of MS applications including (but not limited to) MS Project, Word, Excel, PowerPoint.
  • Knowledge of study tools including electronic system skills such as CTMS/ EDC/ IRT/ eTMF.
  • Knowledge of drug development process. Proactively shares information, ideas, input, and/or expertise with team members. Demonstrates concern for high quality outcomes.
  • Responds flexibly to changing business demands and opportunities, proactively looking for ways to contribute.
Available locations for this role:
  • Stamford, CT
  • South San Francisco, CA
  • US Based-Remote
Physical Demands/ Travel:
 
The physical demands of this job are consistent with light office duties. Up to 15% travel may be required.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
Work Environment:
 
This position’s work environment is in an office.
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position could range from between $103,200 to $151,423 for a Clinical Trial Manager and $118,700 to $174,137 for a Sr. Clinical Trial Manger and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.


*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Computational Chemist (Multiple Locations)
Function:
Discovery Small Molecule
Location:
San Diego, CA
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Loxo Oncology at Lilly Discovery group’s mission is to invent and advance life-changing oncology drugs for cancer patient populations that are poorly treated by existing therapies. To that end, we are building a multi-disciplinary team of dedicated discovery scientists that are passionate about driving the science forward to create and advance highly selective drugs for known oncogenic drivers. We are currently looking for a computational chemist who enjoys tackling cutting edge drug discovery problems and is well versed in the effective use of all current computational techniques and tools. The ideal candidate will be passionate about working with scientists across disciplines to invent and advance novel approaches to drug discovery. The position requires excellent people skills, a positive can-do attitude and the ability to thrive in a highly interactive, fast-paced, team environment.
Roles and Responsibilities for the Position
  • Work closely with our multidisciplinary group on structure-based and ligand-based design and optimization of small molecule oncology drugs.
  • Enable team success by employing a range of modern computational techniques including Quantitative Structural Activity Relationship (QSAR) models, homology modeling, molecular dynamics simulations, multivariate analysis, and in silico predictive models.
  • Provide computational chemistry insight for new target identification and evaluation initiatives in the oncology space across a range of target and binding mode types.
  • Catalyze new hit and lead discovery leaning computation insight to selection of screening collections, database mining and interpretation of results and virtual screening techniques.
  • Work with on-site IT staff to administer and maintain the necessary hardware, software and other computational infrastructure to enable state of the art computational impact on oncology research programs.
  • Proactively investigate new or different technologies to improve the effectiveness of the team.
  • Contribute to the overall strategic thinking for the discovery organization.
Required Qualifications and Background
  • Ph.D. in Chemistry or related field.
  • Experience in small molecule drug discovery across a range of target types, approaches, and drug discovery strategies in a biotechnology or pharmaceutical setting is preferred.
  • Possess a working understanding of medicinal chemistry, in vitro and in vivo ADME, and couple that with modeling-driven approaches that extend to aspects of lead optimization beyond potency.
  • Forward thinking in terms of applying modern computational approaches to current scientific challenges. Apprised of the latest scientific breakthroughs in computational chemistry and ability to apply those techniques to good effect.
  • The ideal candidate will be a key thought leader on the team with a passion for bringing creative approaches to solve challenging problems.
  • Excellent interpersonal skills with ability to communicate effectively with a multidisciplinary team, the LOXO executive team, and outside collaborators. The ability to lead the team in prioritization of activities and programs.
  • Ability to multi-task and shift priorities rapidly to meet tight deadlines.
  • Proficient in Microsoft Office suite and applications.
Available Locations for this Role
  • Boulder, CO
  • San Diego, CA

Physical Demands / Travel

The physical demands of this job are consistent with lab environment.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in a lab.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position could range from between $89,750 to $131672 for a senior scientist and $103,200 to $151,423 for a Principal Scientist and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Consultant, Scientist, Molecular Characterization, Discovery Technologies
Function:
Discovery Biologics
Location:
New York, NY
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Contract Scientist in the Molecular Characterization Group, within Discovery Technologies, will be joining a dynamic group focused on executing experiments on the cutting edge of pharmaceutical sciences. This scientist will work closely with Project Teams and Discovery Informatics to design studies, execute analyses, and interpret data to support the various research programs for identified targets. The successful candidate is expected to demonstrate expertise with basic molecular techniques profiling DNA, RNA and proteins. The scientist will utilize innovative, high throughput, high content molecular platforms to answer genomic, transcriptomic, and proteomic questions posed by project teams across the Loxo portfolio. The Contract Scientist will also be responsible for inspecting, calibrating, cleaning the instruments within the facility at Loxo. Finally, this role will be responsible for operationalizing new techniques in collaboration with the Molecular Characterization Team.  In this role, the incumbent will also be encouraged to develop their own ideas and contribute these to the broader group. They are expected to be a dynamic and motivated scientist who can drive their own experiments and research activities, while collaborating extensively with the entire organization to execute on various research programs.
Roles and Responsibilities of the Position
  • Interact and collaborate with various Discovery functional teams to design and execute studies supporting all projects across the oncology portfolio
  • Work collaboratively with the clinical biomarker team to perform and support retrospective and exploratory efforts for clinical programs
  • Provide quality data and analyses from a variety of high throughput, high content genomic, transcriptomic, and proteomic platforms.
  • Develop and implement novel molecular platforms and applications
  • Work with the entire molecular characterization team to ensure all instrumentation is properly maintained and calibrated
  • Provide scientific expertise on practical implementation of molecular platforms and applications across the entire Loxo organization
  • Proper documentation and archiving of data and analyses.
  • Work interactively with project teams and discovery informatics to interpret data and prepare formal study reports
  • Communicate results via written and oral presentations as needed
  • Discuss results with technical as well as non-technical personnel
  • Extensive cross functional communication and collaboration with internal and external parties
  • Interrogate experimental conduct of third parties/vendors
Required Qualifications and Background
  • BSc. in biological sciences with 5 years of experience or MSc or PhD in biological sciences with 2-3 years of experience
  • Extensive experience with multiple nucleic acid and protein expression platforms, including assay design and development
  • Experience with high content, high throughput laboratory workflows with emphasis on quality and efficiency.
  • Extensive working experience with Illumina next generation sequencing and knowledge of any of the following platforms: Fluidigm, Nanostring, Quanterix, Isoplexis, or Luminex.
  • Demonstrated experience in working collaboratively across various scientific disciplines to meet project goals and timelines
  • Flexibility to adjust priorities over time to meet organizational and scientific goals.
  • Ability to work independently and as an integral part of a larger collaborative team.
  • Demonstrated ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines
  • Excellent interpersonal, written, and verbal communication skills
  • Knowledge and experience documenting and processing clinical samples.
  • Experience processing, analyzing, and interpreting large biological data sets.
  • Experience with Spotfire data visualization software and pathway analysis tools.
  • Deep understanding of cancer disease states (indications, mutational status, tumor cell drivers)
Physical Demands / Travel

TBD <5%. The physical demands of this job are consistent with working in a lab.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in a lab. 

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Contract Manager, Business Operations, Discovery
Function:
Business Operations
Location:
Remote
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Manager of Business Operations is responsible for negotiating complex contracts to support chemistry and biology discovery needs.
Roles and Responsibilities of the Position:
  • Work with discovery, legal, finance, and other teams to draft, negotiate and manage contracts to support drug development and related biomarker needs
  • Identify and mitigate business risks throughout the contracting process

Required Qualifications and Background:
  • Bachelor’s degree (MBA a plus)
  • 3+ years of business development/contract negotiation experience, preferably in the Diagnostics or Biotech/ Pharmaceutical Industries
  • Strong contract drafting, review and analysis skills
  • Ability to communicate efficiently and effectively
  • Ability to manage and meet strict deadlines, work independently, and multi-task
  • Excellent attention to detail
  • MS Office skills (Outlook, Word, Excel, PowerPoint)
Physical Demands/ Travel:
 The physical demands of this job are consistent with light office duties.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:
 
This position’s work environment is in an office.
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
 
Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Contract Recruiter
Function:
Human Resources
Location:
Remote
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Contract Recruiter will support the Talent Acquisition team in a variety of areas including full life cycle recruitment for various open requisitions as well as sourcing and scheduling support as needed. 
Roles and Responsibilities of the Position
  • Support the recruiting process as needed including full life cycle recruitment, sourcing, screening, and scheduling of candidates.
  • Utilize proven sourcing skills to identify passive candidates.
  • Understand market conditions for targeted sources and work with other members of Talent Acquisition as well as Hiring Managers with recruitment efforts.
  • Provide candidates with a best-in-class experience, maintaining contact, responsiveness and transparency throughout the process ensuring a high level of candidate engagement and positive overall experience.  
Required Qualifications and Background
  • BA/BS degree required along with 3+ years recruiting experience with a proven track record of sourcing and recruiting required. Experience with Biotech or Pharmaceutical industry a strong plus.
  • Possess solid resume review and overall assessment skills to reveal candidate's technical background, business capabilities and EQ.
  • Passionate, high-energy, accountable, and collaborative team player with the ability to prioritize and multi-task.
  • Strong communication and interpersonal skills, with the ability to build professional relationships across all levels of the business
  • Proficient in Microsoft Office suite and applications. 
Physical Demands/ Travel:
The physical demands of this job are consistent with light office duties.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
Work Environment:
This position’s work environment is in an office.
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Director, Antibody Discovery
Function:
Discovery Biologics
Location:
South San Francisco, CA
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Director Antibody Discovery will lead a dynamic group of scientists conducting various research projects to identify large molecule/biologics which can effectively treat various forms of cancer. The Director, Antibody Discovery will have design and project oversight of activities related to target validation, discovery enabling reagent & therapeutic antibody generation, screening, engineering, and optimization. This individual will liaise with both internal and external (e.g., BioTDR, CROs) teams to execute these programs. You will report your findings to both the Loxo scientific, director and executive leadership teams. Acting as a key member of the large molecule organization, this individual will be responsible for maintaining the scientific quality and efficiency of your organization, as well as assist and guide the strategic direction of the company or external diligence opportunities. In summary, the position will require deep scientific expertise, pragmatism when designing experiments with the capability of taking into account the “big picture” of the company’s strategic and business goals when executing against the required scientific activities. 
Roles and Responsibilities of the Position
  • Scientific roles and responsibilities:
  • Design and oversee the execution of key antibody discovery activities involving reagent generation, antibody generation, screening, engineering, and optimization, hybridoma, phage/mammalian display, and single B cell platform techniques
  • Oversee/perform assays in antibody discovery activities
  • Liaise with internal Lilly BioTDR resources or external CRO vendors to outsource activities & provide input to management team on vendor selection
  • Provide scientific expertise in the generation of internal antibody discovery platforms
  • Design and execute a scientific research discovery program from idea development to IND filing
  • Leadership roles and responsibilities:
  • Present findings in different forums with clarity and line of sight
  • Lead, coach, develop, and manage team
  • Liaise with internal teams and provide guidance on key strategic decisions of the business
  • Interact with lawyers to file patents and other intellectual property filings
  • Manage resource allocation effectively
  • Build roadmaps to execute on specific targets, and overall strategic projects
Required Qualifications and Background
  • PhD in cellular biology, immunology, biophysics, genetics, or allied disciplines with over 10 years’ experience 
Additional Preferred Qualifications
  • Significant experience in bispecific and multi-specific antibody programs
  • Demonstrated experience in designing protein immunogens, and experience engineering antibodies
  • Deep knowledge of protein analytical technologies needed to support antibody biophysical analysis and ranking of candidates
  • Intimate familiarity with genomics style techniques and thinking and its applications to antibody discovery
  • Early or advanced work in computational discovery utilizing NGS and machine learning, computational library design, and/or use of in silico prediction methods
  • Proven success leading, managing, and coaching large cross functional teams in dynamic organizations
  • Significant experience in bispecific and multi-specific antibody programs
  • Demonstrated experience in working collaboratively across various scientific disciplines to meet end goals of business
  • Demonstrated excellence in making key strategic decisions in support of broader business goals
  • Excellent written and verbal communication skills
Physical Demands/ Travel:
 
The physical demands of this job are consistent with laboratory bench setting.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in a lab.  
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
 

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Director, Medicinal Chemistry
Function:
Discovery Small Molecule
Location:
San Diego, CA
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

Loxo Oncology at Lilly has an immediate opening for an experienced Director of Medicinal Chemistry. The Loxo Oncology at Lilly Drug Discovery team’s mission is to invent life-changing targeted therapies for cancer patient populations that are poorly treated by existing therapies. To that end, we have built a multi-disciplinary team of dedicated drug discovery scientists who are passionate about driving the science forward to create highly selective drugs for known oncogenic drivers. We are currently looking for accomplished medicinal chemistry professional with a proven track records of success in small molecule drug discovery. The ideal candidate will be passionate about leading from the bench to guide a team of Medicinal Chemists in solving medicinal chemistry challenges and will excel at working closely with scientists across disciplines.  The position requires excellent people skills, a positive can-do attitude, and the ability to thrive in a highly interactive, fast-paced, team environment.
Role and Responsibilities for the Position
  • Lead one or more teams of medicinal chemists to drive drug discovery programs from inception to candidate nomination.
  • Empower the medicinal chemists on the team to develop a deep expertise and practical knowledge in all aspects of medicinal chemistry design including structure-based design, multi-variant SAR analysis, selectivity optimization , ADME and PK optimization, and developing robust IP positions. Apply sound scientific methods to propose hypotheses and determine next steps.
  • Apply strategic thinking to advance projects quickly by employing the right strategic focus to solve the unique challenges each project presents.
  • Grow the chemistry team to be highly effective in reducing ideas to practice by employing a broad range of modern organic chemistry transformations, synthetic methods, purification, and characterization techniques. 
  • Expand the group’s productivity by effectively leading CRO relationships and proactively investigating new or different technologies to improve the -efficiency of the drug discovery process.
  • Collaborate closely with the other Discovery disciplines to enable project success. Synergize with the broader team by communicating results, sharing insights, making plans, and setting goals in an open, honest way.
  • Champion bringing new classes of targets or new modalities of target inhibition (e.g. degraders) to expand the breadth of our portfolio.
  • Communicate often and well with translational and clinical groups to develop and refine clinically informed, mechanistically grounded Target Product Profiles with a high confidence in providing drugs candidates meaningful benefits to patients.
  • Present project updates that clearly convey progress and challenges to Loxo Leadership and Scientific Advisory Boards in formal and informal settings.
  • Contribute the business development evaluation of in-license opportunities.
  • Synergize with other Loxo Oncology at Lilly leaders on identifying and advancing new targets into the portfolio.  
Required Qualifications
  • A passion for making drugs that can provide a real benefit for patients.
  • Deep expertise in leading small molecule drug discovery programs in a biotechnology or pharmaceutical company setting.
  • Proven track record of success in advancing programs from leads to advanced candidates.
  • Direct management experience leading medicinal chemistry teams.
  • An advanced degree (M.S. or Ph.D.) in synthetic organic chemistry and 12+ years of relevant experience.
  • An excellent leader and team player with ability to communicate synergistically with a multidisciplinary team and be accountable for the medicinal chemistry progress of the project. Highly organized with excellent analytical, documentation, time management, and multi-tasking skills.
  • Strong passion for growing the organization’s talent and capabilities to stay abreast of new technologies and tackle new targets with the single-minded focus on helping patients.  
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Director/Senior Director Protein Sciences (Multiple Location)
Function:
Discovery Small Molecule
Location:
Boulder, CO
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Director/Senior Director, Protein Sciences will lead a team responsible for expression and purification of proteins to enable the discovery and development of small molecule inhibitors.   The Director/Senior Director, Protein Sciences will oversee team efforts in expression in multiple hosts including bacteria, insect and mammalian cells as well as purification of proteins for biochemical, biophysical, and structural studies.  This role requires significant scientific knowledge and understanding of small molecule discovery and a proven ability in effective prioritization of protein workstreams to support projects across all the Loxo Oncology at Lilly sites.  Capability to work effectively across multiple functional groups is a key attribute for this role. This leader will oversee teams based in both San Diego and Boulder with the anticipation of the leader being based out of one site with occasional travel to other site.  
Roles and Responsibilities for This Position
  • Lead cross-functional Protein Science teams to develop and execute protein expression, purification and characterization strategies to ensure delivery of samples of high quality to support project needs.
  • Lead and direct team effort to identify, assess and implement new technologies to enhance our technical capability and working efficiency ensuring collaboration across Enzymology, Biophysics, Mechanistic Biology, BioAssay, Structural Biology, Mass Spectrometry and Bioinformatics functions
  • Provide oversight for outsourcing activity of CROs, protocol transfer, production outsourcing and quality validation of protein samples for drug discovery programs
Required Qualifications and Preferred Background
  • PhD and and/or post-doctoral training in the area of biochemistry, molecular biology or other related bioscience field with a minimum of 10 years of directly relevant biotechnology or pharmaceutical industry experience.
  • Proven track record of success and a strong scientific background in recombinant protein expression in several expression systems, protein enzymology, biochemistry, structural studies as well as group management.
  • Highly detail-oriented with excellent organizational and communication skills who thrives in a fast-paced dynamic multi-disciplinary environment.

  • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Director will be in the range of $135,300-$198,516 the Senior Director will be in the range of $200,500-$294,109, and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Available Locations for this role
  • Boulder, CO
  • San Diego, CA
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Drug Safety Specialist
Function:
Drug Safety
Location:
South San Francisco, CA
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Drug Safety Specialist will be responsible for providing Drug Safety/Pharmacovigilance support for new and ongoing clinical trials including the collection, processing, and reporting of adverse events/endpoints while adhering to International Council for Harmonization (ICH) guidelines, Good Clinical Practices (GCP), applicable regulatory guidelines, data protection guidelines and study procedures. 
Roles and Responsibilities for this Position
  • Perform triage of incoming Serious Adverse Event (SAE) reports and consider assessments of seriousness, listedness, and causality; coordinate triage review with medical monitor.   
  • Review case narratives, including identifying relevant information from source documents and write/review queries when additional information needed 
  • Review data entry of SAEs in safety database including MedDRA coding
  • Coordinate medical monitor case review
  • Assist with the management of case processing deadlines
  • Assist in reconciliation between the safety and clinical databases for serious adverse events.
  • Compile safety information for aggregate safety reports and other safety related reports.
  • Assist with ongoing safety surveillance
  • Assist with compilation and updating of safety related spreadsheets including metrics and SUSAR submissions
  • Review and update existing standard operating procedures (SOPs) and assist with creation of new SOPs for safety department as indicated  
  • May oversee work performed by a safety Contract Research Organization (CRO)
Required Qualifications and Background
  • RN, BSN or pharmacy degree with at least 3-5 years of industry experience in Clinical Trial Safety; industry experience from CRO or pharmaceutical/biotech setting will be considered.
  • Previous experience in Health care is strongly preferred
  • Hands on experience with SAE case processing including narrative and analysis of similar event (AOSE) writing, and safety report generation.
  • Working knowledge of MedDRA and WHODrug and FDA safety regulations, ICH guidelines, and global safety regulations.
  • Hands on experience with global safety database(s); experience with Argus strongly preferred.
  • Demonstrated ability to work well with other accomplished professionals within and across functions/teams.
  • Willing collaborator with strong written and oral communication skills.
  • Ability to multi-task and shift priorities rapidly to meet tight deadlines.
  • Detail oriented and well organized.
  • Self-motivated and keen to improve processes and overcome inefficiencies.
  • Proficient in Microsoft Office suite and applications.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Lab Operations Assistant
Function:
Discovery Small Molecule
Location:
Boulder, CO
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Lab Operations Assistant will support a robust Discovery Lab environment through sample preparation, sample organization and tracking, data entry, safety maintenance, and additional responsibilities as needed. The Lab Assistant will possess excellent information management skills as well as the ability to communicate, explain, interpret, and share information in order to best support the Discovery team.
Roles and Responsibilities of the Position
  • Implement and maintain an inventory system for laboratory samples and manage sample storage on-site.
  • Prepare samples for testing in biological assays and coordinate sample delivery between lab and external vendors both US and globally.
  • Implement and maintain an inventory system for chemical reagents.
  • Maintain complete, accurate, and organized file systems.
  • Routinely and proactively order commonly used chemicals and laboratory supplies.
  • Contribute to the upkeep and safety of the laboratory and assure a clean, safe, adequately supplied work area.
  • Assist with stocking and organization of glassware
  • Receive and unbox shipments of routine deliveries for laboratories.
  • Assist with chemical inventory maintenance through registration of commercial reagents and periodic audits. 
Required Qualifications and Preferred Background
  • Associates or Bachelor’s degree in the Life Sciences preferred, but will also consider high school diploma with relevant experience.
  • 2+ years' direct industry experience in a lab or sample management related role.
  • Understanding of safe laboratory practices.
  • Proficient in Microsoft Office.
  • Strong attention to detail and very organized.  
  • Demonstrated ability to work well with other scientists within and across functions/teams.
  • Willing to collaborate and communicate with scientists across disciplines as needed.
  • Very flexible and adaptable to change.
  • Enthusiastic, self-motivated and keen to improve process efficiencies. 
Physical Demands/ Travel:
 
The physical demands of this job are consistent with working in a wet-laboratory setting.  Requires ability to lift up to 25lbs.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in a lab.
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
 
Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position could range from between $43,100 to $63,250 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Lab Operations Manager, Discovery Biology
Function:
Target Discovery
Location:
South San Francisco, CA
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Lab Operations Manager will assist in setting up the new Loxo Oncology at Lilly labs at the SSF or NYC site with primary responsibility for management and oversight for the Loxo Discovery Biology labs. The role will also provide support to Loxo Discovery Biology operations in meeting the emerging needs of all programs and projects including maintaining tissue culture stocks and cell line validation. 
Roles and Responsibilities of the Position
  • Coordinate with Loxo Discovery Biology team members and facilities to understand the overall scope for each lab and work directly with  relevant team members to gather, revise, finalize and ensure delivery of the lab requirements (and associated documents) to the lab construction lead coordinators.
  • Actively engage in preparing lab equipment list and coordinate with internal and external resources to finalize and manage all changes to the list.
  • Actively engage in identifying equipment vendors and liaise in enabling purchase and delivery of the equipment to the SSF or NYC site.
  • Coordinate with SSF or NYC internal Facilities to actively monitor the overall progress of the lab build up to ensure alignment with the agreed upon lab build up plan.
  • Actively engage in operationalizing SSF or NYC Loxo Discovery Biology labs.
  • Facilitate in understanding lab ordering needs and coordinate with Loxo operations to create/extend existing procurement set up.
  • Lead in ordering and stocking up all lab reagents and materials once the labs are commissioned and maintain inventory to meet the labs’ daily operational needs.
  • Lead in setting up lab management processes, create necessary documentation, and manager user training to the lab personnel.
  • Contribute to cell line expansion, authentication, and banking.
  • Facilitate in managing day-to-day lab operational activities by coordinating with different team members to ensure the stated set up is appropriate.
  • Apply creative problem solving and resourcefulness to navigate through unknown events, able to find solution with moderate supervision.
  • Adaptive to change in priorities and able to navigate through identifying and managing the changes effectively.
  • Able to effectively communicate and navigate through technical and non-technical audiences across cross-functional departments within the company, vendors, and external collaborators.
  • Contribute to building positive, collaborative teams across various scientific disciplines and encouraging sharing of new ideas, and creative ways to problem solving. 
Required Qualifications and Preferred Background
  • 5+ years of Biotech and Pharmaceutical industry experience in working in the scientific field with up to 2 years of lab management experience, and a bachelor’s degree or advanced degree in relevant scientific fields (e.g., biology) required. Experience in working with diverse set of scientific environments and able to execute requests with moderate supervision
  • Clearly understand the distinction between high-level scope and day-today operations
  • Comfortable in collaborating with the vendors
  • Good verbal, written communication, and interpersonal skills
  • Excellent organizational skills, efficient, with strong attention to detail
  • Ability to anticipate problems and proactively propose solutions
  • Experience with standard tissue culture protocols.
  • Proficient in MS Office suite 
Available locations for this role
  • South San Francisco, CA
  • New York City, NY
Physical Demands/ Travel:
 
The physical demands of this job are consistent with a laboratory bench setting.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in a lab.  
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Laboratory Automation Specialist
Function:
Discovery Biologics
Location:
New York, NY
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Laboratory Automation Specialist, in the Discovery Technologies group at Loxo, will be joining a dynamic team focused on executing experiments on the cutting edge of pharmaceutical sciences. This Specialist will work closely with Discovery Technologies scientists to design, develop, optimize, and validate new and existing molecular and cell biology workflows; optimizing throughput, timelines, and data quality. The successful candidate will have expertise designing, developing, programming, and integrating laboratory automation with high throughput, high content instrumentation and applications. Maintenance, quality control and validation of laboratory instrumentation at the Loxo facility is also a central role for this position. Additionally, this person will be responsible for identifying and operationalizing new techniques in collaboration with the Molecular Characterization Team. The Specialist will also provide related training and support to group members. Platform development and protocol optimization of molecular techniques profiling DNA, RNA and proteins is an opportunity for applicants with scientific lab experience. In this role, the incumbent will be a dynamic and motivated researcher who can drive their own activities, while collaborating extensively with the entire organization to execute on various research programs.
Roles and Responsibilities of the Position
  • Manage automation processes to support a variety of applications across Discovery Technologies, including; application development, improvement, and optimization
  • Interact and collaborate with Discovery Technology scientists to design and establish an integrated biological method and instrumentation laboratory structure.
  • Develop, optimize, and validate custom automation protocols for various molecular and cell-based assays
  • Ensure consistent and high-quality data outputs from a variety of high throughput, high content genomic, transcriptomic, and proteomic platforms.
  • Work with cross-functional personnel to develop and implement novel platforms and applications
  • Provide automation expertise for practical implementation of molecular platforms and applications across the entire Loxo organization
  • Train and support scientists on automation platforms and established SOPs, including hardware and software
  • Work with the entire Molecular Characterization team to ensure all instrumentation is properly maintained and calibrated
  • Maintain proper documentation and archiving of data and analyses. 
  • Communicate results via written and oral presentations as needed
  • Discuss laboratory operational processes with technical as well as non-technical personnel
  • Extensive cross functional communication and collaboration with internal and external parties
  • Interrogate experimental conduct of third parties/vendors
Required Qualifications and Background
  • BS/MS in biological sciences, computer science, engineering, or other relevant field with 2+ years of laboratory automation experience.
  • Extensive knowledge and experience designing and supporting laboratory automation and liquid handling
  • Experience with high content, high throughput laboratory workflows with emphasis on quality and efficiency.
  • Experience converting manual protocols into automated processes, process optimization, and workflow efficiencies on automated equipment.
  • High agility to learn new technologies, with an affinity for automation and high-end equipment
  • Demonstrated experience in working collaboratively across various disciplines to meet project goals and timelines
  • Flexibility to adjust priorities over time to meet organizational and scientific goals.
  • Ability to work independently and as an integral part of a larger collaborative team.
  • Demonstrated ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines
  • Excellent interpersonal, written, and verbal communication skills
Additional Preferred Qualifications
  • Scripting experience on Hamilton STAR liquid handling with in-depth knowledge of Venus software is preferred
  • Hands on experience with multiple nucleic acid, protein, cell-based, and imaging techniques, including assay design and development is a plus
Physical Demands / Travel

Travel for this role will be <5%. The physical demands of this job are consistent with a laboratory/bench setting. 

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in a lab. 

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Lead Clinical Data Manager (Multiple Locations)
Function:
Clinical Data Management
Location:
Remote
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Lead Clinical Data Manager is responsible for leading and overseeing data management tasks from study start-up through database lock for clinical trials.  This individual works collaboratively across multiple cross functional groups including Clinical Trial Managers (CTM’s), Biostatistics and Clinical Data Management vendors to ensure database development, data review/cleaning, database auditing, database lock, and receipt of final database deliverables are in compliance with standard operating procedures and regulatory agency guidelines. The Lead Clinical Data Manager ensures all Clinical Operations activities stay within full compliance of Loxo standard operating procedures (SOP) and regulatory agency guidelines.
Roles and Responsibilities of the Position
  • Represents Clinical Data Management at study team meetings with responsibility for operational execution of CDM activities.
  • Executes and manages data management timelines to coordinate and synchronize deliverables with the overall study timelines.
  • Generates and/or reviews/approves study documents (e.g. Data Management Plans, Case Report Forms, data transfer specifications, SAE and/or external data reconciliation plans, coding conventions, study protocols, UAT execution).
  • Executes and/or distributes data management metrics, listings, and reports, as required.
  • Escalate resource need to PL to meet the current study needs.
  • Effectively apply knowledge of applicable internal, external and regulatory requirements/expectations (MHRA, FDA, ICH, GCP, PhRMA, Privacy, etc) to data collection and DM plans.
  • Collaborate and oversee CRO/service providers on assigned studies.
  • Executes/manages all data management activities on assigned studies to ensure project timelines are met.
  • Continually seek means of improving processes to reduce cycle time and decrease work effort.
  • Provides training on the CRF completion guidelines and EDC system at Investigator meetings and to internal or external team members, as needed.
  • Proactively identifies potential study issues/risks and recommends/ implements solutions.
  • Responsible for the accuracy and completeness of the clinical data collected during a clinical trial for all data deliverables.
  • Provide DM support to Statisticians and Statistical Programmers in production of clinical trial reports and other deliverables.
  • Work with partners to increase vendor/partner efficiencies.
  • Performs any and all other tasks and activities as requested.
Required Qualifications and Background
  • Bachelor’s degree in life sciences, math, computer science or related field required.
  • Minimum of 6+ years’ clinical data management experience.
  • A minimum of 1+ years of direct sponsor experience required.
  • Demonstrated leadership and project management skills.
  • Thorough and broad knowledge of data management processes, including EDC and interactive voice response system (IVRS)experience.
  • Demonstrated proficiency in MS Office (Outlook, MS Word, Excel, PowerPoint).
  • Experience with web-based Electronic Data Capture (EDC), clinical data management systems and industry wide thesauri, such as MedDRA and WHO Drug.
  • Good working knowledge of regulatory guidelines such as GCP, 21 CFR Part 11 etc.
  • Knowledge of industry standards (CDISC, SDTM, ADaM, CDASH).
  • Excellent verbal, written and interpersonal skills required for working successfully in a cross-functional team environment.
  • Able to communicate and collaborate effectively with cross-functional teams in face-to-face conversation, by telephone and by email.
  • Proven ability to work independently as well as in a team environment.
  • Excellent time management skills and a proven ability to work on multiple projects at any given time in a fast-paced environment.
  • Demonstrated ability to stay abreast of trends and new information in the profession.
  • Excellent verbal/written and interpersonal skills required for working successfully in a cross-functional team environment.
  • Able to communicate and collaborate effectively with cross-functional teams in face-to-face conversation, by telephone, and by email.
Additional Preferred Qualifications

  • 5+ years prior oncology/hematology experience highly desirable.
  • Recent Phase 3 registration study and submission experience preferred.
Available locations for this role
  • Stamford, CT
  • South San Francisco, CA
  • US Based-Remote
Physical Demands / Travel

The physical demands of this job are consistent with light office dutiesThis position will travel occasionally; the average travel for this position is 15-20% with some variation based upon the demands of the business imperatives.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in a home-based office setting.  

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Manager, Clinical Supply Management
Function:
Clinical Supply
Location:
Boulder, CO
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Manager, Clinical Supply Management will support Clinical Supply Management by conducting various work streams with internal and external team members for the on-time delivery of clinical supplies across the Loxo portfolio.
Roles and Responsibilities for the Position
  • Support Clinical Supply Management by contributing to various work streams with internal and external team members for the on-time delivery of clinical supplies across the oncology portfolio.
  • Update and maintain study supply plans including drug supply forecasts for manufacturing, packaging, and labeling operations.
  • Provide oversight of packaging and distribution collaboration partners including, but not limited to document review of packaging specifications, master, and executed batch records, distribution instructions and order processing and delivery.
  • Provide on-going monitoring of inventory and expiration dates for assigned program/study. Ensures alignment with supply forecast and study/program requirements.
  • Manage global accountability tracking including destruction for assigned programs.
  • Support clinical label development process including creation of master label text, translations, and label proofs.
  • Review and provide input to documents including, but not limited to: pharmacy manuals, IMPDs, request for proposals, and IRT/IWRS specifications.
  • Participate on project teams and sub-teams as needed and assigned
  • Track progress versus timelines and goals.
  • Ensure documents and records are kept in compliance with regulations and SOPs including the Trial Master File (TMF).
Qualifications and Background for the Role
  • BA/BS and a minimum of 3-5 years of experience working in a Biotech or Pharmaceutical FDA regulated industry in Clinical Supply Management or a related field or an equivalent combination of education, training and/or experience from which comparable knowledge, skills and abilities have been attained.
  • Solid understanding of pharmaceutical development, manufacturing, packaging, and labeling.
  • Eager to communicate and collaborate with team members across functions including but not limited to: clinical operations, CMC, regulatory affairs, and QA.
  • Working knowledge of cGMP’s (CFR/ICH) and GCP and applicable international regulations/guidelines.
  • Prefer experience working with third-party vendors and contractors, knowledge of QP requirements, and import/export.
  • Global experience with phase 1-4 clinical trials.
  • Experience writing and presenting clearly on clinical supply topics.
  • Ability to work in a virtual environment.

  • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Manager level position could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Manager, Compound Management, Discovery Operations
Function:
Discovery Small Molecule
Location:
Boulder, CO
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Compound Manager will work closely with Discovery leaders and team members to establish and oversee a newly created internal compound management team and technologies.  This team will be accountable for establishing SOPs and processes related to storage of inventory, preparation of samples for testing, and shipping/receipt of supplies/samples/compounds for internal assays.  The Compound Manager will also oversee a small team (examples include Coordinator, Specialist, etc.) that will support compound management activities across multiple departments and external CROs.  
Roles and Responsibilities of the Position
  • Evaluate and recommend appropriate capital equipment purchases for establishment of the compound management group and be involved in long term instrument maintenance.
  • Involvement in hiring and recruitment of compound management technicians.
  • Oversee preparation of samples through fluidics automation and manual neat/weigh operations for testing, manage organized storage of samples, provide samples to scientists for internal assays.
  • Coordinate incoming and outgoing sample shipments with external vendors for all Discovery projects including diligent preparation of all associated documentation, manifests, packing slips, shipping labels, and release documents.
  • Maintenance of compound inventory for short/long term storage, and update sample tracking system with LIMS database.
  • Work with lab operations technicians to coordinate MTA establishment and shipment and delivery of samples between lab and external vendors, both US and Globally.
  • Maintain effective oral and written communication to Discovery team members and provide support to ensure timelines, costs and risk assessments are met.
  • Provide additional support to the Discovery Team as requested.
  • Implement and understand operational capacities to provide a consistent product in a predictable timeframe. 
Required Qualifications and Background
  • A BS/MS or equivalent degree in chemistry and/or biological sciences with at least 6+years working full time in a laboratory setting either in academia or industry.
  • Experience with liquid handling automation and acoustic dispensing (e.g., Echo) both in terms of programing and physical instrument maintenance and upkeep
  • Proven knowledge and experience with inventory/request database systems (e.g., Mosaic or Strata preferred) for compound and biological sample management is required.
  • Strong organizational skills and attention to detail.
  • Ability to work both independently and within a multidisciplinary team.
  • Must have high proficiency in MS Office Suite; experience with project management software is a plus.
  • Excellent written, verbal and interpersonal communication skills are required, with ability to work with/across a range of disciplines including biology, medicinal chemistry and bioassay.
  • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands/ Travel:
 
The physical demands of this job are consistent with working in a lab.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in a lab.   
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Manager, Diagnostic Development
Function:
Diagnostic Medical Affairs
Location:
Indianapolis, IN
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Manager, Diagnostic Development will serve as the investigational in vitro diagnostic (diagnostic) trial-level expert for global clinical studies for the Lilly and Loxo Oncology @ Lilly portfolios where a regulatory approved diagnostic is needed to support the therapeutic program.  The ideal candidate will have experience in diagnostics, clinical trial management and/or monitoring.  Must be detail oriented, have high learning agility, able to make judgement-based decisions, achieve specific deliverable tasks in a timely manner and effectively influence internal and external stakeholders.   
Roles and Responsibilities of the Position
  • Lead global, cross-functional discussions with physicians, scientists, and clinical operations to solve complex, unprecedented, and specialized diagnostic implementation issues 
  • Manage the relationship and serve as the focal point of communication with clinical research teams at the trial level for diagnostic trial deliverables
  • Combine scientific, regulatory, operational, and leadership skills to navigate complex issues in areas where no pre-existing policies or procedures are available to provide guidance 
  • Provide clinical operations expertise and input during protocol development and feasibility assessment.  Leverage expertise to make timely decisions, including ambiguous, complex and unprecedented technical situations.  Recognized as a resource across teams for diagnostic operational knowledge of clinical planning and delivery
  • Own the delivery of appropriate language for global study drug protocols when a diagnostic is included to ensure appropriate number and type of samples are collected and the diagnostic is appropriately described
  • Review diagnostic testing protocols, statistical analysis plans, Clinical Study Reports, and other diagnostic project documentation. Maintain project documentation
  • Prepare and ensure documents associated with the implementation of global clinical trials (such as informed consents, case report forms, sample flow, lab manuals and lab requisition forms) contain appropriate information for diagnostic development.  Proactively ensure complete, timely documentation for clinical trial planning and execution
  • Lead work with internal clinical laboratory operations to help select appropriate clinical lab testing sites 
  • Lead efforts with data operations to ensure external diagnostic partners receive data transfers of test results per their specifications and the data collected will meet the needs of regulatory submissions
  • Drive and manage the agreement with external diagnostic partners by holding the diagnostic partner accountable to agreed-upon expectations and deliverables while also ensuring Lilly and Loxo Oncology @ Lilly are meeting required deliverables for the diagnostic partner (access to high quality samples, requirements for data, patient data from case report forms, etc.) are met
  • Serve as primary reviewer of the diagnostic portions of the lab manuals prepared by the central lab to guide the clinical investigational sites (sites enrolling patients) to ensure information on pre-analytical processes is included and is appropriate for the diagnostic. Develop trial-specific training for the diagnostic sample requirements and testing in collaboration with cross-functional team.
  • Manage collection and provision of global investigator site and IRB information for regulatory submissions (IDE and annual reports).  Prepare or provide scientific, technical, and operational consultation for clinical and regulatory documents such as annual reports, briefing documents, pre-market approval applications, and final study reports 
  • Consult, assist and/or draft responses to questions about the diagnostic from regulatory agencies and ethics committees
  • Network with little/no need for direct management support to resolve cross-functional operational or trial-level challenges throughout protocol development and implementation
  • Coordinate and document reviews of key documents for diagnostic development such as intended use statements, user needs, milestone reports, regulatory documents developed by external diagnostic partners
  • Assist with tracking patient enrollment and collaborate with operations team to drive mitigation and contingency actions to address enrollment issues, where applicable 
  • Serve as primary point of contact for trial status updates to external diagnostic partners.  Provide enrollment predictions to enable their kit manufacturing planning
  • Quality check (both content and format) medical contributions and analysis sections in Lilly and Loxo Oncology @ Lilly and external diagnostic partners regulatory submissions
  • Maintain deep clinical development process expertise to ensure implementation of diagnostic strategy is current with At Lilly and Loxo Oncology at Lilly global policies/procedures and best practices
  • Lead/participate in the revision and/or development of new global SOPs to address diagnostic development in collaboration with quality organizations as well as procedures for departmental use
  • Leverage expertise to effect improvements to business practices related to diagnostic development  
Required Qualifications and Preferred Background:
  • Bachelor of Science (Scientific, Engineering or Medical Health-related field) Masters’ degree in biology, molecular biology or genetics preferred. Molecular pathology laboratory experience a plus
  • Understand commercial diagnostic partners’ design control process 
  • Contribute to internal governing bodies’ reviews and approvals (scope, time, budget, resources, etc.)
  • Understand the global drug development process
  • Strong communication skills, both written and oral
  • Excellent interpersonal skills and experience working and negotiating with external diagnostic partners
  • Ability to navigate gray space and engage others appropriately when path forward is not fully defined
  • Experience with clinical operations
  • Experience with performing detailed data reviews
  • Experience with genetic testing or genetic data, including next generation sequencing and polymerase chain reaction
  • Strong self-management skills
  • Excellent problem-solving abilities
  • Multi-tasking capability with the ability to prioritize and meet critical deadlines in all projects
  • Proven track record of well-executed delivery to deadlines
Available locations for this role:
  • Stamford, CT
  • South San Francisco, CA
  • Remote
Physical Demands/ Travel:
 
The physical demands of this job are consistent with light office duties.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in an office based.
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Manager, Quality Assurance, GCP (Multiple Locations)
Function:
Quality Assurance
Location:
South San Francisco, CA
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Manager, Quality Assurance is responsible for all aspects of Quality Assurance and GCP compliance. The Manager Quality Assurance will establish and execute quality plans, policies and quality system elements related to GCP activities. This position will support the design, implementation and maintenance of QA and compliance programs including, but not limited to an SOP system, CAPAs, and work closely with the Clinical Operations team. The Manager, Quality Assurance will establish, maintain, and ensure effectiveness of quality programs and documentation to assure compliance in a GCP international regulatory environment and provide GCP guidance in Quality related areas. 
Role and Responsibilities of the Position
  • Liaise across departments to proactively identify opportunities to streamline and strengthen GCP process
  • Serves as GCP SME in writing and revising SOPs.
  • Reviews and approves Quality Events and associated Corrective and Preventative Actions within a regulated Quality Management System
  • Represents GCP expertise and acts as the QA point person on cross-functional clinical study teams
  • Keeps current with global health authority laws and regulations and implements process improvements resulting from new/revised regulations or guidance
  • Reviews study team and regulatory documentation as requested (e.g. Data Management, Operations, Safety, Regulatory, etc.)
  • Liaises audit requirements between clinical study teams and auditing group and follows up on audits with the auditee
  • Utilizes the Loxo Quality Systems to manage Quality system elements
  • Drives inspection readiness activities for project teams. 
  • Supports external Health Authority inspections
Required Qualifications and Background
  • Bachelor’s degree with 5- 7  years’ experience working in either a clinical compliance or clinical Quality group
  • Must be a hands on Leader who can provide guidance and execute daily tasks
  • Demonstrated Quality Management System experience (GCP specific QMS experience preferred)
  • Demonstrated Issue Management and CAPA experience in a clinical environment.
  • Experience with FDA or other Regulatory Inspections of Investigator sites, Sponsors or CROs.
  • Self-motivated with the ability to work effectively in a dynamic environment
  • Strong leadership with demonstrated ability to interface with senior leaders and different levels of the organization
  • Good problem solving, written and verbal communication skill
  • Ability to effectively manage multiple priorities with a sense of urgency
  • Strong track record of project management, stakeholder management, collaboration skills and negotiation of complex situations
  • Attention to detail and accuracy of work.
  • Demonstrated ability to work well with other accomplished professionals within and across functions/teams. Willing collaborator
  • Strong communication skills both written and oral
  • Works with a sense of urgency and has the ability to multi-task and shift priorities rapidly to meet tight deadlines.
  • Professional demeanor and appearance and an excellent written and verbal communicator.
  • Detail oriented and well organized
  • Good and thoughtful listener
  • Critical thinker and solution oriented
  • Enthusiastic, self-motivated and a self-starter
Available Locations for this role
  • Stamford, CT
  • South San Francisco, CA
  • US Based-Remote


Physical Demands / Travel

The physical demands of this job are consistent with light office duties.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in an office.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Principal/Sr Principal Scientist or Associate Director PBPK Modeling (multiple locations)
Function:
Discovery Small Molecule
Location:
Remote
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

Loxo Oncology is seeking a highly motivated PBPK modeler join our DMPK team. The ideal candidate will have strong background and expertise in pharmacokinetics (PK) and ADME concepts as well as hands-on experience with PBPK modeling.  This position will contribute to the conduct of mechanistic PBPK modeling, human PK predictions, PBBM, and DDI projections to support Discovery and Development projects, enabling compound progression from discovery to early stages of clinical development
Roles and Responsibilities for this Position
  • Work closely with Discovery Project teams to influence programs at TPP design, lead optimiztion, candidate seeking and nomination.
  • Utilize PBPK and translational modeling tools to enable human PK projections throughout the life of a program
  • Evaluate and guide novel in vitro tools and methodology to improve prediction of human PK
  • Proactively lead cutting edge effort to build and refine PBPK models for novel drug modalities (covalent inhibitors, PROTACs, PPI’s etc.).
  • Liaise with DMPK, discovery biology/pharmacology and clinical scientists to generate data and knowledge supporting the build-up of translational, mechanistic models
  • Ensure communication is effective and clear for internally and externally on topics related to PBPK, translational modeling and simulation, human PK and DDI prediction
  • Keep abreast of emerging literature and science in modeling and in vitro approaches
Required Qualifications and Preferred Background
  • Bachelors, Masters, or PhD with 0-4 (PhD), 8-10 (MS), or 10-12 (BS) years of experience in pharmaceutical or related field required; degree in Pharmacology or Pharmaceutical Sciences strongly preferred.
  • Hands-on project experience in PBPK modeling and simulation through internship, industry research collaboration, or direct industry experience strongly preferred.
  • Successful track record of applying PBPK into projects
  • Strong understanding of ADME, PK and DDI concepts as well as significant theoretical and practical understanding of own scientific discipline
  • Focus on and passion for data analysis, solving technical problems and applying new technologies to further scientific goals.
  • Hands-on experience in the use of commercial PBPK modeling software

Available Locations for this role
  • Boulder/Louisville, Colorado
  • Remote (US Based)
Physical Demands/ Travel:
 
The physical demands of this job are consistent with light office duties. 
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
Work Environment:
 
This position’s work environment is in an office.
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position could range from between $103,200 to $151,423 for a Principal Scientist and $118,700 to $174,137 for a Sr. Principal Scientist and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Principal/Sr Principal Scientist, DMPK (Multiple Locations)
Function:
Discovery Small Molecule
Location:
Boulder, CO
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

Loxo Oncology at Lilly’s Drug Discovery team has an immediate opening for an experienced drug metabolism scientist. The Loxo Oncology at Lilly team’s mission is to invent life-changing targeted therapies for cancer patient populations that are poorly treated by existing therapies. To that end, we have built a multi-disciplinary team of dedicated drug discovery scientists who are passionate about driving the science forward to create highly selective drugs for known oncogenic drivers. We are currently looking for accomplished DMPK program representative with a proven track records of success in small molecule drug discovery. The ideal candidate will be passionate about solving complex DMPK challenges and will excel at working closely with scientists across disciplines. The position requires excellent people skills, a positive can-do attitude, and the ability to thrive in a highly interactive, fast-paced, team environment.
Roles and Responsibilities for this Postion
  • Design and execute in vitro and in vivo preclinical studies to understand the pharmacokinetics (PK) and absorption, metabolism, distribution, and excretion (ADME) of new chemical entities (NCE)
  • Provide management and oversight of CROs in the conduct of in vitro and in vivo ADME studies
  • Advise medicinal chemistry teams on complex DMPK issues
  • Perform non-compartmental pharmacokinetic analysis on data
  • Review in vivo protocols and study reports
  • Collate data and present to program teams
  • Contribute to authoring and review of regulatory reports and documents
  • Maintain accurate and timely electronic lab notebook
  • BS, MS or Ph.D. in medicinal chemistry, biochemistry or related discipline
  • BS with 10+, MS with 8+ or Ph.D. with 5+ years of DMPK experience
  • Experience managing and overseeing CROs
  • Experience managing Bioanalytical and Pharmacokinetic studies strongly preferred
  • Must have pharmacokinetic modeling experience
  • Experience with bioanalysis method and assay development
  • Good written and oral presentation capabilities
Available Locations for this Role
  • Boulder/Louisville, Colorado
  • Remote (US Based)
Physical Demands/ Travel:
 
The physical demands of this job are consistent with light office duties. 
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
Work Environment:
 
This position’s work environment is in an office.
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position could range from between $103,200 to $151,423 for a Principal Scientist and $118,700 to $174,137 for a Sr. Principal Scientist and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Program Manager, Large Molecule Discovery Biologics, (Multiple Locations)
Function:
Discovery Biologics
Location:
South San Francisco, CA
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Program Manager will play a critical role in establishing program strategic goals and implementing them through project execution as a part of the Loxo Oncology Large Molecule Discovery Biologics portfolio. Loxo Biologics focuses on research, preclinical, and early development within Loxo Oncology at Lilly.
 
The role will be responsible for facilitating program strategic goals, planning and execution of deliverables within scope, budget and timeline, in a cross-functional, dynamic environment. The role will work closely with Loxo Biologics’ leadership members as well as project team leads to create and implement project strategic plans. This includes assessment of external outsourcing needs in the form of actively engaging, identifying, establishing, and managing external collaborators and vendors to meet any outsourcing needs. 
Roles and Responsibilities of the Position
  • Facilitate in establishing and translating strategic program goals into project plan(s) with clearly outlining deliverables, milestones, and no-go decisions.
  • Engage in establishing program strategic objectives by collaborating with Loxo Biologics’ leadership team.
  • Engage with functional team leads of antibody discovery, translational, mechanistic biology, and protein engineering (and other key stakeholders) to plan, execute, and track project activities ensuring alignment of project deliverables with strategic goals.
  • Actively facilitate project meetings with internal and external stakeholders (create agendas, minutes, and track action items).
  • Proficient in adaptive communications; effectively manage communications vertically and horizontally in a cross-functional environment involving external and internal stakeholders.
  • Proactively contribute and manage project communications. Identify gaps and ambiguities in communication channels and address them to maintain alignment across the team.
  • Actively contribute to create project updates, reports, presentations, and memos and maintain project document repository.
  • Identify and assess the needs for outsourcing, establish relationships with external collaborators, and manage alliances on an ongoing basis.
  • Drive day-to-day operational activities by coordinating with stakeholders from different functional departments - legal/Business operations, procurement, finance, and other relevant functional areas.
  • Proactively identify gaps in processes and actively create processes to meet program needs.
  • Adaptive to change in priorities and able to drive project outcomes ensuring re-alignment with program deliverables in changing landscape.
  • Contribute to implementing visions of building and operationalizing large molecule discovery labs.
  • Contribute to building positive, collaborative teams across various scientific disciplines, and encouraging sharing of new ideas, and creative ways to solve problems often needed in discovery research.
  • Support the creation of an organizational project framework for different functional groups and build operational guidelines and processes. 
Required Qualifications and Background
  • Bachelor’s Degree in relevant scientific discipline (i.e.: Biology, Biochemistry, etc.) and a minimum of 7 years of direct project management/alliance management experience roles in cross-functional Biotech and pharmaceutical research environment. Prior experience is managing strategic program management in early phase large molecule discovery set up will be preferable. 
  • Excellent verbal, written communication and interpersonal skills.
  • Excellent organizational skills, efficient, with strong attention to detail.
Additional Preferred Qualifications
  • Advanced degree in relevant scientific fields (e.g., Biology) strongly preferred.
  • PMP certification is required.
  • Experience managing projects in early stage, large molecule discovery in large molecule discovery operations.
  • Understand distinctions between high-level program goals and day-today operations.
  • Experience in managing external suppliers, vendors, and other external alliances.
  • Ability to anticipate key challenges and proactively propose solutions.
  • Adaptive to changes and apply creative problem-solving skill to meet project and other operational needs.
  • Proficient in identifying and applying tools to effectively manage and track projects - MS Office suite, MS Project.
  • Create and implement new tools and work towards creating and implementing processes customized for furthering discovery research.
Available locations for this role
  • South San Francisco, CA
  • US Based-Remote
Physical Demands / Travel

The physical demands of this job are consistent with light office duties.  Travel (post-COVID) TBD.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in an office or remote based.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Project Manager, Third Party Management, Consultant
Function:
Business Operations
Location:
Remote
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

Loxo Oncology at Lilly is seeking a Project Manager to support third party management. The ideal candidate has an understanding of the various risk domains that are relevant for third party management and is able to multi-task and remain extremely organized to manage risk assessments for many vendors simultaneously. The candidate will work collaboratively with both internal colleagues and external third parties to manage assessments from the initial request to completion as well as monitoring thereafter.
Roles and Responsibilities of the Position:
  • Oversees and acts as Business Operations point person for the third party management process and works closely with Quality and contracting team. Key activities include, but are not limited to: 
  • Checking and communicating the status of third party vendors
  • Maintaining a third party qualification list
  • Facilitating qualification reviews by subject matter experts for various risk domains
  • Managing the third party management IT system
  • Working with internal and external business partners to facilitate timely completion of assessments and periodic reviews
  • Collaborating with stakeholders for continuous process improvement improvement of processes
  • Ensuring seamless communication between Loxo Oncology at Lilly and Lilly
Required Qualifications and Preferred Background:
  • Bachelor's Degree is required with 3+ years experience in the Biotech/Pharmaceutical industry
  • Understanding of key risk areas to be assessed (e.g., privacy, anti-corruption, etc.)
  • Ability to adapt quickly to shifting needs and/or priorities
  • Strong project management skills in order to manage projects at various stages and effectively multi-task
  • Working knowledge of a comprehensive enterprise risk management process
  • Effective communication skills
  • Enjoys fast-paced, dynamic environment
  • Exceptional attention to detail
Physical Demands/ Travel:
 
The physical demands of this job are consistent with light office duties
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in an office or remote based
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Scientific Software Engineer, Biology (Multiple Locations)
Function:
Discovery Small Molecule
Location:
San Diego, CA
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

Loxo Oncology at Lilly has an immediate opening for a Scientific Software Engineer, Biology. The Loxo Oncology at Lilly Drug Discovery team’s mission is to invent life-changing targeted therapies for cancer patient populations that are poor responders to existing therapies. To that end, we have built a multi-disciplinary team of dedicated drug discovery scientists who are passionate about driving the science forward to create highly selective drugs for known oncogenic drivers. This position will drive the design, implementation, integration, and customization of software to support our growing Molecular Biology team and related workflows. This position will work closely with scientists across disciplines to ensure the availability and implementation of appropriate systems, workflows and data related to mechanistic, structural, and translational biology discovery research.  The position requires great people skills, a positive can-do attitude, and the ability to thrive in a highly interactive, fast-paced, team environment.  This position is ideal for a candidate that wants to make a difference and be a main contributor to enabling systems and workflows that have significant impact across the organization and ultimately our patients.
Roles and Responsibilities of the Position
  • The successful candidate will have a flexible, learning mindset to design, deliver and support scientific systems and workflows to enable the biological discovery processes. Other responsibilities include:
  • Be part of the decision making and contribute to the biological Scientific systems group strategy.
  • Design and implement best practices for data profiling of biological systems that promote data integrity, completion and interconnectivity.
  • Document workflows and provide user training where needed.
  • Proactively investigate new or different technologies to improve the effectiveness of the scientific systems and related workflows.
  • Support troubleshooting, debugging, and testing of both vendor and custom scientific systems.
Required Qualifications and Background
  • BS or MS in Computer Science or Life Sciences field with 3+ years demonstrated software engineering experience. Experience within the biotech/pharmaceutical strongly preferred but will also consider 5+ Software Engineering experience in an unrelated industry
  • Knowledge of Drug discovery, biology or related scientific knowledge highly desired
  • Experience with ETL processes or other Data Science activities
  • Proficiency working within a Linux/Unix environment
  • Experience with Web Servers (i.e., Apache, Nginx, IIS, other)
  • Experience with SQL and databases such as Oracle, SQL Server, PostgreSQL, and/or MySQL
  • Strong scripting abilities using Python (preferred), Perl, JavaScript or any other related programming language
  • Experience with Web Services and REST APIs
  • Ability to analyze complex workflows using flow charts or other analysis tools
  • High-level understanding of full-stack web development including implementing RESTful web services with JavaScript and related languages is highly desired
  • Familiarity in using or supporting any Molecular Biology software/system is highly desired
  • Demonstrated ability to learn and apply new technologies according to the changing needs of the project and organization
  • Purpose-driven, innovative, self-motivated, team player and keen to improve processes and design innovative solutions
  • Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels
  • Attention to detail and ability to adapt to evolving priorities
  • Excellent written and verbal communication skills / ability to document and communicate complex scientific concepts for a variety of audiences
This role is offered in the following locations:
  • San Diego, CA
  • Boulder, CO
  • Remote-US Based
  • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands/ Travel:
 
The physical demands of this job are consistent with light office duties.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position is a non-lab position but will require working closely with laboratory staff.    
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Scientist, Discovery Technologies, Organoid
Function:
Discovery Biologics
Location:
New York, NY
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Scientist in the Discovery Technologies, Organoid Group, will be joining a large and dynamic group focused on executing experiments on the cutting edge of pharmaceutical sciences. The candidate will execute experiments needed to support the various research programs for identified targets. They will be expected to demonstrate expertise with various organoid and patient derived models, to be able to troubleshoot technical difficulties encountered in organoid growth, and to interrogate the work of third parties/collaborators. The candidate will also be encouraged to develop their own ideas, contribute these to the broader organoid group as well as project teams, and is expected to be a dynamic and motivated scientist who can drive their own experiments and research activities, while collaborating extensively with the rest of the organization to execute on various research programs. The candidate will collaborate with project teams in NYC, Indianapolis, SSF, and Boulder for design and execution of studies, and will work closely with multi-disciplinary teams, providing expertise throughout all stages of the lifecycle of target modulation and validation to advance our portfolio. 
Roles and Responsibilities of the Position
  • Scientific roles and responsibilities
  • Develop key capabilities for the generation of necessary patient-derived organoid models for detailed functional characterization
  • Design and execute studies to profile candidate molecules in organoid systems
  • Troubleshoot technical difficulties encountered in organoid establishment, growth and testing
  • Test biologics or small molecules in organoid tumor models (dose response experiments, profiling, comparing to control compounds)
  • Grow organoids of various types; have extensive knowledge of media and growth factors on organoid development
  • Perform experiments that modulate target expression in organoid systems
  • Interrogate experimental conduct of third parties/vendors

  • Additional responsibilities
  • Communicate results at project team meetings, be involved in the coordination and preparation of presentations
  • Discuss results with technical as well as non-technical personnel
  • Lead, and work collaboratively across multiple laboratory-based functions to establish the mechanisms, phenotypes, and biology of new targets using modern approaches in molecular and cellular biology and biochemistry
  • Work in cross functional environments via extensive collaboration with other parts of the organization
  • In some cases, direct leadership of a junior scientist may be required

Required Qualifications and Background
  • BS degree in biological sciences with 5 years of experience or MS/PhD in biological sciences with 2-3 years of experience required.
  • Extensive expertise working with organoid models
  • Deep expertise in cancer disease states (indications, mutational status, tumor cell drivers) strongly
  • Demonstrated experience in working collaboratively across various scientific disciplines to meet end goals of business
  • Excellent communication and interpersonal skills
  • Demonstrated ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines
  • Excellent written and verbal communication skills
Physical Demands/ Travel:
 
The physical demands of this job are consistent with laboratory setting.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in a lab. 
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Scientist, BioImaging, Discovery Technologies
Function:
Discovery Biologics
Location:
New York, NY
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

As a Scientist in the Discovery Technologies, Imaging group, you will be joining a large and dynamic group focused on executing experiments on the cutting edge of pharmaceutical sciences. You will design and conduct experiments needed to support the various research programs for identified targets. You will be expected to demonstrate expertise with high-quality imaging needed for biological sciences (e.g., confocal, live cell imaging, 3D assays) and well versed in all aspects of image analysis. You will be responsible for maintenance of the imaging facilities and to liaise with instrument manufacturers to ensure Loxo’s imaging facilities remain state-of-the-art. You will also be encouraged to develop your own ideas and contribute these to the broader group. You are expected to be a dynamic and motivated scientist who can drive their own experiments and research activities, while collaborating extensively with the rest of the organization to execute on various research programs.
Roles and Responsibilities of the Position
  • Scientific roles and responsibilities:
  • Design and execute studies using confocal microscopy and live cell imaging instruments
  • Assay development and cell line engineering to generate fluorescent fusions and novel signaling reporter assays
  • Image cell-cell interactions (i.e., CD3 redirection), cells expressing proteins of interest (i.e., cytokines, tumor associated antigens, organelles etc.), subcellular localization, trafficking, plasma membrane dynamics
  • Image analysis and algorithm development, data management
  • Maintain imaging facility instruments and become point of contact for any and all imaging needs for entire R&D organization
  • Interrogate experimental conduct of third parties/vendors
  • Facilitate experiments with in vivo pharmacology group
  • Additional responsibilities:
  • Communicate results at project team meetings, be involved in the coordination and preparation of presentations
  • Responsible for writing reports (internal and/or regulatory)
  • Discuss results with technical as well as non-technical personnel
  • Work in cross functional environments via extensive collaboration with other parts of the organization
  • Opportunity to directly manage junior scientists in the future
Required Qualifications and Background
  • BSc. in biological sciences with 5+ years of experience or MSc or PhD in biological sciences with 2-3 years of experience
  • PhD preferred
  • Extensive expertise in confocal microscopy and live cell imaging, assay development, high content imaging, signaling reporter assays, TIRF and image analysis
  • Experience with super resolution microscopy highly desirable
  • Experience in drug discovery an asset
  • Experience in automation and high throughput screening an asset
  • Deep expertise in translational biology concepts, history of working with organoids and 3D assays, as well as in vivo models (e.g., mice models) considered an asset
  • Expertise in cancer disease states (indications, mutational status, tumor cell drivers)
  • Demonstrated experience in working collaboratively across various scientific disciplines to meet end goals of business
  • Demonstrated ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines
  • Excellent written, verbal communication and interpersonal skills
Physical Demands / Travel

Travel for this role will be <5%. The physical demands of this job are consistent with a laboratory/bench setting. 

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in a lab. 

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Scientist, Cell Line Generation
Function:
Discovery Small Molecule
Location:
Indianapolis, IN
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

We are looking for a highly capable and motivated laboratory-based scientist experienced in cell line generation and characterization. This Research scientist will be a part of the cell line generation/cell biology team that generates engineered cell lines for our preclinical programs in oncology. The primary responsibilities will include engineering cell lines for use in in vitro functional assays and in vivo studies. The candidate is expected to work within a collaborative team environment, while being able to work independently to design, execute, and optimize experiments. Beyond performing experiments, the scientist will analyze the data from own experiments, present the data in meetings and work with the rest of the team to determine the next steps. Position level will be commensurate with applicant’s experience.
Roles and Responsibilities of the Position
  • Construct knockout and expression vectors using mammalian plasmid and lentiviral, adenoviral, or retroviral systems. Viral titer measurement, and viral stock maintenance.
  • Generate engineered stable cell lines using transfection, CRISPR/Cas9 tools, lentiviral transduction, etc.
  • Optimize cell line development platforms to improve speed and reproducibility of cell line development
  • Perform routine molecular and cell biology techniques like DNA/RNA/protein extraction, qPCR analysis, western blot analysis, fluorescent microscopy and so on.
  • Maintain cultures of frequently used suspension and adherent cell lines.
  • Design, develop, and validate low to medium throughput cell-based assays if needed (independently and within team-based environments)
  • Keep detailed and accurate laboratory records, present results at group meetings and project team meetings
Required Qualifications and Preferred Background
  • BA/BS/MS/PhD in biology, cell biology, molecular biology or a related field
  • 2+ recent experience working with mammalian cell culture
  • Basic tissue culture techniques such as cell propagation, cryo- preservation, maintenance and so on
  • Prior cell culture experience with immortalized cell lines, cancer cell lines and/or primary cells
  • Experience creating stable cell lines, transient transfections, viral transductions
  • Prior experience with various analytical reagents such as Calcein AM, Cell Titer Glo, Alamar Blue, Annexin, PI/7AAD, and immunofluorescent antibodies
  • Experience with performing qPCR, ELISA, western blot, flow cytometry, cell sorting, fluorescent microscopy, all in the context of mammalian cells
  • Experience in or understanding of the techniques used to interrogate cell biology such as RNAi, CRISPR, and chemical inhibition of cellular pathways
  • Experience designing and performing mammalian cell assays in 96 and 384 formats
  • A high level of proficiency with many kinds of scientific software used to operate lab equipment and/or the ability to quickly master new software
  • Experience and proficiency with data analysis using statistical software such as Excel, Prism, Spotfire or others
  • Must be organized and efficient and able to work according to timelines.
  • Pharma/biotech drug discovery experience a plus    
Physical Demands/ Travel:
 
The physical demands of this job are consistent with laboratory bench setting and light office duties.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in a laboratory-based setting.  
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Scientist, Molecular/ Cell Biology
Function:
Discovery Small Molecule
Location:
New York, NY
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Scientist, Molecular/Cell Biology will be part of the Loxo Oncology’s Mechanism and Translational Research team in the Alexandria Center, NY.  The Mechanism and Translational Research team is responsible for characterizing molecular targets and their therapeutic modulators in various tumor cell contexts for creating and evaluating novel drug candidates for developing life-changing oncology drugs. The focus is on small molecule drugs, and providing forward-thinking approaches to advance our clinical portfolio. 
 
The Scientist, Molecular/Cell Biology will be responsible for developing cellular assays, execution strategies to quantitatively determine the potency and selectivity of small molecule compounds and interrogate oncogenic signaling pathways.  This is a hands-on position for an experienced lab scientist, who enjoys working in the lab and applying state-of-the art technology platforms. This scientist must have excellent people and communication skills, and be able to work with a positive, “can-do” attitude in a dynamic, fast-paced team focused on high quality science to deliver innovative cancer drugs
Roles and Responsibilities of the Position:
  • Develop and validate quantitative molecular and mammalian cellular assays to address mechanistic and functional questions in pre-clinical studies.
  • Be responsible for target engagement/receptor occupancy and phenotypic assays to support medicinal chemistry lead optimization programs. Efficiently and effectively communicate results to the project team. 
  • Identify, evaluate, and manage vendors for outsourced services and studies.
  • Collaborate with colleagues throughout the company to ensure assays meet the program needs and results are appropriately interpreted.
  • Prepare reports for internal and external purposes including regulatory submissions.
  • Participate in and present in project and technical team meetings to identify and solve problems, guide work towards project goals, communicate on-going work and progress, and plan forward thinking strategies. 
  • Develop and continually advance one’s knowledge base on the molecular pathways being targeted by our clinical and research programs.
  • Proactively investigate new or different technologies, methods, and service providers to ensure our work is being done in a scientifically sound, efficient, and reasonable way
Required Qualifications and Background:
  • BS/MS in Molecular/Cellular Biology or Biochemistry with 5+ hands-on molecular and cell biology assay experience in Oncology research in an academic or biotech/pharma setting.
  • Experience in creating, developing, and running molecular and cellular assays; engineering cell models to modulate gene expression, interrogating cellular signal transduction pathways, and characterizing enzymatic activities. Experience with primary cell models or co-culture systems is a plus.
  • Experience with general molecular biological techniques including vector engineering, cloning and mutagenesis, qRT-PCR, ELISA, MSD and Western Blotting, NGS platforms, FACS etc.
  • Strong background in experimental quantitative analyses, curve-fitting and statistics.
  • Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels.
  • Highly organized with excellent analytical, documentation and multi-tasking skills.
  • Committed to staying current with the latest scientific breakthroughs in the targeted oncology field from target identification through human clinical trials.
  • Good and thoughtful listener who values collaboration.
  • Enthusiastic, self-motivated and keen to improve processes and overcome inefficiencies.
  • Proficient in Microsoft Office suite and applications. 
Physical Demands/ Travel:
 
The physical demands of this job are consistent with working in a laboratory/ bench environment. Some light lifting, and maneuvering may be required.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in a lab/bench environment.
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Scientist, Pharmacology
Function:
Pharmacology
Location:
Indianapolis, IN
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Pharmacology Scientist will be responsible for identifying, developing, and performing robust, reproducible in vitro and in vivo assays to support tier 1-3 assays.  The Scientist will provide hands-on compound testing to support the small molecule drug discovery oncology pipeline and will be responsible for characterizing the effects of small molecule compounds on specific protein targets using multiple assay formats. A strong background in experimental curve-fitting, statistics, and assay optimization and execution is required.


Roles and Responsibilities
  • This is a “hands-on” laboratory-based position.
  • Highly motivated and actively engage in advancing drug discovery and develop the robust Tier 1 - 3 assays including biochemical (enzyme and binding), cell based (e.g., target inhibition, proliferation etc.), and tumor models (development and analysis).
  • Design, execute and trouble-shoot in vitro and in vivo experiments to understand the mechanisms of action of our compounds (or benchmarks) and characterize the target biology using biochemical, molecular, and cellular assays.
  • Perform comprehensive data analysis and communicate the experimental findings to the project team.
  • Work collaboratively and incorporate diverse perspectives into decision-making, and work successfully in a nimble, fast-paced matrixed environment.
Required Qualifications and Background
  • BS/MS in oncology, biology, biochemistry, or related fields with 3+ year of hands-on bench experience, preferably in an industry setting. 
Additional Preferences
  • Ability to leverage multiple assay platforms to measure target engagement, pathway modulation and cell activity in response to compounds treatment.
  • Strong understanding of oncology and signaling pathways.
  • Hands-on experience in cell viability, proliferation, and apoptosis assays; lentivirus production, titration, and transduction; and cell culture expertise (cell lines and primary cells) including clonal cell isolation techniques. 
  • Demonstrated experience in developing cell-based assay to monitor protein levels and modifications including the following methods: ELISA, In-Cell Westerns, Mesoscale, HTRF, AlphaScreen, MALDI-TOF MS.
  • Experience with the biochemical and kinetic-based assay technologies (e.g. FP, TR-FRET, AlphaScreen, Luminescence) and the multiplexed antibody-based detection methods (e.g. Luminex, Mesoscale).
  • Tumor biology including cell line xenograft and/or PDX models in oncology setting, and tumor and/or tissue sample handling and processing for biomarker analysis.
  • Experience with developing multi-channel flow cytometry-based screening assays including sample preparation, staining, operating flow cytometers, and analyzing flow.
  • Ability to perform quantitative data analysis, curve fitting, statistics etc.
  • Experience with laboratory instrumentation and automation.
  • Ability to multi-task and shift priorities rapidly to meet tight deadlines.
  • Continual learner and possesses a can-do attitude.
  • Excellent oral and written communication skills including experimental documentation.
  • Possess personal accountability for excellent and timely results.
  • Highly organized with exceptional attention to detail.
  • Demonstrating the ability and willingness to work effectively in a highly collaborative research environment.
  • Proficient in Microsoft Office suite and applications.
  • Metabolite analysis in cells and tumors.
  • Experience with small molecule compound testing.
  • Proficient in CRISPR, shRNA and/or siRNA gene regulation.
  • Organoid or 3D culture method development.
  • Colony formation assay experience.
  • High content cellular imaging skills.
  • Expertise in running high-throughput and automated cancer cell proliferation panels.
  • Experience in confocal microscopy.
  • Gene expression profiling of tumor samples.
  • Experience in the generation and analysis of mouse cancer models, tumor implantation techniques and dosing, tumor measurement, health monitoring, and data collection and analysis.
  • Ex vivo experience analyzing biomarkers (examples include flow cytometry, IHC, ELISA, RT-PCR, Westerns, Luminex).
  • Experience with bioluminescent imaging studies.
  • Understanding of PK, PD, and PK/PD relationship.
Physical Demands / Travel
The physical demands of this job are consistent with a lab.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
Work Environment
This position’s work environment is in a lab.
 
The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.


*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Scientist, Protein Expression- Structural Biology
Function:
Discovery Small Molecule
Location:
San Diego, CA
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

This position offers the opportunity to be part of Loxo’s discovery teams focused on creating novel, highly specific and selective drugs for genetically identified targets.  The Molecular Biologist will employ modern cloning methods to support the gene-to-structure pipeline across multiple projects and project teams.  This is an extremely important role where the right person will be able to have a real impact on cutting-edge science, making a real difference in patient’s lives. 
Roles and Responsibilities of the Position
  • Provide recombinant protein expression support within a structural biology & enzymology setting.
  • Execute projects in an efficient manner, working within aggressive timelines.
  • Rapidly communicate scientific results and insights to the team.
  • Prepare reports for internal and external purposes including regulatory submissions.
  • Participate and lead project-based and technical team meetings to identify and solve problems, guide work towards project goals, communicate on-going work and progress, and plan forward thinking strategies.
  • Continually advance your understanding of current methodology and new/emerging technologies by reading scientific literature.
  • Proactively investigate new or different technologies, methods, and service providers to ensure our work is being done in a scientifically sound, efficient, and reasonable way.
Required Qualifications and Background
  • BA/BS/MS/PhD in biology, genetics, biochemistry, molecular biology or a related field.
  • Ideal candidate will have with 5+ years hands-on experience, working in a gene to structure laboratory in a biotech/pharma setting, but less experienced, motivated individuals are encouraged to apply.
  • Experience with a variety of protein expression systems (E.coli, insect cell, mammalian) for recombinant protein expression. Hands-on experience of a variety of insect cell cells (SF9, SF21, T.ni/Hi5) from culture, transfection and characterization is desirable and/or experience utilizing mammalian cell lines such as CHO, Expi, HEK etc.
  • Experience with small scale analysis of biomass, particularly regarding soluble protein expression.
  • Hands-on experience of protein purification techniques such as IMAC, SEC, IEX are desirable as is experience with the Phynexus and Akta FPLC is desirable.
  • SDS-PAGE, Western Blot, Cell Counter experience as well as experience of modern cloning techniques such as Gibson Assembly is a plus.
  • The candidate must be self-motivated but always maintain focus on why we are here and who is important i.e. the patients and their families/caregivers.
  • Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels.
  • Highly organized with excellent analytical, documentation and multi-tasking skills.
  • Experience across the gene-to-structure pipeline is a plus.
  • A learning mindset.  
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Scientist, Protein Purification Biologist-Structural Biology
Function:
Discovery Small Molecule
Location:
San Diego, CA
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

This position offers the opportunity to be part of Loxo’s discovery teams focused on creating novel, highly specific and selective drugs for genetically identified targets. The Scientist, Protein Purification will employ modern cloning methods to support the gene-to-structure pipeline across multiple projects and project teams.  This is an extremely important role where the right person will be able to have a real impact on cutting-edge science, making a real difference in patient’s lives.
Roles and Responsibilities of the Position
  • Provide recombinant protein purification support within a structural biology & enzymology setting.
  • Execute projects in an efficient manner, working within aggressive timelines.
  • Rapidly communicate scientific results and insights to the team.
  • Prepare reports for internal and external purposes including regulatory submissions.
  • Participate and lead project-based and technical team meetings to identify and solve problems, guide work towards project goals, communicate on-going work and progress, and plan forward thinking strategies.
  • Continually advance your understanding of current methodology and new/emerging technologies by reading scientific literature.
  • Investigate new or different technologies, methods, and service providers to ensure our work is being done in a scientifically sound, efficient, and reasonable way
Required Qualifications and Background
  • BA/BS/MS/PhD in biology, genetics, biochemistry, molecular biology or a related field.
  • Ideal candidate will have with 5+ years hands-on experience, working in a gene to structure laboratory in a biotech/pharma setting, but less experienced, motivated individuals are encouraged to apply.
  • Expertise with FPLC protein purification techniques such as IMAC, SEC, IEX, HIC is required, ideally utilizing the Akta FPLC systems.
  • Expertise with protein characterization techniques such as Mass Spectrometry (Orbitrap, QTOF, hybrid traps) and Thermal Denaturation assays such as differential scanning fluorimetry (DSF) is highly desirable.
  • Familiarity with biophysical techniques such as SPR, HDX, DLS, ITC, binding assays, enzyme kinetic assays is desirable.
  • Experience with a variety of protein expression systems (E.coli, BV, mammalian, yeast) is a plus.
  • The candidate must be self-motivated but always maintain focus on why we are here and who is important i.e. the patients and their families/caregivers.
  • Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels.
  • Sample preparation specifically for X-ray crystallography or Cryo-EM is desirable.
  • Highly organized with excellent analytical, documentation and multi-tasking skills.
  • Experience across the gene-to-structure pipeline is a plus.
  • A learners mindset
Physical Demands / Travel

The physical demands of this job are consistent with light office duties.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in an office and the lab. 

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Scientist, Protein Structure and Cryo-EM
Function:
Discovery Small Molecule
Location:
San Diego, CA
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

This position offers the opportunity to be part of Loxo’s discovery teams focused on creating novel, highly specific and selective drugs for genetically identified targets.  The scientist will offer structural and mechanistic insights to a multi-disciplinary discovery team by delivering high quality protein structures to advance our knowledge of mechanistic biology.
Roles and Responsibilities of the Position
  • Deliver cryo-EM protein: ligand structures to drug discovery teams utilizing their expertise in the cryo-EM process from construct design through structure refinement and analysis.
  • Coordinate cryo-EM data collection on multiple protein targets.
  • Optimize sample vitrification conditions and collect high resolution data.
  • Collect and analyze cryo-EM data including, contrast transfer function estimation and motion correction, particle picking through neural network algorithms, 2D classification, 3D reconstructions through particle polishing, masked local refinementand 3D variability.
  • Structure determination, atomic model building and validation.
  • Train scientists in all aspects of the cryo-EM workflow: cryo-EM sample handling and preparation, data acquisition and data processing using various state-of-the-art software for 3D reconstructions, atomic model building and validation.
  • Provide scientific expertise to cross-functional project teams on recent advances and explore the feasibility of experiment proposals.
Required Qualifications and Background
  • Ph.D. or equivalent in structural biology, biophysics, or a related field with postdoctoral/industrial experience in structural biology and 2+ years of documented experience in Single particle cryo-EM.
  • Experience with cryo-EM sample preparation protocols including protein sample purification and analysis.
  • Experience with operation of Cryo-EM microscopes and automatic data collection.
  • Experience with cryo-EM software packages for collecting and processing data such as Cryo-SPARC, RELION, EMAN2, cis-TEM,
  • Experience with software for model building and refinement such as Phenix, CCPEN, Flex-EM, Isolde, ChimeraX, Rosetta etc.
  • Experience with Micro-ED, protein crystallography, and protein:ligand mechanistic studies is desired.
  • A true team player with a track record of successful collaborations.
Physical Demands / Travel

The physical demands of this job are consistent with working in a lab.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in an office and the lab. 

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Scientist, Translational Medicine
Function:
Translational Medicine
Location:
South San Francisco, CA
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

With a strong background in molecular and cell biology and experience using in vivo models, the Scientist, Translational Medicine will support translational research projects associated with Loxo Oncology at Lilly’s preclinical and early development programs. This entails independently planning and managing experiments aimed at characterizing our lead compounds, including their: (1) efficacy (in vitro and in vivo), (2) mechanism of action, (3) target patient populations and (4) biomarkers predicting clinical response. The successful candidate will achieve these objectives by overseeing research at CROs and collaborating with Loxo Oncology at Lilly’s discovery and translational team members.
Role and Responsibilities for the position
  • Drive in vitro and in vivo studies from design to completion to evaluate efficacy of novel therapeutics.
  • Execute in vivo experiments to evaluate the pharmacokinetic and pharmacodynamic effects of compounds.
  • Establish and manage relationships with external CROs, internal research groups, and academic collaborators to drive research.
  • Organize and coordinate multiple projects in parallel.
  • Analyze and interpret experimental data with the ability to troubleshoot assays.
  • Prepare and present scientific results at internal and external meetings.
Required Qualification and Background
  • PhD in a biological discipline with a minimum of 2 years of postdoctoral research experience. Experience in a pharmaceutical/biotech setting preferred.
  • Research experience in disease biology using in vitro and in vivo models, preferably in oncology.
  • Experience using CRISPR, shRNA and/or siRNA to determine mechanism of action.
  • Hands-on in vivo experience, including animal handling, performing routine dosing (IV, PO), necropsy, collection of blood and tissues.
  • Expertise in rodent models of human cancer including GEMMs, CDX, PDX and syngeneic models is highly desirable.
  • Experience in molecular and cell biology techniques and assays including ELISA, immunoblotting, MSD, qPCR, IHC/ICC and functional assays to characterize biomarkers in cells and tissues.
  • Self-organized, detail-oriented, self-directed, highly motivated with strong critical thinking and analytical skills.
  • Willingness to work collaboratively and incorporate diverse perspectives into decision-making.
  • Excellent written and verbal communication skills required.
The physical demands of this job are consistent with working in an office and laboratory environment. Some light lifting and maneuvering may be required.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.




*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Scientist/Senior Scientist, Enzymology
Function:
Bioassay Screening
Location:
Boulder, CO
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Scientist/Senior Scientist, Enzymology will be responsible for developing and performing enzyme and binding assays to support drug discovery and development in a team environment. The scientist fulfilling this position will be responsible for characterizing the effects of small molecules on specific protein targets and will provide enzymology expertise to the project teams.  A strong background in experimental curve-fitting, statistics, and assay optimization and execution is required.
Roles and Responsibilities:
  • Extensive knowledge in assay development, mechanism-of-action studies, enzyme characterization, kinetics, and protein biochemistry is required.
  • Design, develop, and execute enzyme and binding assays in multiple formats.
  • Screen small molecule inhibitors in plate-based assays formats to drive internal structure-based drug design.
  • Perform comprehensive data analysis and communicate experimental findings to the project team members.
  • Operate, implement, and troubleshoot laboratory automation.
  • Actively engage in advancing small molecule drug discovery oncology programs.
  • This is a “hands-on” laboratory, based position.
Required Qualifications and Preferred Background:
  • Ph.D. with >3 years’ experience in industry or academia, or BS or MS with >7 years industrial experience. Degree in Biochemistry, Biophysics, Biology or related field.
  • To be considered for the Senior Scientist position the candidate must have drug discovery experience gained in a biotechnology or pharmaceutical company.

  • Additional Skills/preferences:
  • The successful candidate must have expertise in biochemistry, enzymology, and assay development.
  • Experience with general biochemical and kinetic-based assay technologies (e.g. FP, TR-FRET, AlphaScreen, Luminescence)
  • Experience with laboratory instrumentation and automation for medium to high-throughput screening
  • QTOF experience is a plus
  • Excellent oral and written communication skills including experimental documentation
  • Strong publication record
  • Works well with team members daily across functional areas
  • Ability to multi-task and shift priorities rapidly to meet tight deadlines
  • Highly organized with exceptional attention to detail
  • Good and thoughtful listener
  • Enthusiastic, self-motivated and a continuous learner
  • Proficient in Microsoft Office suite and applications 
Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Scientist level position could range from between $78,000 to $114,498 and the Senior Scientist level position could range from between $89,750 to $131,672 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Scientist/Senior Scientist, Proteomics
Function:
Discovery Small Molecule
Location:
South San Francisco, CA
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

This position is an opportunity to learn and grow within a dynamic team dedicated to creating specific targeted therapeutics for genetically defined oncology targets. We are seeking a Scientist with experience in biochemistry, cell biology and/or mass spectrometry based proteomics. This individual will serve as a technical lead and be responsible for carrying out experimental research aimed at understanding the role of proteins and post-translational modifications in oncology. An important focus is to study how proteins and protein interactomes are modulated by drug candidates. The researcher will have the opportunity to utilize and further develop state-of-the-art technologies for the discovery and characterization of receptor-ligand interactions. Research in the group is fast paced and highly collaborative, drawing on the expertise of experts in biochemistry, cell biology and oncology.
Role and Responsibilities for the Position
  • The ideal candidate should have experience in protein biochemistry and proteomic techniques.
  • Experience with proteomics sample preparation (i.e. proteolytic digestion, solid phase extraction, immunoprecipitation) and operation of an Orbitrap mass spectrometer are preferred, but not essential for success in this role.
  • Computational skills are highly desirable.
  • Strong communication & interpersonal skills are essential for success in this collaborative role.
Required Qualifications and Background
  • PhD preferred, or a BA/BS or MS in Chemistry, Biology, Biochemistry, or related field +
  • Ideal candidate will have hands-on experience with protein characterization and cell culture.
  • Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels.
  • Highly organized with excellent analytical, documentation and multi-tasking skills
  • Committed to staying current with the latest scientific breakthroughs in structure-based drug design and proteomics.
  • Expertise in other methods of enzymology or biophysical characterization and structural biology is a plus
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Senior Associate Scientist/Scientist, Discovery Biology
Function:
Target Discovery
Location:
South San Francisco, CA
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

We are seeking a highly motivated and experienced individual to join a dynamic and fast-paced discovery biology team. Under the guidance of a principal or senior principal scientist, the successful candidate will support lab-based research projects to identify and validate novel druggable targets. The ideal candidate is a team player familiar with routine molecular and cellular biology techniques, and has demonstrated organizational skills. This individual learn various cutting-edge techniques and thrive in a team-oriented environment with career growth opportunity.  
Roles and Responsibilities of the Position
  • Maintain and establish various mammalian cell lines used to credential novel targets.
  • Perform cellular and biochemical assays to evaluate the outcome of various genetic or chemical perturbations.    
  • Analyze, interpret, and present the data to the team and/or organization.
  • Troubleshoot experiments in a timely manner.
  • Learn and apply new techniques to support ongoing efforts.
  • Actively participate in group discussions and collaborate with colleagues throughout the organization.
  • Contribute to a safe and efficient workplace. 
Required Qualifications and Background
  • BS, MS, or PhD in biology, cancer, molecular biology, cell biology, biochemistry, or related discipline, with 3+ years lab-based experience.
  • Expertise in routine molecular and cellular techniques.
  • Experience in gene editing (CRISPR, TALEN, etc.) and/or high-throughput screening is a plus.
  • Excellent collaborative and interpersonal skills.
  • Highly organized, detail-oriented, self-motivated and strong documentation skills.
  • Outstanding communication, writing, and presentation skills are a must.
Available locations for this role
  • Boulder, CO

Physical Demands:
 
The physical demands of this job are consistent with working in a laboratory/ bench environment. Some light lifting, and maneuvering may be required.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
Work Environment:
This position’s work environment is in a laboratory/bench environment.
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Senior Associate Scientist/Scientist, Discovery Biology
Function:
Target Discovery
Location:
New York, NY
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

We are seeking a highly motivated and experienced individual to join a dynamic and fast-paced discovery biology team. Under the guidance of a principal or senior principal scientist, the successful candidate will support lab-based research projects to identify and validate novel druggable targets. The ideal candidate is a team player familiar with routine molecular and cellular biology techniques, and has demonstrated organizational skills. This individual learn various cutting-edge techniques and thrive in a team-oriented environment with career growth opportunity.  
Roles and Responsibilities of the Position
  • Maintain and establish various mammalian cell lines used to credential novel targets.
  • Perform cellular and biochemical assays to evaluate the outcome of various genetic or chemical perturbations.    
  • Analyze, interpret, and present the data to the team and/or organization.
  • Troubleshoot experiments in a timely manner.
  • Learn and apply new techniques to support ongoing efforts.
  • Actively participate in group discussions and collaborate with colleagues throughout the organization.
  • Contribute to a safe and efficient workplace. 
Required Qualifications and Background
  • BS, MS, or PhD in biology, cancer, molecular biology, cell biology, biochemistry, or related discipline, with 3+ years lab-based experience.
  • Expertise in routine molecular and cellular techniques.
  • Experience in gene editing (CRISPR, TALEN, etc.) and/or high-throughput screening is a plus.
  • Excellent collaborative and interpersonal skills.
  • Highly organized, detail-oriented, self-motivated and strong documentation skills.
  • Outstanding communication, writing, and presentation skills are a must.
Available locations for this role
  • New York City, NY

Physical Demands:
 
The physical demands of this job are consistent with working in a laboratory/ bench environment. Some light lifting, and maneuvering may be required.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
Work Environment:
This position’s work environment is in a laboratory/bench environment.
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Senior Manager, Clinical & Biomarker Data Management (Multiple Locations)
Function:
Clinical Data Management
Location:
Remote
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

This position is uniquely situated to support the Clinical Data Management (DM) team as well as the Biomarker Operations (BMO) team. Clinical DM responsibilities include managing the data flow and transfers for clinical and biomarker data received or distributed by Loxo Oncology at Lilly. This individual will also work with all study DM teams in the creation, validation and distribution of clinical data review and data reporting listings. This position will work collaboratively with the BMO team to facilitate the data transfers of biomarker data from various labs, and also support diagnostic development data activities This individual will ensure that all operations activities stay within full compliance of Loxo Oncology at Lilly regulatory and legal policies.
Roles and Responsibilities of the Position
  • Create, execute and/or distribute data management metrics, listings, and reports, as required.
  • Receive, review the quality, and organize biomarker data and incorporate information into internal or external databases as needed.
  • Develop and update current data transfer specifications by gathering input from biomarker scientists to ensure consistent data transfers.
  • Coordinate data requirements with reference labs to ensure data collection are accurate and formatted appropriately for Data Transfer Specification.
  • Author, manage and track all Data Transfer Specifications for DM and BMO.
  • Perform import QC on all data transfers for DM and BMO.
  • Collaborate with study teams to oversee CRO/service providers for all clinical data transfer and biomarker data needs.
  • Coordinate data transfers with diagnostic development partners as needed.
  • Seek means of improving processes to reduce cycle time, increase accuracy, and decrease work effort.
  • Perform any and all other tasks and activities as requested.
Required Qualifications and Background:
  • Bachelor’s degree in life sciences, math, computer science or related field required.
  • 5+ years’ clinical development experience.
  • Knowledge of industry standards (CDISC, SDTM, ADaM, CDASH).
  • Laboratory background and/or working knowledge of commonly tested biomarkers in the oncology setting, with latest and advanced analytical tool and assay experience preferred.
  • Previous LIMS (Laboratory Information Management System) experience and working knowledge of the clinical drug development process.
  • Prior experience with data transfers or management for CDx or diagnostic developments programs in general is a plus Experience with web-based Electronic Data Capture (EDC), clinical data management systems and industry wide thesauri, such as MedDRA and WHO Drug.
  • Excellent verbal/written communication and interpersonal skills and ability to collaborate effectively with cross-functional teams.
  • Proven ability to work both independently and in a team setting.
  • Excellent time management skills and a proven ability to work on multiple projects at any given time in a fast-paced environment.
  • Demonstrated ability to stay abreast of trends and new information in the profession. Demonstrated leadership and project management skills.
  • Good working knowledge of ICH, FDA, and GCP regulations and guidelines.
  • Strong well-rounded technical skills (MS Office; MS Word, Excel, PowerPoint).
Additional Preferred Qualifications
  • 5+ years prior oncology/hematology experience highly desirable.
  • 4+ years of Sponsor experience.
Available Locations for this role:
  • Stamford, CT
  • South San Francisco, CA
  • US Based-Remote
Physical Demands / Travel

The physical demands of this job are consistent with light office duties.  This position will travel rarely; the average travel for this position is 0-10% with some variation based upon the demands of the business imperatives.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in an office setting.  

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Senior Principal Scientist, Mass Spec
Function:
Discovery Biologics
Location:
South San Francisco, CA
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Senior Principal Scientist will play a pivotal role in building and leading a team of scientists in the Protein Science & Engineering within Loxo Oncology Biologics
 
The role requires a clear understanding of strategies laid out for Loxo Large Molecule Biologics and implementation of strategies in the context of bioanalytical and mass-spectrometry. This includes characterization of antibody and ADC candidate molecules, facilitation and providing guidance in epitope mapping studies, developability assessments, and pre-clinical in-vivo/pharmacokinetic studies utilizing bioanalytical techniques, mass-spectrometry, and other discovery-related characterization. 
Roles and Responsibilities of the Position
  • Facilitate in building a team of scientists and associates at various levels within Loxo Oncology Biologics
  • Lead a diverse group encompassing analytical and mass-spectrometry based characterization of large molecule biologics for oncology
  • Responsible for designing, overseeing, and executing key experiments for analytical and mass-spectrometry based characterization of these large molecules from early discovery to early development stage
  • Interact and collaborate with other teams across the company to provide analytical and mass-spec solutions; analyze, collate, and disseminate data to teams in a timely manner
  • Participate and present periodic updates and reports to senior management to significantly influence strategic research decisions and operations
  • Participate in long-term strategies for creation of innovative solutions and intellectual property for securing FTO for Loxo
  • Liaise with CROs and vendors for contract work and evaluations
Required Qualifications and Background
  • Ph.D. in life or analytical sciences or equivalent fields with at least 15 years of relevant job experience in the biopharma industry with good understanding of drug development process with emphasis on antibody-drug conjugates.
Additional Preferred Qualifications
  • Demonstrated leadership skills in leading a team by providing clear direction, setting expectations, and mentoring scientists
  • Demonstrated proven expertise in protein mass-spectrometry for antibodies including LC-MS intact protein analysis, peptide mapping, conjugate analysis, PTMs, de-novo sequencing, and chemical modifications
  • Experienced in small molecule and protein mass-spectrometry of antibody drug-conjugates (ADC) for characterization of conjugation site analysis, positional isomers, free drug, drug stability, and metabolite analysis
  • Experienced in analytical characterization of large molecules and conjugates using SEC/HIC, U/HPLC, cIEF, CE and cLIF
  • Lead in setting up studies for assessment of antibodies and ADCs for developability/CMC and assist in writing of technical reports, SOPs, and regulatory documents for IND
  • Prior experience in participation of team efforts for antibody lead panel generation, lead optimization, and IND enabling studies
  • Hands-on experience on data analysis of mass-spec data, informatics, and tools such as Graphpad Prism,
  • Demonstrated can-do attitude and brings innovative ideas in challenging projects set up in a collaborative, cross-functional organization
  • Excellent communication skills and with strong organizational abilities
Physical Demands/ Travel:
 
The physical demands of this job are consistent with laboratory bench setting.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in a lab.  
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Senior Principal Scientist/ Associate Director, Regulatory Toxicology
Function:
Toxicology
Location:
Boulder, CO
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Toxicologist will be responsible for reviewing DMPK and toxicology data for candidates advancing through early target assay development, lead optimization, candidate selection and into IND-enabling studies and advising on design and progression strategies. They will also advise on and support the development program through NDA. Successful writing and reviewing of regulatory documents for submission will be a critical role.
Roles and Responsibilities of the Position
  • Establish regulatory progression pathways for discovery and clinical candidates.
  • Set strategy, guide, author, and review regulatory documents.
  • Create and evaluate mechanistic and predictive toxicology studies, including DMPK considerations, designed to assess hypotheses for and evaluate mechanisms of toxicity related to physiological or biochemical functions. advise
  • Evaluate safety assessment and toxicology data to support nomination of drug candidates for further development.
  • Communicate results clearly and concisely in both oral and written reports and presentations.
  • Perform in depth pathway/network analysis on data derived from toxicology and other studies and disseminate results to the wider toxicology community (internally and externally).
  • Evaluate new targets for potential toxicological liabilities.
  • Closely interact with scientists in other functional areas.
Required Qualifications and Background
  • Ph.D. in toxicology required, along with 10+ years’ experience as a toxicologist within the biopharmaceutical industry. Board certification in Toxicology strongly preferred.
  • Previous small molecule oncology therapeutic product development experience in a pharmaceutical or biotechnology company is preferred.
  • Familiarity with GLP regulations and regulatory guidelines for the testing of biopharmaceutical products and experience with compilation of toxicology information into various regulatory submission documents is desirable. 
  • Strong experience in writing and submitting regulatory documents for oncology indications and responding to regulatory agency questions.
  • Demonstrated ability to work well with other accomplished professionals within and across functions/teams. Willing collaborator.
  • Strong written and oral communication skills.
  • Ability to multi-task and shift priorities rapidly to meet tight deadlines.
  • Excellent written and verbal communicator.
  • Detail oriented and well organized.
  • Good and thoughtful listener.
  • Enthusiastic, self-motivated and keen to improve processes and overcome inefficiencies.
  • Proficient in Microsoft Office suite and applications.
Physical Demands/ Travel:
 
The physical demands of this position are consistent with working in an office / laboratory/ environment. Some light lifting, and maneuvering may be required.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in an office and lab with some remote responsibilities.
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Senior Scientist, Large Molecule Biology
Function:
Discovery Biologics
Location:
New York, NY
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

As a scientist in the Large Molecule biology group, you will be joining a large and dynamic group focused on executing experiments on the cutting edge of pharmaceutical sciences. You will execute experiments needed to support the various research programs for identified targets. You will oversee aspects of portfolio programs independently and with minimal direct oversight. You will be expected to demonstrate laboratory expertise with biologic assays aimed at drug development (mAb, ADC and CD3 platforms). In addition, assay development for specialized assays related to portfolio programs is required. You may directly oversee junior non-PhD scientists. You will also be encouraged to develop your own ideas and contribute these to the broader group. You are expected to be a dynamic and motivated scientist who can drive their own experiments and research activities, while collaborating extensively with the rest of the organization to execute on various research programs.
Roles and Responsibilities of the Position:
  • Design and execute studies to select and deliver candidates
  • Demonstrate laboratory expertise with biologic assays aimed at drug development (mAb, ADC and CD3 platforms)
  • Perform functional mAb screening and profiling (tumor cell signaling assays, internalization, tumor cell killing assays, cytokine release assays)
  • Conduct candidate evaluation in both in vitro (PK/PD, receptor occupancy, density, cytokine release), and ex vivo assays (tumor isolation, analysis of blood cells)
  • Interrogate experimental conduct of third parties/vendors
  • Work with the project leader and senior leader to design strategy for the development of the molecule
  • Present your work to internal teams and summarize findings in preclinical reports
  • Communicate results at project team meetings, be involved in the coordination and preparation of presentations
  • Discuss results with technical as well as non-technical personnel
  • Work in cross functional environments via extensive collaboration with other parts of the organization
  • In some cases, direct leadership of a junior scientist may be required
Required Qualifications and Preferred Background:
  • PhD in biological sciences with 3 or more years of experience
  • BSc. in biological sciences with 8 or more years of experience
  • Level of role will be consistent with experience
  • Experience with ADC and/or TCE platforms highly preferred
  • Extensive expertise performing in vitro and ex vivo assays
  • Strong data analysis skills with attention to detail
  • Ability to design comprehensive experimental plans and carry out in a timely fashion
  • Deep expertise in cancer disease states (indications, mutational status, tumor cell drivers)
  • Demonstrated experience in working collaboratively across various scientific disciplines to meet end goals of business
  • Excellent communication and interpersonal skills
  • Demonstrated ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines

Physical Demands/ Travel:
 
The physical demands of this job are consistent with a laboratory bench setting.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in a lab based.  
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Senior Specialist, Contracts Consultant
Function:
Business Operations
Location:
Remote
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

Working with internal business functions as well as the legal team, the Senior Specialist, Contracts Consultant will be responsible for drafting, negotiating and managing vendor contracts across the business, including Non-Disclosure Agreements, Master Service Agreements, Statements of Work, and IT License Agreements.  The Senior Specialist will also help maintain the contract database to track terms and metadata across all contracts. 
Roles and Responsibilities of the Position:
  • Help draft, negotiate and manage a wide range of potential contracts ranging from Discovery CRO contracts to contracts for IT, Finance, and Facilities
  • Identify and mitigate business risks throughout the contracting process
  • Manage the lifecycle of contracts, including contract expirations, renewals, extensions, terminations, and amendments
  • Perform administrative tasks specific to contract management, such as creating files, updating files with ongoing correspondence, managing the contract execution process, and entering executed contracts into the internal contract database
Required Qualifications and Background:
  • Associates Degree (or higher) in paralegal studies, Business Law or equivalent discipline or four-year degree in Business, HealthCare, or related field
  • 5+ years of direct generalist contract experience, preferably in the Biotech/ Pharmaceutical or Diagnostics Industries
  • Strong contract drafting, review and analysis skills
  • Ability to manage and meet strict deadlines, as well as support multiple, simultaneous assignments
  • Excellent attention to detail
  • MS Office skills (Outlook, Word, Excel, PowerPoint)
  • Excellent verbal and written communication skills
  • Project management experience a plus
Physical Demands/ Travel:
The physical demands of this job are consistent with light office duties.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in an office.
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
 
 


*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Senior/Principal Computational Biologist, Team Lead(Multiple Locations)
Function:
Discovery Bioinformatics
Location:
South San Francisco, CA
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

We are seeking a talented and highly motivated experienced Computational Biologist to join our Discovery Bioinformatics group. The candidate will lead bioinformatics efforts across multi-disciplinary teams to rapidly advance small molecule drug development efforts. This position is expected to lead and oversee broader strategic involvement in shaping the next generation of cancer therapies through data-driven approaches.
Roles and Responsibilities of the Position
  • The successful candidate will join a dynamic team and oversee computational biology efforts across multiple functions. They will be expected to lead a team, supervise and develop scientists, and help build a research strategy that leverages deep cancer biology knowledge and high-dimensional data. Success critically depends on the ability to effectively present complex analyses and results in a clear and concise manner to a diverse audience of scientists.
Required Qualifications and Background
  • PhD in Bioinformatics, Biostatistics, Computational Biology, or similar area of study required. Post-doctoral training or equivalent prior work experience (3-5+ years).
  • Substantial publication record and/or similar achievements.
  • Demonstrated track record of strategic scientific leadership in the computational biology field with leading and developing scientists.
  • Strong understanding of relevant concepts in cancer biology and molecular biology.
  • Experience in large-scale data analyses involving high-throughput molecular assays such as DNA/RNA-Seq, ATAC/CHiP-Seq, single-cell technologies, etc.
  • Understanding of current best-practices for high-throughput genomics/molecular data analyses and familiarity of their underlying statistical principles.
  • Experience using programming languages such as R, Python, or similar for statistical analysis.
Available Locations for this role
  • South South Francisco, CA
  • New York City, NY
  • US Based-Remote

Physical Demands / Travel:

The physical demands of this job are consistent with light office duties.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in an office.  

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position could range from between $89,750 to $131672 for a senior scientist and $103,200 to $151,423 for a Principal Scientist and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Senior/Principal Scientist, Discovery Biology
Function:
Target Discovery
Location:
South San Francisco, CA
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Senior/Principal Scientist, Discovery Biology will be part of the Loxo Oncology at Lilly’s Discovery group identifying the next generation of molecular targets for cancer therapeutics.  The Senior/Principal Scientist, Discovery Biology will be responsible for creating and executing strategies toward discovery and early validation of oncology targets through close collaboration with other discovery and translational functions. The Senior/Principal Scientist, Discovery Biology will have a strong understanding of oncogenic pathways and experience in designing experiments to evaluate molecular interactions and pathways. The Senior/Principal Scientist, Discovery Biology will be part of a multi-disciplinary effort focused on high-quality, truth-seeking science to bring forward innovative cancer drug therapy.
Roles and Responsibilities of the Position
  • Create, develop and validate quantitative mammalian cellular assays to credential novel targets.
  • Establish robust high-throughput screening assays.
  • Design and manage in vivo pre-clinical studies.
  • Conceive and lead collaborative projects on biomarker-driven programs.
  • Evaluate emerging technologies, methods, and service providers to ensure our work is being done in a scientifically sound, efficient, and reasonable way.
  • Collaborate with colleagues throughout the company to ensure assays meet the program needs and results are appropriately interpreted.
  • Participate and thrive in an interactive, team-oriented culture.
  • Directly manage and mentor lab-based staff.
Required Qualifications and Background
  • PhD in Molecular/Cellular Biology or Biochemistry, or related field.
  • Minimum of 3-6 years of postdoctoral and/or hand-on research experience, preferability in biotech/pharma setting.
  • Experience in relevant areas of cancer and molecular biology.
  • Outstanding communication, writing, and presentation skills is a must.
Additional Preferred Qualifications
  • Experience with cell engineering such as knock-in and knockdown cell lines with CRISPR and/or other technologies.
  • Experience with flow cytometry and general molecular biological techniques including q-PCR, signaling experiments, assays for protein-protein interactions and Western Blot etc.
  • Experience in designing and handling in vivo animal studies.
  • Experience in building models (cell line, organoid or PDX) from patient samples and using them to test drug activities.
  • Experience working with external CROs.
  • Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels and problem solving skills.
  • Ability to summarize complex experiment and results for non-specialists.
  • Enthusiastic, self-motivated and keen to improve processes and overcome inefficiencies.
Physical Demands / Travel

The physical demands of this job are consistent with working in a laboratory/ bench environment. Some light lifting, and maneuvering may be required.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in a lab/bench environment.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Senior/Principal Scientist, Medicinal Chemistry
Function:
Discovery Small Molecule
Location:
Boulder, CO
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

Loxo Oncology at Lilly’s Drug Discovery team has an immediate opening for an experienced medicinal chemist. The Loxo Oncology at Lilly team’s mission is to invent life-changing targeted therapies for cancer patient populations that are poorly treated by existing therapies. To that end, we have built a multi-disciplinary team of dedicated drug discovery scientists who are passionate about driving the science forward to create highly selective drugs for known oncogenic drivers. We are currently looking for accomplished medicinal chemists with a proven track records of success in small molecule drug discovery. The ideal candidate will be passionate about leading from the bench to solve medicinal chemistry challenges and will excel at working closely with scientists across disciplines. The position requires excellent people skills, a positive can-do attitude, and the ability to thrive in a highly interactive, fast-paced, team environment.
Roles and Responsibilities for the Position
  • Drive the project toward the next breakthrough drug candidate by designing and synthesizing new medicinal chemistry analogs that directly address project goals. 
  • Optimize lead series for potency, selectivity, physiochemical properties, in vitro ADME, and PK by coupling multivariant SAR analysis with hypothesis driven medicinal chemistry design principles. Use sound scientific methods to propose hypotheses and determine next steps even with complex or ambiguous data.
  • Work closely with structural biology and computational chemistry colleagues to design novel compounds and hypotheses that address key drug optimization goals.
  • Reduce ideas to practice in the lab quickly by effectively employing a broad range of modern organic chemistry transformations, synthetic methods, purification and characterization techniques.
  • Synergize with the broader team by communicating results, sharing insights, making plans, and setting goals in an open, honest way.
  • Provide medicinal chemistry insight for new target and lead identification and evaluation initiatives in the oncology space.
  • Proactively investigate new or different technologies to improve the effectiveness of the drug discovery process.
  • Analyze complex data streams and conceptualize priority synthesis targets based on a holistic data approach.
Required Qualifications and Background
  • BS, MS, or PhD in chemistry with a focus on synthetic organic chemistry 
  • Experience in small molecule drug discovery in a biotechnology or pharmaceutical setting and a B.S. with 8+ years’ experience, M.S. with 5+ years’ experience or Ph.D. with 2+ years’ experience.
  • Proven track record of success in advancing programs from leads to advanced candidates.
  • Extensive experience in lead compound optimization for potency, selectivity, ADME and PK.  
  • Experienced in the use of synthetic chemistry instrumentation: HPLC, LC-MS, NMR, and purification systems.
  • Expert in using common medicinal chemistry software: electronic notebook, ChemDraw, Excel; data visualization; structure viewing; literature, chemical and database searching.
  • Committed to staying current with the latest scientific breakthroughs in the medicinal chemistry field through continued reading of the literature and attendance of scientific conferences. 
  • An excellent team player with ability to communicate synergistically with a multidisciplinary team and be accountable for the medicinal chemistry progress of the project. Highly organized with excellent analytical, documentation, time management, and multi-tasking skills.

  • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for Senior Scientist level  position could range from between $89,750 to $131,672 and that the base salary for Principal Scientist level  position could range from between $103,200 to $151,423 but will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
This position’s work environment is based in a laboratory/ bench environment.
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job. 
 


*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Senior/Principal Scientist, Medicinal Chemistry (San Diego, CA)
Function:
Discovery Small Molecule
Location:
San Diego, CA
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

Loxo Oncology at Lilly’s Drug Discovery team has an immediate opening for an experienced medicinal chemist. The Loxo Oncology at Lilly team’s mission is to invent life-changing targeted therapies for cancer patient populations that are poorly treated by existing therapies. To that end, we have built a multi-disciplinary team of dedicated drug discovery scientists who are passionate about driving the science forward to create highly selective drugs for known oncogenic drivers. We are currently looking for accomplished medicinal chemists with a proven track records of success in small molecule drug discovery. The ideal candidate will be passionate about leading from the bench to solve medicinal chemistry challenges and will excel at working closely with scientists across disciplines. The position requires excellent people skills, a positive can-do attitude, and the ability to thrive in a highly interactive, fast-paced, team environment.
Roles and Responsibilities for the Position
  • Drive the project toward the next breakthrough drug candidate by designing and synthesizing new medicinal chemistry analogs that directly address project goals. 
  • Optimize lead series for potency, selectivity, physiochemical properties, in vitro ADME, and PK by coupling multivariant SAR analysis with hypothesis driven medicinal chemistry design principles. Use sound scientific methods to propose hypotheses and determine next steps even with complex or ambiguous data.
  • Work closely with structural biology and computational chemistry colleagues to design novel compounds and hypotheses that address key drug optimization goals.
  • Reduce ideas to practice in the lab quickly by effectively employing a broad range of modern organic chemistry transformations, synthetic methods, purification and characterization techniques.
  • Synergize with the broader team by communicating results, sharing insights, making plans, and setting goals in an open, honest way.
  • Provide medicinal chemistry insight for new target and lead identification and evaluation initiatives in the oncology space.
  • Proactively investigate new or different technologies to improve the effectiveness of the drug discovery process.
  • Analyze complex data streams and conceptualize priority synthesis targets based on a holistic data approach.
Required Qualifications and Background
  • BS, MS, or PhD in chemistry with a focus on synthetic organic chemistry 
  • Experience in small molecule drug discovery in a biotechnology or pharmaceutical setting and a B.S. with 8+ years’ experience, M.S. with 5+ years’ experience or Ph.D. with 2+ years’ experience.
  • Proven track record of success in advancing programs from leads to advanced candidates.
  • Extensive experience in lead compound optimization for potency, selectivity, ADME and PK.  
  • Experienced in the use of synthetic chemistry instrumentation: HPLC, LC-MS, NMR, and purification systems.
  • Expert in using common medicinal chemistry software: electronic notebook, ChemDraw, Excel; data visualization; structure viewing; literature, chemical and database searching.
  • Committed to staying current with the latest scientific breakthroughs in the medicinal chemistry field through continued reading of the literature and attendance of scientific conferences. 
  • An excellent team player with ability to communicate synergistically with a multidisciplinary team and be accountable for the medicinal chemistry progress of the project. Highly organized with excellent analytical, documentation, time management, and multi-tasking skills. 
Physical Demands:
 
The physical demands of this position are consistent with working in a laboratory/ bench environment. Some light lifting and maneuvering may be required.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Specialist Quality Assurance, GMP (Multiple Locations)
Function:
Quality Assurance
Location:
South San Francisco, CA
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Specialist, Quality Assurance - GMP supports Loxo QA. The Specialist, Quality Assurance - GMP will function as a QA Generalist. The Specialist, Quality Assurance-GMP will work closely with Loxo Regulatory, Drug Supply, CMC and the contract organizations those departments are partnering with. The Specialist, Quality Assurance – GMP will also support Document Control by routing SOPs for review/approval in the QMS system at Loxo.
Roles and Responsibilities for the Position
  • Ensure GMP work at Loxo and contract organizations is done in compliance with applicable laws, regulations, guidelines, and SOPs.
  • Work closely with Loxo QA, CMC, Regulatory, and Drug Supply colleagues through all phases of drug development, particularly early phase to ensure compliance and timeliness of GMP work.
  • Work closely with CMOs to ensure compliance and timeliness of GMP work.
  • Execute all Quality System elements, which include but are not limited to investigation of product complaints, deviations, CAPAs, document creation and control, change control, validation (e.g. analytical method,.), stability, batch record review, and product disposition. 
  • QC IMPD/IND CMC sections.
  • Facilitate documentation reviews with Qualified Persons (QPs)
  • Review and approve labeling.
  • Participate on project teams and sub-teams as needed and assigned.
  • Ensure documents and records are kept in compliance with regulations and SOPs.
  • Routing SOPs for review/approval in the QMS System.
  • Additional tasks as required.
Required Qualifications and Background
  • BA/BS in science or engineering. 
  • A minimum of 5-7 years of experience working in the Biotech or Pharmaceutical FDA regulated industry in QA or a related area.
  • Experience in Batch Review and Release.
  • Experience writing and reviewing Deviations, CAPAs, and Change Controls.
  • Experience working with solid oral dosage products.
  • Working knowledge of cGMP’s (CFR/ICH) and applicable international regulations/guidelines.
  • Experience working with Contract Manufacturing Organizations.
  • Strong understanding of GMP requirements for early phase drug development.
  • Attention to detail and accuracy of work.
  • Ability to multitask and work in a fast-paced environment to meet tight deadlines.
  • Ability to work in a matrixed environment.
  • Ability to work in a virtual manufacturing environment.
  • Ability tDemonstrated ability to work well with other accomplished professionals.
  • Willing Collaborator
  • Strong communication skills both written and oral.
Available Locations for this role
  • Stamford, CT
  • South San Francisco, CA
  • Boulder, CO
  • Remote- US Based


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position could range from between $67,850 to $99,563 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Warehouse, Associate Manager
Function:
Facilities/EHS
Location:
Boulder, CO
Position Summary:
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

Loxo Oncology at Lilly is seeking a highly motivated, self-starting individual to join the team as a Warehouse Sr. Specialist to develop and oversee warehouse and inventory control systems for Loxo’s new facility in Louisville, CO.  You will be responsible for developing processes for receipt, storage, control and issuance of raw materials and supplies to support the operation of an oncology research facility.
Roles and Responsibilities of the Position:
  • Manage, execute and support the warehouse operations by developing and standardizing systems, processes, and SOP’s.
  • Develop inventory control methods including material bar coding, raw material receipt, material issuance, automatic reorder points and stock levels.
  • Forecast and budget spend for warehouse operation activities and needs.
  • Work with procurement to develop and implement effective warehouse and logistics strategies.
  • Identify, initiate, and manage cross-functional projects using appropriate project management expertise and methodologies.
  • Oversee shipping and receiving of raw materials, supplies and samples, verifying the accuracy of the shipment with the purchase order, packing list/bills of lading and inspecting for damaged goods.
  • Enforce corporate compliance requirements as it pertains to receipt, storage, and transportation of raw materials, hazardous materials and controlled substances.
  • Receive, unload, stock and issue materials to internal customers.
  • Check mechanical aspects of the company vehicles and ensure equipment is in good operating condition.
  • Handle materials and freight using a fork truck, manual and electric pallet jacks and handcarts.  
  • Prepare, package and ship requested packages per DOT / IATA guidelines (includes hazardous materials, international shipping, etc.).
  • Work with co-workers to resolve shipment discrepancies and returns.
  • Prepare and maintain logs, monthly reports, inventory reports.
  • Prepare, package and ship requested packages per DOT / IATA guidelines (includes hazardous materials, international shipping, etc.).
  • Perform inventory cycle counts.
  • Oversee receipt of bulk gases in mechanical courtyard.
  • Receive bulk fuel deliveries for the emergency generator.
  • Monitor the bulk lab waste system to ensure adequate space for ongoing lab operations.  Prepare and ship portable waste totes.
  • Maintain audit-ready environment and cleanliness of warehouse, docks and supply areas.
  • Generate, review and update SOP's as needed.
  • Identify process improvements and manage implementation.
  • Compliance with safety guidelines.
  • Other duties as assigned.
Required Qualifications and Preferred Background:
  • 5+ years of experience in a warehouse environment.
  • Previous experience developing inventory management systems.
  • Proficient in SOPs, Coupa, Microsoft Office, Veeva, or similar operating databases.
  • Must possess a valid driver's license.
  • Strong Verbal, Written, and Customer Service communication skills.
  • Experience in continuous improvement processes.
Available Locations for this role:
  • Boulder/Louisville, CO
Physical Demands/ Travel:
 
The physical demands of this job are consistent with warehouse environments.  Employee must be able to stand/walk for several hours per shift, lift 50 pounds, safely handle hazardous materials and operate material handling equipment such as pallet jacks, drum dollies, company vehicles and lift trucks.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in a warehouse.  
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position could range from between $78,000 to $114,497 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Apply Now


Position:
Outstanding Team Member
Reporting To:
Dedicated, Knowledgeable Supervisor
Location:
United States and Beyond
Position Summary

Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by that goal. We pursue this goal with a tenacity, focus and commitment to excellence that defines who we are and how we work.

We seek dedicated, passionate, hardworking intelligent, thoughtful and authentic individuals who thrive within a collaborative and fast-paced environment and will bring their experiences, unique perspectives and problem-solving skills to the team. In return, we cultivate an environment that rewards and recognizes hard work and provides opportunities for learning and growth as part of a team making a meaningful difference in the field of medicine and for individual patients.

If you share our passion, please let us know how you could contribute to our team. We don't want to pass up an opportunity for the right candidate to join us just because you found us before we found you.

Connect With Us

Submit your resume and your "Who", "What" and "Why" (see below) to careers@loxooncology.com.

Your "Who", "What" and "Why":

  • Who are you?
  • What will you bring to Loxo?
  • Why do we need you on the team?

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

For more information about Loxo Oncology’s privacy practice, please view the Privacy Statement.