Career Opportunities

Career Opportunities

Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by our goal of improving the lives of people living with cancer. We pursue this goal with a tenacity, focus, and commitment to excellence that defines who we are and how we work.

We seek dedicated, passionate, hardworking, intelligent, thoughtful, and authentic individuals who thrive within a collaborative and fast-paced environment and will bring their experiences, unique perspectives and problem-solving skills to the team. In return, we cultivate an environment that rewards and recognizes hard work and provides opportunities for learning and growth as part of a team making a meaningful difference in the lives of patients.

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Position:
Anti-Bribery and Anti-Corruption Consultant (PT)
Function:
Business Operations
Location:
Remote
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

Responsible for assessing third parties to identify and mitigate bribery and corruption risk. Collaborate with cross functional business partners regarding bribery and corruption risks and controls.
Roles and Responsibilities of the Position:
  • Assists more senior compliance professionals and business operations in evaluating bribery and corruption risks related to third party engagements, including reviewing third parties' responses to due diligence questionnaires, identifying and escalating relevant bribery and corruption risks, and working with the business and third party to mitigate such risks.
  • Maintains a high level of awareness and knowledge of Anti-Bribery/Anti-Corruption (ABAC) regulations and requirements.


Required Qualifications and Preferred Background:
  • Bachelor’s Degree in Finance or related field
  • 5+ years of experience in Compliance, Audit, Law, or Risk Management
  • ABAC compliance experience 
  • Risk management certification - TRACE Anti-Bribery Specialist or similar certification - is a plus
  • Collaborative problem-solver
  • Experience with conducting ABAC due diligence on third parties


Physical Demands/Travel:

The physical demands of this job are consistent with light office duties. 

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.


Work Environment:

This position’s work environment is a remote office setting  

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.


*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

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Position:
Associate Director, Data Management
Function:
Clinical Data Management
Location:
Remote
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Associate Director, Clinical Data Management is responsible for leading and overseeing data management tasks for one (or more) clinical programs from study start-up through database lock for clinical trials.  The Associate Director, Data Management will manage a team within the Data Management Group and work collaboratively across multiple cross functional groups including Clinical Operations, Biostatistics and Clinical Science.  The Associate Director will also be responsible for DM vendor management, contracts and relationships to ensure database development, data review/cleaning, database auditing, database lock, and receipt of final database deliverables are in compliance with standard operating procedures and regulatory agency guidelines. The Associate Director, Data Management ensures all Data Management activities stay within full compliance of Loxo regulatory and legal policies.
Roles and Responsibilities of the Position:
  • Represents Data Management for one (or more) clinical programs from a strategic planning and execution capacity in program team meetings and development strategy meetings
  • Oversees the creation and execution of data management timelines used to coordinate and synchronize deliverables with the overall study timelines
  • Evaluate and design DM processes for study execution, data delivery management as well as for initiatives which require cross functional collaboration
  • Manage team within DM group for specific program including day to day operations, resource allocation for study, and career track development
  • Participate in study vendor FRP/bid process for all vendors as required
  • Evaluate and engage CRO/service providers for all studies and relationships as required
  • Monitors the progress of all data management activities on all studies to ensure project timelines are met
  • Proactively identifies potential program and delivery issues/risks and recommends/ implements solutions
  • Collaborate with Statisticians and Statistical Programmers in production of clinical trial reports and other deliverables
  • Performs any and all other tasks and activities as requested by CDO
Required Qualifications and Preferred Background:
  • Bachelor’s degree in life sciences, math, computer science or related field required. Master’s degree in life sciences, math, computer science or related field preferred
  • Minimum of 12+ years’ clinical data management experience
  • Demonstrated leadership, line management and project management skills
  • Oncology/Hematology experience strongly preferred
  • Prior experience with biostatistics and SAS programming preferred
  • Thorough and broad knowledge of data management processes, including EDC and interactive voice response system (IVRS)experience.
  • Knowledge of regulatory guidelines such as GCP, 21 CFR Part 11 etc.
  • Knowledge of study data tabulation model (SDTM)
  • Must have excellent verbal, written and communication skills
  • Ability to work independently as well as in a team environment
  • Excellent time management skills and a proven ability to work on multiple projects at any given time in a fast-paced environment.
  • Demonstrated ability to stay abreast of trends and new information in the profession

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Associate Director level position could range from between $135,300 to $198,516 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.
Available locations for this role:
  • South San Francisco, CA
  • Stamford, CT
  • US Remote-Based
Physical Demands/ Travel:
 
The physical demands of this job are consistent with light office duties. This position will travel occasionally; the average travel for this position is 15-20% with some variation based upon the demands of the business imperatives.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in an office setting.  
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

Apply Now

Position:
Associate Director/Director, Biostatistics and Statistical Programming Process and Infrastructure (BSPPI)
Function:
Biostatistics
Location:
Remote
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Associate Director/Director, Biostatistics and Statistical Programming Process and Infrastructure (BSPPI) will play a key role in modernizing the Biostatistics Department by assessing, improving, and managing its standards, infrastructure, and processes. The Associate Director/Director, BSPPI will work closely with the Loxo@Lilly Biostatistics leadership team, Lilly biostatistics and data management to establish best practices, processes and efficient integrated handoffs from data and analysis perspective. The Associate Director/Director, BSPPI will have an opportunity to influence best practices and innovative processes cross functionally to enable agile drug development in the context of an exciting and growing oncology portfolio.  
Roles and Responsibilities of the Position:
  • Processes: Collaboratively lead assessment, implementation, and management of lean process development and associated documentation for biostatistics and statistical programming
  • Infrastructure: Partner with leads from interfacing cross functions such as Data Management and IT across Loxo@Lilly and Lilly to analyze and continuously improve the computing infrastructure that includes statistical computing environment and standard software utilities 
  • People: Develop collaborative relationships with relevant functions within Loxo@Lilly and Lilly by leading/participating in cross functional initiatives to bridge the differences in standards, processes, and infrastructure.
  • Standards: Lead the development, improvement, and adaption of standards for statistical analysis documents, SAS and R programs, TFLs, and SDTM and ADaM datasets. Keep abreast with industry and regulatory trends related to biostatistics and statistical programming.
  • Technology: Introduce/develop breakthrough and incrementally innovative technical capabilities to ensure optimal operation of Biostatistics department.

Required Qualifications and Preferred Background:
  • Bachelor/Master’s/PhD Degree in Computer Science, Statistics, Mathematics, Life Sciences or other relevant scientific fields with a minimum 7-10 years Pharmaceutical/Biotech data science, programming and/or statistics experience is required
  • Experience in analyzing, designing, developing, and managing the change of implementing innovative solutions is required
  • Knowledge of SAS programming language and familiarity with macro development is required
  • Knowledge of programming languages in addition to SAS such as R and Python, and programming tools used in clinical research and drug development is preferred.
  • Solid knowledge of the drug development process, interaction of statisticians and statistical programmers, and experience in complex technical projects is required.
  • Familiarity with regulatory guidelines, CDISC standards, biostatistics and statistical programming submission deliverables, and validation processes is required.
  • Excellent verbal/written and interpersonal skills including the ability to communicate and collaborate effectively in a cross-functional setting 

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position level could range from between $135,300 to $ 198,516 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Physical Demands/Travel:

The physical demands of this job are consistent with light office duties. 

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.


Work Environment:

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.


*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

Apply Now

Position:
Associate Manager, Business Operations – Licensing Contracts & Project Manager
Function:
Business Operations
Location:
Remote
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Associate Manager of Business Operations is responsible for negotiating material transfer agreements, license agreements, and processing transfer documentation for licensed materials.  This individual will also be responsible for tracking and sharing information related to existing licensed data/materials and any related use restrictions. 
Roles and Responsibilities of the Position:
  • Work with discovery, legal, and finance teams to help draft, negotiate and manage contracts to support drug development with a focus on data/material licenses and related transfer documentation
  • Identify and mitigate business risks throughout the contracting process
  • Help track and share existing licensed data/materials and related use restrictions
  • Potential to manage sponsored research agreements, including working with partners and academic institutions to track data/results as well as financial and resource obligations
Required Qualifications and Background:
  • Bachelor’s degree required
  • 3+ years of contract negotiation with significant experience negotiating and managing license agreements, including licenses for cell lines, genetically modified animal models, and data
  • Experience negotiating software licenses and/or sponsored research agreements would be a plus
  • Experience optimizing the tracking and sharing of information, including establishing new processes and/or systems
  • Strong contract drafting, review and analysis skills
  • Ability to communicate efficiently and effectively
  • Ability to manage and meet strict deadlines, work independently, and multi-task
  • Excellent attention to detail
  • MS Office skills (Outlook, Word, Excel, PowerPoint)

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the {insert position} level position could range from between $78,000 to $114,498 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.

Physical Demands/ Travel:
 The physical demands of this job are consistent with light office duties.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
Work Environment:
 
This position’s work environment is in an office.
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
 

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

Apply Now

Position:
Associate Manager/Specialist, Quality Assurance - GMP
Function:
Quality Assurance
Location:
Remote
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Associate Manager/Specialist, Quality Assurance - GMP will work closely with Loxo@Lilly Regulatory, Drug Supply, CMC, and the associated contract organizations in support of activities associated with GMP manufacturing and release. The Associate Manager/Specialist, Quality Assurance – GMP will additionally provide Quality Systems support, as required.
Roles and Responsibilities of the Position:
  • Work closely with Loxo@Lilly QA, CMC, Regulatory, Drug Supply, and CMO colleagues through all phases of drug development, particularly early phase to ensure compliance and timeliness of GMP work, including:
  • Batch record review (Executed and Master) for all phases of manufacturing (drug substance, drug product, packaging, labeling, and associated intermediates)
  • Final disposition of finished product for clinical use, including country-specific release and collaboration with Qualified Persons (QPs)
  • Authoring and review of deviations, CAPAs, and change controls
  • Investigation of product complaints
  • Quality review of analytical documentation including: analytical methods; validation protocols and reports; specifications; and stability protocols, reports, and expiry extensions
  • QC of IMPD/IND CMC sections
  • Review and approval of clinical product labels
  • Authoring/ revision of SOPs
  • Implementation of process improvements
  • Ensuring that GMP work at Loxo and contract organizations is done in compliance with applicable laws, regulations, guidelines, and SOPs.
  • Participation on project teams and sub-teams as needed and assigned
  • Additional tasks as required.
Required Qualifications and Preferred Background:
  • BA/BS in science or engineering 
  • A minimum of 5 years of experience in Quality Assurance in an FDA regulated Biotech or Pharmaceutical setting at the Specialist level, 8 + years at the Associate Manager level
  • Experience in Batch Review and Release for clinical phase products
  • Experience authoring and reviewing Deviations, CAPAs, and Change Controls
  • Experience working with solid oral dosage products and/or Biologics
  • Working knowledge of cGMP’s (CFR/ICH) and applicable international regulations/guidelines
  • Experience working with Contract Manufacturing Organizations
  • Strong understanding of GMP requirements for early phase drug development
  • Attention to detail and accuracy of work
  • Ability to work in a fast-paced environment to meet tight deadlines
  • Ability to problem solve and implement process improvements
  • Ability to serve as an active participant and contributor in cross-functional meetings
  • Ability to escalate issues when necessary
  • Ability to work in a cross-functional environment
  • Ability to work in a virtual manufacturing environment
  • Demonstrated ability to work well with other accomplished professionals
  • Willing collaborator
  • Strong communication skills, both written and oral

Additional locations for this role:
  • Louisville, CO
  • Stamford, CT
  • South San Francisco, CA

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Specialist level position could range from between $67,850 to $99,563 and $78,000 to $114,498 at the Associate Manager level and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.


Physical Demands/ Travel:
 
The physical demands of this job are consistent with light office duties.
Domestic and International Travel 10-15%
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 Work Environment:
 
This position’s work environment is in an office, manufacturing facility.
 
The work environment characteristics described here are representative of those an employee encounters while performing the
essential functions of this job.
  

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

Apply Now

Position:
Associate Scientist/Senior Associate Scientist/Scientist Cell Line Generation
Function:
Large Molecule Biology & Discovery Technologies
Location:
New York, NY
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

We are looking for a highly capable and motivated laboratory-based scientist experienced in cell line generation and characterization. This individual will be a part of the cell line generation/cell biology team that generates engineered cell lines for our preclinical programs in oncology. The primary responsibilities will include engineering cell lines for use in in vitro mechanistic assays and studies. The right candidate is expected to work within a collaborative team environment, while being able to work independently to design, execute, and optimize experiments. Beyond performing experiments, the scientist will analyze the data from experiments, present the data in meetings and work with the rest of the team to determine the next steps. Position level will be commensurate with applicant’s experience.
Roles and Responsibilities of the Position:
  • Construct knockout and expression vectors using mammalian plasmid and lentiviral, adenoviral, or retroviral systems. Viral titer measurement, and viral stock maintenance.
  • Generate engineered stable cell lines using transfection, CRISPR/Cas9 tools, lentiviral transduction, etc.
  • Optimize cell line development platforms to improve speed and reproducibility of cell line development
  • Perform routine molecular and cell biology techniques like DNA/RNA/protein extraction, qPCR analysis, western blot analysis, fluorescent microscopy and so on.
  • Maintain cultures of frequently used suspension and adherent cell lines.
  • Deposit and archive cell lines in the company’s repository cell line bank.
  • Keep detailed and accurate laboratory records, present results at group meetings and project team meetings
Required Qualifications and Preferred :
  • BA/BS/MS/PhD in biology, cell biology, molecular biology or a related field and 2+ years recent experience working with mammalian cell culture in industry, academic or research setting
  • Basic tissue culture techniques such as cell propagation, cryo- preservation, maintenance and so on
  • Prior cell culture experience with immortalized cell lines, cancer cell lines and/or primary cells
  • Experience creating stable cell lines, transient transfections, viral transductions
  • Experience with performing qPCR, ELISA, western blot, flow cytometry, and cell sorting, all in the context of mammalian cells. Fluorescent microscopy experience would be a plus.
  • Experience in RNAi, CRISPR, and chemical inhibition of cellular pathways
  • Prior experience with various analytical reagents such as Calcein AM, Cell Titer Glo, Alamar Blue, Annexin, PI/7AAD, and immunofluorescent antibodies
  • A high level of proficiency with many kinds of scientific software used to operate lab equipment and/or the ability to quickly master new software
  • Experience and proficiency with data analysis using statistical software such as Excel, Prism, Spotfire or others
  • Must be organized and efficient and able to work according to timelines.
  • Pharma/biotech drug discovery experience a plus    

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Associate Scientist level position could range from between $59,00 to $86,577 and that the base salary for the Senior Associate Scientist level position could range from between $67,850 to to $99,563 and that the base salary for the Scientist level position could range from between $78,000 to $114,498 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.
Physical Demands/ Travel:
 
The physical demands of this job are consistent with laboratory bench setting and light office duties.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in a laboratory-based setting.
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

Apply Now

Position:
Associate Scientist/Senior Associate Scientist/Scientist Cell Line Generation
Function:
Biology Operations
Location:
Louisville, CO
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

We are looking for a highly capable and motivated laboratory-based scientist experienced in cell line generation and characterization. This individual will be a part of the cell line generation/cell biology team that generates engineered cell lines for our preclinical programs in oncology. The primary responsibilities will include engineering cell lines for use in in vitro mechanistic assays and studies. The right candidate is expected to work within a collaborative team environment, while being able to work independently to design, execute, and optimize experiments. Beyond performing experiments, the scientist will analyze the data from experiments, present the data in meetings and work with the rest of the team to determine the next steps. Position level will be commensurate with applicant’s experience.
Roles and Responsibilities of the Position:
  • Construct knockout and expression vectors using mammalian plasmid and lentiviral, adenoviral, or retroviral systems. Viral titer measurement, and viral stock maintenance.
  • Generate engineered stable cell lines using transfection, CRISPR/Cas9 tools, lentiviral transduction, etc.
  • Optimize cell line development platforms to improve speed and reproducibility of cell line development
  • Perform routine molecular and cell biology techniques like DNA/RNA/protein extraction, qPCR analysis, western blot analysis, fluorescent microscopy and so on.
  • Maintain cultures of frequently used suspension and adherent cell lines.
  • Deposit and archive cell lines in the company’s repository cell line bank.
  • Keep detailed and accurate laboratory records, present results at group meetings and project team meetings
Required Qualifications and Preferred Background:
  • BA/BS/MS/PhD in biology, cell biology, molecular biology or a related field and 2+ years recent experience working with mammalian cell culture in industry, academic or research setting
  • Basic tissue culture techniques such as cell propagation, cryo- preservation, maintenance and so on
  • Prior cell culture experience with immortalized cell lines, cancer cell lines and/or primary cells
  • Experience creating stable cell lines, transient transfections, viral transductions
  • Experience with performing qPCR, ELISA, western blot, flow cytometry, and cell sorting, all in the context of mammalian cells. Fluorescent microscopy experience would be a plus.
  • Experience in RNAi, CRISPR, and chemical inhibition of cellular pathways
  • Prior experience with various analytical reagents such as Calcein AM, Cell Titer Glo, Alamar Blue, Annexin, PI/7AAD, and immunofluorescent antibodies
  • A high level of proficiency with many kinds of scientific software used to operate lab equipment and/or the ability to quickly master new software
  • Experience and proficiency with data analysis using statistical software such as Excel, Prism, Spotfire or others
  • Must be organized and efficient and able to work according to timelines.
  • Pharma/biotech drug discovery experience a plus    

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Associate Scientist level position could range from between $59,00 to $86,577 and that the base salary for the Senior Associate Scientist level position could range from between $67,850 to to $99,563 and that the base salary for the Scientist level position could range from between $78,000 to $114,498 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.
Physical Demands/ Travel:
 
The physical demands of this job are consistent with laboratory bench setting and light office duties.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in a laboratory-based setting.
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

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Position:
Bioinformatics Engineer/Sr Bioinformatics Engineer
Function:
Target Discovery
Location:
Remote
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

We are seeking a talented and highly motivated Bioinformatics Engineer to join our Discovery Bioinformatics group. The successful candidate will build informatics solutions using high-performance computing and cloud technology multidimensional clinical and preclinical -omics data. They will provide the engineering leadership to build creative solutions to challenging data problems.
Roles and Responsibilities for the Position
  • The successful candidate will have a flexible, learning mindset to design and work in a highly dynamic team, creating workflows to process and analyze high-dimensional data. This will include development of self-service analytics tools to enable and facilitate the real-time analysis of scientific data within our research community.
Required Qualifications and Preferred Background
  • Bachelor’s/Master’s/PhD in computer science, bioinformatics, or equivalent experience
  • 2+ years of software development experience, including experience in computer science, bioinformatics or other applied science
  • Documented track record delivering and deploying large-scale informatics production solutions in the cloud using AWS/Azure and Docker
  • Experience implementing bioinformatics pipelines using scalable cloud solutions. Familiarity with Nextflow is a plus.
  • A strong knack for creating visually appealing UX/UI, and ability to abide by clear design rules.
  • Understanding of NGS technology, and downstream -omics data analysis (RNAseq, ATACseq, ChIPseq, etc.).
  • Familiarity with designing, maintaining and implementing relational databases. Experience with NoSQL databases a plus
  • Proficiency in working within a Linux/Unix environment

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Scientist level position could range from between $78,000 to $114,498 and the Senior Scientist level position could range from between $89,750 to $131,672 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

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Position:
Computational Biologist (Multiple Locations)
Function:
Target Discovery
Location:
New York, NY
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

We are seeking a talented and highly motivated Computational Biologist to join our Discovery Bioinformatics group. The successful candidate will work closely with a multi-disciplinary team to rapidly advance small molecule drug development efforts. This position is expected to develop and validate data-driven hypotheses to advance transformative medicines.
Roles and Responsibilities of the Position:
  • The successful candidate will work in a face-paced and highly collaborative environment to tackle important questions in oncology drug development. They will employ the latest genomics and statistical approaches to interrogate these questions. Success critically depends on an ability to effectively present complex analyses and results in a clear and concise manner to a diverse audience of scientists.
Required Qualifications and Preferred Background:
  • MS/PhD in Bioinformatics, Biostatistics, Computational Biology, or similar area of study. Alternatively, post-graduate training in high-dimensional data analyses, supported by scientific achievements (eg., publications, patents, etc), would also be considered equivalent
  • Relevant experience must be supported by scientific accomplishments such as publications, scientific presentations, patents, etc.
  • Strong understanding of relevant concepts in cancer biology and molecular biology
  • Hands-on experience with data analysis involving high-throughput molecular assays such as DNA/RNA-Seq, ATAC/ChIP-Seq, single-cell technologies, etc.
  • Understanding of current best-practices for high-throughput genomics/molecular data analyses and their underlying statistical principles
  • Experience using programming languages such as R, Python, or similar for statistical analysis

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position could range from between $78,000 to $114,497 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Available Locations for this role:
  • South South Francisco, CA
  • New York City, NY
  • US Based- Remote

Physical Demands / Travel:

The physical demands of this job are consistent with light office duties.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in an office.  

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.



*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

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Position:
Consultant, Scientist, Molecular Characterization, Discovery Technologies
Function:
Large Molecule Biology & Discovery Technologies
Location:
New York, NY
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Consultant Scientist in the Molecular Characterization Group, within Discovery Technologies, will be joining a dynamic group focused on executing experiments on the cutting edge of pharmaceutical sciences. This scientist will work closely with Project Teams and Discovery Informatics under the guidance of the Platform Development Scientist in Molecular Characterization to expand applications of current next generation sequencing (NGS) related platforms, as well as to develop other novel molecular platforms and applications. The successful candidate is expected to have demonstrated expertise in a variety of molecular techniques profiling DNA, RNA, and proteins. The Contract Scientist will also help design studies, execute analyses, and interpret data to support the various research programs for identified targets. The scientist will utilize innovative, high throughput, high content molecular platforms to answer genomic, transcriptomic, and proteomic questions posed by project teams across the Loxo portfolio. The Contract Scientist will also be responsible for inspecting, calibrating, cleaning the instruments within the facility at Loxo. Finally, this role will be responsible for operationalizing new techniques in collaboration with the Molecular Characterization Team.  In this role, the incumbent will also be encouraged to develop their own ideas and contribute these to the broader group. They are expected to be a dynamic and motivated scientist who can drive their own experiments and research activities, while collaborating extensively with the entire organization to execute on various research programs.
Roles and Responsibilities of the Position:
  • Interact and collaborate with various Discovery functional teams to design and execute studies supporting all projects across the oncology portfolio
  • Work collaboratively with the clinical biomarker team to perform and support retrospective and exploratory efforts for clinical programs
  • Provide quality data and analyses from a variety of high throughput, high content genomic, transcriptomic, and proteomic platforms
  • Develop and implement sequencing applications related to cell free, single cell and FFPE sequencing
  • Support existing and novel targeted panel development for NGS
  • Responsible for establishing and updating lab SOPs and training lab scientists as needed
  • Develop and implement novel molecular platforms and applications
  • Work with the entire molecular characterization team to ensure all instrumentation is properly maintained and calibrated
  • Provide scientific expertise on practical implementation of molecular platforms and applications across the entire Loxo organization
  • Proper documentation and archiving of data and analyses.
  • Work interactively with project teams and discovery informatics to interpret data and prepare formal study reports

    • Additional roles and responsibilities:
  • Communicate results via written and oral presentations as needed
  • Discuss results with technical as well as non-technical personnel
  • Extensive cross functional communication and collaboration with internal and external parties
  • Interrogate experimental conduct of third parties/vendors
Required Qualifications and Preferred Background:
  • BS in biological sciences with 5 years of experience or MSc or PhD in biological sciences with 2-3 years of experience
  • Broad experience with multiple nucleic acid and protein expression platforms, including assay design and development
  • Experienced with high content, high throughput laboratory workflows with emphasis on quality and efficiency
  • Demonstrated experience in working collaboratively across various scientific disciplines to meet project goals and timelines
  • Flexibility to adjust priorities over time to meet organizational and scientific goals.
  • Ability to work independently and as an integral part of a larger collaborative team.
  • Demonstrated ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines
  • Excellent interpersonal, written, and verbal communication skills
  • Experience processing, analyzing, and interpreting large biological data sets
Physical Demands/ Travel: TBD <5%
The physical demands of this job are consistent with working in a lab.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
Work Environment:
This position’s work environment is in a lab. 
 

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

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Position:
Contracts Consultant, CMC
Function:
Business Operations
Location:
Remote
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Contracts Consultant, CMC is responsible for negotiating complex contracts to support CMC and Clinical Supply needs, including contracting with CMOs, packaging, labelling, logistics, supply chain and other vendors who support drug product development and manufacturing.  
*Roles and Responsibilities of the Position:
  • Work cross-functionally with CMC, legal, finance, and other teams  to help draft, negotiate and manage contracts to support the overall product development process
  • Identify and mitigate business risks throughout the contracting process
Required Qualifications and Background:
  • Bachelor’s degree required, science degree a plus
  • 3+ years of business development/contract negotiation experience, preferably supporting CMC/Clinical Supply
  • Strong contract drafting, review and analysis skills
  • Ability to communicate efficiently and effectively
  • Ability to manage and meet strict deadlines, work independently, and multi-task
  • Excellent attention to detail
  • MS Office skills (Outlook, Word, Excel, PowerPoint)
Physical Demands/ Travel:
 The physical demands of this job are consistent with light office duties.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in an office.
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
 
 

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

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Position:
Director, Discovery Bioinformatics
Function:
Target Discovery
Location:
South San Francisco, CA
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

We are seeking a talented and experienced scientist to join our growing Discovery Bioinformatics team, operating in an interdisciplinary and tightly integrated research community at Loxo@Lilly. The successful candidate will be responsible for developing a vision with Oncology Leadership and oversee the strategy to guide computational biology efforts for target discovery in support of oncology drug development and translational research. This leadership position leads a team of diverse and talented computational scientists contributing to projects across multiple departments in Discovery, Research, and Clinical Development.
Roles and Responsibilities for the Position:
  • The successful candidate will join a dynamic team and oversee computational biology efforts at the intersection of discovery, translational, and clinical research.
  • They will lead a team, develop scientists, and help build a research strategy that leverages deep cancer biology knowledge and high-dimensional data.
  • Success critically depends on the ability to foster a team to execute and communicate the broader computational biology vision and strategy.
Required Qualifications and Preferred Background:
  • PhD in Bioinformatics, Biostatistics, Computational Biology, or similar area of study required with a minimum of 8 years of experience in computational biology, bioinformatics, and/or cancer biology
  • Demonstrated track record of strategic scientific leadership leveraging computational biology to drive discovery in the clinical and pre-clinical settings
  • Strong understanding of relevant concepts in cancer biology, drug development, and current therapeutic landscape in oncology
  • Knowledge of current best-practices for high-throughput genomics/molecular data analyses and familiarity of their underlying statistical principles
  • Excellent communication and interpersonal skills 

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position level could range from between $135,300 to $198,516 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Additional Locations for the Position:
  • South San Francisco, CA
  • Alexandria Center, NY


*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

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Position:
Director, Discovery Biology, Target Discovery (multiple locations)
Function:
Target Discovery
Location:
South San Francisco, CA
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Discovery Biology team will be part of a multi-disciplinary effort focused on bringing forward innovative cancer drug therapies. The Associate Director/Director will be responsible for leading a research team to identify the next generation of molecular targets for cancer therapeutics. Experience in systems biology, molecular and cell biology, and/or chemical biology is required. The Director will lead the discovery and early validation of oncology targets through close collaborations with other discovery and translational functions.
 
Roles and Responsibilities of the Position:
  • Lead cross-functional teams that will be responsible for novel small and large molecule target discovery , and Validation including Discovery Biology team members in SSF and NYC
  • Supervise and mentor PhD and non-PhD scientists engaged in target identification and validation to think deeply and work creatively while delivering excellent scientific results and insights to the project teams and their colleagues
  • Develop and implement strategies that will enable Discovery Biology team members to continually advance internal drug development efforts through our discovery, clinical and research programs
  • Innovate technologies and methods to advance our discovery projects
  • Engage leaders across Loxo@Lilly to identify, credential, and advance new targets and serve as a liaison for the Discovery Biology team and the company at large
  • Provide strategic input, in partnership with Discovery leadership, into computational and experimental validation for key new targets
  • Contribute to due diligence evaluation of external opportunities, participate in KOL engagement around target programs, and help identify academic and industry partnerships and collaboration
Required Qualifications and Preferred Background:
  • PhD in systems biology, molecular & cellular biology, chemical biology, or related field
  • Minimum of 8-10 years research experience following post-doctoral training with prior experience in target discovery/credentialing and cancer biology in the biotech or pharma setting
  • Extensive experience in areas of cancer biology and cancer genomics
  • Demonstrated evidence for the ability to partner with computational biologists to leverage systems-scale datasets
  • Expertise in designing and commissioning studies using a variety of research tools in cancer cell lines and murine models of cancer
  • Experience in leading PhD level scientists
  • Outstanding communication, writing, and presentation skills is a must
  • Highly organized with excellent analytical, documentation and multi-tasking skills
  • Provide strategic input to target identification and validation strategy to leadership team
  • Ability to collaborate, lead, and influence others


Additional Preferred Qualifications:
  • Experience with cell engineering, and ex vivo and in vivo models of cancer
  • Experience with incorporating massively parallel genetic screening data in target identification and credentialing workflow (ie CRISPR screens)
  • Experience with early clinical trial studies and the development and implementation of pharmacodynamic and patient selection biomarker assays
  • Experience working with external CROs to optimize internal/external resources

  • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position level could range from between $135,300 to $198,516 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.


Additional Locations for this position:
  • This position can be located in South San Francisco OR New York City
Physical Demands/ Travel:
The physical demands of this job are consistent with light office duties and some laboratory work. Some light lifting, and maneuvering may be required.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:
This position’s work environment is in an office and laboratory environment.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.



*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

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Position:
Drug Safety Physician
Function:
Drug Safety Operations
Location:
Remote
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Drug Safety Physician will lead and support the expansion of clinical development programs (or one large, complex program) in support of the overall product development plan with a focus on development of the safety profile. This physician will serve as an ambassador and resource to various physicians and clinical trial sites, based on strong medical and scientific principles, knowledge of compliance and regulatory requirements, Loxo Oncology at Lilly customers, markets, business operations, and emerging issues, and perform other responsibilities as requested.
Roles and Responsibilities for the Position
  • Primary responsibility for daily safety case review and will contribute to the design, analysis, interpretation, and reporting of safety findings within a program and will review and contribute to the content of protocols, Investigator Brochures, Clinical Study reports, regulatory submissions and responses, and other program documents.
  • Primary responsibility for reviewing safety data periodically and on an ongoing basis (inclusive of planning and conducting all safety surveillance governance meetings [e.g. LOSOC] for the assigned program) to ensure quality control (QC) as required by program needs
  • May participate in or lead review of protocol deviations (PD) which may impact patient safety as required by program needs
  • May participate in, or lead safety development contributions to, due diligence or other business development activity. As required by program needs, contributes in partnership with research colleagues to design and implement translational strategies.
  • Actively solicits opinion leader interactions related to the disease area(s); partners with Clinical leads, Commercial and other functions in these activities as required, consistent with corporate policies, to ensure that broad cross-functional perspectives are incorporated into Safety Development Plans and protocols as appropriate.
  • Stays abreast of professional information and technology through conferences, medical literature, and other available training, to augment expertise in the therapeutic and safety area. May represent Loxo at key external meetings.
  • Responsible for understanding the regulatory requirements related to the clinical studies and global drug development and accountable for complying with those requirements.
  • May serve as a safety representative for key regulatory discussions.
  • Ensures adherence to Good Clinical Practices, pharmacovigilance standards, standard operating procedures, organization policies and to all other quality standards in conducting research. 
Required Qualifications and Preferred Background
  • MD, Board certified or eligible; PhD advantageous.
  • At least 2 years of oncology experience strongly preferred.
  • Ability to exercise judgment and address complex problems and create solutions for one or more projects.
  • Ability to develop collaborative working relationships with physicians, expert consultants, and contracted vendors.
  • Strong analytical mind and problem-solving skills, attention to detail, strong organizational skills, and ability to work independently and as part of a team.
  • Proven leadership skills and ability to bring out the best in others on a cross-functional global team. Must be able to lead through influence.
  • Proven ability to interact externally and internally to support a global scientific and business strategy.
  • Excellent English written and verbal communication skills. Strong document management skills, including proficiency with MS Word, EndNote, PowerPoint and Excel.
  • Demonstrated ability to work well with other accomplished professionals within and across functions/teams. Willing collaborator.
  • Strong communication skills both written and oral.
  • Ability to multi-task and shift priorities rapidly to meet tight deadlines.
  • Professional demeanor and appearance and an excellent written and verbal communicator.
  • Good and thoughtful listener.
  • Enthusiastic, self-motivated and keen to improve processes and overcome inefficiencies. 
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

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Position:
Manager – QA Audits (GLP/GCP)
Function:
Quality Assurance
Location:
Remote
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

Loxo@Lilly is seeking a highly motivated QA Audit Manager who is an excellent influencer and enjoys a fast paced, dynamic work environment. The ideal candidate has demonstrated strong knowledge in GXPs (specifically in GLP, GCP and clinical labs) for small and large molecule pharmaceuticals.  The candidate will be responsible for working the third party risk management team as well as managing assigned audits (scheduling, conducting, following up and closing).

Roles and Responsibilities of the Position:
  • Conducts Audits for which Loxo@Lilly is responsible (e.g.qualification and internal)
  • Key activities include, but are not limited to: 
  • Plan, execute, and monitor Loxo@Lilly qualification audits
  • Plan and execute internal audits
  • Support development of an audit schedule
  • Support audits conducted of Loxo@Lilly by outside auditors
  • Partner with Loxo@Lilly functional areas to support Health Authority audits
  • Provide input in Quality Management review, which includes metric generation and data analysis.
  • Support process improvement projects
  • Perform other duties as assigned 
Required Qualifications and Preferred Background:
  • Bachelor's Degree plus 8-10 years plus years relevant experience in the Biotech/Pharmaceutical industry
  • Working knowledge of Microsoft 365 suite, Veeva, etc.
  • Comprehensive working knowledge of GCPs, GLPs, GMPs, or CAP and CLIA requirements
  • Strong working knowledge of global regulations and guidelines (e.g., FDA/EU and ICH) for early phase pharmaceutical development in both clinical trials execution, clinical/biomarker laboratories and nonclinical/preclinical work      
  • Ability to adapt quickly to shifting needs and/or priorities
  • Strong Project Management skills in order to manage projects at various stages and effectively multi-task
  • Able to interface well with all levels of personnel
  • Capacity to produce high quality results across multiple projects and demands, through effective prioritization, while working under short deadlines associated with a fast-paced dynamic scientific environment
  • Excellent communications skills, both written and verbal
  • Excellent teamwork, interpersonal skills and negotiation skills, both internally and externally
  • Strategic thinker, open-minded and flexible to adopting new ideas
  • Motivated, committed and self-managed
  • Willingness to work in a dynamic and changing corporate environment
  • Requires a flexible work schedule to accommodate program priorities and international activities as needed.
  • Exceptional attention to detail

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the {insert position} level position could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.
Physical Demands:
No physical demands.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
Work Environment:
Ability to travel to travel 50%
No specific work demands.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
 

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

Apply Now

Position:
Manager, Quality Assurance - GCP
Function:
Quality Assurance
Location:
Remote
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Manager, Quality Assurance is responsible for all aspects of Quality Assurance and GCP compliance. The Manager, Quality Assurance will establish and execute quality plans, policies and quality system elements related to GCP activities. This position will support the design, implementation and maintenance of QA and compliance programs including, but not limited to an SOP system, CAPAs, and work closely with the Clinical Operations team. The Manager, Quality Assurance will establish, maintain, and ensure effectiveness of quality programs and documentation to assure compliance in a GCP international regulatory environment and provide GCP guidance in Quality related areas. 
Roles and Responsibilities of the Position:
  • Liaise across departments to proactively identify opportunities to streamline and strengthen GCP processes
  • Serves as GCP SME in writing and revising SOPs
  • Reviews and approves Quality Events and associated Corrective and Preventative Actions within a regulated Quality Management System
  • Represents GCP expertise and acts as the QA point person on cross-functional clinical study teams
  • Keeps current with global health authority laws and regulations; identifies gaps and implements process improvements resulting from new/revised regulations or guidance
  • Reviews study team and regulatory documentation as requested (e.g., Data Management, Operations, Safety, Regulatory, etc.)
  • Liaises audit requirements between clinical study teams and auditing group and follows up on audits with the auditee
  • Utilizes the Loxo Quality Systems to manage Quality system elements
  • Drives inspection readiness activities for project teams
  • Supports external Health Authority inspections
Required Qualifications and Preferred Background:
  • Bachelor’s degree with 5- 7 years’ experience working in either a clinical compliance or clinical quality group
  • Must be a hands-on leader who can provide guidance and execute daily tasks
  • Demonstrated Quality Management System experience (GCP specific QMS experience preferred)
  • Demonstrated Issue Management and CAPA experience in a clinical environment
  • Strong knowledge of global clinical trial regulations and guidelines
  • Proficient in risk management principles
  • Experience with FDA or other Regulatory Inspections of Investigator sites, Sponsors or CROs
  • Self-motivated with the ability to work effectively in a dynamic environment with initiative and great organization skills
  • Strong leadership with demonstrated ability to interface with senior leaders and different levels of the organization
  • Ability to deal with ambiguity, creative and pragmatic approach to problem solving
  • Ability to be adaptable and effectively manage multiple priorities with a sense of urgency
  • Strong track record of project management, stakeholder management, collaboration skills and negotiation of complex situations
  • Attention to detail and accuracy of work
  • Demonstrated ability to work well with other accomplished professionals within and across functions/teams. Willing collaborator.
  • Excellent interpersonal and communication skills (both written and oral)
  • Works with a sense of urgency and has the ability to multi-task and shift priorities rapidly to meet tight deadlines
  • Professional demeanor and appearance and a team player
  • Detail oriented with analytical and problem-solving skills and well organized
  • Good and thoughtful listener
  • Critical thinker and solution oriented
  • Enthusiastic, self-motivated and self-starter

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Manager position level could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands/ Travel:
 
The physical demands of this job are consistent with light office duties.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in an office.  
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.




*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

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Position:
Manager/Senior Manager, Data Management (Multiple Locations)
Function:
Clinical Data Management
Location:
Remote
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Manager/Senior Manager, Data Management is responsible for leading and overseeing data management tasks from study start-up through database lock for clinical trials.  This individual works collaboratively across multiple cross functional groups including Clinical Trial Managers (CTM’s), Biostatistics and Clinical Data Management vendors to ensure database development, data review/cleaning, database auditing, database lock, and receipt of final database deliverables are in compliance with standard operating procedures and regulatory agency guidelines. The Lead Clinical Data Manager ensures all Clinical Operations activities stay within full compliance of Loxo standard operating procedures (SOP) and regulatory agency guidelines.
Roles and Responsibilities of the Position:
  • Represents Clinical Data Management at study team meetings with responsibility for operational execution of CDM activities.
  • Executes and manages data management timelines to coordinate and synchronize deliverables with the overall study timelines.
  • Generates and/or reviews/approves study documents (e.g. Data Management Plans, Case Report Forms, data transfer specifications, SAE and/or external data reconciliation plans, coding conventions, study protocols, UAT execution).
  • Executes and/or distributes data management metrics, listings, and reports, as required.
  • Escalate resource need to PL to meet the current study needs.
  • Effectively apply knowledge of applicable internal, external and regulatory requirements/expectations (MHRA, FDA, ICH, GCP, PhRMA, Privacy, etc) to data collection and DM plans.
  • Collaborate and oversee CRO/service providers on assigned studies.
  • Executes/manages all data management activities on assigned studies to ensure project timelines are met.
  • Continually seek means of improving processes to reduce cycle time and decrease work effort.
  • Provides training on the CRF completion guidelines and EDC system at Investigator meetings and to internal or external team members, as needed.
  • Proactively identifies potential study issues/risks and recommends/ implements solutions.
  • Responsible for the accuracy and completeness of the clinical data collected during a clinical trial for all data deliverables.
  • Provide DM support to Statisticians and Statistical Programmers in production of clinical trial reports and other deliverables.
  • Work with partners to increase vendor/partner efficiencies.
  • Performs any and all other tasks and activities as requested.
Required Qualifications and Preferred Background:
  • Bachelor’s degree in life sciences, math, computer science or related field required.
  • Minimum of 6+ years’ clinical data management experience.
  • A minimum of 1+ years of direct sponsor experience required.
  • Demonstrated leadership and project management skills.
  • Thorough and broad knowledge of data management processes, including EDC and interactive voice response system (IVRS)experience.
  • Demonstrated proficiency in MS Office (Outlook, MS Word, Excel, PowerPoint).
  • Experience with web-based Electronic Data Capture (EDC), clinical data management systems and industry wide thesauri, such as MedDRA and WHO Drug.
  • Good working knowledge of regulatory guidelines such as GCP, 21 CFR Part 11 etc.
  • Knowledge of industry standards (CDISC, SDTM, ADaM, CDASH).
  • Excellent verbal, written and interpersonal skills required for working successfully in a cross-functional team environment.
  • Able to communicate and collaborate effectively with cross-functional teams in face-to-face conversation, by telephone and by email.
  • Proven ability to work independently as well as in a team environment.
  • Excellent time management skills and a proven ability to work on multiple projects at any given time in a fast-paced environment.
  • Demonstrated ability to stay abreast of trends and new information in the profession.
  • Excellent verbal/written and interpersonal skills required for working successfully in a cross-functional team environment.
  • Able to communicate and collaborate effectively with cross-functional teams in face-to-face conversation, by telephone, and by email.

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Manager position level could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.
Additional Preferred Qualifications:
  • 5+ years prior oncology/hematology experience highly desirable.
  • Recent Phase 3 registration study and submission experience preferred.
Available locations for this role:
  • Stamford, CT
  • South San Francisco, CA
  • US Based-Remote


Physical Demands / Travel

The physical demands of this job are consistent with light office duties. This position will travel occasionally; the average travel for this position is 15-20% with some variation based upon the demands of the business imperatives.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in a home-based office setting.  

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

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Position:
Manager/Senior Manager, Statistical Programming
Function:
Biostatistics
Location:
Remote
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Manager/Senior Manager, Statistical Programming is responsible for performing statistical programming activities in support of one or more clinical stage programs and/or studies.  Manager/Senior Manager, Statistical Programming will create analysis datasets, and tables, figures, and listings to produce planned and adhoc analyses or validate outputs generated by a CRO/statistical programming vendor. Statistical Programming will be implemented using SAS: Base SAS, SAS Macros, SAS/STAT, SAS/Graph, SAS/SQL and SAS/ODS.
Roles and Responsibilities of the Position:
  • Perform data analysis using primarily the SAS programming language for the summary and interpretation of clinical trial data
  • Perform data analysis, statistical analysis, generate safety and efficacy tables, listings and graphs using Base SAS, SAS Macros, SAS/STAT, SAS/Graph, SAS/SQL and SAS/ODS
  • Create and review CDISC SDTM and ADaM files, SAS export files and Define.xml use for Electronic Submission from the data received in non-standard form from various sources
  • Contribute to the development and review of CRFs, Data Management Plan, Data Validation Plan and edit check specifications
  • Implement and contribute to statistical analysis plans; provide additional expertise in the analysis of clinical trial as it relates to protocol development, case report form design and data collection
  • Work with Statisticians and development team members to specify and perform ad hoc and prespecified analyses  
  • Establish monitoring of data transfers for ongoing trials to identify study conduct or data quality issues
    •  
Required Qualifications and Preferred Background:
  • Bachelors or Masters degree in Statistics, Life Sciences, Computer Sciences, Mathematics, or related field with a minimum of 5-7 years Pharmaceutical/Biotech programming experience is required
  • Experience with NDA submissions, integrated summaries (ISE/ISS) and Clinical Study Reports statistical deliverables is preferred.
  • Expert proficiency SAS Programming language is required
  • Experience in the analysis of complex oncology clinical trial data is preferred
  • Experience in managing multiple projects
  • Proven ability to work both independently and in a team setting
  • Strong well-rounded technical skills (EDC systems, MS Word, Excel, PowerPoint)
  • Ability to work effectively in a fast-paced environment with a positive “can-do” proactive attitude

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Manager level position could range from between $103,200 to $151,423 and that the base salary for the Senior Manager level positions could range between $118,700 to $174,137 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.


Physical Demands / Travel:
 
This position will travel occasionally based upon the demands of the business imperatives.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 Work Environment
 
This position’s work environment is based in a typical office setting.
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

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Position:
Office Support (Contractor)
Function:
Administrative/Support
Location:
Louisville, CO
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

We are seeking an energetic, outgoing Receptionist/Office Support professional to provide support for our Discovery Lab in Louisville, CO. This candidate will serve as a key point of contact in the Louisville office, assisting with employee inquiries, ordering and organizing supplies, planning team lunches, preparing conference rooms, stocking kitchens and working on special projects as needed. Independent judgment is required to plan, prioritize and organize diversified workload and recommend changes in office practices or procedures.
 
This position will have the opportunity to work in an innovative and growing Office/Discovery Lab environment and will interact with a highly motivated and skilled team. The successful candidate will have the opportunity to learn about our precision medicine approach in the Oncology space and will take an important and proactive role in providing high quality support to employees.
Roles and Responsibilities of the Position:
  • Maintain front desk area ensuring it is neat, organized and welcoming.
  • Welcome outside visitors and escort vendors. Greet new employees and escort to workstation. Inform manager they have arrived. 
  • Provide backup administrative support when needed including typing, filing, calendar management, booking travel, reconciling expenses, meeting coordination and other administrative tasks.
  • Order kitchen and office supplies Stock and maintain 3 kitchens and shared office areas upon arrival and midafternoon. This will require lifting and moving of boxes on a regular basis.
  • Stock and maintain copy rooms upon arrival and midafternoon. Set up new employee stations. 
  • Restock towels in fitness center. 
  • Prepare conference rooms for meetings and lunches, including set up and clean up
  • Coordinate team breakfast/lunches/treats and facilitate weekly GrubHub lunch orders
  • Act as a point of contact for the team, field questions and inquiries, and proactively problem solve as needed.
  • Assist with special projects as needed. 

Required Qualifications and Preferred Background:
  • 3+ years previous Administrative/Reception/Support experience required.
  • Bachelors or Associates degree preferred but not required.
  • Proficient in Microsoft Office suite and applications. 
  • Ability to multi-task and shift priorities rapidly
  • Enthusiastic, friendly, self-motivated and can-do attitude.
  • Demonstrated ability to work well with other accomplished professionals within and across functions/teams. Willing collaborator. 
  • Ability to lift up to 10-15lbs and utilize hand cart is required.
  • Professional, calm demeanor with excellent written and verbal communication. 
  • Detail oriented and well organized. 
  • This role requires an on-site presence between the hours of 8:30AM-5:00PM, Monday through Friday, with occasional additional hours if needed.

PhysicalDemands/ Travel:
 
The physical demands of this job are consistent with office duties. The ability to lift 10-15 lbs is required.
 
The physicaldemandsherearerepresentativeofthosethatmustbemetby anemployeeto successfullyperformtheessential functionsofthis job.
 
WorkEnvironment:
 
This position’s work environment is in an office/laboratory setting.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

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Position:
Office/Facilities Assistant (Contractor)
Function:
Administrative/Support
Location:
San Diego, CA
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Office/Facilities Assistant contractor will provide support to the Associate Manager of Facilities, including overseeing and coordinating all site-related activities for Loxo@Lilly personnel in their designated site. The right candidate will be a positive, proactive individual who enjoys working with and supporting our internal team as well as guests and external vendors visiting our San Diego office.  We seek a detail-oriented professional excited to contribute to our mission, learn and grow within the role. 
Roles and Responsibilities of the Position:
  • Point of contact for Loxo@Lilly employees and external visitors. 
  • Ensuring visitors are added to security log and escorted to conference room or designated area. 
  • Primary contact for food delivery & catering needs, including set up and clean up.
  • Order all office supplies, beverages, and snacks.
  • Stock conference rooms and kitchen areas.
  • Reserve conference rooms for all onsite meetings including scheduling AV equipment set up, ordering catering, stocking supplies, and clean up.
  • Assisting researchers with ordering lab supplies in Coupa.
  • Put in work tickets/requests.
  • Back up point of contact when Associate Manager is out of the office.
  • Assist with new hire onboarding, including setting up workstations and supplies.
  • Manage Grub hub account and point of contact for daily deliveries. 
  • Work with Office Manager for Global Day of Service and special events. 
  • Assisting Associate Manager with special projects as needed.
  • Act as Fire Marshall for Facility. 

Required Qualifications and Preferred Background:
  • 2+years of experience in a Office/Facilities role. Background in pharma/biotech in a laboratory setting a plus.
  • Proficient in Microsoft Office suite and applications. Experience with Coupa a plus.
  • Detail orientated, excellent verbal, written and organizational skills. 
  • Assists team members when needed to accomplish company goals.
  • Able to multitask, prioritize, and manage time efficiently.
  • Strict adherence to company philosophy/goals. Enthusiastic, friendly, self-motivated and can-do attitude.
  • Demonstrated ability to work well with other accomplished professionals within and across functions/teams. Willing collaborator. 
  • Ability to lift up to 10-15lbs and utilize hand cart is required.
  • This role requires an on-site presence between the hours of 8:30AM-5:00PM, Monday through Friday, with occasional additional hours if needed.

Physical Demands/ Travel:

The physical demands of this job are consistent with office duties. The ability to lift 10-15 lbs is required.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in an office/laboratory setting.


*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

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Position:
Principal Scientist, Biophysical Chemistry
Function:
Large Molecule Discovery
Location:
South San Francisco, CA
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Principal Scientist, Biophysical Chemistry, Large Molecule Discovery of Loxo@Lilly will play a critical role in characterization of antibody hits, stability/developability assessments and lead optimization.
 
The role will be responsible for screening and characterization of antibodies and antibody-drug conjugate candidate molecules generated by discovery and bioconjugation, and subject candidate molecules to developability assessment and optimization, using various biophysical platforms.  This individual contributor within the Biophysical Chemistry group will require a clear understanding of the strategies laid out by the Loxo Large Molecule Discovery team.
Roles and Responsibilities of the Position:
  • Participate in building a team with scientists and associates (at various levels) to be part of the larger Protein Engineering Group of the Large Molecule Discovery team at Loxo@Lilly
  • Work with other Protein Engineering team members to screen, characterize and investigate, using analytical and biophysical platforms and methodologies, large biologicals comprised of antibodies, antibody conjugates, multi specifics and other modalities, created for treatment of several oncological indications
  • Hands-on role to design, independently execute key experiments for biophysical characterization of these large molecules from early discovery to early development stage that includes accelerated stability and developability assessments
  • Experience in lead optimization would a plus
  • Interact and collaborate with other teams across the company to provide biophysical solutions; analyze, collate, and disseminate data to teams in a timely manner
  • Participate and present periodic updates and reports to senior management to significantly influence strategic research decisions and operations
  • Liaise with CROs and vendors for contract work and evaluations
  • Participate in long-term strategies for creation of innovative solutions and intellectual property for securing FTO for Loxo
Required Qualifications and Preferred Background:
  • Ph.D. in life or analytical sciences or equivalent fields with at least 5 years of relevant job experience in the biopharma industry with good understanding of drug development process of therapeutic antibodies, antibody conjugates, bi and multi-specific molecules and other modalities
  • Extensive demonstrated expertise in characterization of biomolecular interactions using various industry standard SPR, BLI, and other relevant platforms for characterization of high/low affinities, concentrations, cross-blocking, activity, binding models, heterogeneities, and other product defining characteristics
  • Experience in laboratory automation for liquid handling and screening
  • Experience with spectroscopic techniques for characterization of biomolecules (e.g. UV/Fluorescence)
  • Knowledge of biophysical techniques and platforms for characterization of physical, chemical, and conformational stabilities of biologics. Experience with cIEF, CE-SDS, or DSF or SEC-MALS would be a plus
  • Knowledge of antibody design and engineering approaches (e.g. modeling, cloning & expression) for optimization of CMC properties will be a plus
  • Hands-on experience with vendor provided software for biosensor data analysis and visualization. Experience with additional software tools such as GraphpadPrism, R, Matlab, Spotfire etc would be a plus
  • Prior experience participating in team efforts for antibody lead panel generation, lead optimization and IND enabling studies
  • Supervision of a team by providing clear direction, setting expectations, and mentoring young scientists
  • Must have a can-do attitude to take on challenging projects and innovative ideas to accomplish in a collaborative matrixed organization
  • Excellent communication skills and with strong organizational abilities

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Principal Scientist level position could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.
Physical Demands/ Travel:
 
Travel: TBD
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
Work Environment:
 
This position’s work environment is in a lab setting
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

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Position:
Principal Scientist, Cell Line Generation
Function:
Biology Operations
Location:
Louisville, CO
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

We are looking for a highly capable and motivated laboratory-based scientist with strong experience in cell line generation and characterization. The Principal Scientist will play a key role in helping to establish and build out cell line generation/cell biology team that will be tasked with generating engineered cell lines for our preclinical programs in oncology. The primary responsibilities will include engineering cell lines for use in in vitro mechanistic assays and studies. Working in a collaborative environment, this individual, in addition to independently designing, executing, and optimizing experiments, will also provide supervision and mentorship to more junior team members. Additionally, the Principal Scientist will be tasked with analyzing data from experiments and presenting data to various cross functional team members and leadership as needed. 
Roles and Responsibilities of the Position:
  • Construct knockout and expression vectors using mammalian plasmid and lentiviral, adenoviral, or retroviral systems. Viral titer measurement, and viral stock maintenance.
  • Generate engineered stable cell lines using transfection, CRISPR/Cas9 tools, lentiviral transduction, etc.
  • Optimize cell line development platforms to improve speed and reproducibility of cell line development
  • Perform routine molecular and cell biology techniques like DNA/RNA/protein extraction, qPCR analysis, western blot analysis, fluorescent microscopy and so on.
  • Maintain cultures of frequently used suspension and adherent cell lines.
  • Deposit and archive cell lines in the company’s repository cell line bank.
  • Keep detailed and accurate laboratory records, present results at group meetings and project team meetings
Required Qualifications and Preferred Background:
  • BA/BS with 8 years’ experience/MS with 6 years’ experience/PhD with 3+ years’ experience in biology, cell biology, molecular biology or a related field
  • Recent experience working with mammalian cell culture
  • 1+ year of supervisory experience
  • Tissue culture techniques such as cell propagation, cryo- preservation, and maintenance
  • Proven cell culture experience with immortalized cell lines, cancer cell lines and/or primary cells
  • Experience creating stable cell lines, transient transfections, viral transductions
  • Experience with performing qPCR, ELISA, western blot, flow cytometry, and cell sorting, all in the context of mammalian cells. Fluorescent microscopy experience would be a plus.
  • Experience in RNAi, CRISPR, and chemical inhibition of cellular pathways
  • Prior experience with various analytical reagents such as Calcein AM, Cell Titer Glo, Alamar Blue, Annexin, PI/7AAD, and immunofluorescent antibodies
  • A high level of proficiency with many kinds of scientific software used to operate lab equipment and/or the ability to quickly master new software
  • Experience and proficiency with data analysis using statistical software such as Excel, Prism, Spotfire or others
  • Must be organized and efficient and able to work according to timelines.
  • Pharma/biotech drug discovery experience a plus    

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Principal Scientist level position could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.
Physical Demands/ Travel:
 
The physical demands of this job are consistent with laboratory bench setting and light office duties.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in a laboratory-based setting.
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
 

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

Apply Now

Position:
Principal Scientist, Cell Line Generation
Function:
Large Molecule Biology & Discovery Technologies
Location:
New York, NY
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

We are looking for a highly capable and motivated laboratory-based scientist with strong experience in cell line generation and characterization. The Principal Scientist will play a key role in helping to establish and build out cell line generation/cell biology team that will be tasked with generating engineered cell lines for our preclinical programs in oncology. The primary responsibilities will include engineering cell lines for use in in vitro mechanistic assays and studies. Working in a collaborative environment, this individual, in addition to independently designing, executing, and optimizing experiments, will also provide supervision and mentorship to more junior team members. Additionally, the Principal Scientist will be tasked with analyzing data from experiments and presenting data to various cross functional team members and leadership as needed. 
Roles and Responsibilities of the Position:
  • Construct knockout and expression vectors using mammalian plasmid and lentiviral, adenoviral, or retroviral systems. Viral titer measurement, and viral stock maintenance.
  • Generate engineered stable cell lines using transfection, CRISPR/Cas9 tools, lentiviral transduction, etc.
  • Optimize cell line development platforms to improve speed and reproducibility of cell line development.
  • Perform routine molecular and cell biology techniques like DNA/RNA/protein extraction, qPCR analysis, western blot analysis, fluorescent microscopy and so on.
  • Maintain cultures of frequently used suspension and adherent cell lines.
  • Deposit and archive cell lines in the company’s repository cell line bank.
  • Keep detailed and accurate laboratory records, present results at group meetings and project team meetings.
Required Qualifications and Preferred Background:
  • BA/BS with 8 years’ experience/MS with 6 years’ experience/PhD with 3+ years’ experience in biology, cell biology, molecular biology or a related field.
  • 8+ recent experience working with mammalian cell culture.
  • 1+ year of supervisory experience.
  • Tissue culture techniques such as cell propagation, cryo- preservation, and maintenance.
  • Proven cell culture experience with immortalized cell lines, cancer cell lines and/or primary cells.
  • Experience creating stable cell lines, transient transfections, viral transductions.
  • Experience with performing qPCR, ELISA, western blot, flow cytometry, and cell sorting, all in the context of mammalian cells. Fluorescent microscopy experience would be a plus.
  • Experience in RNAi, CRISPR, and chemical inhibition of cellular pathways.
  • Prior experience with various analytical reagents such as Calcein AM, Cell Titer Glo, Alamar Blue, Annexin, PI/7AAD, and immunofluorescent antibodies.
  • A high level of proficiency with many kinds of scientific software used to operate lab equipment and/or the ability to quickly master new software.
  • Experience and proficiency with data analysis using statistical software such as Excel, Prism, Spotfire or others.
  • Must be organized and efficient and able to work according to timelines.
  • Pharma/biotech drug discovery experience a plus. 

  • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Principal Scientist level position could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.
    •   
Physical Demands/ Travel:
 
The physical demands of this job are consistent with laboratory bench setting and light office duties.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in a laboratory-based setting.
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
 

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

Apply Now

Position:
Principal Scientist, Clinical Biomarker Development
Function:
Clinical Biomarkers & Diagnostics Development
Location:
Remote
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Principal Scientist, Clinical Biomarker Development will integrate biomarker research and clinical development, and will be accountable for the design, delivery, and execution of biomarker and diagnostics plans in early phase clinical programs. Programs include early proof of concept through registrational studies in a variety of targets. The role involves cross functional collaborations across Biomarker Operations, Clinical Development and Translational Medicine as well as Diagnostic Medical Affairs. Responsibilities encompass strategic planning to optimize the clinical and registrational utility of Biomarker development plans for assigned projects as well as management and career development of biomarker scientists. This person must thrive in a fast-paced, team-oriented environment and be adaptable to rapidly changing priorities. 
Roles and Responsibilities of the Position:
  • Oversee the integration of biomarker and diagnostic development plans in clinical development with the current oncology treatment landscape, registrational and launch needs for the asset and with external competitors
  • Ensure individual biomarker scientist plans are developed and implemented optimally according to the strategic needs of the assets and are aligned to company positions and guidelines
  • Create and foster strong strategic partnerships with colleagues that include Biomarker Operations, pre-Clinical Development, Clinical Operations/Development, Dx Regulatory Affairs and Dx Medical Affairs 
  • Apply Biomarker Development strategy to the design and interpretation of clinical trials
  • Provide strategic input into data analysis, and engage in critical thinking, to deliver key data generation and interpretation essential for decision making as well as public scientific disclosure
  • Lead integration with functional teams such as discovery, translational medicine, data science, clinical science etc. to ensure timely analysis, interpretation and disclosure of data to support development of our oncology pipeline
  • Demonstrate substantial and relevant knowledge of scientific and medical literature with genomics and biomarker expertise and its application to strategic drug development and registration
  • Apply scientific and operational knowledge to identify and analyze problems and information of considerable complexity and implement effective plans and solutions. Collaborate with operational teams to ensure cohesive planning and strategy
  • Ability to prioritize effectively and meet multiple deadlines successfully with attention to detail, setting high performance standards.
  • Proactively  generate  ideas  for  improvements  and  take  action  to  solve problems and achieve goals beyond what is required
Required Qualifications and Preferred Background:
  • PhD required along with 5-7 years of biomarker experience within an academic or industry setting
  • Strong preferably within laboratory-based cancer research or clinical trials is preferred
  • Clinical   trial   expertise   along   with   experience  in  oncology  with  drug development highly desirable 
  • The skills required for success in the job include scientific and analytic ability, ability to think strategically and tactically, an interest in applied clinical research, an ability to work effectively in multifunctional teams and  excellent organizational and communication skills.
  • The candidate must demonstrate proven ability to evaluate, interpret and present   complex  scientific  data  to  both  technical and non-technical audiences
  • Demonstrated ability to work well with other accomplished professionals within and across functions/teams

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Principal Scientist level position could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.
Physical Demands/ Travel:
 
The physical demands of this job are consistent with an office setting.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
Work Environment:
 
This position’s work environment is office/remote based.
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

Apply Now

Position:
Principal Scientist, Laboratory Automation
Function:
Small Molecule Discovery
Location:
Louisville, CO
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Principal Scientist, Laboratory Automation, Bioassay Screening group at Loxo@Lilly, will be joining a dynamic and fast-paced team focused on identifying and advancing small molecule drugs and providing forward-thinking approaches to expand Loxo clinical portfolio. This individual will work closely with Small Molecules Discovery scientists to design, develop, optimize, and validate new and existing molecular and cell biology workflows for automation, optimizing throughput, timelines, and data accuracy and quality. The successful candidate will have expertise designing, developing, programming, and integrating laboratory automation with high-throughput applications as well as working with databases. Regular maintenance, quality control, and validation of laboratory instrumentation at the Loxo facility is also a central role for this position. Additionally, this person will be responsible for identifying and operationalizing new techniques and applications in collaboration with the Bioassay Screening Team. The Principal Scientist, Lab Automation will also provide related training and support to group members. In this role, the incumbent will be a dynamic and motivated researcher who can drive their own activities, while collaborating extensively with the entire organization to execute on various research programs.
Roles and Responsibilities of the Position:
  • Manage automation processes to support a variety of applications across the Bioassay Screening team, including application development, improvement, and optimization
  • Interact and collaborate with Small Molecule Discovery and Bioassay scientists to design, establish, and maintain integrated biological methods and a lab automation infrastructure
  • Develop, optimize, and validate custom automation protocols for various biochemical, molecular, and cell-based assays
  • Ensure consistent and high-quality data outputs from a variety of high-throughput and high-content platforms
  • Work with cross-functional personnel to develop and implement novel platforms and applications
  • Provide automation expertise for practical implementation of various applications across the entire Loxo organization
  • Train and support scientists on automation platforms and established SOPs, including hardware and software
  • Work with the entire Bioassay team to ensure all instrumentation is properly maintained and calibrated on a regular basis
  • Maintain proper documentation and archiving of data and analyses
  • Communicate results via written and oral presentations as needed
  • Discuss laboratory operational processes with technical as well as non-technical personnel
  • Maintain good interactions with third parties/vendors on new developments and products
Required Qualifications and Preferred Background:
  • BS/MS in biological sciences, computer science, engineering, or other relevant field with 5+ years of laboratory automation experience.
  • Extensive knowledge and experience designing and supporting laboratory automation and liquid handling
  • Experience with high-content, high-throughput laboratory workflows with emphasis on quality and efficiency
  • Experience converting manual protocols into automated processes, process optimization, and workflow efficiencies on automated equipment
  • HTS experience running both enzyme and cell based assays
  • High agility to learn new technologies, with an affinity for automation and high-end equipment
  • Demonstrated experience in working collaboratively across various disciplines to meet project goals and timelines
  • Flexibility to adjust priorities over time to meet organizational and scientific goals
  • Ability to work independently and as an integral part of a larger collaborative team
  • Demonstrated ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines
  • Outstanding interpersonal, written, and verbal communication skills

Additional Preferred Preferred Qualifications:
  • Experience with ECHO acoustic dispensers, HighRes PRIME liquid handling, and  lab automation scheduling software (e.g., Cellario) is highly preferred

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Manager level could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands/ Travel:
 
Travel for this role will be <5%. The physical demands of this job are consistent with a lab.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in a lab.  
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

Apply Now

Position:
Principal/Senior Principal Scientist, DMPK (multiple locations)
Function:
Small Molecule Discovery
Location:
Remote
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

Loxo@Lilly’s Drug Discovery team has an immediate opening for an experienced drug metabolism scientist. The Loxo@Lilly team’s mission is to invent life-changing targeted therapies for cancer patient populations that are poorly treated by existing therapies. To that end, we have built a multi-disciplinary team of dedicated drug discovery scientists who are passionate about driving the science forward to create highly selective drugs for known oncogenic drivers. We are currently looking for accomplished DMPK program representative with a proven track records of success in small molecule drug discovery. The ideal candidate will be passionate about solving complex DMPK challenges and will excel at working closely with scientists across disciplines. The position requires excellent people skills, a positive can-do attitude, and the ability to thrive in a highly interactive, fast-paced, team environment.
Roles and Responsibilities for this Position:
  • Design and execute in vitro and in vivo preclinical studies to understand the pharmacokinetics (PK) and absorption, metabolism, distribution, and excretion (ADME) of new chemical entities (NCE)
  • Provide management and oversight of CROs in the conduct of in vitro and in vivo ADME studies
  • Advise medicinal chemistry teams on complex DMPK issues
  • Perform non-compartmental pharmacokinetic analysis on data
  • Review in vivo protocols and study reports
  • Collate data and present to program teams
  • Contribute to authoring and review of regulatory reports and documents
  • Maintain accurate and timely electronic lab notebook
Required Qualifications and Preferred Background:
  • BS, MS or Ph.D. in medicinal chemistry, biochemistry or related discipline
  • BS with 10+, MS with 8+ or Ph.D. with 5+ years of DMPK experience
  • Experience managing and overseeing CROs
  • Experience managing Bioanalytical and Pharmacokinetic studies strongly preferred
  • Must have pharmacokinetic modeling experience
  • Experience with bioanalysis method and assay development
  • Good written and oral presentation capabilities

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Principal Scientist position level could range from between $103,200 to $151,423 and that the base salary for the Senior Principal Scientist position level could range from between $118,700 to $174,137 will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Available Locations for this role:
  • New York, NY
  • US Based-Remote
Physical Demands/ Travel:
 
The physical demands of this job are consistent with light office duties. 
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
Work Environment:
 
This position’s work environment is in an office.
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.


*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

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Position:
Principal/Senior Principal Scientist, Mass Spec, Large Molecule Discovery
Function:
Large Molecule Discovery
Location:
South San Francisco, CA
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Principal/Senior Principal Scientist, Mass Spec, Large Molecule Discovery will play an important role in the discovery and development of transformative therapeutics in the Loxo@Lilly Large Molecule Discovery team. The role requires a clear understanding of Large Molecule Discovery strategy. This role will potentially lead a team that will  address challenges in characterization of antibodies, reagent proteins and ADCs with mass-spectrometry. This includes conducting and overseeing experiments for protein/ antibody peptide mapping, intact mass analysis, post-translational modification (PTM) analysis, ADC characterization,  developability assessment, and pre-clinical in-vivo/pharmacokinetic studies utilizing bioanalytical techniques, mass-spectrometry, and other analytical characterization. 
Roles and Responsibilities of the Position:
  • Lead a team that will specialize in characterization of therapeutic proteins that include ADCs, bispecific and other format antibodies, with mass-spectrometry and analytical techniques
  • Responsible for developing strategies that include identification of above listed therapeutic proteins and protein reagents by peptide mapping, intact mass analysis, and post-translational modification (PTM) analysis
  • This role will be tasked with ADC characterization, and developability assessment, and pre-clinical in-vivo/pharmacokinetic studies utilizing bioanalytical techniques
  • Present data at meetings that may include representatives from other departments and/or outside parties and participates in brainstorming and troubleshooting within team, offering, and implementing solutions to problems.
  • Participate in designing, overseeing, and executing key experiments for analytical and mass-spectrometry based characterization of these large molecules from early discovery to early development stage.
  • Interact and collaborate with other teams across the company to provide analytical and mass-spec solutions; analyze, collate, and disseminate data to teams in a timely manner
  • Work cross-functionally as part of internal multi-disciplinary teams, as well as working with external partners and CROs.
Required Qualifications and Background:
  • PhD degree in Chemistry or Biological Science with 6 years’ experience at the Principal Scientist level and 8+ years at the Senior Principal Scientist level or MS/BSc degree in Life or analytical sciences or equivalent fields with at least 12 years of relevant job experience in the biopharma industry with good understanding of drug development process with emphasis on antibody-drug conjugates.
  • Experienced in setting up and maintaining mass-spectrometry and analytical research lab.
  • Demonstrated proven expertise in protein mass-spectrometry for antibodies including LC-MS intact protein analysis, peptide mapping, conjugate analysis, PTMs, de-novo sequencing, and chemical modifications
  • Experienced in small molecule and protein mass-spectrometry of antibody drug-conjugates (ADC) for characterization of conjugation site analysis, positional isomers, free drug, drug stability, and metabolite analysis
  • Experienced in setting up studies for assessment of antibodies and ADCs for developability/CMC and assist in writing of technical reports, SOPs, and regulatory documents for IND
  • Prior experience in participation of team efforts for antibody lead panel generation, lead optimization, and IND enabling studies
  • Demonstrated can-do attitude and brings innovative ideas in challenging projects set up in a collaborative, cross-functional organization
  • Excellent communication skills and with strong organizational abilities

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Principal Scientist position level could range from between $103,200 to $151,423 and the Senior Principal Scientist position level could range from between $118,700 to $174,137 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands/ Travel:
 
The physical demands of this job are consistent with laboratory bench setting.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in a lab.
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
 

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

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Position:
Project Manager, Third Party Management, Consultant
Function:
Business Operations
Location:
Remote
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

Loxo@Lilly is seeking a Project Manager to support third party management. The ideal candidate has an understanding of the various risk domains that are relevant for third party management and is able to multi-task and remain extremely organized to manage risk assessments for many vendors simultaneously. The candidate will work collaboratively with both internal colleagues and external third parties to manage assessments from the initial request to completion as well as monitoring thereafter.
Roles and Responsibilities of the Position:
  • Oversees and acts as Business Operations point person for the third party management process and works closely with Quality and contracting team. Key activities include, but are not limited to: 
  • Checking and communicating the status of third party vendors.
  • Maintaining a third party qualification list.
  • Facilitating qualification reviews by subject matter experts for various risk domains.
  • Managing the third party management IT system.
  • Working with internal and external business partners to facilitate timely completion of assessments and periodic reviews.
  • Collaborating with stakeholders for continuous process improvement improvement of processes.
  • Ensuring seamless communication between Loxo@Lilly and Lilly.
Required Qualifications and Preferred Background:
  • Bachelor's Degree is required with 3+ years experience in the Biotech/Pharmaceutical industry.
  • Understanding of key risk areas to be assessed (e.g., privacy, anti-corruption, etc.).
  • Ability to adapt quickly to shifting needs and/or priorities.
  • Strong project management skills in order to manage projects at various stages and effectively multi-task.
  • Working knowledge of a comprehensive enterprise risk management process.
  • Effective communication skills.
  • Enjoys fast-paced, dynamic environment.
  • Exceptional attention to detail.
Physical Demands/ Travel:
 
The physical demands of this job are consistent with light office duties
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in an office or remote based
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

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Position:
Research Associate, Proteomics
Function:
Molecular & Cellular Biology
Location:
South San Francisco, CA
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

This position is an opportunity to learn and grow within a dynamic discovery biology team dedicated to creating specific targeted therapeutics for genetically defined oncology targets. The ideal candidate is someone who enjoys technical challenges, has the protein handling and cell culture skills needed to drive basic oncology research forward, and will excel in a collaborative environment.  Experience with cell culture and biochemical techniques will be critical.  Direct experience with sample preparation and method development for mass spectrometry are desirable.  The ideal candidate will be enthusiastic about cancer research and is not afraid to get their hands dirty by helping with core lab functions including cell culture, protein characterization, mass spectrometry, and laboratory automation. The qualified candidate will have experience with basic chemistry/biology laboratory practices and is passionate to learn additional techniques working in a growing and dynamic group focused on discovery research. The candidate will work as part of a collaborative team of scientists with expertise in protein characterization, cell culture, chemistry, biochemistry, structure, and biophysics, supporting hit-to-lead and lead-ID phases of our oncology drug programs. The candidate will have opportunities to learn cutting edge techniques and to learn and develop technical expertise in proteomics.
Required Qualifications and Preferred Background:
  • BA/BS, MS in Chemistry, Biology, Biochemistry, or related field
  • Ideal candidate will have hands-on experience with cell culture, sample preparation, and sample handling.
  • Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels.
  • Highly organized with excellent analytical, documentation and multi-tasking skills.
  • Familiarity with Thermo Orbitrap and/or Bruker timsTOF Pro instrumentation is ideal.
  • Experience in cell line generation is a plus.
  • Experience with mass spectrometry/proteomics is a plus.
  • Expertise in other methods of enzymology or biophysical characterization and structural biology is a plus.

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Research Associate level position could range from between $50,000 to $63,250 and the Senior Research Associate level position will range from $58,000 to $85,109, and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.
Physical Demands/ Travel:
 
The physical demands of this job are consistent with laboratory setting.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in a lab. 
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

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Position:
Research Associate/Associate Scientist, Biophysics
Function:
Biophysics
Location:
Louisville, CO
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

Loxo@Lilly's newly formed Drug Discovery group in Louisville, Colorado has an immediate opening for a researcher in Biophysics. The Loxo Drug Discovery group’s mission is to invent life-changing targeted therapies for cancer patient populations that are poorly treated by existing therapies. To that end, we are building a multi-disciplinary team of dedicated drug discovery scientists who are passionate about driving the science forward to create highly selective drugs for known oncogenic drivers.

The ideal candidate is self-motivated, responsible, and a productive scientist who enjoys collaborating with biologists, chemists, and assay scientists.  In this role, he/she will utilize a variety of assay technologies including mass spectrometry, fluorescence spectroscopy, surface plasmon resonance, and isothermal titration calorimetry to evaluate protein/ligand interactions.  Experience in protein purification and characterization is a plus. This position requires excellent people skills, a positive can-do attitude, passion for lab work, attention to detail, and the ability to thrive in a highly interactive, fast-paced, team environment.
 

Roles and Responsibilities of the Position:
  • Prosecute biophysical assays to identify and characterize small-molecule modulators using a variety of techniques and detection methods, including chromogenic, MS, SPR, ITC, FP, FRET and TR-FRET
  • Continuously expand our biochemical characterization repertoire by exploring and developing additional assay and technological instrumentation
  • Calculate and report assay results to the project teams
  • Document experiments and results in electronic notebook, and results database
Required Qualifications and Preferred Background:
  • A BS or MS with 0-3+ years relevant work experience. Level commensurate with education and experience
  • Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels
  • Highly organized and detail oriented with excellent analytical, documentation, and multi-tasking skills
  • Committed continual learner, who is accustomed to staying current with the latest scientific breakthroughs in structure-based drug design and biophysics
  • Expertise in other methods of enzymology or biophysical characterization and structural biology is a plus
  • Protein Purification and characterization a plus

    • Loxo Oncology, Inc. currently anticipates that the base salary for the Research Associate level position could range from between $50,000 to $73,370 and that the base salary for the Associate Scientist could range from between $59,000 to $86,577 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.
Physical Demands/Travel:
 
The physical demands of this position are consistent with working in a laboratory/ bench environment. Some lifting, and maneuvering of equipment may be required.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
Work Environment:
 
This position’s work environment is based in a laboratory/ bench environment.

The work environment characteristics described here are representative of those an employee encounters while preforming the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

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Position:
Scientist, ADME/DMPK
Function:
Small Molecule Discovery
Location:
Louisville, CO
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
Roles an Responsibilities for the Position
  • Analyze in vitro samples utilizing LC-MS/MS (Sciex 6500)
  • Run weekly in vitro ADME (absorption, distribution, metabolism, and excretion) assays to guide chemistry structure-activity relationships (SAR)
  • Develop, and validate novel ADME screens
  • Collate data and present to program team
  • Contribute to authoring and review of regulatory reports and documents
  • Maintain accurate and timely electronic lab notebook
  • Work effectively both independently and in a team environment
Required Qualifications and Preferred Background:
  • BS, MS or PhD degree in pharmacology, analytical chemistry or related discipline
  • 2-6 years of laboratory experience
  • 5+ year LC-MS/MS experience (Sciex systems preferred)
  • Experience with bioanalysis method and assay development
  • Good written and oral presentation capabilities

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Scientist level could range from between $78,000 to $114,498 will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands/ Travel:
 
The physical demands of this job are consistent with laboratory setting.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in a lab. 
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
 

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

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Position:
Scientist, Cancer Biology
Function:
Cancer Biology
Location:
South San Francisco, CA
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

With a strong background in cancer biology, the Scientist, Cancer Biology will support lab-based research projects associated with Loxo@Lilly’s discovery and development programs. This entails independently planning and executing experiments focused on developing a deep understanding of target biology and drug mechanisms of action. The successful candidate will achieve these objectives by prioritizing scientific rigor, by exhibiting a “can-do” approach to solving complex challenges, and by effectively collaborating with Loxo@Lilly discovery and development team members. 
Roles and Responsibilities of the Position:
  • Drive and execute in vitro and in vivo studies to investigate mechanisms of cancer cell growth and survival in support of the discovery and development of new cancer therapeutics
  • Establish and perform state-of-the-art cell-based and biochemical assays
  • Design and execute cross-assay validation studies
  • Identify and evaluate new technologies to advance drug discovery and development
  • Analyze and interpret data, with ability to troubleshoot assays
  • Organize and coordinate multiple projects in parallel
  • Identify, evaluate, and manage vendors for outsourced services and studies
  • Prepare and present scientific results at congresses and in peer-reviewed journals

Required Qualifications and Preferred Background:
  • BS, MS, or PhD in biology, molecular biology, cell biology, biochemistry or related discipline. Minimum of 10 years for BS, >5 years for MS and >0-3 years for PhD, either in industry or academic environment
  • Proven track record in design and development of robust assays to study protein expression, protein turnover and protein-protein and protein-small molecule interactions (e.g. MSD, HTRF, AlphaLISA, flow cytometry, co-IP etc.)
  • Extensive experience with aseptic mammalian cell culture and familiarity with solid tumor and/or hematologic cell lines is preferred
  • Demonstrated ability to engineer knock-in & knockout cell lines with CRISPR and/or other technologies
  • Experience working with in vivo mouse models including tissue/blood collection, processing, and analysis
  • Self-organized, detail-oriented, self-directed, highly motivated with strong critical thinking and analytical skills
  • Willingness to work collaboratively and incorporate diverse perspectives into decision-making
  • Demonstrated ability to work successfully in a nimble, fast-paced, matrixed environment

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Scientist position level could range from between $78,000 to $114,498 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands/ Travel:
 
The physical demands of this job are consistent with laboratory setting.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in a lab. 
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

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Position:
Scientist, Organoid Team, Discovery Technologies
Function:
Large Molecule Biology & Discovery Technologies
Location:
New York, NY
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Scientist in the Discovery Technologies, Organoid Group, will be joining a large and dynamic group focused on executing experiments on the cutting edge of pharmaceutical sciences. The candidate will execute experiments to support various research programs for identified targets and will be expected to demonstrate expertise with various organoid and patient-derived models, to be able to troubleshoot technical difficulties encountered in organoid growth, and to interrogate the work of third parties and collaborators. The candidate will also be encouraged to develop their own ideas, contribute these to the broader organoid group as well as project teams, and is expected to be a dynamic and motivated scientist who can drive their own experiments and research activities, while collaborating extensively with the rest of the organization to execute on various research programs. The candidate will collaborate with project teams in NYC, Indianapolis, SSF, and Boulder for design and execution of studies, and will work closely with multi-disciplinary teams, providing expertise throughout all stages of the lifecycle of target modulation and validation to advance our portfolio. 
Roles and Responsibilities of the Position:
  • Scientific roles and responsibilities:
  • Develop key capabilities for the generation of necessary patient-derived organoid models for detailed functional characterization
  • Design and execute studies to profile candidate molecules in organoid systems
  • Troubleshoot technical difficulties encountered in organoid establishment, growth and testing
  • Test biologics or small molecules in organoid tumor models (dose response experiments, profiling, comparing to control compounds)
  • Grow organoids of various types; have extensive knowledge of media and growth factors on organoid development
  • Perform experiments that modulate target expression in organoid systems
  • Interrogate experimental conduct of third parties/vendors
  • Additional responsibilities:
  • Communicate results at project team meetings, be involved in the coordination and preparation of presentations
  • Discuss results with technical as well as non-technical personnel
  • Lead, and work collaboratively across multiple laboratory-based functions to establish the mechanisms, phenotypes, and biology of new targets using modern approaches in molecular and cellular biology and biochemistry
  • Work in cross functional environments via extensive collaboration with other parts of the organization
  • Direct leadership of a junior scientist may be required

Required Qualifications and Preferred Background:
  • BS degree in biological sciences with 5 years of experience or MS/PhD in biological sciences with 2-3 years of experience required
  • Extensive expertise working with organoid models
  • Deep expertise in cancer disease states (indications, mutational status, tumor cell drivers)
  • Demonstrated experience in working collaboratively across various scientific disciplines to meet end goals of business
  • Excellent communication and interpersonal skills
  • Demonstrated ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines
  • Excellent written and verbal communication skills

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the {insert position} level position could range from between $78,000 to $ $114,498 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.
Physical Demands/ Travel:
 
The physical demands of this job are consistent with laboratory setting.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in a lab. 
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
 


*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

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Position:
Scientist, Structural Biology
Function:
Structural Biology
Location:
Louisville, CO
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

This position offers the opportunity to be part of Loxo’s discovery teams focused on creating novel, highly specific and selective drugs for genetically identified targets.  The Structural Biologist will offer structural and mechanistic insights to a multi-disciplinary discovery team by providing high-resolution protein-ligand crystal structures.  This role also provides the opportunity to work on larger, collaborative structural biology projects involving cryo-EM.

Roles and Responsibilities for the Position:
  • Generate protein-small molecule complex x-ray crystal structures with hands-on lab involvement throughout the entire gene to structure process including protein expression, purification, crystallization, and structure determination
  • Coordinate protein construct design, expression, and purification with the project team to support biochemical and biophysical assays.
  • Rapidly communicate scientific results and insights to the team
  • Identify, evaluate, and manage vendors for outsourced services and studies
  • Collaborate with colleagues throughout the company to ensure structural work meets the program needs and results are appropriately interpreted
  • Participate and lead project-based and technical team meetings to identify and solve problems, guide work towards project goals, communicate on-going work and progress, and plan forward thinking strategies
  • Develop and continually advance one’s knowledge base on genetically targeted drugs and structure-based drug design
  • Proactively investigate new or different technologies, methods, and service providers to ensure our work is being done in a scientifically sound, efficient, and reasonable way
  • In the future, this position’s responsibilities may include supervision of scientists and associates
Required Qualifications and Preferred Background:
  • PhD in Biochemistry, Biophysics, Chemistry, or related field
  • Ideal candidate will have with 5+ years hands-on gene to structure protein-small molecule crystallography experience in a biotech/pharma setting
  • Experienced in crystallization of protein-small molecule complexes and high-resolution x-ray structure determination
  • Extensive experience in protein construct design, expression, purification, and characterization
  • Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels
  • Highly organized with excellent analytical, documentation and multi-tasking skills
  • Committed to staying current with the latest scientific breakthroughs in structure-based drug design and structural biology.
  • Experience in other methods of biophysical and structural biology, such as Cryo-EM, is a plus
  • A learners mindset

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Scientist level position could range from between $78,000 to $114,498 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands/ Travel:
 
The physical demands of this job are consistent with laboratory setting.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is in a lab.  
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.


*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

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Position:
Scientist/Senior Scientist, Antibody Discovery
Function:
Large Molecule Discovery
Location:
South San Francisco, CA
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Scientist/Senior Scientist, Antibody Discovery will be responsible for executing antibody binding and functional screens to identify hit sequences from internal and external antibody discovery campaigns. This individual will generate critical in vitro characterization data and reagents to rank order antibody sequences by affinity, in vitro potency, and developability for various Large Molecule Discovery programs. Working closely with other internal teams, the Scientist/Sr Scientist will also support collaborative activities related to lead identification and optimization.
Roles and Responsibilities of the Position:
  • Perform high-throughput antibody binding screens by ELISA and multi-plex flow cytometry to identify hits
  • Develop, optimize, and perform in vitro potency assays to deliver key data for selecting lead panel of antibodies, including bispecific antibodies and antibody drug conjugates
  • Perform tissue cultures to expand and maintain mammalian cell lines (CHO, HEK293, and established cancer cell lines) and primary immune cells for antibody/protein expression and in vitro assays
  • Work collaboratively with Large Molecule Discovery Biologics functional teams to ensure materials and results are delivered on time
  • Demonstrate collection and thorough analysis of data, and update Electronic Notebook records
Required Qualifications and Preferred Background:
  • MS in Biology, Biochemistry, Biomedical Engineering, or related field with minimum of 3+ years of industry experience, or BS with 5+ years of industry experience in biologics drug discovery for Scientist; 7+ years of industry experience for Senior Scientist
  • Must have in tissue cultures experience using mammalian cell lines and primary immune cells using aseptic laboratory techniques
  • Experience in operating and maintaining flow cytometers, plate readers, and liquid handlers, as well as software for data analysis and visualization (Microsoft Office and GraphPad Prism)
  • Highly motivated, fast learner with strong organization skills
  • Demonstrate experience in working collaboratively across various scientific disciplines to meet end goals of business
  • Demonstrate ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines
  • Excellent written and verbal communication skills
  • Strong interpersonal skills
Preferred Qualifications:
  • Single B cell cloning or hybridoma based antibody discovery experience

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Scientist position level could range from between $78,000 to $114,498 and the base salary at the Sr. Scientist level could range between $89,750 and $131,672 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands/ Travel: TBD <5%
The physical demands of this job are consistent with working in a lab.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
This position’s work environment is in a lab.  
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.



*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

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Position:
Scientist/Senior Scientist, Biophysics
Function:
Biophysics
Location:
Louisville, CO
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

Loxo's newly formed Drug Discovery group in Louisville, Colorado has an immediate opening for a researcher in Biophysics. The Loxo Drug Discovery group’s mission is to invent life-changing targeted therapies for cancer patient populations that are poorly treated by existing therapies. To that end, we are building a multi-disciplinary team of dedicated drug discovery scientists who are passionate about driving the science forward to create highly selective drugs for known oncogenic drivers.

The ideal candidate is self-motivated, responsible, and a productive scientist who enjoys collaborating with biologists, chemists, and assay scientists.  In this role, he/she will utilize a variety of assay technologies including mass spectrometry, fluorescence spectroscopy, surface plasmon resonance, and isothermal titration calorimetry to evaluate protein/ligand interactions.  Successful candidate will have a demonstratable history of developing, and executing, creative biophysical assays.  Some experience in coding is a plus, including but not limited to Python, R, Go, and SAS. This position requires excellent people skills, a positive can-do attitude, passion for lab work, attention to detail, and the ability to thrive in a highly interactive, fast-paced, team environment. 
Roles and Responsibilities of the Position:
  • Design and develop novel biophysical assays to identify and characterize small-molecule or biological modulators using a variety of techniques and detection methods including chromogenic, MS, SPR, ITC, FP, FRET and TR-FRET
  • Experimentally explore biological consequence of mechanism of inhibition by coordinating experiments with our cell biology team.
  • Creatively address biologic/biophysical questions across a wide variety of techniques and technologies
  • Continuously expand our biochemical characterization repertoire by exploring and developing additional assay and technological instrumentation
  • Calculate and report assay results to the project teams
  • Document experiments and results in electronic notebook, and results database
  • Software coding experience is a plus
Required Qualifications and Preferred Background:
  • A BS, MS, or PhD in a Life Sciences discipline, with training in molecular biology, enzymology or biochemistry, and a record of lab based independent research experience, minimum of 10 years for BS, >5 years for MS and >0-3 years for PhD, either in industrial or academic environment
  • Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels
  • Highly organized and detail oriented with excellent analytical, documentation, and multi-tasking skills
  • Committed continual learner, who is accustomed to staying current with the latest scientific breakthroughs in structure-based drug design and biophysics

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Scientist level position could range from between $78,000 to $114,498 and the base salary at the Sr. Scientist level could range between $89,750 and $131,672 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.

Physical Demands/Travel:
 
The physical demands of this position are consistent with working in a laboratory/ bench environment. Some lifting, and maneuvering of equipment may be required.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
Work Environment:
 
This position’s work environment is based in a laboratory/ bench environment.

The work environment characteristics described here are representative of those an employee encounters while preforming the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

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Position:
Scientist/Senior Scientist, Enzymology
Function:
Small Molecule Discovery
Location:
San Diego, CA
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Enzymology Scientist or Sr. Scientist will be responsible for developing and performing enzyme and binding assays to support drug discovery and development in a team environment. The scientist fulfilling this position will be responsible for characterizing the effects of small molecules on specific protein targets and will provide enzymology expertise to the project teams.  A strong background in experimental curve-fitting, statistics, and assay optimization and execution is required.
Roles and Responsibilities of the Position:
  • Design, develop, and execute enzyme and binding assays in multiple formats
  • Screen small molecule inhibitors in plate-based assays formats to drive internal structure-based drug design
  • Operate, implement, and troubleshoot laboratory automation
  • Actively engage in advancing small molecule drug discovery oncology programs
  • Perform comprehensive data analysis 
  • Communicate experimental findings to team members
  • Operate, implement, and troubleshoot laboratory automation
  • Actively engaged in advancing drug discovery programs  
  • This is a “hands-on” laboratory, based position

Required Qualifications and Preferred Background:
  • BS/MS/Ph.D. in biochemistry, biophysics, or related fields
  • Ph.D. with >2 years’ experience in industry or academia, or BS or MS with >5 years industrial experience
  • The successful candidate is expected to have expertise in biochemistry, enzymology, and assay development
  • Experience with general biochemical and kinetic-based assay technologies (e.g. TR-FRET, AlphaLISA® FP, Luminescence)
  • Experience with laboratory instrumentation and automation for medium to high-throughput screening
  • Excellent oral and written communication skills including experimental documentation
  • Works well with team members across functional areas
  • Ability to multi-task and shift priorities rapidly to meet tight deadlines
  • Highly organized with exceptional attention to detail.
  • Good and thoughtful listener
  • Enthusiastic, self-motivated and a continuous learner
  • Proficient in Microsoft Office suite and applications

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Scientist level position could range from between $78,000 to $114,498 and the Senior Scientist level position could range from between $89,750 to $131,672 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands / Travel
The physical demands of this job are consistent with a lab.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
Work Environment
This position’s work environment is in a lab.
 
The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

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Position:
Scientist/Senior Scientist, Proteomics
Function:
Biophysics
Location:
Louisville, CO
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

This position is an opportunity to learn and grow within a dynamic team dedicated to creating specific targeted therapeutics for genetically defined oncology targets.  We are seeking a Scientist with experience in biochemistry, cell biology and/or mass spectrometry-based proteomics. This individual will serve as a technical lead and be responsible for carrying out experimental research aimed at understanding the role of proteins and post-translational modifications in oncology. An important focus is to study how proteins and protein interactomes are modulated by drug candidates. The researcher will have the opportunity to utilize and further develop state-of-the-art technologies for the discovery and characterization of receptor-ligand interactions. Research in the group is fast paced and highly collaborative, drawing on the expertise of experts in biochemistry, cell biology and oncology.
Roles and Responsibilities of the Position:
  • The ideal candidate should have experience in protein biochemistry and proteomic techniques. Experience with proteomics sample preparation (i.e., proteolytic digestion, solid phase extraction, immunoprecipitation) and operation of an Orbitrap mass spectrometer are preferred, but not essential for success in this role. Additionally, this position will be asked to evaluate technologies and techniques to evaluate protein structure dynamics, such as HDX or hyroxy-radical footprinting.  Computational skills are highly desirable. Strong communication & interpersonal skills are essential for success in this collaborative role.
Required Qualifications and Preferred Background:
  • BS, MS, or PhD in a Life Sciences discipline, with training in molecular biology, enzymology or biochemistry, and a record of lab based independent research experience along with a minimum of 10 years for BS, >5 years for MS and >0-3 years for PhD, either in industrial or academic environment. The ideal candidate will have hands-on experience with protein characterization and cell culture
  • Demonstrated ability to work well with other accomplished professionals within and across functions/teams. Willing collaborator
  • Familiarity with techniques and instrumentation relevant to automated semi-automated sample handling
  • Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels
  • Highly organized with excellent analytical, documentation and multi-tasking skills
  • Committed to staying current with the latest scientific breakthroughs in structure-based drug design and proteomics and related technology. A continuous learner
  • Expertise in other methods of enzymology or biophysical characterization and structural biology is a plus

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Scientist level could range from between $78,000 to $114,498 and that the base salary for the Senior Scientist could range from between $89,750 and $131,672 but will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands/ Travel:
 
The physical demands of this job are consistent with standard laboratory duties.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 
Work Environment:
 
This position’s work environment is based equally in a wet lab and office environment.  
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
 

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

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Position:
Senior Associate Scientist/Scientist, Biology, Target Discovery
Function:
Target Discovery
Location:
South San Francisco, CA
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

We are seeking a highly motivated and experienced individual to join a dynamic and fast-paced biology team in Target Discovery. The successful candidate will support lab-based research projects to identify and validate novel druggable targets. The ideal candidate is a team player familiar with routine molecular and cellular biology techniques, and has demonstrated organizational skills. This individual learn various cutting-edge techniques and thrive in a team-oriented environment with career growth opportunity.  
Roles and Responsibilities of the Position:
  • Maintain and establish various mammalian cell lines used to credential novel targets.
  • Perform cellular and biochemical assays to evaluate the outcome of various genetic or chemical perturbations.    
  • Analyze, interpret, and present the data to the team and/or organization.
  • Troubleshoot experiments in a timely manner.
  • Learn and apply new techniques to support ongoing efforts.
  • Actively participate in group discussions and collaborate with colleagues throughout the organization.
  • Contribute to a safe and efficient workplace. 
Required Qualifications and Preferred Background:
  • BS or MS in biology, cancer, molecular biology, cell biology, biochemistry, or related discipline, with 3+ years lab-based experience.
  • Expertise in routine molecular and cellular techniques.
  • Experience in gene editing (CRISPR, TALEN, etc.) and/or high-throughput screening is a plus.
  • Excellent collaborative and interpersonal skills.
  • Highly organized, detail-oriented, self-motivated and strong documentation skills.
  • Outstanding communication, writing, and presentation skills are a must.


  • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Senior Associate Scientist position level could range from between $67,850 to $99,563 and the Scientist position level could range between $78,000 and $114,498 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands:
 
The physical demands of this job are consistent with working in a laboratory/ bench environment. Some light lifting, and maneuvering may be required.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
Work Environment:
This position’s work environment is in a laboratory/bench environment.
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

Apply Now

Position:
Senior Associate Scientist/Scientist, Cell Biology
Function:
Discovery Signaling
Location:
New York, NY
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Senior Associate Scientist/Scientist, Cell Biology will be part of the Loxo@Lilly’s Discovery Signaling group in Alexandria Center, NY. The Discovery Signaling group is responsible for identifying molecular targets for life-changing oncology drugs, establishing the cellular reporters for onco-pathways and investigating the mechanism of actions of novel drug candidates with a focus on small molecule drugs, and providing forward-thinking approaches to advance our clinical portfolio. 
 
The Senior Associate Scientist/Scientist, Cell Biology will be responsible for creating and evaluating cellular models, assays, execution strategies to quantitatively determine the potency and selectivity of small molecule compounds and interrogate signaling pathways.  This is a hands-on position for an experienced lab scientist who enjoys working in the lab. This scientist must have excellent people skills and be able to work with a positive, “can-do” attitude in a dynamic, fast-paced, team environment focused on high quality science to deliver innovative cancer drugs. 
Roles and Responsibilities of the Position:
  • Create, develop and validate quantitative mammalian cellular assays to address the project team’s mechanistic and functional needs. 
  • Establish engineered cell models to determine the actions of drugs on the specific oncogenic signaling. 
  • Collaborate with colleagues throughout the company to ensure assays meet the program needs and results are appropriately interpreted.
  • Prepare reports for internal and external purposes including regulatory submissions.
  • Participate and lead project-based and technical team meetings to identify and solve problems, guide work towards project goals, communicate on-going work and progress, and plan forward thinking strategies. 
  • Develop and continually advance one’s knowledge base on the molecular pathways being targeted by our clinical and research programs.
  • Proactively investigate new or different technologies, methods, and service providers to ensure our work is being done in a scientifically sound, efficient, and reasonable way.

Required Qualifications and Preferred Background:
  • BS degree with 5+ years experience, MS degree with 3+ years experience or PhD with 1+ years experience in Molecular/Cellular Biology, Biochemistry, or related field with 2+ years hands-on molecular biology and cell assay experience in a biotech/pharma setting or BS/MS in Molecular/Cellular Biology or Biochemistry with 3+years hands-on molecular biology and cell assay experience in a biotech/pharma setting.

    • Ideal candidate will also have:
  • Experience in culture cancer cell lines and/or patients-derived primary tumor cells, in both 2D and 3D system.
  • Demonstrated hands-on experience in flow cytometry-based cell analysis and cell sorting.  
  • Experience in creating, developing, and running cellular assays; engineering cell lines to express or knock-down genes of interest, interrogating cellular signal transduction pathways, and characterizing kinase activity.
  • Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels.
  • Highly organized with excellent analytical, documentation and multi-tasking skills. Proficient in Microsoft Office suite and applications. 
  • Good and thoughtful listener who values collaboration. 
  • Enthusiastic, self-motivated and keen to improve processes and overcome inefficiencies. 

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Associate Scientist level could range from between $59,000 to $86,577 and that the base salary for the Scientist level could range from between $78,000 to $114,498 will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

This position’s work environment is in a lab/bench environment.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

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Position:
Senior Associate Scientist/Scientist, Target Discovery (in-vivo)
Function:
Target Discovery
Location:
South San Francisco, CA
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

We are seeking a highly motivated and experienced individual to join a dynamic and fast-paced Target Discovery Biology team. Under the guidance of a principal or senior principal scientist. The successful candidate will apply state-of-the-art technologies to design and execute in vivo studies as well as ex vivo experiments to identify and validate novel druggable targets.

The ideal candidate is a team player familiar with routine molecular, cellular biology and in vivo techniques and has demonstrated organizational skills. He/She will learn various cutting-edge techniques and thrive in a team-oriented environment with career growth opportunity.  
Roles and Responsibilities of the Position:
  • Design vectors to generate transgenic mouse models to study novel targets
  • Maintain and establish various mammalian cell lines used to credential novel targets
  • Design, plan and/or execute in vivo experiments by using mouse models to evaluate the outcome of tumor progression in mouse models for different cancers
  • Perform cellular and biochemical assays to evaluate the outcome of various genetic or chemical perturbations. 
  • Mouse colony management
  • Analyze, interpret, and present the data to the team and/or organization
  • Troubleshoot experiments in a timely manner
  • Learn and apply new techniques to support ongoing efforts
  • Actively participate in group discussions and collaborate with colleagues throughout the organization.
  • Contribute to a safe and efficient workplace
Required Qualifications and Preferred Background:
  • BS, MS, or PhD in biology, cancer, molecular biology, cell biology, biochemistry, or related discipline, with 3+ years lab-based experience
  • Mouse experience is highly desired but not required
  • Expertise in routine molecular and cellular techniques
  • Experience in gene editing (CRISPR, TALEN, etc.) and/or high-throughput screening is a plus.
  • Excellent collaborative and interpersonal skills
  • Highly organized, detail-oriented, self-motivated and strong documentation skills
  • Outstanding communication, writing, and presentation skills are a must
    •  
    Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Senior Associate Scientist level position could range from between $67,850 to $99,563 and the that the base salary for the Scientist level position could range from between $78,000 to $114,498 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.
Physical Demands:
 
The physical demands of this job are consistent with working in a laboratory/ bench environment. Some light lifting, and maneuvering may be required.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
Work Environment:

This position’s work environment is in a laboratory/bench environment.
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

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Position:
Senior Full Stack Developer (PHP, JavaScript, Oracle SQL), Scientific LIMS Lead
Function:
Structural Biology
Location:
San Diego, CA
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

Loxo@Lilly is seeking a talented and highly motivated Senior Full Stack Developer, Scientific Laboratory Information Management System (LIMS) Lead, to join our Discovery Protein Sciences and Structural Biology groups. The successful candidate will be responsible for developing innovative solutions to seamlessly integrate experimental workflows (sample tracking and experimental details) in a custom LIMS. Web development and database skills we be used to create solutions that impact portfolio progression.
Roles and Responsibilities of the Position:
  • With an aptitude for developing web applications and an interest in using today's technologies, you will contribute to developing tools that support LIMS database development. The successful candidate will have a flexible, learning mindset to design and deliver scientific databases, create workflows to track inventory experimental details for gene to structure processes (target details, plasmid sequences, protein purification, protein characterization, antibody and large molecule production, protein crystallization, synchrotron X-ray crystallographic data, crystallography datasets, cryo-EM grid preparation, cryo-EM data analysis & processing, and protein structures). This position is responsible for delivering Oracle based LIMS database informatics solutions focused on ease of data input and accessibility, to ensure data quality. The successful candidate will be responsible to implement and deploy LIMS by coordinating with internal scientists to develop web-based tools to enhance laboratory processes and data tracking. An ideal candidate would be able to design, develop, test, and debug code through the entire development cycle. Integration experience with Benchling or Signals electronic notebook is considered highly desirable. Experience with liquid handling robots, barcode readers and other lab technologies can be beneficial.
Required Qualifications and Preferred Background:
  • Bachelor’s/Master’s/PhD in computer science, bioinformatics, or equivalent experience
  • 4+ years of software development experience, including experience in computer science, bioinformatics or other applied science
  • Experience delivering and deploying large-scale informatics production solutions using laboratory information management system (LIMS) a very strong plus
  • Familiarity with designing, maintaining, and implementing relational databases
  • Experience building and maintaining shared code libraries in a team environment using version control systems
  • Ability to work collaboratively with other team members to develop complex applications
  • Understanding of molecular biology, protein sciences, antibody production, protein crystallization, crystallography, and cryo-EM technologies is highly desirable
  • Excellent communication skills and desire to learn is essential
  • Technical skills in order of importance:
  • Database skills in SQL, Oracle PL/SQL, Oracle triggers, relational database theory
  • Web skills in PHP, HTML, JavaScript, JQUERY, AJAX, and CSS
  • Experience with Python, Django, MySQL, Pandas, machine learning a plus 
  • Familiarity with Perl compatible regular expression (PCRE) syntax
  • Experience with containers (Docker, Docker Compose)
  • eLN integration experience with ‘Benchling’ or ‘Signals Notebook’
  • Git / Git Hub
  • C#, RockImager / RockMaker experience


    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for Sr. Principal Scientist position would range from $118,700 to $174,137, and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.


Additional Locations for this Role:
  • Louisville, CO
Physical Demands/Travel:

The physical demands of this job are consistent with an office

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.


Work Environment:

This position’s work environment is in an office/laboratory setting  

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.


*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

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Position:
Senior Manager/Associate Director, Biostatistics
Function:
Biostatistics
Location:
Remote
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Senior Manager/Associate Director, Biostatistics will provide statistical leadership and work as a study statistician within Loxo development including working collaboratively with cross functional clinical and development teams including clinicians, clinical scientists, statistical programmers, data managers, regulatory and clinical operations professionals to plan, conduct, and analyze clinical studies of all phases.  Perform ad hoc analyses and support statistical programming team in specification and verification of analyses.
Roles and Responsibilities of the Position:
  • Works as the study statistician collaboratively with statistical programmers, other biostatisticians, clinical research associates, clinical data managers and other development functions to meet project and study deliverables for statistical data analysis and reporting.
  • Ensure the use of appropriate statistical methodologies and its clear communication in a cross functional setting. 
  • Interacts with and oversees statistical vendors as needed. 
  • Provide instructions for derivations and analyses to statistical programming to ensure quality of deliverables.
  • Develop statistical programs as necessary to perform analyses, prepare data displays and verify the correctness of data and analyses.
  • Help design data capture methods and select appropriate study endpoints for clinical programs.
  • Contribute to development of policies, procedures, and standards within the biostatistics department. 

Required Qualifications and Preferred Background:
  • For Associate Director Level: 
  • PhD with minimum 6 years OR Master’s with minimum 8 years of experience in statistics/biostatistics/related field is required
  • Minimum 5 years of clinical development experience in the pharmaceutical/biotech industry is required
  • For Senior Manager Level:
  • PhD with minimum 2-4 years OR Master’s with minimum 4-6 years of experience in statistics/biostatistics/related field is required
  • Minimum 3 years of clinical development experience in the pharmaceutical/biotech industry is required
  • Additional: 
  • Strong knowledge of clinical trial design, drug development regulations pertinent to statistical analysis, and sound understanding of statistical applications for clinical trials is required
  • Proficient SAS programming skills and an understanding of CDISC models and standards are required
  • Oncology experience is preferred.
  • Ability to plan, develop timelines, multi-task, and shift priorities rapidly to meet tight deadlines.
  • Excellent writing, interpersonal and communication skills. 

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Senior Manager level position could range between $118,700 to $174,137 and that the base salary for the Associate Director level position could range between $135,300 to $198,516 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.

Physical Demands/ Travel:

The physical demands of this job are consistent with light office duties. 

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in an office. 

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.


*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

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Position:
Senior Principal/Principal Scientist, Translational Sciences
Function:
Translational Sciences
Location:
Indianapolis, IN
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Senior Principal/Principal Scientist, will be part of the Loxo@Lilly’s Translational Sciences group in Indianapolis, IN. The Translational Sciences group is responsible for developing and executing strategies for precision medicine including identifying and validating biomarkers, establishing combination strategies and understanding drug resistance. The Senior Principal/Principal Scientist, will have a strong understanding of signal transduction pathways. This is a hands-on position for an experienced scientist who enjoys working in the lab. The successful candidate must have excellent people skills and be able to work with a positive, “can-do” attitude in a dynamic, fast-paced, team environment focused on high quality science to deliver innovative cancer drugs.
 
Roles and Responsibilities of the Position:
  • Design and execute key experiments to evaluate compounds, identify combination partners and investigate drug resistance.
  • Translate preclinical findings to biomarker and combination strategies to advance programs to clinical development
  • Work closely with clinical team to develop and test hypotheses that could determine the clinical response and define the patient populations  
  • Engage in cross-functional collaborations across the company
  • Identify, evaluate, and manage vendors for outsourced services and studies
  • Prepare reports for internal and external purposes including regulatory submissions
  • Participate and lead project-based and technical team meetings to identify and solve problems, guide work towards project goals, communicate on-going work and progress, and plan forward thinking strategies
  • In the future, this position’s responsibilities may include supervision of scientists 
Required Qualifications and Preferred Background:
  • PhD in Molecular/Cellular Biology or Biochemistry, or related field with either:
  • 6+ years hands-on molecular and cell biology experience AND 2+ years work experience in a biotech/pharma setting or
  • 10+ years hands-on molecular and cell biology experience
  • OR a BS/MS in Molecular/Cellular Biology or Biochemistry with either
  • 10+ hands-on molecular and cell biology experience AND 4+ years work experience in a biotech/pharma setting or
  • 15+ years hands-on molecular and cell biology experience

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Principal Scientist position level could range from between $103,200 to $151,423 and the Senior Principal Scientist position level could range from between $118,700 to $174,137 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion
Physical Demands/ Travel:
 
The physical demands of this job are consistent with working in a laboratory/ bench environment. Some light lifting, and maneuvering may be required.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 Work Environment:
 
This position’s work environment is in a lab/bench environment.
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
 

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

Apply Now

Position:
Senior Project Manager, Small Molecule Discovery
Function:
Program and Alliance Management
Location:
Louisville, CO
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

The Senior Project Manager will establish and implement project-specific strategic goals from early-stage discovery, lead identification, lead optimization through candidate seeking and advancement as a part of the Loxo Small Molecule Discovery portfolio, in a cross-functional, dynamic environment.
 
The role will work closely with team leaders and Loxo's Small Molecule Discovery leadership to create and implement project’s strategic plans. The Project Manager is expected to support 2-4 projects depending upon the project’s requirements. 
Roles and Responsibilities for the Position:
  • Establish strategic project goals and translate goals into project plan(s) with clear deliverables, milestones, and go/ no-go decisions
  • Establish project strategic objectives by collaborating with Loxo Small Molecule- Discovery leadership team
  • Engage with functional team leads of medicinal chemistry, biology, DMPK, CMC, and toxicology (and other key stakeholders) to plan, execute, and track project activities, ensuring alignment of project deliverables with strategic goals
  • Actively manage assays and studies conducted at external collaborators and vendors to meet outsourcing needs as needed.
  • Actively facilitate project meetings: create agendas, minutes, and track action items
  • Create and maintain organizational documents and tools, e.g., screening cascades, data summaries, project timelines, Spotfire dashboards, compound demand-supply forecasts, and various other trackers to ensure clear, effective, transparent, and efficient implementation of projects
  • Create project updates, reports, presentations, and memos and maintain project document repository in collaboration with team members
  • Proficient in adaptive communications; effectively manage communications vertically and horizontally in a cross-functional environment
  • Proactively contribute to and manage project communications. Identify gaps and ambiguities in communication channels and address them to maintain alignment across the team
  • Drive day-to-day operational activities by coordinating with stakeholders from different functional departments – legal, business operations, procurement, finance, and other relevant functional areas as needed
  • Proactively identify gaps in processes and actively create processes to meet project needs
  • Adaptive to change in priorities and able to drive project outcomes ensuring re-alignment with project deliverables in changing landscape
  • Contribute to building positive, collaborative teams across scientific disciplines, and encourage sharing of new ideas and creative ways to solve problems often needed in drug discovery research
Required Qualifications and Preferred Background:
  • BS, MS, or PhD  in chemistry, biology, or related sciences
  • Small molecule drug discovery experience: BS with 7 years, MS with 4 years, or PhD  with 2 years. Part of the experience could come from project management/ alliance management responsibilities in pharmaceutical research & development
  • Must be self-motivated and have excellent time management skills
  • Excellent verbal, written communication and interpersonal skills.
  • Excellent organizational skills, efficient, with strong attention to detail

  • Additional Preferences:  
  • PMP certification is preferred, but not required
  • Proficient in identifying and applying tools to effectively manage and track projects - MS Office suite, MS Project
  • Experience with data visualization software, such as Spotfire
  • Create and implement new tools and processes customized for furthering discovery research

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Senior Manager level position could range from between $118,700 to $174,137 but will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.



*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

Apply Now

Position:
Senior Scientist/Principal Scientist, Protein Sciences
Function:
Protein Sciences
Location:
Louisville, CO
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

This position offers the opportunity to be part of Loxo@Lilly's discovery teams focused on creating novel, highly specific and selective drugs for genetically identified targets. The Protein Purification Scientist will support the internal and external discovery research efforts across multiple projects and project teams. This is an extremely important role where the right person will be able to have a real impact on cutting-edge science, making a real difference in patient’s lives. 
Roles and Responsibilities of the Position:
  • Provide recombinant protein expression and protein purification expertise to deliver proteins central to research activities for small molecule discovery
  • Understand the quality of proteins required for functional and biophysical assays, and develop protocols to deliver well characterized proteins accordingly
  • Execute projects in an efficient manner, working with aggressive timelines
  • Values quality over quantity, with the ability to prioritize
  • Rapidly communicate scientific results and insights to the team
  • Prepare reports for internal and external purposes including regulatory submissions
  • Participate and lead project-based and technical team meetings to identify and solve problems, guide work towards project goals, communicate on-going work and progress, and plan forward thinking strategies
  • Continually advance your understanding of current methodology and emerging technologies by reading scientific literature
  • Proactively investigate new or different technologies, methods, and service providers to ensure our work is being done in a scientifically sound, efficient, and reasonable way
Required Qualifications and Preferred Background:
  • BA/BS/MS/PhD in protein sciences, biology, biochemistry, molecular biology, or a related field along with hands-on experience, working in a laboratory in a biotechnology/pharmaceutical setting
  • (3+ years’ experience with a PhD; 5+ years’ experience with an MS degree; 8+ years’ experience with BS/BA degree); may also consider experience out of an academic/research setting
  • Strong team player who inspires colleagues to solve difficult problems and develop efficient workflows
  • Experience designing expression constructions for functional assays and crystallography
  • Proficient with molecular biology techniques including cloning
  • Expertise with a variety of protein expression systems including E. coli and Baculovirus infected insect cells
  • Expertise with protein purification techniques such as IMAC, SEC, IEX and affinity chromatography is required, ideally utilizing the AKTA FPLC systems
  • Expertise with protein characterization techniques such as LCMS, western blotting, and thermal stability assays, is desirable.
  • Familiarity with biophysical and functional techniques such as SPR, ASMS, fluorescent binding assays, and enzyme kinetic assays is beneficial
  • The candidate must be self-motivated but always maintain focus on why we are here and who is important i.e. the patients and their families/caregivers
  • Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels
  • Desire and ability to flex between protein expression/purification/characterization is a must
  • Highly organized with excellent analytical, documentation and multi-tasking skills

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Senior Scientist position level could range from between $89,750 to $131,672 and that the base salary for the Principal Scientist position level could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands/ Travel:
 
The physical demands of this job are consistent with light office duties.
 
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
 Work Environment:
 
This position’s work environment is in an office and the lab. 
 
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.


*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

Apply Now

Position:
Senior/Principal Computational Biologist, Team Lead (Multiple Locations)
Function:
Target Discovery
Location:
South San Francisco, CA
Position Summary:
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

We are seeking a talented and highly motivated experienced Computational Biologist to join our Discovery Bioinformatics group. The candidate will lead bioinformatics efforts across multi-disciplinary teams to rapidly advance small molecule drug development efforts. This position is expected to lead and oversee broader strategic involvement in shaping the next generation of cancer therapies through data-driven approaches.
Roles and Responsibilities of the Position:
  • The successful candidate will join a dynamic team and oversee computational biology efforts across multiple functions. They will be expected to lead a team, supervise and develop scientists, and help build a research strategy that leverages deep cancer biology knowledge and high-dimensional data. Success critically depends on the ability to effectively present complex analyses and results in a clear and concise manner to a diverse audience of scientists.
Required Qualifications and Preferred Background:
  • PhD in Bioinformatics, Biostatistics, Computational Biology, or similar area of study required. Post-doctoral training or equivalent prior work experience (3-5+ years)
  • Substantial publication record and/or similar achievements
  • Demonstrated track record of strategic scientific leadership in the computational biology field with leading and developing scientists.
  • Strong understanding of relevant concepts in cancer biology and molecular biology
  • Experience in large-scale data analyses involving high-throughput molecular assays such as DNA/RNA-Seq, ATAC/CHiP-Seq, single-cell technologies, etc.
  • Understanding of current best-practices for high-throughput genomics/molecular data analyses and familiarity of their underlying statistical principles
  • Experience using programming languages such as R, Python, or similar for statistical analysis

    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Senior Scientist position level could range from between $89,750 to $131,672 and that the base salary for the Principal Scientist position level could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Available Locations for this role
  • South South Francisco, CA
  • New York City, NY
  • US Based-Remote

Physical Demands / Travel:

The physical demands of this job are consistent with light office duties.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in an office.  

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.



*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
 
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).  
 
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance.  Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
 

Apply Now

Position:
Outstanding Team Member
Reporting To:
Dedicated, Knowledgeable Supervisor
Location:
United States and Beyond
Position Summary

Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by that goal. We pursue this goal with a tenacity, focus and commitment to excellence that defines who we are and how we work.

We seek dedicated, passionate, hardworking intelligent, thoughtful and authentic individuals who thrive within a collaborative and fast-paced environment and will bring their experiences, unique perspectives and problem-solving skills to the team. In return, we cultivate an environment that rewards and recognizes hard work and provides opportunities for learning and growth as part of a team making a meaningful difference in the field of medicine and for individual patients.

If you share our passion, please let us know how you could contribute to our team. We don't want to pass up an opportunity for the right candidate to join us just because you found us before we found you.

Connect With Us

Submit your resume and your "Who", "What" and "Why" (see below) to careers@loxooncology.com.

Your "Who", "What" and "Why":

  • Who are you?
  • What will you bring to Loxo?
  • Why do we need you on the team?

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

For more information about Loxo Oncology’s privacy practice, please view the Privacy Statement.