Career Opportunities

Roles and Responsibilities of the Position:

• Represents Data Management for one (or more) clinical programs from a strategic planning and execution capacity in program team meetings and development strategy meetings
• Oversees the creation and execution of data management timelines used to coordinate and synchronize deliverables with the overall study timelines
• Evaluate and design DM processes for study execution, data delivery management as well as for initiatives which require cross functional collaboration
• Manage team within DM group for specific program including day to day operations, resource allocation for study, and career track development
• Participate in study vendor FRP/bid process for all vendors as required
• Evaluate and engage CRO/service providers for all studies and relationships as required
• Monitors the progress of all data management activities on all studies to ensure project timelines are met
• Proactively identifies potential program and delivery issues/risks and recommends/ implements solutions
• Collaborate with Statisticians and Statistical Programmers in production of clinical trial reports and other deliverables
• Performs any and all other tasks and activities as requested by CDO

Required Qualifications and Preferred Background:

• Bachelor’s degree in life sciences, math, computer science or related field required. Master’s degree in life sciences, math, computer science or related field preferred
• Minimum of 12+ years’ clinical data management experience
• Demonstrated leadership, line management and project management skills
• Oncology/Hematology experience strongly preferred
• Prior experience with biostatistics and SAS programming preferred
• Thorough and broad knowledge of data management processes, including EDC and interactive voice response system (IVRS)experience.
• Knowledge of regulatory guidelines such as GCP, 21 CFR Part 11 etc.
• Knowledge of study data tabulation model (SDTM)
• Must have excellent verbal, written and communication skills
• Ability to work independently as well as in a team environment
• Excellent time management skills and a proven ability to work on multiple projects at any given time in a fast-paced environment.
• Demonstrated ability to stay abreast of trends and new information in the profession


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Associate Director level position could range from between $135,300 to $198,516 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.

Available locations for this role:

• South San Francisco, CA
• Stamford, CT
• US Remote-Based

Roles and Responsibilities of the Position:

• Lead Biologics project management group ensuring leadership, coaching, and mentoring (with direct oversight and hands on implementation) adapted to Loxo’s dynamic, start-up, discovery-tuned environment
• Liaise between Biologics’ leadership management and cross functional project teams ensuring continuous alignment between program strategies and implementation of the strategies
• Direct oversight in managing project management resources and accountable for ensuring that the existing project management structure (PMO framework) is implemented and extended to support the needs for the expanded program portfolio
• Actively involved (hands on leadership with project managers) in project initiation, planning, execution, monitoring, and closing of all programs in the portfolio
• Actively manage Biologics’ portfolio budget
• Proficient in managing resource allocation and application of risk management across the portfolio
• Actively manage communication plans for all programs outlining clearly determined escalation path aligning with stakeholder management requirements. Maintain transparency with strategic partners and stakeholders in all communications
• Actively facilitate in creating progress reports, PowerPoint slide presentations, and present them to Biologics’ and extended Loxo leadership for Biologics programs
• Provide support in due diligence efforts for in-license and out-license evaluation
• Lead in overseeing and actively engage in day-to-day operational activities involving with other functional groups (Business Operations – procurement, finance, accounting etc.). Ensure all external collaborations (suppliers, CRO’s and vendors) and alliances with strategic partners within and outside the company are appropriately managed
• Coordinate with CMC and other relevant functional groups to successfully transition programs from preclinical to clinical stage.
• Adaptive to change in priorities and able to drive program outcomes ensuring re-alignment with program strategies in changing landscape
• Proficient in strategic and adaptive communications. Able to effectively communicate and navigate through technical and non-technical audiences across cross-functional departments within the company and external collaborators
• Adept in seeing high-level overview and granular details of a program and able to steer between both sides
• Demonstrate “team spirit” through day to day actions and actively contributes to team development
• Foster “growth mindset” and “can do” attitude
• Demonstrate exceptional problem-solving skills      

Required Qualifications and Preferred Background:

• 8+ years of project management experience in leading project management roles in Biotech and pharmaceutical research and discovery set up
• Bachelor’s degree in relevant scientific field (e.g., Biology) required; advanced degree strongly preferred
• PMP certification required

Additional Preferences:

• Proven success in building, managing, and mentoring cross-functional teams in a dynamic environment from ground up to meet end goals of business
• Possess sound knowledge in Biologics drug discovery and development process starting with target identification, early-stage antibody discovery through preclinical stage, and apply them effectively in managing discovery research projects
• Demonstrate business acumen and demonstrate excellence in facilitating key strategic decisions in support of broader business goals and objectives
• Navigate clearly between strategies and day-today operations
• Manage and balance both laterally and horizontally
• Proven success in managing suppliers, vendors, and strategic alliances
• Excellent verbal/written communication and interpersonal skills
• Expert in building positive, collaborative teams across various scientific disciplines and encouraging sharing of new ideas, and creative ways to solve problems often needed in discovery research
• Seasoned facilitator aligning people of diverse mindset to achieve common goals and objectives
• Mentor and coach Project Managers and team members to function optimally in a dynamic, cross-functional environment while maintaining alignment with strategic assets
• Excellent organizational skills adaptive to program requirements
• Proficient in identifying gaps in the existing processes and facilitate in creating framework and processes (including applying tools e.g., MS Office suite, MS Project. SmartSheet) aligning with the needs for effective project management


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Associate Director level position could range from between $135,300 to $198,516 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.

Additional Locations for this role:

• Remote
• South San Francisco, CA
• New York City, NY

Roles and Responsibilities for the Position:

• Oversee the proper and timely collection and reporting of AE information from all sources
• Assist in the preparation and management of aggregate safety reports (e.g. IND safety reports, DSURs, PSLLs etc.)
• Perform medical review of AEs/SAEs from clinical trials, interfacing with reporters as needed
• Provide support for safety sections of clinical documents, including the review and approval of the safety portion of protocols, ICFs, CSRs, IBs and other documents as needed
• Review of protocols, case report forms, guidelines, CSRs and manuscripts as requested
• Assist with the development and maintenance of pharmacovigilance related SOPs, policies and work instructions
• Create and track case processing metrics for internal monthly safety reports
• Contribute to regulatory authority submissions by reviewing safety data and assisting in the preparation of relevant sections
• Participate in regulatory and inspections/audits as it relates to pharmacovigilance activities
• Collaborate cross functionally with other departments including clinical, biostatistics, data management, clinical operations and regulatory affairs with respect to safety related issues
• Liaise to provide drug safety oversight of processes overseen by vendors
• Participate in addressing drug safety-related questions from Regulators or to support Company internally
• Mentor and train junior team members
• May have direct reports

Required Qualifications and Preferred Background:

• Health science degree: Nursing (RN, BSN, MSN or NP),  RPH, PharmD, PA or MD
• Minimum of 7 years of experience in the pharmaceutical industry or CRO, with 5 years in drug safety, pharmacovigilance and risk assessment or relevant experience
• Experience in the management of safety information originating from clinical trials and post-marketing sources
• Experience in Hematology/Oncology desired
• Experience and working knowledge of Good Pharmacovigilance Practices (GPvP)required
• Knowledge of U.S. and International Regulatory Reporting Requirements for Product Safety, and of the clinical development process.
• Working knowledge of relevant regulations and guidance documents governing both safety reporting and processing for both clinical trial and post-marketing environments
• Ability to interpret scientific and clinical trial data
• Strong verbal and written communications and presentation skills
• Proven problem solving, decision-making and interpersonal skills
• Detailed knowledge of drug safety databases
• Expertise working with MedDRA
• Possess strong leadership skills and the ability to compile and disseminate information to others in a cohesive fashion to assure a clear understanding of project status and direction
• Proficiency in MS Office Suite
• Strong ability to prioritize tasks and keen attention to detail
• Ability to be both enterprising and resourceful
• Proven ability to work on multiple projects in a fast-paced environment


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Associate Director level position could range from between $135,300 to $198,516 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.

Available Locations

• South San Francisco, CA
• Remote (US Based only)

Roles and Responsibilities of the Position:

• Evaluate new targets for potential toxicological liabilities
• Create novel experimental designs for mechanistic toxicology studies, including DMPK considerations, designed to assess hypotheses for and evaluate mechanisms of toxicity related to physiological or biochemical functions
• Support predictive toxicology experimental efforts within Discovery (e.g., in vitro cell-culture based, animal models of disease) analyze safety-related data and use it to make decisions
• Develop early safety assessment and ensure appropriate toxicology studies and liability screens are performed to support nomination of drug candidates for further development
• Communicate results clearly and concisely in both oral and written reports and presentations
• Perform in depth pathway/network analysis on data derived from toxicology and other studies and disseminate results to the wider toxicology community (internally and externally)
• Closely interact with scientists in other functional areas

Required Qualifications and Preferred Background:

• Ph.D. in toxicology required, along with 10+ years’ experience as a toxicologist within the biopharmaceutical industry. Board certification in Toxicology strongly preferred
• Previous large molecule development experience and/or oncology therapeutic product development experience in a pharmaceutical or biotechnology company is preferred
• Familiarity with GLP regulations and regulatory guidelines for the testing of biopharmaceutical products and experience with compilation of toxicology information into various regulatory submission documents is desirable
• Demonstrated ability to work well with other accomplished professionals within and across functions/teams. Willing collaborator.
• Strong written and oral communication skills
• Ability to multi-task and shift priorities rapidly to meet tight deadlines
• Excellent written and verbal communicator
• Detail oriented and well organized
• Good and thoughtful listener
• Enthusiastic, self-motivated and keen to improve processes and overcome inefficiencies
• Proficient in Microsoft Office suite and applications


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Associate Director level position could range from between $135,300 to $198,516 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.

Roles and Responsibilities of the Position:

• Collaborate with the relevant functional groups, legal, and finance teams to draft, negotiate and manage contracts to support Toxicology, Biomarkers, Human Resources, IT, Hospitality/T&E, and consulting needs
• Identify and mitigate business risks throughout the contracting process
• Manage other contracts experts and address their questions/concerns as they arise

Required Qualifications and Preferred Background:

• Bachelor’s degree; MBA preferred
• Scientific background preferred
• 10+ years of business development/contract negotiation experience, preferably in a BioPharma or Diagnostics setting
• Strong contract drafting, review and analysis skills across a variety of contracts, including Master Service Agreements, Statements of Work, and Consulting Agreements
• Ability to communicate and negotiate efficiently and effectively
• Ability to manage and meet strict deadlines, work independently, and multi-task
• Excellent attention to detail
• Collaborative mindset
• MS Office skills (Outlook, Word, Excel, PowerPoint)


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position level could range from between $135,300 to $198,516 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Available locations for this role:

• US Based-Remote
• Stamford, CT
• South San Francisco, CA
• Indianapolis, IN

Roles and Responsibilities of the Position:

• Manage the outsourced EDC programming function and the support model for all active EDC databases, by providing consistent team direction, guidance, and monitoring of quality of work through robust vendor governance, audits, quality plans, and oversight of key performance metrics
• Manage the personnel resources, workload allocation, career development and compensation for all FTEs within their group.  Planning horizon is typically up to 12 months
• Develop the infrastructure, people, standard processes, and tools to build out the EDC programming capability within the department, in coordination with CDM leadership
• Develop the outsourcing strategy, resources, and standard processes to manage the clinical programming function for the department, in coordination with CDM leadership
• Develop partnerships and collaborations with key cross functional teams, such as Information Technology, Quality Assurance, Clinical Operations, Biostatistics and Statistical Programming
• Support and lead the development of standards implementation activities for both internal data management as well as cross functional projects.  Provide oversight for the maintenance and governance of the standards library
• Support the evaluation and selection of future CDM systems infrastructure and solutions, including programming and data visualization tools, eSAE, and clinical data repository/data lake solutions to support standardized data review and data cleaning goals. Planning horizon is typically 6-36 months
• Sponsor the evaluation, prioritization and execution of department projects and initiatives related to CDMS and Clinical Programming.
• Evaluate and support the development of CDM processes for study start up, execution, and data delivery. Reviews and approves all new processes and templates impacting their area/s of oversight
• Represents Data Management from a technology planning and execution capacity in development and/or strategic meetings
• Sustain and grow industry knowledge with regards to innovations in trial execution best practices, database technology, and information delivery to key stakeholders (analytics, dashboards, metrics, etc.)
• Evaluate innovative technologies, as appropriate
• Perform all other tasks or activities as requested

Required Qualifications and Preferred Background:

• Bachelor’s degree in life sciences, math, computer science or related field required. Master’s degree in life sciences, math, computer science or related field preferred.
• Minimum of 10 years’ clinical data management/clinical programming experience and at least 6 years of managerial experience  supervising direct reports in the biotech, pharmaceutical, medical device or CRO industry, in all phases of drug development.
• 8 years of experience leading CDM technical project teams is also acceptable in lieu of 6 years of direct report management.
• Prior experience implementing EDC system infrastructure, as well as developing the teams, operating procedures, and continuous process improvement mechanisms to support the system.
• Demonstrated leadership and project management skills.
• Working knowledge of common industry data programming software and applications (e.g. SAS, BI / analytics tools, EDC Programming) required.
• Oncology experience required.
• Thorough and broad knowledge of data management processes, including EDC and interactive voice response system (IxRS).
• Knowledge of regulatory guidelines such as GCP, 21 CFR Part 11 etc.
• Knowledge of data standards (CDISC, CDASH, SDTM) in the clinical environment.
• Must have excellent verbal and written communication skills.
• Ability to work independently as well as in a team environment.
• Excellent time management skills and a proven ability to work on multiple projects at any given time in a demanding environment.
• Demonstrated ability to stay abreast of trends and the latest information in the profession.


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Associate Director/Director level position could range from between $135,300 to $198,516 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Roles and Responsibilities for the Position:

• The successful candidate will join a dynamic team and oversee computational biology efforts at the intersection of discovery, translational, and clinical research.
• They will lead a team, develop scientists, and help build a research strategy that leverages deep cancer biology knowledge and high-dimensional data.
• Success critically depends on the ability to foster a team to execute and communicate the broader computational biology vision and strategy.

Required Qualifications and Preferred Background:

• PhD in Bioinformatics, Biostatistics, Computational Biology, or similar area of study required with a minimum of 8 years of experience in computational biology, bioinformatics, and/or cancer biology
• Demonstrated track record of strategic scientific leadership leveraging computational biology to drive discovery in the clinical and pre-clinical settings
• Strong understanding of relevant concepts in cancer biology, drug development, and current therapeutic landscape in oncology
• Knowledge of current best-practices for high-throughput genomics/molecular data analyses and familiarity of their underlying statistical principles
• Excellent communication and interpersonal skills 


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position level could range from between $135,300 to $198,516 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Additional Locations for the Position:

• South San Francisco, CA
• Alexandria Center, NY

Roles and Responsibilities of the Position:

• Work with discovery, translational medicine, biologics, biomarker, toxicology, and/or CMC teams as well as legal and finance teams to help draft, negotiate and manage contracts and related amendments in support of drug development and related discovery pipeline needs
• Identify and mitigate business risks throughout the contracting process
• Help manage projects resulting from these contracts, including working with project managers and finance to track results as well as financial and resource obligations

Required Qualifications and Preferred Background:

• Bachelor’s Degree in Science related discipline required
• 3+years of business development/vendor management experience, preferably in a biotechnology or pharmaceutical setting
• Ability to communicate efficiently and effectively
• Ability to manage and meet strict deadlines, work independently, and multi-task
• Excellent attention to detail and critical thinking skills


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Associate Manager level position could range from between $78,000 to $114,498 and that the base salary for the Specialist level position could range from $67,850 and $99,563 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.

Roles and Responsibilities of the Position:

• 
  
Work closely with Loxo@Lilly QA, CMC, Regulatory, Drug Supply, and CMO colleagues through all phases of drug development, particularly early phase to ensure compliance and timeliness of GMP work, including:
• Batch record review (Executed and Master) for all phases of manufacturing (drug substance, drug product, packaging, labeling, and associated intermediates)
• Final disposition of finished product for clinical use, including country-specific release and collaboration with Qualified Persons (QPs)
• Authoring and review of deviations, CAPAs, and change controls
• Investigation of product complaints
• Quality review of analytical documentation including: analytical methods; validation protocols and reports; specifications; and stability protocols, reports, and expiry extensions
• QC of IMPD/IND CMC sections
• Review and approval of clinical product labels
• Authoring/ revision of SOPs
• Leading process improvements
• Ensuring that GMP work at Loxo and contract organizations is done in compliance with applicable laws, regulations, guidelines, and SOPs.
• Participation on project teams and sub-teams as needed and assigned
• Additional tasks as required

Required Qualifications and Preferred Background:

• BA/BS in science or engineering 
• A minimum of 8 years of experience in Quality Assurance in an FDA regulated Biotech or Pharmaceutical setting
• Experience in Batch Review and Release for clinical phase products
• Experience authoring and reviewing Deviations, CAPAs, and Change Controls
• Experience working with solid oral dosage products and/or Biologics
• Working knowledge of cGMP’s (CFR/ICH) and applicable international regulations/guidelines
• Experience working with Contract Manufacturing Organizations
• Strong understanding of GMP requirements for early phase drug development
• Attention to detail and accuracy of work
• Ability to work in a fast-paced environment to meet tight deadlines
• Ability to problem solve and lead process improvements
• Ability to lead cross-functional meetings and make decisions as a QA representative
• Ability to escalate issues when necessary
• Ability to work in a cross-functional environment
• Ability to work in a virtual manufacturing environment
• Demonstrated ability to work well with other accomplished professionals
• Willing collaborator
• Strong communication skills, both written and oral


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the {insert position} level position could range from between $78,000 to $114,498 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.

Roles and Responsibilities of the Position:

• Provide recombinant protein expression expertise to deliver proteins central to research activities for small molecule discovery.
• Evaluate small-scale expression and solubility for recombinant proteins expressed in E. coli
• Conduct experiments using E. coli expression to produce biomasses (6-10L) of various constructs in parallel
• Work closely with protein purification colleagues to understand the quality of proteins required for functional and biophysical assays
• Execute projects in an efficient manner, working with aggressive timelines
• Values quality over quantity, with the ability to prioritize
• Rapidly communicate scientific results and insights to the team
• Prepare reports for internal and external purposes including regulatory submissions
• Participate in project and team meetings to identify and solve problems, communicate on-going work and progress, and plan next experiments
• Continually advance your understanding of current methodology and emerging technologies by reading scientific literature
• Proactively investigate new or different technologies, methods to ensure our work is being done in a scientifically sound, and efficient

Required Qualifications and Preferred Background:

• BA/BS/MS in protein sciences, biology, biochemistry, molecular biology, life sciences or a related field
• Preference will be given to candidates with hands-on experience, working in a laboratory in a biotechnology/pharmaceutical/academic setting
• Experience or familiarity with molecular biology techniques including cloning for expression constructs is required
• Expertise with a variety of protein expression systems including E. coli and Baculovirus infected insect cells is preferable
• Demonstrated ability in tissue culture techniques
• Strong team player who inspires colleagues to solve difficult problems and develop efficient workflows
• Familiarity with protein purification techniques such as IMAC, SEC, IEX and affinity chromatography is beneficial
• The candidate must be self-motivated but always maintain focus on why we are here and who is important i.e. the patients and their families/caregivers
• Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels
• Desire and ability to learn a variety of expression and small-scale purification techniques
• Highly organized with excellent analytical, documentation and multi-tasking skills


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Associate Scientist level position could range from between $59,000 to $86,577 and for the Senior Associate Scientist level position could range from between $67,850  to $99,563 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.

Roles and Responsibilities of the Position

• Construct knockout and expression vectors using mammalian plasmid and lentiviral, adenoviral, or retroviral systems. Viral titer measurement, and viral stock maintenance.
• Generate engineered stable cell lines using transfection, CRISPR/Cas9 tools, lentiviral transduction, etc.
• Optimize cell line development platforms to improve speed and reproducibility of cell line development
• Perform routine molecular and cell biology techniques like DNA/RNA/protein extraction, qPCR analysis, western blot analysis, fluorescent microscopy and so on.
• Maintain cultures of frequently used suspension and adherent cell lines.
• Deposit and archive cell lines in the company’s repository cell line bank.
• Keep detailed and accurate laboratory records, present results at group meetings and project team meetings

Required Qualifications and Preferred Background

• BA/BS/MS/PhD in biology, cell biology, molecular biology or a related field
and 2+ years recent experience working with mammalian cell culture in industry, academic or research setting
• Basic tissue culture techniques such as cell propagation, cryo- preservation, maintenance and so on
• Prior cell culture experience with immortalized cell lines, cancer cell lines and/or primary cells
• Experience creating stable cell lines, transient transfections, viral transductions
• Experience with performing qPCR, ELISA, western blot, flow cytometry, and cell sorting, all in the context of mammalian cells. Fluorescent microscopy experience would be a plus.
• Experience in RNAi, CRISPR, and chemical inhibition of cellular pathways
• Prior experience with various analytical reagents such as Calcein AM, Cell Titer Glo, Alamar Blue, Annexin, PI/7AAD, and immunofluorescent antibodies
• A high level of proficiency with many kinds of scientific software used to operate lab equipment and/or the ability to quickly master new software
• Experience and proficiency with data analysis using statistical software such as Excel, Prism, Spotfire or others
• Must be organized and efficient and able to work according to timelines.
• Pharma/biotech drug discovery experience a plus    

Available locations for this role

• Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Associate Scientist level position could range from between $59,00 to $86,577 and that the base salary for the Senior Associate Scientist level position could range from between $67,850 to to $99,563 and that the base salary for the Scientist level position could range from between $78,000 to $114,498 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.

Roles and Responsibilities of the Position

• Construct knockout and expression vectors using mammalian plasmid and lentiviral, adenoviral, or retroviral systems. Viral titer measurement, and viral stock maintenance.
• Generate engineered stable cell lines using transfection, CRISPR/Cas9 tools, lentiviral transduction, etc.
• Optimize cell line development platforms to improve speed and reproducibility of cell line development
• Perform routine molecular and cell biology techniques like DNA/RNA/protein extraction, qPCR analysis, western blot analysis, fluorescent microscopy and so on.
• Maintain cultures of frequently used suspension and adherent cell lines.
• Deposit and archive cell lines in the company’s repository cell line bank.
• Keep detailed and accurate laboratory records, present results at group meetings and project team meetings

Required Qualifications and Preferred Background

• BA/BS/MS/PhD in biology, cell biology, molecular biology or a related field
and 2+ years recent experience working with mammalian cell culture in industry, academic or research setting
• Basic tissue culture techniques such as cell propagation, cryo- preservation, maintenance and so on
• Prior cell culture experience with immortalized cell lines, cancer cell lines and/or primary cells
• Experience creating stable cell lines, transient transfections, viral transductions
• Experience with performing qPCR, ELISA, western blot, flow cytometry, and cell sorting, all in the context of mammalian cells. Fluorescent microscopy experience would be a plus.
• Experience in RNAi, CRISPR, and chemical inhibition of cellular pathways
• Prior experience with various analytical reagents such as Calcein AM, Cell Titer Glo, Alamar Blue, Annexin, PI/7AAD, and immunofluorescent antibodies
• A high level of proficiency with many kinds of scientific software used to operate lab equipment and/or the ability to quickly master new software
• Experience and proficiency with data analysis using statistical software such as Excel, Prism, Spotfire or others
• Must be organized and efficient and able to work according to timelines.
• Pharma/biotech drug discovery experience a plus    

• Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Associate Scientist level position could range from between $59,00 to $86,577 and that the base salary for the Senior Associate Scientist level position could range from between $67,850 to to $99,563 and that the base salary for the Scientist level position could range from between $78,000 to $114,498 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.

Roles and Responsibilities of the Position:

• Contribute to the execution of clinical trials, drive to solutions across a multi-functional study team
• Anticipate and resolve complex and key technical, operational or business problems with multi-functional study team; evaluate and determine issues that require escalation
• Use performance metrics and quality indicators to drive study execution
• Support Health Authority inspections and CQA audits as required, including driving inspection/audit readiness through life of study
• Collaborate with study team and/or CRO to ensure completeness & accuracy of the required data in study management tools including clinical trial management systems, patient enrollment forecasting, etc.
• Proactively identify potential risks and lead the development/implementation of actions to avoid or mitigate; identify points for escalation
• Collaborate with vendors and other study team members regarding study specific issues
• Lead and/or collaborate in the creation and review of study documents, including but not limited to the Protocol, Informed Consent Form (ICF) and other patient facing materials, case report forms, and clinical study reports. Manage completion of these deliverables to ensure timelines are upheld. Ensure study documents are updated as needed throughout the trial
• Plan site and country identification and selection in collaboration with internal partners
• As appropriate per vendor/scope of work, manage and/or participate in vendor selection, specification development and management/oversight
• Ensure management of the TMF set-up, ongoing quality review, and final reconciliation
• Liaise as needed with CRO and investigative sites to ensure clinical trial data is captured and resolved as required
• Contribute to data review/cleaning of clinical data as needed and as defined by study plans
• Manage the development/coordination of study training and study training materials for study team, investigational sites, and vendors
• Contribute to oversight of the required country regulatory (e.g. CTA, MoH) and country/site IRB/IEC submissions/approvals/notifications
• Ensure the collection of various study documents such as country/site insurance, CSR appendices, etc. is completed as needed

Required Qualifications and Preferred Background:

• BA/BS degree in a relevant discipline with 5+ years’ experience in clinical drug development required Oncology and/or Hematology experience preferred and/or Clinical Pharmacology/Healthy Volunteer experience preferred
• Experience in managing global clinical trials preferred
• Experience with managing clinical research budgets
• Knowledge of ICH/GCP and regulatory guidelines/directives
• Experience with managing a multi-functional team, including leadership skills and driving deliverables
• Demonstrates analytical approach and anticipation of problems
• Identifies gaps and provides constructive feedback and solutions
• Follows issues to resolution and escalates as appropriate
• Ability to multi-task effectively and prioritize assignments from multiple sources
• Excellent organizational skills
• Strong communication skills, both written and oral; proficiency in English
• Strong knowledge of MS applications including (but not limited to) MS Project, Word, Excel, PowerPoint
• Knowledge of study tools including electronic system skills such as CTMS/ EDC/ IRT/ eTMF
• Knowledge of drug development process. Proactively shares information, ideas, input, and/or expertise with team members Demonstrates concern for high quality outcomes
• Responds flexibly to changing business demands and opportunities, proactively looking for ways to contribute 

Roles and Responsibilities of the Position:

• The successful candidate will work in a face-paced and highly collaborative environment to tackle important questions in oncology drug development. They will employ the latest genomics and statistical approaches to interrogate these questions. Success critically depends on an ability to effectively present complex analyses and results in a clear and concise manner to a diverse audience of scientists.

Required Qualifications and Preferred Background:

• MS/PhD in Bioinformatics, Biostatistics, Computational Biology, or similar area of study. Alternatively, post-graduate training in high-dimensional data analyses, supported by scientific achievements (eg., publications, patents, etc), would also be considered equivalent
• Relevant experience must be supported by scientific accomplishments such as publications, scientific presentations, patents, etc.
• Strong understanding of relevant concepts in cancer biology and molecular biology
• Hands-on experience with data analysis involving high-throughput molecular assays such as DNA/RNA-Seq, ATAC/ChIP-Seq, single-cell technologies, etc.
• Understanding of current best-practices for high-throughput genomics/molecular data analyses and their underlying statistical principles
• Experience using programming languages such as R, Python, or similar for statistical analysis


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position could range from between $78,000 to $114,497 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Available Locations for this role:

• South South Francisco, CA
• New York City, NY
• US Based- Remote

Roles and Responsibilities of the Position:

• Interact and collaborate with various Discovery functional teams to design and execute studies supporting all projects across the oncology portfolio
• Work collaboratively with the clinical biomarker team to perform and support retrospective and exploratory efforts for clinical programs
• Provide quality data and analyses from a variety of high throughput, high content genomic, transcriptomic, and proteomic platforms
• Develop and implement sequencing applications related to cell free, single cell and FFPE sequencing
• Support existing and novel targeted panel development for NGS
• Responsible for establishing and updating lab SOPs and training lab scientists as needed
• Develop and implement novel molecular platforms and applications
• Work with the entire molecular characterization team to ensure all instrumentation is properly maintained and calibrated
• Provide scientific expertise on practical implementation of molecular platforms and applications across the entire Loxo organization
• Proper documentation and archiving of data and analyses.
• Work interactively with project teams and discovery informatics to interpret data and prepare formal study reports


Additional roles and responsibilities:
• Communicate results via written and oral presentations as needed
• Discuss results with technical as well as non-technical personnel
• Extensive cross functional communication and collaboration with internal and external parties
• Interrogate experimental conduct of third parties/vendors

Required Qualifications and Preferred Background:

• BS in biological sciences with 5 years of experience or MSc or PhD in biological sciences with 2-3 years of experience
• Broad experience with multiple nucleic acid and protein expression platforms, including assay design and development
• Experienced with high content, high throughput laboratory workflows with emphasis on quality and efficiency
• Demonstrated experience in working collaboratively across various scientific disciplines to meet project goals and timelines
• Flexibility to adjust priorities over time to meet organizational and scientific goals.
• Ability to work independently and as an integral part of a larger collaborative team.
• Demonstrated ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines
• Excellent interpersonal, written, and verbal communication skills
• Experience processing, analyzing, and interpreting large biological data sets

Roles and Responsibilities of the Position:

• Provide operational input on development, management and maintenance of study deliverables [i.e. timelines, study plans, documents, etc.] through collaboration with internal and external stakeholders
• Contribute to deliverables within study, drive to solutions across a multi-functional study team
• Anticipate and resolve key technical operational problems with multi-functional study team; evaluate and determine issues that require escalation
• Use performance metrics and quality indicators to assist with driving study execution
• Manage the monitoring visit report review process in order to maintain oversight of clinical monitoring quality and adherence to protocol and established processes and plans
• Support Health Authority inspections and CQA audits as required
• Ensure completeness & accuracy of the required data in study management tools including clinical trial management systems, patient enrollment forecasting, etc.
• Provide proactive identification of potential risks and development/implementation of actions to avoid or mitigate
• Develop and maintain collaborative relationships with internal and external partners/stakeholders including both vendors and investigational sites
• Collaborate with vendors and other study team members regarding study specific issues and follow through to resolution
• Assist in the creation and review of study documents, including but not limited to the Protocol, Informed Consent Form (ICF) and other patient facing materials and assist in updating these study documents as needed.  The CRA may have opportunities to lead creation/updates/review of study documents, as agreed upon with assigned Clinical Trial Manager or Clinical Operations leadership
• Participate in vendor specification development and management/oversight.  Vendor oversight activities may include responsibility for specific tasks associated with oversight (ie, review of monitoring visit reports generated by CRO) or may opportunities to lead the overall management of a specific vendor (ie, travel vendor), as agreed upon with assigned Clinical Trial Manager or Clinical Operations leadership
• Management of TMF set-up, ongoing quality review, and final reconciliation
• In conjunction with Drug Supply Management, manage shipment and reconciliation of Investigational Product (IP) at study and site level as needed
• Liaise as needed with CRO and investigative sites to ensure clinical trial data is captured and resolved as required.
• Contribute to data review/cleaning of clinical data as needed and as defined by study plans
• Actively contribute during study meetings including presenting as a subject matter expert as well as generating and distributing study team agendas and meeting minutes
• Contribute to development / coordination of study training and study training materials for study team, investigational sites, and vendors 
• Contribute to oversight of the required country regulatory (e.g. CTA, MoH) and country/site IRB/IEC submissions/approvals/notifications
• Assist with the collection of various study documents such as country/site insurance, CSR appendices, etc.
• Assist with Investigator Meeting coordination and planning

Required Qualifications and Preferred Background:

• BA/BS Degree in a relevant discipline with 2-4 years’ experience in the clinical trial environment required (inclusive of site level or other relevant experience) for Clinical Research Associate level; direct sponsor and/or CRO experience or 5+ years relevant non-sponsor or CRO experience required for Senior CRA level
• Knowledge of ICH/GCP and regulatory guidelines/directives
• Demonstrates analytical approach and anticipation of problems
• Identifies gaps and provides constructive feedback and solutions
• Ability to multi-task effectively and prioritize assignments from multiple sources.
• Excellent organizational skills
• Strong communication skills, both written and oral; proficiency in English
• Strong knowledge of MS applications including (but not limited to) MS Project, Word, Excel, PowerPoint
• Knowledge of study tools including electronic system skills such as CTMS/ EDC/ IRT/ eTMF
• Knowledge of drug development process. Proactively shares information, ideas, input, and/or expertise with team members Demonstrates concern for high quality outcomes
• Responds flexibly to changing business demands and opportunities, proactively looking for ways to contribute 

Available locations for this role:

• Stamford, CT
• South San Francisco, CA
• Indianapolis, IN
• US Based-Remote

Roles and Responsibilities of the Position

• Work in a team environment to drive and manage analytical development activities primarily at third-party partners including analytical method implementation, qualification/validation, and transfer for assigned drug substance and drug product projects
• Develop release/stability and characterization for assigned products/projects
• Manage product characterization and analytical comparability assessment activities
• Author and review analytical documents including but not limited to protocols, report and procedures
• Write and review analytical sections in regulatory submission documents (e.g., IND, IMPD, BLA)
• Manage, review, and analyze stability programs for assigned product/projects
• Serve as a technical expert and aid in analytical investigations and assay trouble shooting
• Key member of the interdisciplinary CMC project teams

Required Qualifications and Background

• BS degree required. Prefer candidates with a Master’s and/or PhD in Biochemistry
• Minimum of ten (10) years of experience working in a Biotech or Pharmaceutical FDA regulated industry or an equivalent combination of education, training and/or experience from which comparable knowledge, skills and abilities have been attained
• Five (5) years of experience in mass spectrometry, chromatography (e.g., SEC, RP-HPLC, IEX), and capillary electrophoresis (e.g., iCIEF, CE-SDS) techniques for protein therapeutics
• Experience with structural characterization of both large and/or small molecules
• Experience in analytical method development and qualification/validation for GMP testing including cell-based assays
• Experience with antibodies (including bispecific), highly potent cytotoxic active pharmaceutical ingredients, and/or antibody-drug conjugates is desired
• Direct experience with managing outsourcing of assay development, stability, and quality control in support of CMC activities
• Experience managing and conducting stability programs, including real time, accelerated/forced degradation, and freeze thaw studies
• Knowledge of regulatory environment (ICH/FDA/EMA regulations) and experience with organizing and writing regulatory submissions
• Experience writing and presenting clearly on CMC topics
• Demonstrable ability to work proactively, independently, and tenaciously


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position could range from between $135,300 to $198,516 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Available Locations for the Position

• US Based Remote
• Louisville, Colorado

Roles and Responsibilities of the Position:

• Lead cross-functional teams that will be responsible for novel small and large molecule target discovery , and Validation including Discovery Biology team members in SSF and NYC
• Supervise and mentor PhD and non-PhD scientists engaged in target identification and validation to think deeply and work creatively while delivering excellent scientific results and insights to the project teams and their colleagues
• Develop and implement strategies that will enable Discovery Biology team members to continually advance internal drug development efforts through our discovery, clinical and research programs
• Innovate technologies and methods to advance our discovery projects
• Engage leaders across Loxo@Lilly to identify, credential, and advance new targets and serve as a liaison for the Discovery Biology team and the company at large
• Provide strategic input, in partnership with Discovery leadership, into computational and experimental validation for key new targets
• Contribute to due diligence evaluation of external opportunities, participate in KOL engagement around target programs, and help identify academic and industry partnerships and collaboration

Required Qualifications and Preferred Background:

• PhD in systems biology, molecular & cellular biology, chemical biology, or related field
• Minimum of 8-10 years research experience following post-doctoral training with prior experience in target discovery/credentialing and cancer biology in the biotech or pharma setting
• Extensive experience in areas of cancer biology and cancer genomics
• Demonstrated evidence for the ability to partner with computational biologists to leverage systems-scale datasets
• Expertise in designing and commissioning studies using a variety of research tools in cancer cell lines and murine models of cancer
• Experience in leading PhD level scientists
• Outstanding communication, writing, and presentation skills is a must
• Highly organized with excellent analytical, documentation and multi-tasking skills
• Provide strategic input to target identification and validation strategy to leadership team
• Ability to collaborate, lead, and influence others

Additional Preferred Qualifications:

• Experience with cell engineering, and ex vivo and in vivo models of cancer
• Experience with incorporating massively parallel genetic screening data in target identification and credentialing workflow (ie CRISPR screens)
• Experience with early clinical trial studies and the development and implementation of pharmacodynamic and patient selection biomarker assays
• Experience working with external CROs to optimize internal/external resources


• Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position level could range from between $135,300 to $198,516 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Additional Locations for this position:

• This position can be located in South San Francisco OR New York City

Roles and Responsibilities of the Position:

• Lead GMP QA Team and point person for GMP QA
• Responsible for oversight of release and disposition of drug substance and drug product for clinical use
• Negotiate Quality Agreements
• Support new business ventures from a GMP QA perspective
• Responsible for process improvement projects in GMP QA
• Support transition of products between Loxo and Lilly organizations
• Liaise with QPs for Batch release activities
• Interact and develop relationships with contract manufacturing organizations, internal Loxo departments, and Lilly Quality departments
• Oversight of review and approval of product specifications, product labeling, master batch records, deviations and CAPAs, etc.
• Update Quality SOPs in support of Loxo GMP Quality
• Ensure compliance with corporate policies and procedures as well as health authority laws and regulations
• Support regulatory inspections of Sponsor and contract organizations
• Provide reviews of regulatory dossiers (IND, IMPD, NDA)
• Mentor junior Quality team members and act as a back up to the Vice President

Required Qualifications and Preferred Background:

• Minimum BS, master’s degree or PhD with focus in Chemistry, Life Sciences, Engineering or similar technical field
• 10+ years current work experience in pharmaceutical industry Quality Assurance required
• Knowledge of CMC and analytical laboratories in small molecules and Biologics
• Experience in working in all phases of drug development (Phase 1 through commercial)
• Working knowledge of ex-US batch release requirements (i.e., Qualified Person requirements)
• Solid and demonstrable knowledge of international GMP regulations and guidelines, and industry practices
• Expert knowledge in Quality systems
• Experience supporting regulatory inspections
• Strong organization and time management skills
• Attention to detail with an ability to perform critical review of various types of documents
• Outstanding written and verbal skills
• Demonstrated ability to work well with other accomplished professionals within and across functions/teams. Willing collaborator.
• Strong written and oral communication skills
• Ability to multi-task and shift priorities rapidly to meet tight deadlines
• Detail oriented and well organized
• Good and thoughtful listener
• Critical thinker and solution oriented
• Enthusiastic, self-motivated, self-starter, and keen to improve processes and overcome inefficiencies
• Proficient in Microsoft Office suite and applications


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position level could range from between $135,300 to $198,500 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus(depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Available locations for this role:

• Stamford, CT
• South San Francisco, CA
• Louisville, CO
• Indianapolis, IN

*Roles and Responsibilities of the Position:

• Enable Strategy for Assigned Asset(s) 
• Lead the development of the molecule/platform strategy, leveraging quality decision making principles
• Accountable for ensuring alignment of strategy with the approved scope (indications, resources, etc.)
• Accountable for obtaining alignment with Loxo Senior Leadership on the timing of and data package that will support Commercial Decision for the assigned asset
• Accountable for obtaining alignment with Loxo Senior Leadership to determine appropriate transition timing for the assigned asset from early phase to late phase and ensuring appropriate transition plan in place
• Lead the alignment between molecule/platform strategy and implementation.
• Ensure there is a change management process in place on the team to manage scope
• Understand and incorporate the concepts of portfolio management, where appropriate, to the assigned molecule


• Integrated plan development for Assigned Asset(s) 
• Lead creation of a global plan that articulates the strategy for the molecule/platform and provides the foundation for operational objectives (Clinical Plan, CM&C development Plan, Regulatory Plan, R&D Capacity Plan, Intellectual Property Plan, Commercial/PRA Plan and Publication Strategy/Plan).
• Provide or drive immediate and accurate communication of key decisions/results that have team, asset, and/or organizational impact.  Work with Loxo CEO, Loxo communications lead and Lilly Investor Relations to manage communication about the asset outside of the company.
• Portfolio Alignment: Lead delivery of a plan that is in alignment with Loxo priorities and the approved molecule/indication scope.
• Cost Management: Drive development of an integrated project budget always keeping a minimum of eight quarters in planning horizon.
• Risk Management: Owns risk management strategy and plan for the team. 
• Obtain required approvals for the molecule/platform plan.


• Deliver Results for Assigned Asset(s)
• Accountable for delivery of project milestones with quality, on time, on budget, and within scope.
• Lead the team to meet or exceed overall project goals (completion of clinical studies, submission and approval timing, publications, etc.)
• Accountable for delivery of high quality, timely, data driven decisions.
• Accountable for ensuring that cost, timeline, scope, and risk management processes are in place on the team to monitor and control performance of the overall project that utilizes appropriate tools and techniques (Prism, budget: plan vs actual, change control, etc.). 
• Hold functions accountable for achievement of key project deliverables in alignment with the agreed to project plan and in compliance with Loxo quality standards.
• Deliver cross-functional results through people utilizing project management, influence and communication skills rather than direct or positional authority.


• Contribution to Project Management Excellence 
• Accountable for the implementation, application, and integration of standard project management processes and tools including but not limited to the development, monitor, and control of integrated scope, timelines, budgets, risk management plans, and communication plans to all assigned asset(s).
• Accountable for ensuring project management tools and techniques and the data they generate are used to manage the assigned asset(s).
• Key resource for shared learning, process improvement, and Loxo and Lilly integration (in coordination with the Loxo Integration Leader)
• Drive retrospective project/process review meetings (i.e., after action reviews) to identify issues and strengths and help capture learning.
• Mentor and coach to others in the development of project management skills and knowledge in drug development/drug discovery.
• Experts in integrated drug development, drug discovery and project management within and external to the department.
• Be a leader in the AOL community and actively mentor/partner with your peers.

*Required Qualifications and Preferred Background:

• Bachelor's Degree, preferably in a health-related, scientific or engineering field required.
• 15+ years of work experience in the pharmaceutical industry and/or drug development required.


• Additional/Preferred Qualifications:
• Advanced graduate degree (PhD, MPH, PharmD, etc)
• Previous experience with or knowledge of drug development processes in oncology
• Successful history of delivering drug development projects
• Excellent oral and written communication skills; able to communicate clearly and succinctly with team members and leadership
• Excellent problem-solving skills with ability to anticipate and recognize problems, diagnose root causes and take corrective action to prevent recurrence within the team
• Excellent self-management and organizational skills; able to manage workload, set personal and team priorities, and adjust as needed.  Must be able to manage working with a large number of different teams with varying styles, issues, complexity.
• Excellent interpersonal and teambuilding skills; able to develop effective teamwork between team members with diverse interpersonal styles; able to deliver effective coaching and feedback
• Excellent leadership, interpersonal and influence skills; Ability to provide leadership to others, to appropriately network across a wide variety of functional components, external vendors/partners.
• Excellent business acumen and ability to leverage business principles within the team while maintaining a corporate view of the portfolio.
• Flexibility to adjust quickly and effectively to frequent change and altered priorities
• Applied knowledge of project management tools and processes (e.g., management of integration, scope, time, cost, quality, human resources, communications, risk and procurement)
• Strong computer skills; skilled at using Word, Excel, PowerPoint, and Microsoft Project
• Practical experience performing project management for a cross-functional project
• In depth understanding of the drug discovery and development process
• Strong scientific background

Roles and Responsibilities of the Position:

• Primary responsibility for daily safety case review and will contribute to the design, analysis, interpretation, and reporting of safety findings within a program and will review and contribute to the content of protocols, Investigator Brochures, Clinical Study reports, regulatory submissions and responses, and other program documents
• Primary responsibility for reviewing safety data periodically and on an ongoing basis to ensure quality control (QC) as required by program needs   
• May participate in or lead review of protocol deviations (PD) which may impact patient safety as required by program needs
• May participate in, or lead safety development contributions to, due diligence or other business development activity.  As required by program needs, contributes in partnership with research colleagues to design and implement translational strategies
• Actively solicits opinion leader interactions related to the disease area(s); partners with Clinical leads, Commercial and other functions in these activities as required, consistent with corporate policies, to ensure that broad cross-functional perspectives are incorporated into Safety Development Plans and protocols as appropriate
• Stays abreast of professional information and technology through conferences, medical literature, and other available training, to augment expertise in the therapeutic and safety area. May represent Loxo at key external meetings
• Responsible for understanding the regulatory requirements related to the clinical studies and global drug development and accountable for complying with those requirements. May serve as a safety representative for key regulatory discussions
• Ensures adherence to Good Clinical Practices, pharmacovigilance standards, standard operating procedures, organization policies and to all other quality standards in conducting research

Required Qualifications and Preferred Background:

• MD, Board certified or eligible; PhD advantageous
• At least 2 years of oncology experience strongly preferred
• Ability to exercise judgment and address complex problems and create solutions for one or more projects
• Ability to develop collaborative working relationships with physicians, expert consultants, and contracted vendors
• Strong analytical mind and problem-solving skills, attention to detail, strong organizational skills, and ability to work independently and as part of a team
• Proven leadership skills and ability to bring out the best in others on a cross-functional global team. Must be able to lead through influence
• Proven ability to interact externally and internally to support a global scientific and business strategy
• Excellent English written and verbal communication skills. Strong document management skills, including proficiency with MS Word, EndNote, PowerPoint and Excel
• Demonstrated ability to work well with other accomplished professionals within and across functions/teams. Willing collaborator
• Strong communication skills both written and oral
• Ability to multi-task and shift priorities rapidly to meet tight deadlines
• Professional demeanor and appearance and an excellent written and verbal communicator
• Good and thoughtful listener
• Enthusiastic, self-motivated and keen to improve processes and overcome inefficiencies


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for this position could range from between $154,300 to $226,307 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Roles and Responsibilities of the Position:

• Provide administrative support including heavy calendar management and cross functional meeting coordination, travel and expense management, as well as other administrative tasks
• Answer non-routine correspondence and assemble highly confidential and sensitive information
• Assist with other special projects as needed, including assisting with external vendor coordination and support for Discovery programs/projects
• Coordinate and facilitate the use of conference rooms for team and vendor meetings
• Greet on-site visitors and work closely with the team to ensure meetings remain on schedule

Required Qualifications and Preferred Background:

• Minimum of 5+ years in a comparable Administrative Support role with a preference for experience within the Biotech or Pharma environment
• Positive, eager and helpful attitude
• Professional demeanor and excellent written and verbal communication skills
• Able to work within a fast-paced environment, adept at juggling multiple tasks and priorities and prioritizing independently
• Enthusiastic, self-motivated and keen to improve processes and overcome inefficiencies
• Effective collaborator with a variety of stakeholders, thoughtful listener and team player
• Able to maintain a calm, patient and “can-do” approach
• Conscientious, detail-oriented, well-organized and takes initiative to anticipate and address needs
• Able to bring a proactive and creative approach to problem solving
• Proficient in Microsoft Office suite and applications
• Please note: Post COVID, this role requires an on-site presence from 8:30am-5pm, Monday to Friday.

Roles and Responsibilities of the Position:

• Conducts Audits for which Loxo@Lilly is responsible (e.g.qualification and internal)
• Key activities include, but are not limited to: 
• Plan, execute, and monitor Loxo@Lilly qualification audits
• Plan and execute internal audits
• Support development of an audit schedule
• Support audits conducted of Loxo@Lilly by outside auditors
• Partner with Loxo@Lilly functional areas to support Health Authority audits
• Provide input in Quality Management review, which includes metric generation and data analysis.
• Support process improvement projects
• Perform other duties as assigned 

Required Qualifications and Preferred Background:

• Bachelor's Degree plus 8-10 years plus years relevant experience in the Biotech/Pharmaceutical industry
• Working knowledge of Microsoft 365 suite, Veeva, etc.
• Comprehensive working knowledge of GCPs, GLPs, GMPs, or CAP and CLIA requirements
• Strong working knowledge of global regulations and guidelines (e.g., FDA/EU and ICH) for early phase pharmaceutical development in both clinical trials execution, clinical/biomarker laboratories and nonclinical/preclinical work      
• Ability to adapt quickly to shifting needs and/or priorities
• Strong Project Management skills in order to manage projects at various stages and effectively multi-task
• Able to interface well with all levels of personnel
• Capacity to produce high quality results across multiple projects and demands, through effective prioritization, while working under short deadlines associated with a fast-paced dynamic scientific environment
• Excellent communications skills, both written and verbal
• Excellent teamwork, interpersonal skills and negotiation skills, both internally and externally
• Strategic thinker, open-minded and flexible to adopting new ideas
• Motivated, committed and self-managed
• Willingness to work in a dynamic and changing corporate environment
• Requires a flexible work schedule to accommodate program priorities and international activities as needed.
• Exceptional attention to detail


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the {insert position} level position could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.

Roles and Responsibilities of the Position:

• Negotiates and executes agreements and budgets including but not limited to: master agreements, clinical trial agreements, general services agreements and amendments
• Independently collaborates with clinical trial teams and other internal stakeholders, study start-up groups, investigational sites, and vendors to verify and develop budget, negotiate cost savings and ensure delivery of fully executed contracts in support of timely study start-up to meet departmental and organizational goal to meet departmental and organizational goals
• Evaluates potential investigator sites from a financial and historical study start-up time perspective for critical site feasibility and selection to provide input for investigator selection decisions
• Formulate request for proposals (RFP) for clinical services including bidding process and scope of work (SOW)
• Maintains proactive relationship with finance to ensure that all financial requirements are satisfied  
• Liaison between clinical service groups (SMO, CRO), legal and clinical trial teams for outsourced trials
• Provides a high level of negotiation expertise to resolve complex and “deal breaker” issues with external parties
• Meet regularly with Legal to review agreements and business decision issues.
• Aids in developing contracts concepts and techniques and solves complex contractual problems that require ingenuity, innovation, and creativity
• Independently collaborates cross functionally with Legal, Regulatory, Compliance, and Finance to negotiate contract wording changes

Required Qualifications and Preferred Background:

• BS degree in business administration, finance, science or related field or equivalent on the job experience may be considered; advanced degree a plus
• Minimum 5-7 years of experience in pharmaceutical services with 5 years of hands-on, vendor side clinical contract management; full life cycle management of vendor side clinical contracts including, but not limited to: requests for RFPs, budgeting, benchmarking, contract negotiations and management, change orders, etc.
• High degree of organizational, analytical, and team management skills
• Ability to handle complex budgets
• Computer literacy with document and spreadsheet applications
• Ability to work on complex, multi-faceted projects
• Proven negotiation skills and vast knowledge of clinical trial agreements 
• Demonstrated ability to work well with other accomplished professionals within and across functions/teams; Strong collaborator
• Strong communication skills both written and oral
• Ability to multi-task and shift priorities rapidly to meet tight deadlines
• Professional demeanor
• Detail oriented and well organized
• Good and thoughtful listener
• Enthusiastic, self-motivated and keen to improve processes and overcome any inefficiencies
• Proficient in Microsoft Office suite and applications


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Manager position level could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Available locations for this role:

• Remote
• South San Francisco, CA
• Stamford, CT

Roles and Responsibilities for the Position:

• Perform triage of incoming Serious Adverse Event (SAE) reports and consider assessments of seriousness, listedness, and causality, coordinate triage review with medical monitor   
• Review case narratives, including identifying relevant information from source documents and write/review queries when additional information needed 
• Review data entry of SAEs in safety database including MedDRA coding
• Coordinate medical monitor case review
• Assist with the management of case processing deadlines
• Assist in reconciliation between the safety and clinical databases for serious adverse events
• Compile safety information for aggregate safety reports and other safety related reports.
• Assist with ongoing safety surveillance
• Assist with compilation and updating of safety related spreadsheets including metrics and SUSAR submissions
• Review and update existing standard operating procedures (SOPs) and assist with creation of new SOPs for safety department as indicated  
• Provide oversight of work performed by a safety Contract Research Organization (CRO)
• Contributor of safety input in study documents including DSUR, ICF, study protocols

Required Qualifications and Preferred Background:

• RN, BSN or pharmacy degree with at least 3-5 years of industry experience in Clinical Trial Safety; industry experience from CRO or pharmaceutical/biotech setting will be considered
• Previous experience in Health care is strongly preferred
• Hands on experience with SAE case processing including narrative and analysis of similar event (AOSE) writing, and safety report generation
• Working knowledge of MedDRA and WHODrug and FDA safety regulations, ICH guidelines, and global safety regulations
• Hands on experience with global safety database(s); experience with Argus strongly preferred
• Demonstrated ability to work well with other accomplished professionals within and across functions/teams
• Willing collaborator with strong written and oral communication skills
• Ability to multi-task and shift priorities rapidly to meet tight deadlines
• Detail oriented and well organized
• Self-motivated and keen to improve processes and overcome inefficiencies
• Proficient in Microsoft Office suite and applications 


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Manager position level could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Available Locations for this Role

• Remote (US Based only)
• South San Francisco, CA

Roles and Responsibilities of the Position:

• Manage automation processes to support a variety of applications across the Bioassay Screening team, including application development, improvement, and optimization
• Interact and collaborate with Small Molecule Discovery and Bioassay scientists to design, establish, and maintain integrated biological methods and a lab automation infrastructure
• Develop, optimize, and validate custom automation protocols for various biochemical, molecular, and cell-based assays
• Ensure consistent and high-quality data outputs from a variety of high-throughput and high-content platforms
• Work with cross-functional personnel to develop and implement novel platforms and applications
• Provide automation expertise for practical implementation of various applications across the entire Loxo organization
• Train and support scientists on automation platforms and established SOPs, including hardware and software
• Work with the entire Bioassay team to ensure all instrumentation is properly maintained and calibrated on a regular basis
• Maintain proper documentation and archiving of data and analyses
• Communicate results via written and oral presentations as needed
• Discuss laboratory operational processes with technical as well as non-technical personnel
• Maintain good interactions with third parties/vendors on new developments and products

Required Qualifications and Preferred Background:

• BS/MS in biological sciences, computer science, engineering, or other relevant field with 5+ years of laboratory automation experience.
• Extensive knowledge and experience designing and supporting laboratory automation and liquid handling
• Experience with high-content, high-throughput laboratory workflows with emphasis on quality and efficiency
• Experience converting manual protocols into automated processes, process optimization, and workflow efficiencies on automated equipment
• High agility to learn new technologies, with an affinity for automation and high-end equipment
• Demonstrated experience in working collaboratively across various disciplines to meet project goals and timelines
• Flexibility to adjust priorities over time to meet organizational and scientific goals
• Ability to work independently and as an integral part of a larger collaborative team
• Demonstrated ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines
• Outstanding interpersonal, written, and verbal communication skills

Additional Preferred Preferred Qualifications:

• Experience with ECHO acoustic dispensers, HighRes PRIME liquid handling, and  lab automation scheduling software (e.g., Cellario) is highly preferred


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Manager level could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Roles and Responsibilities of the Position:

• Liaise across departments to proactively identify opportunities to streamline and strengthen GCP processes
• Serves as GCP SME in writing and revising SOPs
• Reviews and approves Quality Events and associated Corrective and Preventative Actions within a regulated Quality Management System
• Represents GCP expertise and acts as the QA point person on cross-functional clinical study teams
• Keeps current with global health authority laws and regulations; identifies gaps and implements process improvements resulting from new/revised regulations or guidance
• Reviews study team and regulatory documentation as requested (e.g., Data Management, Operations, Safety, Regulatory, etc.)
• Liaises audit requirements between clinical study teams and auditing group and follows up on audits with the auditee
• Utilizes the Loxo Quality Systems to manage Quality system elements
• Drives inspection readiness activities for project teams
• Supports external Health Authority inspections

Required Qualifications and Preferred Background:

• Bachelor’s degree with 5- 7 years’ experience working in either a clinical compliance or clinical quality group
• Must be a hands-on leader who can provide guidance and execute daily tasks
• Demonstrated Quality Management System experience (GCP specific QMS experience preferred)
• Demonstrated Issue Management and CAPA experience in a clinical environment
• Strong knowledge of global clinical trial regulations and guidelines
• Proficient in risk management principles
• Experience with FDA or other Regulatory Inspections of Investigator sites, Sponsors or CROs
• Self-motivated with the ability to work effectively in a dynamic environment with initiative and great organization skills
• Strong leadership with demonstrated ability to interface with senior leaders and different levels of the organization
• Ability to deal with ambiguity, creative and pragmatic approach to problem solving
• Ability to be adaptable and effectively manage multiple priorities with a sense of urgency
• Strong track record of project management, stakeholder management, collaboration skills and negotiation of complex situations
• Attention to detail and accuracy of work
• Demonstrated ability to work well with other accomplished professionals within and across functions/teams. Willing collaborator.
• Excellent interpersonal and communication skills (both written and oral)
• Works with a sense of urgency and has the ability to multi-task and shift priorities rapidly to meet tight deadlines
• Professional demeanor and appearance and a team player
• Detail oriented with analytical and problem-solving skills and well organized
• Good and thoughtful listener
• Critical thinker and solution oriented
• Enthusiastic, self-motivated and self-starter


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Manager position level could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Roles and Responsibilities of the Position:

• Support the policy and training implementation strategy of Lilly corporate and local policies.  This includes but is not limited to the areas of Ethics and Compliance, IT, Communications/Publications, Finance, Discovery/Clinical Development, and other functional areas across the company   
• Support the records retention program
• Work cross functionally with Lilly corporate policy owners, Learning and Development team members, Lilly Policy Committees and functional area to assess policies, perform gap assessments, and complete curriculum clean-up
• Work as part of the training team to develop an enterprise-wide training program that streamlines training across Loxo@Lilly functional areas (Ethics & Compliance, HR, QA, etc).  This includes but is not limited to developing “right sized” curricula for Loxo@Lilly, while ensuring all corporate and local requirements are being met, appropriate training is assigned to personnel and business risks are mitigated
• Apply Learning best practices to Loxo@Lilly's required trainings, ensuring all trainings are as user-friendly as possible
• Partner with SMEs to create and update trainings as appropriate, ensuring relevance to and alignment with Loxo@lilly culture
• Work on adhoc projects to support the business and streamline training business processes

Required Qualifications and Preferred Background:

• Bachelor’s degree required with 7-10 years’ experience working in the Biotech/Pharmaceutical industry
• Proven experience in training and policy strategy for complex/matrixed organizations and processes
• Experience working in Learning Management Systems (LMS) (e.g. SuccessFactors preferred)
• Demonstrated ability to work well with senior leaders and accomplished professionals within and across functions/companies.
• Ability to collaborate with various teams across the company at all levels of the organization and drive results while working with matrixed organization and SMEs throughout Loxo@Lilly, Lilly Corporate
• Experience working with records retention programs.
• Good project management skills and ability to drive execution of projects within projected timelines.
• Willing collaborator. Solution-oriented.
• Strong written and oral communication skills.
• Ability to multi-task and shift priorities rapidly to meet tight deadlines.
• Requires a flexible work schedule to accommodate program priorities and international activities as needed
• Excellent written and verbal communicator.
• Strategic thinker, open-minded and flexible to adopting new ideas.
• Motivated, committed and self-managed.
• Detail oriented and well organized.
• Good and thoughtful listener.
• Enthusiastic, self-motivated and keen to improve processes and overcome inefficiencies.
• Proficient in Microsoft Office suite and applications.
• Works with a sense of urgency
• Ability to switch gears and wear multiple hats
• Prior pharma/biotech oncology discovery & clinical development Training experience preferred, but not required


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Manager position level could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.

Available locations for this role:

• US based remote
• Stamford, CT
• South San Francisco, CA
• Indianapolis, IN

Roles and Responsibilities of the Position:

• Support Clinical Supply Management by contributing to various work streams with internal and external team members for the on-time delivery of clinical supplies across the oncology portfolio
• Update and maintain study supply plans including drug supply forecasts for manufacturing, packaging, and labeling operations
• Provide oversight of packaging and distribution collaboration partners including, but not limited to document review of packaging specifications, master, and executed batch records, distribution instructions and order processing and delivery.
• Provide on-going monitoring of inventory and expiration dates for assigned program/study. Ensures alignment with supply forecast and study/program requirements
• Manage global accountability tracking including destruction for assigned programs
• Support clinical label development process including creation of master label text, translations, and label proofs
• Review and provide input to documents including, but not limited to: pharmacy manuals, IMPDs, request for proposals, and IRT/IWRS specifications
• Participate on project teams and sub-teams as needed and assigned
• Track progress versus timelines and goal
• Ensure documents and records are kept in compliance with regulations and SOPs including the Trial Master File (TMF)

Required Qualifications and Preferred Background:

• BA/BS and 8+ years of experience working in a Biotech or Pharmaceutical FDA regulated industry in Clinical Supply Management or a related field or an equivalent combination of education, training and/or experience from which comparable knowledge, skills and abilities have been attained
• Solid understanding of pharmaceutical development, manufacturing, packaging, and labeling
• Eager to communicate and collaborate with team members across functions including but not limited to: clinical operations, CMC, regulatory affairs, and QA
• Working knowledge of cGMP’s (CFR/ICH) and GCP and applicable international regulations/guidelines
• Prefer experience working with third-party vendors and contractors, knowledge of QP requirements, and import/export.
• Global experience with phase 1-4 clinical trials
• Experience writing and presenting clearly on clinical supply topics
• Ability to work in a virtual environment


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Manager level position could range from between $103,200 to $151,423 and that the base salary for the Senior Manager level positions could range between $118,700 to $174,137 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.

Roles and Responsibilities of the Position:

• Represents Clinical Data Management at study team meetings with responsibility for operational execution of CDM activities.
• Executes and manages data management timelines to coordinate and synchronize deliverables with the overall study timelines.
• Generates and/or reviews/approves study documents (e.g. Data Management Plans, Case Report Forms, data transfer specifications, SAE and/or external data reconciliation plans, coding conventions, study protocols, UAT execution).
• Executes and/or distributes data management metrics, listings, and reports, as required.
• Escalate resource need to PL to meet the current study needs.
• Effectively apply knowledge of applicable internal, external and regulatory requirements/expectations (MHRA, FDA, ICH, GCP, PhRMA, Privacy, etc) to data collection and DM plans.
• Collaborate and oversee CRO/service providers on assigned studies.
• Executes/manages all data management activities on assigned studies to ensure project timelines are met.
• Continually seek means of improving processes to reduce cycle time and decrease work effort.
• Provides training on the CRF completion guidelines and EDC system at Investigator meetings and to internal or external team members, as needed.
• Proactively identifies potential study issues/risks and recommends/ implements solutions.
• Responsible for the accuracy and completeness of the clinical data collected during a clinical trial for all data deliverables.
• Provide DM support to Statisticians and Statistical Programmers in production of clinical trial reports and other deliverables.
• Work with partners to increase vendor/partner efficiencies.
• Performs any and all other tasks and activities as requested.

Required Qualifications and Preferred Background:

• Bachelor’s degree in life sciences, math, computer science or related field required.
• Minimum of 6+ years’ clinical data management experience.
• A minimum of 1+ years of direct sponsor experience required.
• Demonstrated leadership and project management skills.
• Thorough and broad knowledge of data management processes, including EDC and interactive voice response system (IVRS)experience.
• Demonstrated proficiency in MS Office (Outlook, MS Word, Excel, PowerPoint).
• Experience with web-based Electronic Data Capture (EDC), clinical data management systems and industry wide thesauri, such as MedDRA and WHO Drug.
• Good working knowledge of regulatory guidelines such as GCP, 21 CFR Part 11 etc.
• Knowledge of industry standards (CDISC, SDTM, ADaM, CDASH).
• Excellent verbal, written and interpersonal skills required for working successfully in a cross-functional team environment.
• Able to communicate and collaborate effectively with cross-functional teams in face-to-face conversation, by telephone and by email.
• Proven ability to work independently as well as in a team environment.
• Excellent time management skills and a proven ability to work on multiple projects at any given time in a fast-paced environment.
• Demonstrated ability to stay abreast of trends and new information in the profession.
• Excellent verbal/written and interpersonal skills required for working successfully in a cross-functional team environment.
• Able to communicate and collaborate effectively with cross-functional teams in face-to-face conversation, by telephone, and by email.


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Manager position level could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.

Additional Preferred Qualifications:

• 5+ years prior oncology/hematology experience highly desirable.
• Recent Phase 3 registration study and submission experience preferred.

Available locations for this role:

• Stamford, CT
• South San Francisco, CA
• US Based-Remote

Roles and Responsibilities of the Position:

• Evaluate and design DM processes for lab data flow
• Evaluate and design DM processes for quality control of lab data
• Coordination with study Core Team to ensure lab data flow and process is consistent with delivery needs for end point analysis
• Monitors the progress of all data management activities in correlation to the lab needs on all studies to ensure project timelines are met.
• Provides day to day support of overseeing the quality review and reconciliation of safety and efficacy laboratory data.
• Provides oversight and support of the local lab reference range management process.
• Proactively identifies potential program and delivery issues/risks with lab data and recommends/ implements solutions. 
• Collaborate with Statisticians and Statistical Programmers in production of clinical trial reports and other deliverables.
• Attends internal, vendor and CRO meetings as directed. 
• Performs all other tasks and activities as requested by program lead and data management leadership.

Required Qualifications and Preferred Background:

• Bachelor’s degree in life sciences, math, computer science or related field required. Master’s degree in life sciences, math, computer science or related field preferred.
• Minimum of 5 years’ clinical data management experience. 
• Knowledge of lab reconciliation process.
• Demonstrated leadership, line management and project management skills.
• Oncology/Hematology experience strongly preferred.
• Thorough and broad knowledge of data management processes.
• Must have excellent verbal, written and communication skills.
• Proficiency in MS Office (Outlook, Word, Excel, PowerPoint)
• Experience in MS Project is preferred.
• Experience with web-based Electronic Data Capture (EDC) and clinical data management systems and industry wide thesauri, such as MedDRA and WHO Drug. 
• Excellent time management skills and a proven ability to work on multiple projects at any given time in a fast-paced environment.
• Available to assist the study team to achieve important data deliverables across all North American time zones.
• Self-driven and high achieving while maintaining a focus on quality in all aspects of work.
• Ability to work independently as well as in a team environment.


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Manager level position could range from between $103,200 to $151,423 and that the base salary for the Senior Manager level positions could range between $118,700 to $174,137 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.

Additional Locations for this role:

• Stamford, CT
• South San Francisco, CA

Roles and Responsibilities of the Position:

• Serve as Loxo's scientific representative to the pathology, diagnostic laboratory and medical communities; facilitate the appropriate exchange of scientific information
• Communicate clinical diagnostic and technology trends which may impact biomarker testing on both early and late phase assets  
• Support companion diagnostic development timelines associated with assigned programs
• Provide content expertise through knowledge transfer and training materials to the medical affairs team in the development and implementation of the launch strategy for assigned programs
• Work closely and in synergy with product development teams as well as therapeutic medical affairs team
• Participate and support advisory boards and steering committees
• Provide support through development and/or review of field based diagnostic educational and promotional materials for scientific accuracy

Required Qualifications and Preferred Background:

• MD with formal Training in Anatomic Pathology, American Board of Pathology – Anatomic Pathology/Molecular Pathology board eligible or certified; and 3 + years of experience in a clinical lab setting
• Strong knowledge of pathology laboratory clinical diagnostic testing processes, regulatory oversight, technologies, and methods used.
• Ability to apply diagnostic medical experience and knowledge to business needs
• Excellent verbal and written communications. Proficient with evaluating and reporting complex scientific and clinical data and translating them into simple messages. Quick understanding of a disease landscape
• Must have proven experience working in a matrixed environment and be an effective collaborator 
• Self-directed and proactive individual with ability to thrive in a fast-paced, entrepreneurial, dynamic environment with high performing colleagues 
• Comfortable executing on multiple projects independently
• Ability to build strong relationships with co-workers of various backgrounds and expertise 
• Ability to function at a high level in a team setting whether leading the group or acting as an individual contributor 
• Excellent interpersonal skills, with the ability to gain respect and influence and to build lasting relationships with internal colleagues as well as external thought leaders within the diagnostics community
• Ability to critically review current Dx literature, providing relevance to our products and markets
• Planning and organizational ability as well as budget management
• Proficient in Microsoft Office suite and applications

Strongly desired additional skills and experiences:

• Experience with both anatomic and molecular pathology laboratories and test methods
• Experience and knowledge of IVD and CDx market, regulatory processes and reimbursement
• Prior direct management experience
• Experience interacting with pathologists and pathology laboratories


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Medical Director level position could range from between $161,750 to $236,501 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.

Roles and Responsibilities of the Position:

• Participate in building a team with scientists and associates (at various levels) to be part of the larger Protein Engineering Group of the Large Molecule Discovery team at Loxo@Lilly
• Work with other Protein Engineering team members to screen, characterize and investigate, using analytical and biophysical platforms and methodologies, large biologicals comprised of antibodies, antibody conjugates, multi specifics and other modalities, created for treatment of several oncological indications
• Hands-on role to design, independently execute key experiments for biophysical characterization of these large molecules from early discovery to early development stage that includes accelerated stability and developability assessments
• Experience in lead optimization would a plus
• Interact and collaborate with other teams across the company to provide biophysical solutions; analyze, collate, and disseminate data to teams in a timely manner
• Participate and present periodic updates and reports to senior management to significantly influence strategic research decisions and operations
• Liaise with CROs and vendors for contract work and evaluations
• Participate in long-term strategies for creation of innovative solutions and intellectual property for securing FTO for Loxo

Required Qualifications and Preferred Background:

• Ph.D. in life or analytical sciences or equivalent fields with at least 5 years of relevant job experience in the biopharma industry with good understanding of drug development process of therapeutic antibodies, antibody conjugates, bi and multi-specific molecules and other modalities
• Extensive demonstrated expertise in characterization of biomolecular interactions using various industry standard SPR, BLI, and other relevant platforms for characterization of high/low affinities, concentrations, cross-blocking, activity, binding models, heterogeneities, and other product defining characteristics
• Experience in laboratory automation for liquid handling and screening
• Experience with spectroscopic techniques for characterization of biomolecules (e.g. UV/Fluorescence)
• Knowledge of biophysical techniques and platforms for characterization of physical, chemical, and conformational stabilities of biologics. Experience with cIEF, CE-SDS, or DSF or SEC-MALS would be a plus
• Knowledge of antibody design and engineering approaches (e.g. modeling, cloning & expression) for optimization of CMC properties will be a plus
• Hands-on experience with vendor provided software for biosensor data analysis and visualization. Experience with additional software tools such as GraphpadPrism, R, Matlab, Spotfire etc would be a plus
• Prior experience participating in team efforts for antibody lead panel generation, lead optimization and IND enabling studies
• Supervision of a team by providing clear direction, setting expectations, and mentoring young scientists
• Must have a can-do attitude to take on challenging projects and innovative ideas to accomplish in a collaborative matrixed organization
• Excellent communication skills and with strong organizational abilities


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Principal Scientist level position could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.

Roles and Responsibilities of the Position

• Construct knockout and expression vectors using mammalian plasmid and lentiviral, adenoviral, or retroviral systems. Viral titer measurement, and viral stock maintenance.
• Generate engineered stable cell lines using transfection, CRISPR/Cas9 tools, lentiviral transduction, etc.
• Optimize cell line development platforms to improve speed and reproducibility of cell line development
• Perform routine molecular and cell biology techniques like DNA/RNA/protein extraction, qPCR analysis, western blot analysis, fluorescent microscopy and so on.
• Maintain cultures of frequently used suspension and adherent cell lines.
• Deposit and archive cell lines in the company’s repository cell line bank.
• Keep detailed and accurate laboratory records, present results at group meetings and project team meetings

Required Qualifications and Preferred Background

• BA/BS with 8 years’ experience/MS with 6 years’ experience/PhD with 3+ years’ experience in biology, cell biology, molecular biology or a related field
• 8+ recent experience working with mammalian cell culture
• 1+ year of supervisory experience
• Tissue culture techniques such as cell propagation, cryo- preservation, and maintenance
• Proven cell culture experience with immortalized cell lines, cancer cell lines and/or primary cells
• Experience creating stable cell lines, transient transfections, viral transductions
• Experience with performing qPCR, ELISA, western blot, flow cytometry, and cell sorting, all in the context of mammalian cells. Fluorescent microscopy experience would be a plus.
• Experience in RNAi, CRISPR, and chemical inhibition of cellular pathways
• Prior experience with various analytical reagents such as Calcein AM, Cell Titer Glo, Alamar Blue, Annexin, PI/7AAD, and immunofluorescent antibodies
• A high level of proficiency with many kinds of scientific software used to operate lab equipment and/or the ability to quickly master new software
• Experience and proficiency with data analysis using statistical software such as Excel, Prism, Spotfire or others
• Must be organized and efficient and able to work according to timelines.
• Pharma/biotech drug discovery experience a plus    

Available locations for this role

• Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Principal Scientist level position could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.

Roles and Responsibilities of the Position

• Construct knockout and expression vectors using mammalian plasmid and lentiviral, adenoviral, or retroviral systems. Viral titer measurement, and viral stock maintenance.
• Generate engineered stable cell lines using transfection, CRISPR/Cas9 tools, lentiviral transduction, etc.
• Optimize cell line development platforms to improve speed and reproducibility of cell line development
• Perform routine molecular and cell biology techniques like DNA/RNA/protein extraction, qPCR analysis, western blot analysis, fluorescent microscopy and so on.
• Maintain cultures of frequently used suspension and adherent cell lines.
• Deposit and archive cell lines in the company’s repository cell line bank.
• Keep detailed and accurate laboratory records, present results at group meetings and project team meetings

Required Qualifications and Preferred Background

• BA/BS with 8 years’ experience/MS with 6 years’ experience/PhD with 3+ years’ experience in biology, cell biology, molecular biology or a related field
• 8+ recent experience working with mammalian cell culture
• 1+ year of supervisory experience
• Tissue culture techniques such as cell propagation, cryo- preservation, and maintenance
• Proven cell culture experience with immortalized cell lines, cancer cell lines and/or primary cells
• Experience creating stable cell lines, transient transfections, viral transductions
• Experience with performing qPCR, ELISA, western blot, flow cytometry, and cell sorting, all in the context of mammalian cells. Fluorescent microscopy experience would be a plus.
• Experience in RNAi, CRISPR, and chemical inhibition of cellular pathways
• Prior experience with various analytical reagents such as Calcein AM, Cell Titer Glo, Alamar Blue, Annexin, PI/7AAD, and immunofluorescent antibodies
• A high level of proficiency with many kinds of scientific software used to operate lab equipment and/or the ability to quickly master new software
• Experience and proficiency with data analysis using statistical software such as Excel, Prism, Spotfire or others
• Must be organized and efficient and able to work according to timelines.
• Pharma/biotech drug discovery experience a plus    

Available locations for this role

• Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Principal Scientist level position could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.

Roles and Responsibilities of the Position:

• Oversee the integration of biomarker and diagnostic development plans in clinical development with the current oncology treatment landscape, registrational and launch needs for the asset and with external competitors
• Ensure individual biomarker scientist plans are developed and implemented optimally according to the strategic needs of the assets and are aligned to company positions and guidelines
• Create and foster strong strategic partnerships with colleagues that include Biomarker Operations, pre-Clinical Development, Clinical Operations/Development, Dx Regulatory Affairs and Dx Medical Affairs 
• Apply Biomarker Development strategy to the design and interpretation of clinical trials
• Provide strategic input into data analysis, and engage in critical thinking, to deliver key data generation and interpretation essential for decision making as well as public scientific disclosure
• Lead integration with functional teams such as discovery, translational medicine, data science, clinical science etc. to ensure timely analysis, interpretation and disclosure of data to support development of our oncology pipeline
• Demonstrate substantial and relevant knowledge of scientific and medical literature with genomics and biomarker expertise and its application to strategic drug development and registration
• Apply scientific and operational knowledge to identify and analyze problems and information of considerable complexity and implement effective plans and solutions. Collaborate with operational teams to ensure cohesive planning and strategy
• Ability to prioritize effectively and meet multiple deadlines successfully with attention to detail, setting high performance standards.
• Proactively  generate  ideas  for  improvements  and  take  action  to  solve problems and achieve goals beyond what is required

Required Qualifications and Preferred Background:

• PhD required along with 5-7 years of biomarker experience within an academic or industry setting
• Strong preferably within laboratory-based cancer research or clinical trials is preferred
• Clinical   trial   expertise   along   with   experience  in  oncology  with  drug development highly desirable 
• The skills required for success in the job include scientific and analytic ability, ability to think strategically and tactically, an interest in applied clinical research, an ability to work effectively in multifunctional teams and  excellent organizational and communication skills.
• The candidate must demonstrate proven ability to evaluate, interpret and present   complex  scientific  data  to  both  technical and non-technical audiences
• Demonstrated ability to work well with other accomplished professionals within and across functions/teams


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Principal Scientist level position could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.

Roles and Responsibilities for this Position:

• Design and execute in vitro and in vivo preclinical studies to understand the pharmacokinetics (PK) and absorption, metabolism, distribution, and excretion (ADME) of new chemical entities (NCE)
• Provide management and oversight of CROs in the conduct of in vitro and in vivo ADME studies
• Advise medicinal chemistry teams on complex DMPK issues
• Perform non-compartmental pharmacokinetic analysis on data
• Review in vivo protocols and study reports
• Collate data and present to program teams
• Contribute to authoring and review of regulatory reports and documents
• Maintain accurate and timely electronic lab notebook

Required Qualifications and Preferred Background:

• BS, MS or Ph.D. in medicinal chemistry, biochemistry or related discipline
• BS with 10+, MS with 8+ or Ph.D. with 5+ years of DMPK experience
• Experience managing and overseeing CROs
• Experience managing Bioanalytical and Pharmacokinetic studies strongly preferred
• Must have pharmacokinetic modeling experience
• Experience with bioanalysis method and assay development
• Good written and oral presentation capabilities


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Principal Scientist position level could range from between $103,200 to $151,423 and that the base salary for the Senior Principal Scientist position level could range from between $118,700 to $174,137 will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Roles and Responsibilities for the Position:

• Establish strategic project goals and translate goals into project plan(s) with clear deliverables, milestones, and go/ no-go decisions.
• Establish project strategic objectives by collaborating with Loxo Small Molecule- Discovery leadership team
• Engage with functional team leads of medicinal chemistry, biology, DMPK, CMC, and toxicology (and other key stakeholders) to plan, execute, and track project activities, ensuring alignment of project deliverables with strategic goals
• Actively manage assays and studies conducted at external collaborators and vendors to meet outsourcing needs as needed.
• Actively facilitate project meetings: create agendas, minutes, and track action items
• Create and maintain organizational documents and tools, e.g., screening cascades, data summaries, project timelines, Spotfire dashboards, compound demand-supply forecasts, and various other trackers to ensure clear, effective, transparent, and efficient implementation of projects
• Create project updates, reports, presentations, and memos and maintain project document repository in collaboration with team members
• Proficient in adaptive communications; effectively manage communications vertically and horizontally in a cross-functional environment
• Proactively contribute to and manage project communications. Identify gaps and ambiguities in communication channels and address them to maintain alignment across the team
• Drive day-to-day operational activities by coordinating with stakeholders from different functional departments – legal, business operations, procurement, finance, and other relevant functional areas as needed
• Proactively identify gaps in processes and actively create processes to meet project needs
• Adaptive to change in priorities and able to drive project outcomes ensuring re-alignment with project deliverables in changing landscape
• Contribute to building positive, collaborative teams across scientific disciplines, and encourage sharing of new ideas and creative ways to solve problems often needed in drug discovery research

Required Qualifications and Preferred Background:

• BS, MS, or PhD  in chemistry, biology, or related sciences
• Small molecule drug discovery experience: BS with 7 years, MS with 4 years, or PhD  with 2 years. Part of the experience could come from project management/ alliance management responsibilities in pharmaceutical research & development
• Must be self-motivated and have excellent time management skills
• Excellent verbal, written communication and interpersonal skills.
• Excellent organizational skills, efficient, with strong attention to detail


• Additional Preferences:  
• PMP certification is preferred, but not required
• Proficient in identifying and applying tools to effectively manage and track projects - MS Office suite, MS Project
• Experience with data visualization software, such as Spotfire
• Create and implement new tools and processes customized for furthering discovery research

Role can be based out of the following locations:

• Louisville, CO
• San Diego, CA
• Indianapolis, IN

Roles and Responsibilities of the Position:

• Prosecute biophysical assays to identify and characterize small-molecule modulators using a variety of techniques and detection methods, including chromogenic, MS, SPR, ITC, FP, FRET and TR-FRET
• Continuously expand our biochemical characterization repertoire by exploring and developing additional assay and technological instrumentation
• Calculate and report assay results to the project teams
• Document experiments and results in electronic notebook, and results database

Required Qualifications and Preferred Background:

• A BS or MS with 0-3+ years relevant work experience. Level commensurate with education and experience
• Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels
• Highly organized and detail oriented with excellent analytical, documentation, and multi-tasking skills
• Committed continual learner, who is accustomed to staying current with the latest scientific breakthroughs in structure-based drug design and biophysics
• Expertise in other methods of enzymology or biophysical characterization and structural biology is a plus
• Protein Purification and characterization a plus


Loxo Oncology, Inc. currently anticipates that the base salary for the Research Associate level position could range from between $50,000 to $73,370 and that the base salary for the Associate Scientist could range from between $59,000 to $86,577 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.

Roles and Responsibilities for the Position:

• Develop a user-friendly web interface to automate scientific workflows, standardize analysis scripts, and organize -omics datasets
• Utilize third-party API’s and SDK’s to communicate and integrate with off-the-shelf and custom software
• Work closely with scientists and collaborators to understand their needs, propose solutions and implement new features
• Work jointly with other developers and engineers to maintain best practices within a bioinformatics cloud ecosystem

Required Qualifications and Preferred Background:

• Bachelor’s/Master’s/PhD in computer science, bioinformatics, or equivalent experience
• Exposure to computer science coursework including data structures and algorithms
• 2+ years of full-stack web development with at least one Javascript framework (React, Angular, NodeJS)
• A strong knack for creating visually appealing UX/UI, and ability to abide by clear design rules
• Firm understanding of back-end web development design patterns and principles (RESTful API’s, JSON, SQL/NoSQL databases)
• Experience communicating and executing systems design proposals
• Comfortable with the Linux Command Line on a POSIX-compliant system
• Proficiency in one or more scripting languages (Python/Perl/Go/Bash)
• Domain knowledge of NGS bioinformatics pipelines, workflows, and analyses a plus
• Working knowledge of AWS Cloud Technologies (S3, Lambda, RDS, EC2, SES, Cloudwatch) a plus
• Excellent communication skills, both written and verbal


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Senior Scientist level position could range from between $103,200 to $151,423 and the Principal Scientist position would range from $118,700 to $172,13, and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.

Available Locations for this Role:

• South San Francisco, CA
• Alexandria Center, NY
• US Based- Remote

Roles and Responsibilities of the Position:

• Drive and execute in vitro and in vivo studies to investigate mechanisms of cancer cell growth and survival in support of the discovery and development of new cancer therapeutics
• Establish and perform state-of-the-art cell-based and biochemical assays
• Design and execute cross-assay validation studies
• Identify and evaluate new technologies to advance drug discovery and development
• Analyze and interpret data, with ability to troubleshoot assays
• Organize and coordinate multiple projects in parallel
• Identify, evaluate, and manage vendors for outsourced services and studies
• Prepare and present scientific results at congresses and in peer-reviewed journals

Required Qualifications and Preferred Background:

• BS, MS, or PhD in biology, molecular biology, cell biology, biochemistry or related discipline. Minimum of 10 years for BS, >5 years for MS and >0-3 years for PhD, either in industry or academic environment
• Proven track record in design and development of robust assays to study protein expression, protein turnover and protein-protein and protein-small molecule interactions (e.g. MSD, HTRF, AlphaLISA, flow cytometry, co-IP etc.)
• Extensive experience with aseptic mammalian cell culture and familiarity with solid tumor and/or hematologic cell lines is preferred
• Demonstrated ability to engineer knock-in & knockout cell lines with CRISPR and/or other technologies
• Experience working with in vivo mouse models including tissue/blood collection, processing, and analysis
• Self-organized, detail-oriented, self-directed, highly motivated with strong critical thinking and analytical skills
• Willingness to work collaboratively and incorporate diverse perspectives into decision-making
• Demonstrated ability to work successfully in a nimble, fast-paced, matrixed environment


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Scientist position level could range from between $78,000 to $114,498 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Roles and Responsibilities of the Position:

• Scientific roles and responsibilities:
• Develop key capabilities for the generation of necessary patient-derived organoid models for detailed functional characterization
• Design and execute studies to profile candidate molecules in organoid systems
• Troubleshoot technical difficulties encountered in organoid establishment, growth and testing
• Test biologics or small molecules in organoid tumor models (dose response experiments, profiling, comparing to control compounds)
• Grow organoids of various types; have extensive knowledge of media and growth factors on organoid development
• Perform experiments that modulate target expression in organoid systems
• Interrogate experimental conduct of third parties/vendors
• Additional responsibilities:
• Communicate results at project team meetings, be involved in the coordination and preparation of presentations
• Discuss results with technical as well as non-technical personnel
• Lead, and work collaboratively across multiple laboratory-based functions to establish the mechanisms, phenotypes, and biology of new targets using modern approaches in molecular and cellular biology and biochemistry
• Work in cross functional environments via extensive collaboration with other parts of the organization
• Direct leadership of a junior scientist may be required

Required Qualifications and Preferred Background:

• BS degree in biological sciences with 5 years of experience or MS/PhD in biological sciences with 2-3 years of experience required
• Extensive expertise working with organoid models
• Deep expertise in cancer disease states (indications, mutational status, tumor cell drivers)
• Demonstrated experience in working collaboratively across various scientific disciplines to meet end goals of business
• Excellent communication and interpersonal skills
• Demonstrated ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines
• Excellent written and verbal communication skills


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the {insert position} level position could range from between $78,000 to $ $114,498 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.

Roles and Responsibilities for the Position:

• Generate protein-small molecule complex x-ray crystal structures with hands-on lab involvement throughout the entire gene to structure process including protein expression, purification, crystallization, and structure determination
• Coordinate protein construct design, expression, and purification with the project team to support biochemical and biophysical assays.
• Rapidly communicate scientific results and insights to the team
• Identify, evaluate, and manage vendors for outsourced services and studies
• Collaborate with colleagues throughout the company to ensure structural work meets the program needs and results are appropriately interpreted
• Participate and lead project-based and technical team meetings to identify and solve problems, guide work towards project goals, communicate on-going work and progress, and plan forward thinking strategies
• Develop and continually advance one’s knowledge base on genetically targeted drugs and structure-based drug design
• Proactively investigate new or different technologies, methods, and service providers to ensure our work is being done in a scientifically sound, efficient, and reasonable way
• In the future, this position’s responsibilities may include supervision of scientists and associates

Required Qualifications and Preferred Background:

• PhD in Biochemistry, Biophysics, Chemistry, or related field
• Ideal candidate will have with 5+ years hands-on gene to structure protein-small molecule crystallography experience in a biotech/pharma setting
• Experienced in crystallization of protein-small molecule complexes and high-resolution x-ray structure determination
• Extensive experience in protein construct design, expression, purification, and characterization
• Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels
• Highly organized with excellent analytical, documentation and multi-tasking skills
• Committed to staying current with the latest scientific breakthroughs in structure-based drug design and structural biology.
• Experience in other methods of biophysical and structural biology, such as Cryo-EM, is a plus
• A learners mindset


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Scientist level position could range from between $78,000 to $114,498 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Roles and Responsibilities of the Position:

• Perform high-throughput antibody binding screens by ELISA and multi-plex flow cytometry to identify hits
• Develop, optimize, and perform in vitro potency assays to deliver key data for selecting lead panel of antibodies, including bispecific antibodies and antibody drug conjugates
• Perform tissue cultures to expand and maintain mammalian cell lines (CHO, HEK293, and established cancer cell lines) and primary immune cells for antibody/protein expression and in vitro assays
• Work collaboratively with Large Molecule Discovery Biologics functional teams to ensure materials and results are delivered on time
• Demonstrate collection and thorough analysis of data, and update Electronic Notebook records

Required Qualifications and Preferred Background:

• MS in Biology, Biochemistry, Biomedical Engineering, or related field with minimum of 3+ years of industry experience, or BS with 5+ years of industry experience in biologics drug discovery for Scientist; 7+ years of industry experience for Senior Scientist
• Must have in tissue cultures experience using mammalian cell lines and primary immune cells using aseptic laboratory techniques
• Experience in operating and maintaining flow cytometers, plate readers, and liquid handlers, as well as software for data analysis and visualization (Microsoft Office and GraphPad Prism)
• Highly motivated, fast learner with strong organization skills
• Demonstrate experience in working collaboratively across various scientific disciplines to meet end goals of business
• Demonstrate ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines
• Excellent written and verbal communication skills
• Strong interpersonal skills

Preferred Qualifications:

• Single B cell cloning or hybridoma based antibody discovery experience


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Scientist position level could range from between $78,000 to $114,498 and the base salary at the Sr. Scientist level could range between $89,750 and $131,672 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Roles and Responsibilities of the Position:

• Design and develop novel biophysical assays to identify and characterize small-molecule or biological modulators using a variety of techniques and detection methods including chromogenic, MS, SPR, ITC, FP, FRET and TR-FRET
• Experimentally explore biological consequence of mechanism of inhibition by coordinating experiments with our cell biology team.
• Creatively address biologic/biophysical questions across a wide variety of techniques and technologies
• Continuously expand our biochemical characterization repertoire by exploring and developing additional assay and technological instrumentation
• Calculate and report assay results to the project teams
• Document experiments and results in electronic notebook, and results database
• Software coding experience is a plus

Required Qualifications and Preferred Background:

• A BS, MS, or PhD in a Life Sciences discipline, with training in molecular biology, enzymology or biochemistry, and a record of lab based independent research experience, minimum of 10 years for BS, >5 years for MS and >0-3 years for PhD, either in industrial or academic environment
• Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels
• Highly organized and detail oriented with excellent analytical, documentation, and multi-tasking skills
• Committed continual learner, who is accustomed to staying current with the latest scientific breakthroughs in structure-based drug design and biophysics


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Scientist level position could range from between $78,000 to $114,498 and the base salary at the Sr. Scientist level could range between $89,750 and $131,672 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.

Roles and Responsibilities of the Position:

• Cell Culture Expertise
• Develop robust cell-based assays
• Design, execute, and trouble-shoot experiments
• Experience in the following assay formats: HTRF, AlphaLISA®, Mesoscale, and Chemiluminescence 
• CRISPR and Cloning experience is a plus
• Perform comprehensive data analysis 
• Communicate experimental findings to team members
• Operate, implement, and troubleshoot laboratory automation
• Actively engaged in advancing drug discovery programs  
• This is a “hands-on” laboratory, based position

Required Qualifications and Preferred Background:

• BS/MS/Ph.D. in biology, biochemistry, or related fields
• Ph.D. with >2 years’ experience in industry or academia, or BS or MS with >5 years industrial experience
• Experience culturing cells and performing cell assays in biotech or a pharma environment 
• A scientific foundation in the understanding and implementation of a wide range of cell-based screening assays and readouts
• Excellent oral and written communication skills including experimental documentation
• Works well with team members across functional areas
• Continual learner who works independently and possesses a can-do attitude
• Good and thoughtful listener
• Ability to multi-task and shift priorities rapidly to meet tight deadlines
• Highly organized with exceptional attention to detail.
• Proficient in Microsoft Office suite and applications




Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Scientist level position could range from between $78,000 to $114,498 and the Senior Scientist level position could range from between $89,750 to $131,672 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Roles and Responsibilities of the Position:

• Design, develop, and execute enzyme and binding assays in multiple formats
• Screen small molecule inhibitors in plate-based assays formats to drive internal structure-based drug design
• Operate, implement, and troubleshoot laboratory automation
• Actively engage in advancing small molecule drug discovery oncology programs
• Perform comprehensive data analysis 
• Communicate experimental findings to team members
• Operate, implement, and troubleshoot laboratory automation
• Actively engaged in advancing drug discovery programs  
• This is a “hands-on” laboratory, based position

Required Qualifications and Preferred Background:

• BS/MS/Ph.D. in biochemistry, biophysics, or related fields
• Ph.D. with >2 years’ experience in industry or academia, or BS or MS with >5 years industrial experience
• The successful candidate is expected to have expertise in biochemistry, enzymology, and assay development
• Experience with general biochemical and kinetic-based assay technologies (e.g. TR-FRET, AlphaLISA® FP, Luminescence)
• Experience with laboratory instrumentation and automation for medium to high-throughput screening
• Excellent oral and written communication skills including experimental documentation
• Works well with team members across functional areas
• Ability to multi-task and shift priorities rapidly to meet tight deadlines
• Highly organized with exceptional attention to detail.
• Good and thoughtful listener
• Enthusiastic, self-motivated and a continuous learner
• Proficient in Microsoft Office suite and applications


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Scientist level position could range from between $78,000 to $114,498 and the Senior Scientist level position could range from between $89,750 to $131,672 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Roles and Responsibilities of the Position:

• Design, execute and oversee the execution of in vivo studies with pre-clinical  discovery and translational biology teams
• Interact and collaborate with various discovery technologies functional teams to develop and implement novel in vivo models
• Prepare drug solutions and inoculations, multiple route drug administration, animal health monitoring, anesthesia, blood samplings, necropsies, xenografts, syngeneic mouse models, humanized mouse models
• Culture tumor cells according to SOPs and contribute to the development of SOPs
• Work collaboratively with the discovery and clinical teams to support retrospective and exploratory efforts for clinical programs
• Perform cardiac, retro-orbital bleeds, and tumor injections
• Perform tumor measurements using calipers
• Harvest tumor and tissue samples from treated animals to help establish PK/PD and toxicity measurements
• Process blood and tissue samples for monitoring PD markets, hematological and tissue toxicities
• Liaise with CROs and vendors to outsource activities, provide input to management team on vendor selection
• Stay current on cutting edge technologies and work collaboratively with the in vivo team to validate and implement new in vivo model systems
• Provide scientific expertise on practical implementation of various in vivo applications to support projects across the entire Loxo organization
• Work with the entire in vivo team to ensure all instrumentation is properly maintained and calibrated
• Provide scientific expertise when determining organizations to strategically partner with
• Proper documentation and archiving of data and analyses
• Work interactively with project teams and discovery teams to plan and execute experiments as well as be involved in data interpretation and preparation of study reports
• Work interactively with project teams as an in vivo pharmacology expert to ensure appropriate applications and priorities are considered
• Additional roles and responsibilities:
• Communicate results via written and oral presentations at project team meetings, be involved in the coordination and preparation of presentations
• Discuss results with technical as well as non-technical personnel
• Support archiving as well as curating data in internal databases
• Extensive cross functional communication and collaboration with internal and external parties
• Interrogate experimental conduct of third parties/vendors

Required Qualifications and Preferred Background:

• PhD in biological sciences with a focus in in vivo pharmacology or MSc in biological sciences with 5+ years’ experience preferably in the pharma/biotech industry
• Extensive expertise in: in vivo pharmacology, cell line xenograft establishment, humanized mouse model systems, imaging, standard flow cytometry experiments, bioanalytical functions, small animal handling, carrying out preclinical rodent oncology modeling
• Diverse experience in cell biology and biochemical techniques to monitor PK/PD relationships
• Experience in drug discovery with regulator reporting
• Proven success working in cross-functional teams in dynamic organizations
• Demonstrated experience in working collaboratively across various scientific disciplines to meet end goals of business
• Demonstrated business acumen
• Demonstrated excellence in making key strategic decisions in support of broader business goals
• Excellent written and verbal communication skills
• Flexibility to adjust priorities over time to meet organizational and scientific goals
• Ability to work independently and as an integral part of a larger collaborative team
• Demonstrated ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines
• Excellent interpersonal, written, and verbal communication skills
• Knowledge and experience documenting and processing in vivo studies


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Scientist level position could range from between $78,000 to $114,498 and the base salary at the Sr. Scientist level could range between $89,750 and $131,672 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.

Roles and Responsibilities of the Position:

• The ideal candidate should have experience in protein biochemistry and proteomic techniques. Experience with proteomics sample preparation (i.e., proteolytic digestion, solid phase extraction, immunoprecipitation) and operation of an Orbitrap mass spectrometer are preferred, but not essential for success in this role. Additionally, this position will be asked to evaluate technologies and techniques to evaluate protein structure dynamics, such as HDX or hyroxy-radical footprinting.  Computational skills are highly desirable. Strong communication & interpersonal skills are essential for success in this collaborative role.

Required Qualifications and Preferred Background:

• BS, MS, or PhD in a Life Sciences discipline, with training in molecular biology, enzymology or biochemistry, and a record of lab based independent research experience along with a minimum of 10 years for BS, >5 years for MS and >0-3 years for PhD, either in industrial or academic environment. The ideal candidate will have hands-on experience with protein characterization and cell culture
• Demonstrated ability to work well with other accomplished professionals within and across functions/teams. Willing collaborator
• Familiarity with techniques and instrumentation relevant to automated semi-automated sample handling
• Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels
• Highly organized with excellent analytical, documentation and multi-tasking skills
• Committed to staying current with the latest scientific breakthroughs in structure-based drug design and proteomics and related technology. A continuous learner
• Expertise in other methods of enzymology or biophysical characterization and structural biology is a plus


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Scientist level could range from between $78,000 to $114,498 and that the base salary for the Senior Scientist could range from between $89,750 and $131,672 but will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Roles and Responsibilities of the Position:

• Create, develop and validate quantitative mammalian cellular assays to credential novel targets
• Establish robust high-throughput screening assays
• Design and manage in vivo pre-clinical studies
• Conceive and lead collaborative projects on biomarker-driven programs
• Evaluate emerging technologies, methods, and service providers to ensure our work is being done in a scientifically sound, efficient, and reasonable way
• Collaborate with colleagues throughout the company to ensure assays meet the program needs and results are appropriately interpreted
• Participate and thrive in an interactive, team-oriented culture
• Directly manage and mentor lab-based staff

Required Qualifications and Preferred Background:

• PhD in Molecular/Cellular Biology or Biochemistry, or related field
• Minimum of 1-3+ years of postdoctoral and/or hand-on research experience, preferability in biotech/pharma setting
• Experience in relevant areas of cancer and molecular biology
• Outstanding communication, writing, and presentation skills is a must

Additional Preferred Qualifications:

• Experience with cell engineering such as knock-in and knockdown cell lines with CRISPR and/or other technologies
• Experience with flow cytometry and general molecular biological techniques including q-PCR, signaling experiments, assays for protein-protein interactions and Western Blot etc.
• Experience in designing and handling in vivo animal studies
• Experience in building models (cell line, organoid or PDX) from patient samples and using them to test drug activities
• Experience working with external CROs
• Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels and problem solving skills
• Ability to summarize complex experiment and results for non-specialists
• Enthusiastic, self-motivated and keen to improve processes and overcome inefficiencies


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Scientist position level could range from between $78,000 to $114,498 and that the base salary for the Senior Scientist position level could range from between $89,750 to $131,672 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Roles and Responsibilities for the Position:

• Drive the team forward with new medicinal chemistry analogs that consistently move the project toward the next breakthrough drug candidate
• Optimize lead series for potency, selectivity, physiochemical properties, in vitro ADME, and PK by coupling multivariate SAR analysis with hypothesis-driven medicinal chemistry design principles
• Work closely with structural biology and computational chemistry colleagues to design novel compounds and hypotheses that address key drug optimization goals
• Reduce ideas to practice in the lab quickly by effectively employing a broad range of modern organic chemistry transformations, synthetic methods, purification and characterization techniques
• Synergize with the broader team by communicating results, sharing insights, making plans, and setting goals in an open, honest way

Required Qualifications and Preferred Background:

• B.S. with 5+ years, M.S. with 3+ years, or Ph.D. with 0-1 years’ experience with a focus on synthetic organic chemistry or experience in small molecule organic synthesis and/or drug discovery experience in a biotechnology or pharmaceutical setting.
• Proficiency in modern synthetic methodology and variable reaction scales
• Ability to design feasible synthetic routes to target molecules and choose appropriate reaction conditions
• Skilled user of synthetic chemistry instrumentation: HPLC, LC-MS, NMR, and purification systems
• Experience in lead compound optimization for potency, selectivity, ADME and PK is preferred but not required
• Experience in using common synthetic chemistry software: electronic notebook, ChemDraw, Excel, literature search engines
• An excellent team player with ability to communicate synergistically with a multidisciplinary team. Highly organized with excellent analytical, documentation, time management, and multi-tasking skills


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Associate Scientist level could range from between $67,850 to $99,563 and that the base salary for the Scientist level could range from between $78,000 to $114,498 will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Roles and Responsibilities of the Position:

• Design vectors to generate transgenic mouse models to study novel targets
• Maintain and establish various mammalian cell lines used to credential novel targets
• Design, plan and/or execute in vivo experiments by using mouse models to evaluate the outcome of tumor progression in mouse models for different cancers
• Perform cellular and biochemical assays to evaluate the outcome of various genetic or chemical perturbations. 
• Mouse colony management
• Analyze, interpret, and present the data to the team and/or organization
• Troubleshoot experiments in a timely manner
• Learn and apply new techniques to support ongoing efforts
• Actively participate in group discussions and collaborate with colleagues throughout the organization.
• Contribute to a safe and efficient workplace

Required Qualifications and Preferred Background:

• BS, MS, or PhD in biology, cancer, molecular biology, cell biology, biochemistry, or related discipline, with 3+ years lab-based experience
• Mouse experience is highly desired but not required
• Expertise in routine molecular and cellular techniques
• Experience in gene editing (CRISPR, TALEN, etc.) and/or high-throughput screening is a plus.
• Excellent collaborative and interpersonal skills
• Highly organized, detail-oriented, self-motivated and strong documentation skills
• Outstanding communication, writing, and presentation skills are a must
 
Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Senior Associate Scientist level position could range from between $67,850 to $99,563 and the that the base salary for the Scientist level position could range from between $78,000 to $114,498 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.

Roles and Responsibilities of the Position:

• Design and execute key experiments to evaluate compounds, identify combination partners and investigate drug resistance.
• Translate preclinical findings to biomarker and combination strategies to advance programs to clinical development
• Work closely with clinical team to develop and test hypotheses that could determine the clinical response and define the patient populations  
• Engage in cross-functional collaborations across the company
• Identify, evaluate, and manage vendors for outsourced services and studies
• Prepare reports for internal and external purposes including regulatory submissions
• Participate and lead project-based and technical team meetings to identify and solve problems, guide work towards project goals, communicate on-going work and progress, and plan forward thinking strategies
• In the future, this position’s responsibilities may include supervision of scientists 

Required Qualifications and Preferred Background:

• PhD in Molecular/Cellular Biology or Biochemistry, or related field with either:
• 6+ years hands-on molecular and cell biology experience AND 2+ years work experience in a biotech/pharma setting or
• 10+ years hands-on molecular and cell biology experience
• OR a BS/MS in Molecular/Cellular Biology or Biochemistry with either
• 10+ hands-on molecular and cell biology experience AND 4+ years work experience in a biotech/pharma setting or
• 15+ years hands-on molecular and cell biology experience


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Principal Scientist position level could range from between $103,200 to $151,423 and the Senior Principal Scientist position level could range from between $118,700 to $174,137 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion

Roles and Responsibilities for the Position:

• Establish strategic project goals and translate goals into project plan(s) with clear deliverables, milestones, and go/ no-go decisions
• Establish project strategic objectives by collaborating with Loxo Small Molecule- Discovery leadership team
• Engage with functional team leads of medicinal chemistry, biology, DMPK, CMC, and toxicology (and other key stakeholders) to plan, execute, and track project activities, ensuring alignment of project deliverables with strategic goals
• Actively manage assays and studies conducted at external collaborators and vendors to meet outsourcing needs as needed.
• Actively facilitate project meetings: create agendas, minutes, and track action items
• Create and maintain organizational documents and tools, e.g., screening cascades, data summaries, project timelines, Spotfire dashboards, compound demand-supply forecasts, and various other trackers to ensure clear, effective, transparent, and efficient implementation of projects
• Create project updates, reports, presentations, and memos and maintain project document repository in collaboration with team members
• Proficient in adaptive communications; effectively manage communications vertically and horizontally in a cross-functional environment
• Proactively contribute to and manage project communications. Identify gaps and ambiguities in communication channels and address them to maintain alignment across the team
• Drive day-to-day operational activities by coordinating with stakeholders from different functional departments – legal, business operations, procurement, finance, and other relevant functional areas as needed
• Proactively identify gaps in processes and actively create processes to meet project needs
• Adaptive to change in priorities and able to drive project outcomes ensuring re-alignment with project deliverables in changing landscape
• Contribute to building positive, collaborative teams across scientific disciplines, and encourage sharing of new ideas and creative ways to solve problems often needed in drug discovery research

Required Qualifications and Preferred Background:

• BS, MS, or PhD  in chemistry, biology, or related sciences
• Small molecule drug discovery experience: BS with 7 years, MS with 4 years, or PhD  with 2 years. Part of the experience could come from project management/ alliance management responsibilities in pharmaceutical research & development
• Must be self-motivated and have excellent time management skills
• Excellent verbal, written communication and interpersonal skills.
• Excellent organizational skills, efficient, with strong attention to detail


• Additional Preferences:  
• PMP certification is preferred, but not required
• Proficient in identifying and applying tools to effectively manage and track projects - MS Office suite, MS Project
• Experience with data visualization software, such as Spotfire
• Create and implement new tools and processes customized for furthering discovery research


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Senior Manager level position could range from between $118,700 to $174,137 but will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.

Roles and Responsibilities for the Position:

• Drive and execute studies to investigate mechanisms of cancer cell growth and survival in support of the discovery and development of new cancer therapeutics
• Establish and perform state-of-the-art cell-based and biochemical assays
• Design and execute cross-assay validation studies
• Identify and evaluate new technologies to advance drug discovery and development
• Analyze and interpret data, with ability to troubleshoot assays
• Organize and coordinate multiple projects in parallel
• Identify, evaluate, and manage vendors for outsourced services and studies
• Prepare and present scientific results at congresses and in peer-reviewed journals

Required Qualifications and Preferred Background:

• PhD in in biology, molecular biology, cell biology, biochemistry or related discipline, with 3+ years of lab-based experience in a biotech/pharma setting
• Proven track record in design and development of robust assays to study protein expression, protein turnover and protein-protein and protein-small molecule interactions (e.g. MSD, HTRF, AlphaLISA, co-immunoprecipitation etc.)
• Extensive experience with aseptic mammalian cell culture and familiarity with solid tumor and/or hematologic cell lines is preferred.
• Demonstrated ability to engineer knock-in & knockout cell lines with CRISPR and/or other technologies
• Self-organized, detail-oriented, self-directed, highly motivated with strong critical thinking and analytical skills
• Willingness to work collaboratively and incorporate diverse perspectives into decision-making
• Demonstrated ability to work successfully in a nimble, fast-paced, matrixed environment


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Senior Scientist position level could range from between $89,750 to $131,672 and that the base salary for the Principal Scientist position level could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Roles and Responsibilities for the Position:

• Drive the project toward the next breakthrough drug candidate by designing and synthesizing new medicinal chemistry analogs that directly address project goals. 
• Optimize lead series for potency, selectivity, physiochemical properties, in vitro ADME, and PK by coupling multivariant SAR analysis with hypothesis driven medicinal chemistry design principles. Use sound scientific methods to propose hypotheses and determine next steps even with complex or ambiguous data.
• Work closely with structural biology and computational chemistry colleagues to design novel compounds and hypotheses that address key drug optimization goals.
• Reduce ideas to practice in the lab quickly by effectively employing a broad range of modern organic chemistry transformations, synthetic methods, purification and characterization techniques.
• Synergize with the broader team by communicating results, sharing insights, making plans, and setting goals in an open, honest way.
• Provide medicinal chemistry insight for new target and lead identification and evaluation initiatives in the oncology space.
• Proactively investigate new or different technologies to improve the effectiveness of the drug discovery process.
• Analyze complex data streams and conceptualize priority synthesis targets based on a holistic data approach.

Required Qualifications and Preferred Background:

• BS, MS, or PhD in chemistry with a focus on synthetic organic chemistry 
• Experience in small molecule drug discovery in a biotechnology or pharmaceutical setting and a B.S. with 8+ years’ experience, M.S. with 5+ years’ experience or Ph.D. with 2+ years’ experience.
• Proven track record of success in advancing programs from leads to advanced candidates.
• Extensive experience in lead compound optimization for potency, selectivity, ADME and PK.  
• Experienced in the use of synthetic chemistry instrumentation: HPLC, LC-MS, NMR, and purification systems.
• Expert in using common medicinal chemistry software: electronic notebook, ChemDraw, Excel; data visualization; structure viewing; literature, chemical and database searching.
• Committed to staying current with the latest scientific breakthroughs in the medicinal chemistry field through continued reading of the literature and attendance of scientific conferences. 
• An excellent team player with ability to communicate synergistically with a multidisciplinary team and be accountable for the medicinal chemistry progress of the project. Highly organized with excellent analytical, documentation, time management, and multi-tasking skills.


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for Senior Scientist level position could range from between $89,750 to $131,672 and that the base salary for Principal Scientist level position could range from between $103,200 to $151,423 but will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Roles and Responsibilities for the Position:

• Work closely with Discovery Project teams to influence programs at TPP design, lead optimization, candidate seeking and nomination.
• Utilize PBPK and translational modeling tools to enable human PK projections throughout the life of a program
• Evaluate and guide novel in vitro tools and methodology to improve prediction of human PK
• Proactively lead cutting edge effort to build and refine PBPK models for novel drug modalities (covalent inhibitors, PROTACs, PPI’s etc.)
• Liaise with DMPK, discovery biology/pharmacology and clinical scientists to generate data and knowledge supporting the build-up of translational, mechanistic models
• Ensure communication is effective and clear for internally and externally on topics related to PBPK, translational modeling and simulation, human PK and DDI prediction
• Keep abreast of emerging literature and science in modeling and in vitro approaches

Required Qualifications and Preferred Background:

• Bachelors, Masters, or PhD with 0-4 (PhD), 8-10 (MS), or 10-12 (BS) years of experience in pharmaceutical or relate
• Hands-on project experience in PBPK modeling and simulation through internship, industry research collaboration, or direct industry experience strongly preferred
• Successful track record of applying PBPK into projects
• Strong understanding of ADME, PK and DDI concepts as well as significant theoretical and practical understanding of own scientific discipline
• Focus on and passion for data analysis, solving technical problems and applying new technologies to further scientific goals.
• Hands-on experience in the use of commercial PBPK modeling software (SimCyp or GastroPlus is preferred)


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Senior Scientist position level could range from between $89,750 to $131,672 and that the base salary for the Principal Scientist position level could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Available Locations for this Role:

• US Based-Remote
• Louisville, Colorado
• San Diego, CA

Roles and Responsibilities of the Position:

• Provide recombinant protein expression and protein purification expertise to deliver proteins central to research activities for small molecule discovery
• Understand the quality of proteins required for functional and biophysical assays, and develop protocols to deliver well characterized proteins accordingly
• Execute projects in an efficient manner, working with aggressive timelines
• Values quality over quantity, with the ability to prioritize
• Rapidly communicate scientific results and insights to the team
• Prepare reports for internal and external purposes including regulatory submissions
• Participate and lead project-based and technical team meetings to identify and solve problems, guide work towards project goals, communicate on-going work and progress, and plan forward thinking strategies
• Continually advance your understanding of current methodology and emerging technologies by reading scientific literature
• Proactively investigate new or different technologies, methods, and service providers to ensure our work is being done in a scientifically sound, efficient, and reasonable way

Required Qualifications and Preferred Background:

• BA/BS/MS/PhD in protein sciences, biology, biochemistry, molecular biology, or a related field along with hands-on experience, working in a laboratory in a biotechnology/pharmaceutical setting
• (3+ years’ experience with a PhD; 5+ years’ experience with an MS degree; 8+ years’ experience with BS/BA degree); may also consider experience out of an academic/research setting
• Strong team player who inspires colleagues to solve difficult problems and develop efficient workflows
• Experience designing expression constructions for functional assays and crystallography
• Proficient with molecular biology techniques including cloning
• Expertise with a variety of protein expression systems including E. coli and Baculovirus infected insect cells
• Expertise with protein purification techniques such as IMAC, SEC, IEX and affinity chromatography is required, ideally utilizing the AKTA FPLC systems
• Expertise with protein characterization techniques such as LCMS, western blotting, and thermal stability assays, is desirable.
• Familiarity with biophysical and functional techniques such as SPR, ASMS, fluorescent binding assays, and enzyme kinetic assays is beneficial
• The candidate must be self-motivated but always maintain focus on why we are here and who is important i.e. the patients and their families/caregivers
• Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels
• Desire and ability to flex between protein expression/purification/characterization is a must
• Highly organized with excellent analytical, documentation and multi-tasking skills


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Senior Scientist position level could range from between $89,750 to $131,672 and that the base salary for the Principal Scientist position level could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Roles and Responsibilities of the Position:

• The successful candidate will join a dynamic team and oversee computational biology efforts across multiple functions. They will be expected to lead a team, supervise and develop scientists, and help build a research strategy that leverages deep cancer biology knowledge and high-dimensional data. Success critically depends on the ability to effectively present complex analyses and results in a clear and concise manner to a diverse audience of scientists.

Required Qualifications and Preferred Background:

• PhD in Bioinformatics, Biostatistics, Computational Biology, or similar area of study required. Post-doctoral training or equivalent prior work experience (3-5+ years)
• Substantial publication record and/or similar achievements
• Demonstrated track record of strategic scientific leadership in the computational biology field with leading and developing scientists.
• Strong understanding of relevant concepts in cancer biology and molecular biology
• Experience in large-scale data analyses involving high-throughput molecular assays such as DNA/RNA-Seq, ATAC/CHiP-Seq, single-cell technologies, etc.
• Understanding of current best-practices for high-throughput genomics/molecular data analyses and familiarity of their underlying statistical principles
• Experience using programming languages such as R, Python, or similar for statistical analysis


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Senior Scientist position level could range from between $89,750 to $131,672 and that the base salary for the Principal Scientist position level could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Available Locations for this role

• South South Francisco, CA
• New York City, NY
• US Based-Remote

Role and Responsibilities of the Position:

• In collaboration with clinical and regulatory, manages the authoring and document life cycle of clinical protocols and amendments, clinical study reports (CSRs), Investigator’s Brochures (IBs), electronic Common Technical Document (eCTD) summaries and other documents for submission to the Food and Drug Administration (FDA) or other regulatory agencies.
• Compiles, analyzes, and summarizes data from statistical tables and other sources, as needed.
• Liaises with cross-functional team members (e.g., clinical operations, clinical science, regulatory affairs, biostatistics, nonclinical) to ensure that information is accurately captured in documents.
• Coordinates document reviews; schedules and hosts meetings to resolve team comments.
• Acts as the medical writing representative for a program; may work with medical writing contractors on a program to ensure consistency in messaging across a program.
• Participates in the development/update of departmental procedures and templates.
• Other duties as needed.

Required Qualifications and Preferred Background:

• BS and at least 4 years of related experience; advanced degree (e.g., MS/PhD/PharmD) may compensate for years of experience.
• Prior medical technical writing experience within the biotech/pharmaceutical/clinical research organization (CRO) realm.
• Experience and significant participation in preparation of clinical documents for regulatory submissions (e.g., clinical protocols, Investigational New Drug applications [INDs], New Drug Applications [NDAs], Biologic License Applications [BLAs]).
• Familiarity with therapeutic area of oncology desirable.
• Exceptional written and oral communication skills; strong attention to detail.
• Ability to write and edit complex material to ensure accuracy, clarity, and effectiveness.
• Knowledge of International Council for Harmonisation (ICH) guidelines for clinical and regulatory submission documents.
• Expert abilities in Microsoft Office.
• Ability to work in a fast-paced dynamic environment that involves frequent communication with project team.
• Excellent time management skills and ability to manage several projects simultaneously.
• Ability to communicate with cross-functional team members (e.g., clinical development, biometrics, regulatory affairs, quality assurance, manufacturing, nonclinical) and incorporate diverse feedback into a high-quality document.


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Senior Scientist (Senior Medical Writer) level could range from between $89,750 to $131,672 and that the base salary for the Principal Scientist (Principal Medical Writer) position level could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Roles and Responsibilities of the Position:

• Lead Biomolecular NMR efforts to support the Discovery Organization in lead generation, hit validation, hit to lead and lead optimization phase of projects
• Design and implement a variety of 1D and nD NMR experiments for quantitation, characterization of binding dynamics, conformation, and structure of ligand-biomolecule interactions
• Use multinuclear protein and ligand observed NMR methods for Fragment-Based Drug Discovery (FBDD) efforts
• Use well-manicured results from NMR spectroscopy to quickly provide go/no-go decision making to project teams
• Work seamlessly with the structural biology organization and medicinal chemistry teams to understand and rapidly address project needs
• Operate and maintain a 600 MHz cryo-probe equipped NMR spectrometer
• Actively engage with instrumentation and software vendors as well as academic collaborators to enable innovative analytical solutions.
• Contribute to and stay abreast of journal publications and conference presentations
• Implement new techniques for the continuous development of processes and NMR methodologies that will improve quality, productivity, timelines and scientific impact
• Collaborate cross-functionally with internal and external teams to deliver key decision-making results and to continue development of the analytical and medicinal chemistry capabilities
• Contribute to the scientific development of team members by organizing tutorials, vendor led training, laboratory-based coaching in new techniques, good scientific practices and laboratory safety
• Work effectively across sites and organizational structures to champion an collaborative environment
• Keep safety as the top priority at any time, striving to maintain a strong, generative, safety culture

Required Qualifications and Preferred Background:

• M.S. or Ph.D. in Chemistry (preferably Analytical), Biophysics, Biochemistry or other related field
• 3+ years (for Ph.D.) or 7+ years (for M.S.) of relevant post-academic experience
• Demonstrated hands-on experience with 1D-nD NMR experiments in the Biophysical NMR area with a strong publication record
• Deep theoretical understanding of 1D-nD NMR spectroscopy
• Experience with Bruker NMR hardware and software
• Strong attention to detail, highly organized, high level of learning agility, exceptional problem-solving skills, and the ability to manage several projects simultaneously
• Excellent English language oral and written communication skills, ability to engage highly effectively as team player in a multidisciplinary and international environment

Additional Desired Skills:

• Experience with 3rd party software such as NMRPipe, Mestre and ACD
• Experience with new NMR pulse sequence development/implementation and writing/implementing python scripts
• Well versed in IT enterprise infrastructure
• Solid understanding of medicinal chemistry


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Senior Scientist position level could range from between $89,750 to $131,672 and that the base salary for the Principal Scientist position level could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Roles and Responsibilities for the Position:

• Drive the project toward the next breakthrough drug candidate by designing and synthesizing new medicinal chemistry analogs that directly address project goala 
• Optimize lead series for potency, selectivity, physiochemical properties, in vitro ADME, and PK by coupling multivariant SAR analysis with hypothesis driven medicinal chemistry design principles. Use sound scientific methods to propose hypotheses and determine next steps even with complex or ambiguous data
• Work closely with structural biology and computational chemistry colleagues to design novel compounds and hypotheses that address key drug optimization goals
• Reduce ideas to practice in the lab quickly by effectively employing a broad range of modern organic chemistry transformations, synthetic methods, purification and characterization techniques
• Synergize with the broader team by communicating results, sharing insights, making plans, and setting goals in an open, honest way.
• Provide medicinal chemistry insight for new target and lead identification and evaluation initiatives in the oncology space
• Proactively investigate new or different technologies to improve the effectiveness of the drug discovery process
• Analyze complex data streams and conceptualize priority synthesis targets based on a holistic data approach

Required Qualifications and Preferred Background:

• BS, MS, or PhD in chemistry with a focus on synthetic organic chemistry 
• Experience in small molecule drug discovery in a biotechnology or pharmaceutical setting and a B.S. with 8+ years’ experience, M.S. with 5+ years’ experience or Ph.D. with 2+ years’ experience
• Proven track record of success in advancing programs from leads to advanced candidates
• Extensive experience in lead compound optimization for potency, selectivity, ADME and PK  
• Experienced in the use of synthetic chemistry instrumentation: HPLC, LC-MS, NMR, and purification systems
• Expert in using common medicinal chemistry software: electronic notebook, ChemDraw, Excel; data visualization; structure viewing; literature, chemical and database searching
• Committed to staying current with the latest scientific breakthroughs in the medicinal chemistry field through continued reading of the literature and attendance of scientific conferences
• An excellent team player with ability to communicate synergistically with a multidisciplinary team and be accountable for the medicinal chemistry progress of the project. Highly organized with excellent analytical, documentation, time management, and multi-tasking skills


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for Senior Scientist level position could range from between $89,750 to $131,672 and that the base salary for Principal Scientist level position could range from between $103,200 to $151,423 but will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Roles and Responsibilities of the Position:

• Work closely with Loxo@Lilly QA, CMC, Regulatory, Drug Supply, and CMO colleagues through all phases of drug development, particularly early phase to ensure compliance and timeliness of GMP work, including:
• Batch record review (Executed and Master) for all phases of manufacturing (drug substance, drug product, packaging, labeling, and associated intermediates)
• Final disposition of finished product for clinical use, including country-specific release and collaboration with Qualified Persons (QPs)
• Authoring and review of deviations, CAPAs, and change controls
• Investigation of product complaints
• Quality review of analytical documentation including: analytical methods; validation protocols and reports; specifications; and stability protocols, reports, and expiry extensions
• QC of IMPD/IND CMC sections
• Review and approval of clinical product labels
• Authoring/ revision of SOPs
• Implementation of process improvements
• Ensuring that GMP work at Loxo and contract organizations is done in compliance with applicable laws, regulations, guidelines, and SOPs.
• Participation on project teams and sub-teams as needed and assigned
• Additional tasks as required.

Required Qualifications and Preferred Background:

• BA/BS in science or engineering 
• A minimum of 5 years of experience in Quality Assurance in an FDA regulated Biotech or Pharmaceutical setting
• Experience in Batch Review and Release for clinical phase products
• Experience authoring and reviewing Deviations, CAPAs, and Change Controls
• Experience working with solid oral dosage products and/or Biologics
• Working knowledge of cGMP’s (CFR/ICH) and applicable international regulations/guidelines
• Experience working with Contract Manufacturing Organizations
• Strong understanding of GMP requirements for early phase drug development
• Attention to detail and accuracy of work
• Ability to work in a fast-paced environment to meet tight deadlines
• Ability to problem solve and implement process improvements
• Ability to serve as an active participant and contributor in cross-functional meetings
• Ability to escalate issues when necessary
• Ability to work in a cross-functional environment
• Ability to work in a virtual manufacturing environment
• Demonstrated ability to work well with other accomplished professionals
• Willing collaborator
• Strong communication skills, both written and oral

Available locations for this role:

• Louisville, CO
• Stamford, CT
• South San Francisco, CA

Roles and Responsibilities of the Position:

• Support travel and expense management
• Respond to travel policy inquiries
• Reconcile monthly corporate credit card expenditure
• Assist with audit reporting
• Maintain vendor relationships
• Create/enhance reports in Excel
• Assist with new and ongoing T&E projects

Required Qualifications and Preferred Background:

• At least five years of prior experience with T&E management, corporate credit cards, or relevant knowledge
• Experience working with T&E systems
• Detail oriented and organized
• Creative approach to problem solving 
• Biotech or pharmaceutical experience a plus 
• Proficient in Microsoft Office suite and applications 

Roles and Responsibilities of the Position:

• With an aptitude for developing web applications and an interest in using today's technologies, you will contribute to developing tools that support LIMS database development. The successful candidate will have a flexible, learning mindset to design and deliver scientific databases, create workflows to track inventory experimental details for gene to structure processes (target details, plasmid sequences, protein purification, protein characterization, protein crystallization, synchrotron X-ray crystallographic data, crystallography datasets, cryo-EM grid preparation, cryo-EM data analysis & processing, and protein structures). This position is responsible for delivering oracle-based LIMS database informatics solutions focused on ease of data input and accessibility, to ensure data quality. The successful candidate will be responsible for implement and deploy Loxo-LIMS by coordinating with the SB-LIMS team, and internal scientists to develop web-based tools to enhance laboratory processes and data tracking. An ideal candidate would be able to design, develop, test, and debug code through the entire development cycle.

Required Qualifications and Preferred Background:

• Bachelor’s/Master’s/PhD in computer science, bioinformatics, or equivalent experience
• 2+ years of software development experience, including experience in computer science, bioinformatics or other applied science
• Documented track record delivering and deploying large-scale informatics production solutions using laboratory information management system (LIMS)
• Strong demonstrated programming skills in PHP and/or Perl
• Experience with SQL, Oracle PL/SQL, Oracle triggers
• Strong web skills in HTML, JavaScript, JQUERY, AJAX, and CSS
• Familiarity with designing, maintaining, and implementing relational databases
• Familiarity in working within Linux/Unix/Apache environments
• Strong SQL and database skills, preferably with Oracle databases
• Familiarity with Perl compatible regular expression (PCRE) syntax
• Experience with C#, Python, and/or TensorFlow with deep learning would beneficial
• Understanding of molecular biology, protein sciences, protein crystallization, crystallography, and cryo-EM technologies is highly desirable
• Ability to work collaboratively with other team members to develop more complex applications
• Ability to development strategies to implement, troubleshoot and migrate existing tools to newer technologies
• Excellent communication skills and desire to learn is essential


Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Specialist  level position could range from between $67,850 to $99,563 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance).  In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items.  The compensation described above is subject to change and could be higher or lower than the range described.