Career Opportunities

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Reports To:

Senior Director, Bioassay Screening

Position Summary

Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by that goal. We pursue this goal with a tenacity, focus and commitment to excellence that defines who we are and how we work.

The Bioassay Screening Scientist will be responsible for identifying, developing, and performing robust, reproducible biological assays to support drug discovery and development in a team environment.  The Bioassay Screening Scientist will provide hands-on compound screening efforts in support of Loxo’s small molecule drug discovery pipeline in Oncology.   The scientist fulfilling this position will be responsible for characterizing the effects of small molecule compounds on specific protein targets in enzymes and cells using multiple plate-based assay formats including HTRF, ELISA, In-Cell Western, and proliferation.  A strong background in experimental curve-fitting, statistics, and assay optimization and execution is required.The Bioassay Screening Scientist will be responsible for identifying, developing, and performing robust, reproducible biological assays to support drug discovery and development in a team environment.  The Bioassay Screening Scientist will provide hands-on compound screening efforts in support of Loxo’s small molecule drug discovery pipeline in Oncology.   The scientist fulfilling this position will be responsible for characterizing the effects of small molecule compounds on specific protein targets in enzymes and cells using multiple plate-based assay formats including HTRF, ELISA, In-Cell Western, and proliferation.  A strong background in experimental curve-fitting, statistics, and assay optimization and execution is required.

Roles and Responsibilities of the Position*

• Design, execute, and trouble-shoot experiments utilizing fluorescence, ELISA, In-Cell Western, and proliferation readouts
• Perform comprehensive data analysis while communicating experimental findings to team members.
• Operate, implement and troubleshoot laboratory automation.
• Interact on work projects with CROs.
• Support regulatory filings and be actively engaged in advancing drug discovery programs. 
• This is a “hands-on” laboratory, based position.

Required Qualifications and Background

• BA/BS/MS in biology, biochemistry or related field.
• 2-8 years of highly relevant hands-on lab experience in biotech or pharma environment including 1+ years culturing cells and performing cell assays.
• A scientific foundation in the understanding and implementation of a wide range of biochemical and cell-based screening assays and readouts.
• Excellent oral and written communication skills including experimental documentation.
• Works well with team members daily across functional areas.
• Continual learner who works independently and possesses a can-do attitude.
• Ability to multi-task and shift priorities rapidly to meet tight deadlines.
• Highly organized with exceptional attention to detail.
• Proficient in Microsoft Office suite and applications.

Physical Demands / Travel

The physical demands of this job are consistent with a lab.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in a lab.  

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each roles and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Apply Now

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Reports To:

Clinical Trial Operations Lead

Position Summary

Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by that goal. We pursue this goal with a tenacity, focus and commitment to excellence that defines who we are and how we work.

The Clinical Research Associate in collaboration with the Clinical Trial Manager, contributes to the operational execution of clinical studies to ensure delivery on time, within budget, and of high quality in compliance with ICH/GCP, Regulatory Authorities’ regulations/guidelines, and applicable SOPs/WPs.  Responsibilities may include participation on one or more cross-functional study team(s) and/or performance and quality oversight of one or more Contract Research Organization (CRO) teams and vendors.

Roles and Responsibilities of the Position*

• Provide operational input on development, management and maintenance of study deliverables [i.e. timelines, study plans, documents, etc.] through collaboration with internal and external stakeholders.
• Use performance metrics and quality indicators to assist the clinical trial manager in driving study execution.
• Participate in monitoring visit report review process in order to maintain oversight of clinical monitoring quality and adherence to protocol and established processes and plans.
• Support Health Authority inspections and CQA audits as required. 
• Ensure full compliance (completeness & accuracy) of the required data in study management tools including clinical trial management systems, patient enrollment forecasting, etc.
• Provide proactive identification of potential risks and development/implementation of actions to avoid or mitigate.
• Develop and maintain collaborative relationships with internal and external partners/stakeholders.
• Collaborate with vendors and Loxo CTM’s regarding study specific issues and follow through to resolution.  
• Assist in the creation and review of study documents, including but not limited to the Protocol, Protocol Synopsis, Informed Consent Form (ICF) and other patient facing materials and assist in updating these study documents as needed.
• Participate in vendor specification development and management/oversight. 
• Assist with management of TMF set-up, ongoing quality review, and final reconciliation.
• Assist with shipment and reconciliation of Investigational Product (IP)at study and site level as needed.
• Actively contribute to study meetings including presentation subject matter expert, generate, finalize and distribute study team agendas and meeting minutes as needed.
• Contribute to development / coordination of study training and study training materials for study team, investigational sites, and vendors. 
• Contribute to oversight of the required country regulatory (e.g. CTA, MoH) and country/site IRB/IEC submissions/approvals/notifications.
• Assist with the collection of various study documents such as country/site insurance, CSR appendices, etc.
• Assist with Investigator meeting coordination and planning.

Required Qualifications and Background

• BS Degree in a relevant discipline with 2-4 years’ experience in the Clinical Trial environment required.
• Strong oral and written skills with proficiency in English.
• Knowledge of ICH/GCP and regulatory guidelines/directives.
• Demonstrates analytical approach and anticipation of problems.
• Identifies gaps and provides constructive feedback and solutions.
• Ability to multi-task effectively and prioritize assignments from multiple sources.
• Basic knowledge of clinical research budgets including processing and tracking of site and vendor payments; basic understanding of project management desired.
• Excellent organizational skills.
• Strong knowledge of MS applications including (but not limited to) MS Project, Word, Excel, PowerPoint.
• Knowledge of study tools including electronic system skills such as CTMS / EDC/ IRT/eTMF.
• Knowledge of drug development process. Proactively shares information, ideas, input, and/or expertise with team members. Demonstrates concern for high quality outcomes.
• Responds flexibly to changing business demands and opportunities, proactively looking for ways to contribute.

Physical Demands / Travel

The physical demands of this job are consistent with light office duties.  Up to 25% travel may be required.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in an office.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each roles and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Apply Now

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Reports To:

Senior Clinical Trial Manager

Position Summary

Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by that goal. We pursue this goal with a tenacity, focus and commitment to excellence that defines who we are and how we work.

CRA/Field Site Monitor will coordinate clinical studies and be responsible for all major stages of study development, execution, monitoring, and close-out. This individual will also be responsible for clinical study site maintenance, data and source documentation collection, as well as field monitoring of clinical trials. Duties will include ensuring compliance to the study protocol, and Monitoring Plan by ensuring completeness and accuracy of data as well as compliance with domestic and international regulations, Good Clinical Practices, applicable regulatory standards, and Standard Operating Procedures.

Roles and Responsibilities of the Position*

• Drafts materials including informed consents, case report forms (CRFs), CRF completion guidelines, and technical instructions.
• Carries out clinical site qualification, IRB/ethical committee submissions, protocol initiation, site monitoring, and site close-out
• Coordinates and manages the activities of investigative sites to ensure compliance with study protocol requirements
• Ensures preparation, collection and distribution of trial master file (TMF) documents and maintenance of regulatory files at investigative site
• Conducts clinical site and data monitoring and completes monitoring visit reports
• Evaluates clinical data and coordinates data query resolutions
• Supports internal departmental quality compliance
• Prepares progress reports and performance metrics

Required Qualifications and Background

• Minimum of 2 years field monitoring experience
• Oncology experience highly preferred
• Understands and can apply knowledge of clinical trial designs to trial execution
• Advanced knowledge and experience with GCP/ICH and local regulations
• Experience in web-based data collection applications, knowledge of key areas of Compliance
• Strong communication skills as single point of contact for investigator
• Strong skills in building and maintaining relationships with investigative sites
• Excellent organizational skills with high attention to detail is required
• Strong computer skills (spreadsheets, word processing, etc.) is required
• Ability to manage, prioritize, and routinely report progress on multiple projects and tasks
• Strong presentation skills to internal professionals and external collaborators
•  

Physical Demands / Travel

Physical Demands:

The physical demands of this job are consistent with light office duties

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

This role can require up to 40% domestic and international travel

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

Work Environment:

This position’s work environment is in an office.   

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

No specific work demands.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each roles and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Apply Now

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Reports To:

Senior Medical Director, Medical Affairs

Position Summary

Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by that goal. We pursue this goal with a tenacity, focus and commitment to excellence that defines who we are and how we work.

The Diagnostics Medical Science Liaison (DxMSL) is responsible for the identification and engagement of targeted groups of regional thought leaders within the pathology, laboratory, and oncology communities with specific responsibility for providing consistent delivery of educational and compliant scientific information surrounding clinical/scientific aspects of cancer diagnosis and biomarker/genomic testing.

Roles and Responsibilities of the Position*

• Identify and develop relationships with clinical/community/academic thought leaders on a local and regional level.
• Serve as Loxo Oncology’s scientific representative to the Pathology, Diagnostic and Medical communities and facilitate the appropriate exchange of scientific information.
• Utilize approved resources to address inquiries, ensuring they are in compliance with all guidelines and regulations.
• Communicate diagnostic and therapeutic market trends which may impact biomarker/genomic testing.  
• Participate and support advisory boards and steering committees.
• Lead and/or participate on committee/project teams which support Diagnostic MSL strategies as delegated by MSL leadership. 
• Attend identified relevant national/regional/local education meetings and conferences, maximizing opportunities at these events.
• Develop and implement educational speaker programs for the pathology/lab audience.
• Educate on high quality comprehensive testing for relevant biomarkers in precision oncology and make ties to Loxo pipeline assets.

Required Qualifications and Background

• Advanced doctoral degree strongly preferred (e.g. PharmD, MD, DO, or PhD). Candidates with a diagnostic laboratory and or clinical pathology background (e.g. MSN, PA) and extensive hematology/oncology MSL experience will also be considered.
• 0-3+years’ MSL experience in Oncology or Oncology Diagnostics required
• Ability to establish and maintain relationships with influential thought leaders.
• Product launch experience a plus; Laboratory or Clinical Diagnostics experience beneficial.
• Exceptional interpersonal skills.
• Ability to excel in dynamic settings with short timelines.
• Strong written/verbal communication and presentation skills.
• Proficient in Microsoft Office suite and applications.

Physical Demands / Travel

Please note this role will require up to 50% travel, primarily within assigned region but also nationally and globally as required.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is remote based, with significant travel on a regional basis to various sites.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each roles and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Apply Now

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Reports To:

Office Manager

Position Summary

Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by that goal. We pursue this goal with a tenacity, focus and commitment to excellence that defines who we are and how we work.

The Laboratory/Administrative Assistant will provide critical support in a robust Discovery Lab environment.  This role will be broken down into two areas: 1. Lab support consisting primarily of safety maintenance, sample management and tracking, and data entry.  2. Administrative support consisting of visitor management, overseeing deliveries, provide expense reporting, assisting with coordination of meetings and conferences, ordering and organizing supplies, planning team lunches/dinners, and working on special projects as needed.

Roles and Responsibilities of the Position*

Lab Support:

• Prepare samples for testing, manage organized storage of samples, provide samples to assay scientists for internal assays, and ship samples to external vendors for testing.
• Maintain complete, accurate and organized systems; file addition/correction sheets, requisitions and scientific/date results according to internal SOPs and guidelines.
• Entry of data into electronic lab notebooks
• Assist with obtaining quotes for external assays and the coordination of delivery of samples between lab and external vendors, both US and international. 
• Contribute to the upkeep and safety of the laboratory and ensure a clean, safe, adequately supplied work area.

Administrative Support:

• Schedule key meetings and calls for team members and process expense reports.
• Organize complex activities such as travel, conferences and department activities.
• Coordinate team lunches and dinners and facilitate weekly GrubHub lunch orders.  
• Welcome outside visitors.
• Receive and organize multiple deliveries per week, requiring some lifting and moving of boxes on a regular basis.
• Process both US and international outgoing shipments.
• Coordinate office maintenance and support and work closely with our IT vendor.
• Stock and maintain kitchen and shared office areas as well as order office supplies.
• Act as a point of contact for the team, field questions and inquiries, and proactively problem solve.
• Assist with the coordination and facilitation of onsite candidate interviews and employee onboarding.
• Assist with special projects as needed.

Required Qualifications and Background

• Bachelor’s degree in the Life Sciences preferred;  
• 1-2 years’ experience as a Lab Assistant or an Administrative Assistant supporting a Discovery Lab Environment.  Excellent opportunity for a recent college graduate with a Biology or Chemistry degree in search of their  first industry job.
• Proficient in Microsoft Office suite and applications including proficient use of Excel.
• Strong attention to detail and communication skills.
• Collaborative, enthusiastic and self-motivated; driven to improve processes and eliminate inefficiencies

Physical Demands / Travel

The physical demands of this job are consistent with working in a wet-laboratory setting.  Requires ability to lift 15lbs.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in a wet-laboratory setting.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each roles and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Apply Now

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Reports To:

Executive Director, Drug Discovery

Position Summary

Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by that goal. We pursue this goal with a tenacity, focus and commitment to excellence that defines who we are and how we work.

Loxo Oncology’s newly formed Drug Discovery group in Boulder, Colorado has an immediate opening for an experienced medicinal chemist. The Loxo Drug Discovery group’s mission is to invent life-changing targeted therapies for cancer patient populations that are poorly treated by existing therapies. To that end, we are building a multi-disciplinary team of dedicated drug discovery scientists who are passionate about driving the science forward to create highly selective drugs for known oncogenic drivers. We are currently looking for an accomplished Medicinal Chemist with a proven track record of success in small molecule drug discovery. The ideal candidate will be passionate about leading from the bench to solve medicinal chemistry challenges and excel at working closely with scientists across disciplines. The position requires excellent people skills, a positive can-do attitude and the ability to thrive in a highly interactive, fast-paced, team environment.

Roles and Responsibilities of the Position*

• Drive the team forward with new medicinal chemistry analogs that consistently move the project toward the next breakthrough drug candidate.
• Optimize lead series for potency, selectivity, physiochemical properties, in vitro ADME and PK by coupling multivariant SAR analysis with hypothesis driven medicinal chemistry design principles. Use sound scientific methods to propose hypotheses and determine next steps even with complex or ambiguous data.
• Work closely with structural biology and computational chemistry colleagues to design novel compounds and hypotheses that address key drug optimization goals.
• Reduce ideas to practice in the lab quickly by effectively employing a broad range of modern organic chemistry transformations, synthetic methods, tactics, purification and characterization techniques.
• Synergize with the broader team by communicating results, sharing insights, making plans and setting goals in an open, honest way.
• Provide medicinal chemistry insight for new target and lead identification and evaluation initiatives in the oncology space.
• Implement and maintain the necessary equipment, processes, software and infrastructure to enable a state of the art medicinal chemistry facility.
• Proactively investigate new or different technologies to improve the effectiveness of the drug discovery process.

Required Qualifications and Background

• B.S., M.S. or Ph.D. in Chemistry with a focus on synthetic organic chemistry.
• 5-15+ years of experience in small molecule drug discovery experience in biotechnology or pharmaceutical setting.
• Proven track record of success in advancing programs from leads to advanced candidates.
• Extensive experience lead compound optimization in the areas or potency, selectivity, ADME and PK.
• Highly versed the all current medicinal chemistry instrumentation: HPLC, LC-MS, NMR and purification systems.
• Expert in using common medicinal chemistry software: electronic notebook, structure drawing, data spreadsheet analysis; data visualization; structure viewing; literature, chemical and database searching.
• Committed to staying current with the latest scientific breakthroughs in the medicinal chemistry field through continued reading of the literature and attendance of scientific conferences.
• An excellent team player with ability to communicate synergistically with a multidisciplinary team and be accountable for the medicinal chemistry progress of the project. Highly organized with excellent analytical, documentation, time management and multi-tasking skills.

Physical Demands / Travel

The physical demands of this position are consistent with working in a laboratory/ bench environment. Some light lifting and maneuvering may be required.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is based in a laboratory/ bench environment.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each roles and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Apply Now

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Reports To:

Vice President, Discovery Biology

Position Summary

Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by that goal. We pursue this goal with a tenacity, focus and commitment to excellence that defines who we are and how we work.

This position offers the opportunity to be part of Loxo’s discovery teams focused on creating novel, highly specific and selective drugs for genetically identified targets.  The Senior Structural Biologist will offer structural and mechanistic insights to a multi-disciplinary discovery team by providing high-resolution protein-ligand crystal structures.

Roles and Responsibilities of the Position*

• Generate protein-small molecule complex x-ray crystal structures with hands-on lab involvement throughout the entire gene to structure process including protein expression, purification, crystallization, and structure determination.
• Coordinate protein construct design, expression, and purification with the project team to support biochemical and biophysical assays.
• Rapidly communicate scientific results and insights to the team.
• Identify, evaluate, and manage vendors for outsourced services and studies.
• Collaborate with colleagues throughout the company to ensure structural work meets the program needs and results are appropriately interpreted.
• Prepare reports for internal and external purposes including regulatory submissions.
• Participate and lead project-based and technical team meetings to identify and solve problems, guide work towards project goals, communicate on-going work and progress, and plan forward thinking strategies. 
• Develop and continually advance one’s knowledge base on genetically targeted drugs and structure-based drug design.
• Proactively investigate new or different technologies, methods, and service providers to ensure our work is being done in a scientifically sound, efficient, and reasonable way.
• In the future, this position’s responsibilities may include supervision of scientists and associates.

Required Qualifications and Background

• PhD in Biochemistry, Chemistry, or related field
• Ideal candidate will have with 5+ years hands-on gene to structure protein-small molecule crystallography experience in a biotech/pharma setting.
• Highly skilled in crystallization of protein-small molecule complexes and high-resolution x-ray structure determination
• Extensive experience in protein construct design, expression, purification, and characterization
• Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels.
• Highly organized with excellent analytical, documentation and multi-tasking skills
• Committed to staying current with the latest scientific breakthroughs in structure-based drug design and structural biology.
• Expertise in other methods of biophysical and structural biology is a plus

Physical Demands / Travel

The physical demands of this job are consistent with light office duties.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in an office and the lab.  

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each roles and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Apply Now