Career Opportunities
Patients are at the heart of everything we do at Loxo@Lilly, and we continue to be motivated by our goal of improving the lives of people living with cancer. We pursue this goal with a tenacity, focus, and commitment to excellence that defines who we are and how we work.
We seek dedicated, passionate, hardworking, intelligent, thoughtful, and authentic individuals who thrive within a collaborative and fast-paced environment and will bring their experiences, unique perspectives and problem-solving skills to the team. In return, we cultivate an environment that rewards and recognizes hard work and provides opportunities for learning and growth as part of a team making a meaningful difference in the lives of patients.
- All Functions
- Bioassay (1)
- Biophysics (3)
- Biostatistics (1)
- Business Operations (2)
- CMC (7)
- Clinical Data Management (4)
- Drug Safety Operations (1)
- Finance (2)
- Large Molecule Biology & Discovery Technologies (4)
- Large Molecule Discovery (4)
- Molecular & Cellular Biology (2)
- Program and Alliance Management (1)
- Protein Sciences (2)
- Quality Assurance (3)
- Small Molecule Discovery (4)
- Structural Biology (1)
- Target Discovery (3)
- All Locations
- Indianapolis, IN (1)
- Louisville, CO (12)
- New York, NY (4)
- Remote (16)
- San Diego, CA (1)
- South San Francisco, CA (10)
- Stamford, CT (1)
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- Position:
- Anti-Bribery and Anti-Corruption Consultant (PT)
- Function:
- Business Operations
- Location:
- Remote
Position Summary
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
Responsible for assessing third parties to identify and mitigate bribery and corruption risk. Collaborate with cross functional business partners regarding bribery and corruption risks and controls.
Roles and Responsibilities of the Position:
- Assists more senior compliance professionals and business operations in evaluating bribery and corruption risks related to third party engagements, including reviewing third parties' responses to due diligence questionnaires, identifying and escalating relevant bribery and corruption risks, and working with the business and third party to mitigate such risks.
- Maintains a high level of awareness and knowledge of Anti-Bribery/Anti-Corruption (ABAC) regulations and requirements.
Required Qualifications and Preferred Background:
- Bachelor’s Degree in Finance or related field
- 5+ years of experience in Compliance, Audit, Law, or Risk Management
- ABAC compliance experience
- Risk management certification - TRACE Anti-Bribery Specialist or similar certification - is a plus
- Collaborative problem-solver
- Experience with conducting ABAC due diligence on third parties
Physical Demands/Travel:
The physical demands of this job are consistent with light office duties.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is a remote office setting
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Associate Director, GMP Auditor
- Function:
- Quality Assurance
- Location:
- Remote
Position Summary
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
Loxo@Lilly is seeking a highly motivated QA Audit Professional who is an excellent influencer and enjoys a fast paced, dynamic work environment. The ideal candidate has demonstrated strong knowledge in GXPs for small and large molecule pharmaceuticals in both clinical trials and product manufacturing. The candidate will manage the GxP audit program for third party qualifications as well as the internal audit program. The candidate will execute GxP audits as well as collaborate both internally and externally to oversee the planning and execution of all audits.
Roles and Responsibilities of the Position:
- Conducts Audits for which L@L is responsible
- Key activities include, but are not limited to:
- o Plan, execute, and monitor L@L qualification audits
- o Plan and execute internal audits
- o Support development of an audit schedule
- o Support audits conducted of L@L by outside auditors
- o Partner with L@L functional areas to support Health Authority audits
- o Partner with L@L Third Party Risk Management Team to determine required audits
- o Partner with parent company to support strategic auditing initiatives
- Provide input in Quality Management review, which includes metric generation and data analysis.
- Support process improvement projects
- Perform other duties as assigned.
Required Qualifications and Preferred Background:
- Bachelor's Degree is required in science, health or related field 8+ years experience in the Biotech/Pharmaceutical industry
- Working knowledge of Microsoft 365 suite, Veeva, etc.
- Comprehensive working knowledge of global GMPs requirements
- Strong working knowledge of global regulations and guidelines (e.g., FDA/EU and ICH) for early phase pharmaceutical development in both clinical trials execution and drug substance/drug product manufacturing (small and large molecule)
- Ability to adapt quickly to shifting needs and/or priorities.
- Strong Project Management skills in order to manage projects at various stages and effectively multi-task
- Able to interface well with all levels of personnel.
- Capacity to produce high quality results across multiple projects and demands, through effective prioritization, while working under short deadlines associated with a fast-paced dynamic scientific environment.
- Excellent communications skills, both written and verbal.
- Excellent teamwork, interpersonal skills and negotiation skills, both internally and externally.
- Strategic thinker, open-minded and flexible to adopting new ideas.
- Motivated, committed and self-managed.
- Willingness to work in a dynamic and changing corporate environment.
- Requires a flexible work schedule to accommodate program priorities and international activities as needed.
- Exceptional attention to detail.
Loxo@Lilly currently anticipates that the base salary for the Manager level position could range from between $90,000 to $132,000 and that the base salary for the Associate Director level position could range from between $109,500 to $160,600 and will depend in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands:
No physical demands.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
Ability to travel to travel 50%No specific work demands.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Associate Director, Project Management, Small Molecule Discovery
- Function:
- Program and Alliance Management
- Location:
- Louisville, CO
Position Summary
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
The ideal candidate will establish and implement project-specific strategic goals from early-stage discovery, lead identification, lead optimization through candidate seeking and advancement as a part of the Loxo Small Molecule Discovery portfolio, in a cross-functional, dynamic environment. The role will work closely with team leaders and Loxo@Lilly Small Molecule Discovery leadership to create and implement project’s strategic plans. The Project Manager is expected to support 2-4 projects depending upon the project’s requirements.
Roles and Responsibilities for the Position:
- Establish strategic project goals and translate goals into project plan(s) with clear deliverables, milestones, and go/ no-go decisions
- Establish project strategic objectives by collaborating with Loxo Small Molecule- Discovery leadership team
- Engage with functional team leads of medicinal chemistry, biology, DMPK, CMC, and toxicology (and other key stakeholders) to plan, execute, and track project activities, ensuring alignment of project deliverables with strategic goals
- Actively manage assays and studies conducted at external collaborators and vendors to meet outsourcing needs as needed.
- Actively facilitate project meetings: create agendas, minutes, and track action items
- Create and maintain organizational documents and tools, e.g., screening cascades, data summaries, project timelines, Spotfire dashboards, compound demand-supply forecasts, and various other trackers to ensure clear, effective, transparent, and efficient implementation of projects
- Create project updates, reports, presentations, and memos and maintain project document repository in collaboration with team members
- Proficient in adaptive communications; effectively manage communications vertically and horizontally in a cross-functional environment
- Proactively contribute to and manage project communications. Identify gaps and ambiguities in communication channels and address them to maintain alignment across the team
- Drive day-to-day operational activities by coordinating with stakeholders from different functional departments – legal, business operations, procurement, finance, and other relevant functional areas as needed
- Proactively identify gaps in processes and actively create processes to meet project needs
- Adaptive to change in priorities and able to drive project outcomes ensuring re-alignment with project deliverables in changing landscape
- Contribute to building positive, collaborative teams across scientific disciplines, and encourage sharing of new ideas and creative ways to solve problems often needed in drug discovery research
Required Qualifications and Preferred Background:
- BS, MS, or PhD in chemistry, biology, or related sciences
- Small molecule drug discovery experience: BS with 7 years, MS with 4 years, or PhD with 2 years. Part of the experience could come from project management/ alliance management responsibilities in pharmaceutical research & development
- Must be self-motivated and have excellent time management skills
- Excellent verbal, written communication and interpersonal skills.
- Excellent organizational skills, efficient, with strong attention to detail
- Additional Preferences:
- PMP certification is preferred, but not required
- Proficient in identifying and applying tools to effectively manage and track projects - MS Office suite, MS Project
- Experience with data visualization software, such as Spotfire
- Create and implement new tools and processes customized for furthering discovery research
Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Associate Director, Project Management, Small Molecule Discovery level position could range from between $109,500 to $160,600 but will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.
Physical Demands/ Travel:
The physical demands of this job are consistent with laboratory setting.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in a lab.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Clinical Application Programmer (Contract)
- Function:
- Clinical Data Management
- Location:
- Remote
Position Summary
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
The Clinical Application Programmer (Contract) is responsible for configuration and script writing for in-house clinical database builds for studies conducted by Loxo@Lilly, while maintaining a high degree of quality in all work performed. This role ensures all assigned database builds are appropriately tracked, resourced, and budgeted for successful completion, and ensures the project status is transparently disseminated throughout the organization. They maintain effective working relationships at all levels within and outside of Loxo@Lilly. The ideal candidate will have varied experience in electronic data collection technologies, such as Veeva EDC, Medidata Rave, and Oracle InForm, etc., as well as a sufficient knowledge of industry clinical data standards, the management of CRF library collections, developing CRFs, dynamics and rules, and the integration of third-party data. A general understanding of the requirements for GxP systems implementation and maintaining systems in a validated state, is a plus. The individual will be a self-starter with excellent leadership skills, strong focus on innovation, collaboration, and most importantly, application programming and tools.
*Roles and Responsibilities of the Position
- Serve as a subject matter expert in the use of EDC platforms and their suite of products including Studio/Designer, EDC, Local Lab Module, Coder, Data Extract and Reporting, among others.
- Provide oversight, technical support, and guidance to the study teams in the efficient use of the EDC product suite in the study planning, execution, and close out activities of clinical studies.
- Contribute to the quality of the data management clinical database programming deliverables including specification development, eCRF development, edit checks programming, and Quality Testing.
- Expertise in the development, support, and optimal use of the CRF library collections (Veeva CDMS, et al) and other data environments.
- Ability to support business initiatives along with being an advocate for business stakeholders to various system owners
- Proactively identifies potential technical and operational issues/risks and recommends/ implements solutions.
- Engage in the governance and management of the CRF Library Standards; maintain and support Library documentation.
- Establish and implement programming standards and comply with regulatory requirements.
- Participate in the development of, and ensure compliance to, standard operating procedures (SOPs), policies, guidelines, and programming standards.
- Perform all other tasks and activities as requested
Required Qualifications and Preferred Background
- Bachelor’s degree preferred.
- Minimum of 3 years’ experience in electronic data collection application programming within life sciences.
- Minimum 2 years’ oncology experience, preferred.
- Expertise in Clinical Programming, methods, and techniques
- Knowledge of regulatory guidelines such as GCP, 21 CFR Part 11 etc.
- Knowledge of industry standard clinical technologies including CTMS, EDC (Veeva CDMS preferred, Rave, InForm), eCOA, IxRS, Clinical Data Repositories, etc.
- Knowledge of CDISC and CDASH standards/standard terminology
- Ability to work independently as well as in a team environment.
- Excellent time management skills and a proven ability to work on multiple projects at any given time in a fast-paced environment.
- Demonstrated ability to stay abreast of trends and new information in the profession.
Physical Demands/Travel:
The physical demands of this job are consistent with light office duties. This position will travel occasionally; the average travel for this position is 10% with some variation based upon the demands of the business imperatives.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in a home-based office settingThe work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Director, Scientific Lead, ADME/DMPK
- Function:
- Small Molecule Discovery
- Location:
- Louisville, CO
Position Summary
About Loxo@Lilly:
Loxo@Lilly aims to create medicines that make life better for all those affected by cancer around the world. Bringing together the focus and spirit of a biotech with the scale, resources, and heritage of Lilly, our team is focused on rapidly delivering impactful new medicines for people with cancer. Our approach centers on creating oncology medicines that unequivocally show early signs of clinical activity and will matter to patients. We intend to curate a balanced pipeline of medicines, either internally or externally discovered, with the potential to treat cancer with dramatic effect. Loxo@Lilly was created in December 2019, combining the Lilly Oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. Loxo@Lilly is a global organization with team members in Louisville, Colorado; Indianapolis, Indiana; New York City, New York; San Diego, California; South San Francisco, California; Stamford, Connecticut; and Madrid, Spain.
Roles and Responsibilities of the Position:
- Lead a group of 6-7 ADME scientists running HTS ADME assays
- Design and execute preclinical and absorption, metabolism, distribution, and excretion (ADME) studies to understand the pharmacokinetics (PK) of drug candidates
- Run weekly ADME assay to guide chemistry structure activity relationships (SAR)
- Participate in the management of CROs in the conduct of in vitro ADME studies
- Analyze in vitro sample utilizing LC-MS/MS
- QC in vivo protocols and study reports
- Collate data and present to program team
- Contribute to authoring and review of regulatory reports and documents
- Maintain accurate and timely electronic lab notebook
- Work effectively both independently and in a team environment
Required Qualifications and Preferred Background:
- BS degree in chemistry, biochemistry or related with 15+ years of ADME experience OR MS degree in chemistry, biochemistry or related with 12+ ADME years OR PhD degree in chemistry, biochemistry or related with 10+ years ADME years is required
- Must have 10+ years of direct ADME/DMPK experience
- 5+ year LC-MS/MS experience (Sciex systems preferred)
- Experience with bioanalysis method and assay development
- Good written and oral presentation capabilities
Loxo@Lilly currently anticipates that the base salary for the Director, Scientific Lead could range from between $135,300 to $198,516 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands/ Travel:
The physical demands of this job are consistent with laboratory setting.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in a lab.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Director, Upstream Process Development and Manufacturing, CMC Biologics
- Function:
- CMC
- Location:
- Remote
Position Summary
About Loxo@Lilly:
Loxo@Lilly aims to create medicines that make life better for all those affected by cancer around the world. Bringing together the focus and spirit of a biotech with the scale, resources, and heritage of Lilly, our team is focused on rapidly delivering impactful new medicines for people with cancer. Our approach centers on creating oncology medicines that unequivocally show early signs of clinical activity and will matter to patients. We intend to curate a balanced pipeline of medicines, either internally or externally discovered, with the potential to treat cancer with dramatic effect. Loxo@Lilly was created in December 2019, combining the Lilly Oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. Loxo@Lilly is a global organization with team members in Louisville, Colorado; Indianapolis, Indiana; New York City, New York; San Diego, California; South San Francisco, California; Stamford, Connecticut; and Madrid, Spain.
The CMC Biologics team has an exciting opportunity for an innovative individual to join our organization and develop the growing oncology portfolio of therapeutic proteins of various modalities (mAbs, bispecifics, antibody-drug conjugates, etc.). In this role, you will lead phase appropriate upstream development and manufacturing efforts to develop high yield, robust, and scalable cell culture processes including CHO cell line development.
Roles and Responsibilities for the Position:
- Work in a team environment to drive and manage CHO cell line development and upstream bioreactor process development, characterization and manufacturing activities primarily at third-party partners for assigned projects.
- Provide technical and scientific direction to third-party partners.
- Partner with colleagues in discovery, downstream process development and analytical to develop integrated clinical process and manufacturing solutions that achieve quality by design targets with robust control strategies.
- Oversee the preparation of technical reports, data summaries and CMC related documents required for various regulatory submissions.
- Write and review sections in regulatory submission documents (e.g., IND, IMPD, BLA).
- Key member of the interdisciplinary CMC project teams.
Required Qualifications and Preferred Background:
- BS degree required. Prefer candidates with a Master’s and/or PhD in chemical engineering, bioengineering, biological engineering or related field.
- Minimum of 8+ years of experience working in a Biotech or Pharmaceutical FDA regulated industry or an equivalent combination of education, training and/or experience from which comparable knowledge, skills and abilities have been attained. Level is commensurate of experience and education.
- Technical background and hands-on experience with mammalian cell culture and fed-batch processes to produce recombinant proteins.
- Scientific understanding and working knowledge of CHO cell biology, metabolism, cell culture media and engineering principles for large scale recombinant protein production systems. Understanding of cell culture bioreactors including microbioreactors, bench-scale and pilot scale, and scale up principles.
- Working knowledge of statistical methods (design of experiments, multivariate data analysis) and tools.
- Direct experience with managing third-party partners for process development and manufacturing in support of CMC activities.
- Knowledgeable in chemical and physical characterization of biologic proteins and antibodies.
- Knowledge of regulatory environment (ICH/FDA/EMA regulations) and experience with organizing and writing regulatory submissions.
- Experience writing and presenting clearly on CMC topics.
- Demonstrable ability to work proactively, independently, and tenaciously.
Loxo@Lilly currently anticipates that the base salary for the Director position level could range from between $138,000 to $202,400 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus(depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands/Travel:
The physical demands of this job are consistent with light office duties.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in the employee’s home office.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Executive Director, Biostatistics and Statistical Programming Process and Infrastructure (BSPPI)
- Function:
- Biostatistics
- Location:
- Remote
Position Summary
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
The Executive Director, Biostatistics and Statistical Programming Process and Infrastructure (BSPPI) will play a key role in modernizing the Biostatistics Department by assessing, improving, and managing its standards, infrastructure, and processes. This individual will work closely with the Loxo@Lilly Biostatistics leadership team, Lilly biostatistics and data management to establish best practices, processes and efficient integrated handoffs from data and analysis perspective. The Executive Director, BSPPI will have an opportunity to influence best practices and innovative processes cross functionally to enable agile drug development in the context of an exciting and growing oncology portfolio.
Roles and Responsibilities of the Position
- Processes: Collaboratively lead assessment, implementation, and management of lean process development and associated documentation for biostatistics and statistical programming
- Infrastructure: Partner with leads from interfacing cross functions such as Data Management and IT across Loxo@Lilly and Lilly to analyze and continuously improve the computing infrastructure that includes statistical computing environment and standard software utilities
- People: Develop collaborative relationships with relevant functions within Loxo@Lilly and Lilly by leading/participating in cross functional initiatives to bridge the differences in standards, processes, and infrastructure.
- Standards: Lead the development, improvement, and adaption of standards for statistical analysis documents, SAS and R programs, TFLs, and SDTM and ADaM datasets. Keep abreast with industry and regulatory trends related to biostatistics and statistical programming.
- Technology: Introduce/develop breakthrough and incrementally innovative technical capabilities to ensure optimal operation of Biostatistics department.
Required Qualifications and Preferred Background
- Bachelor/Master’s/PhD Degree in Computer Science, Statistics, Mathematics, Life Sciences or other relevant scientific fields with a minimum 7-10 years Pharmaceutical/Biotech data science, programming and/or statistics experience is required.
- Experience in analyzing, designing, developing, and managing the change of implementing innovative solutions is required
- Knowledge of SAS programming language and familiarity with macro development is required.
- Knowledge of programming languages in addition to SAS such as R and Python, and programming tools used in clinical research and drug development is preferred.
- Solid knowledge of the drug development process, interaction of statisticians and statistical programmers, and experience in complex technical projects is required.
- Familiarity with regulatory guidelines, CDISC standards, biostatistics and statistical programming submission deliverables, and validation processes is required.
- Excellent verbal/written and interpersonal skills including the ability to communicate and collaborate effectively in a cross-functional setting.
Loxo@Lilly currently anticipates that the base salary for this position level could range from between $186,000 to $272,800 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus(depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands/Travel:
The physical demands of this job are consistent with light office duties.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Executive Director, Clinical Quality Assurance
- Function:
- Quality Assurance
- Location:
- Remote
Position Summary
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
The Executive Director, Clinical Quality Assurance is responsible for end-to-end Clinical Quality Assurance. The Executive Director, Clinical Quality Assurance will be responsible for the oversight and execution of third-party qualifications, inspection readiness program, quality plans, policies and quality system elements related to clinical quality activities in support of clinical programs. The Executive Director, Clinical Quality Assurance will establish, maintain, and ensure effectiveness of quality programs and documentation to assure compliance in a international regulatory environment and provide guidance in clinical Quality related areas.
Roles and Responsibilities:
- Responsible for leading the clinical Quality team which includes third party and internal auditing and day to day clinical study team support.
- Liaise across Loxo@Lilly departments and with Lilly colleagues to proactively identify opportunities to streamline and strengthen clinical Quality process.
- Reviews and approves internal and external audit reports, Quality Events and associated Corrective and Preventative Actions within a regulated Quality Management System.
- Represents Clinical Quality expertise across the Loxo @Lilly development organization in GCLP and GCP.
- Keeps current with global health authority laws and regulations; identifies gaps and implements process improvements resulting from new/revised regulations or guidance.
- Reviews study team and regulatory documentation as requested (e.g., Data Management, Operations, Safety, Regulatory, etc.).
- Leads external Health Authority inspections and internal audits
- Provides guidance in global regulatory reporting requirements (e.g. serious breach, etc).
- Establishes a global inspection readiness program.
Required Qualifications and Preferred Background:
- Bachelor’s degree with 15 or more years’ experience working in clinical development, preferably in either a clinical compliance or clinical Quality Assurance.
- Must be strategic as well as a hands-on leader who can see “the big picture” while providing guidance to execute daily tasks
- Must have experience in managing a team of QA professionals
- Demonstrated Quality Management System experience appropriate for the clinical development.
- Demonstrated understanding in third party/internal Quality audits, Issue Management and CAPA in a clinical environment.
- Experience leading FDA or other Health Authority Inspections
- Strong knowledge of global clinical trial regulations (e.g. ICH, FDA, etc) and guidelines, particularly in GCLP, CAP, CLIA and GCP
- Proficient in risk management principles
- Self-motivated with the ability to work effectively in a dynamic environment
- Strong leadership with demonstrated ability to interface with senior leaders and different levels of the organization to provide solutions to complex situations.
- Excellent critical thinking and problem-solving skills and strong collaborator.
- Ability to effectively manage multiple priorities with a sense of urgency
- Strong track record of project management, stakeholder management, collaboration skills and negotiation of complex situations.
- Attention to detail and accuracy of work.
- Demonstrated ability to work well with other accomplished professionals within and across functions/teams.
- Strong communication skills both written and oral.
Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Executive Director level position could range from between $144,000 to $232,100 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.
Physical Demands/ Travel:
The physical demands of this job are consistent with light office duties.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in an office setting with up to 25% travel required.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Executive Director, Discovery Bioinformatics
- Function:
- Target Discovery
- Location:
- South San Francisco, CA
Position Summary
About Loxo@Lilly:
Loxo@Lilly aims to create medicines that make life better for all those affected by cancer around the world. Bringing together the focus and spirit of a biotech with the scale, resources, and heritage of Lilly, our team is focused on rapidly delivering impactful new medicines for people with cancer. Our approach centers on creating oncology medicines that unequivocally show early signs of clinical activity and will matter to patients. We intend to curate a balanced pipeline of medicines, either internally or externally discovered, with the potential to treat cancer with dramatic effect. Loxo@Lilly was created in December 2019, combining the Lilly Oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. Loxo@Lilly is a global organization with team members in Louisville, Colorado; Indianapolis, Indiana; New York City, New York; San Diego, California; South San Francisco, California; Stamford, Connecticut; and Madrid, Spain.
We are seeking a talented and experienced scientist to join our growing Discovery Bioinformatics team, operating in an interdisciplinary and tightly integrated research community at Loxo@Lilly. The successful candidate will be responsible for developing a vision with Oncology Leadership and oversee the strategy to guide computational biology efforts for target discovery in support of oncology drug development and translational research. This leadership position leads a team of diverse and talented computational scientists contributing to projects across multiple departments in Discovery, Research, and Clinical Development.
Roles and Responsibilities for the Position:
- The successful candidate will join a dynamic team and oversee computational biology efforts at the intersection of discovery, translational, and clinical research.
- They will lead a team, develop scientists, and help build a research strategy that leverages deep cancer biology knowledge and high-dimensional data.
- Success critically depends on the ability to foster a team to execute and communicate the broader computational biology vision and strategy.
Required Qualifications and Preferred Background:
- PhD in Bioinformatics, Biostatistics, Computational Biology, or similar area of study required with a minimum of 8 years of experience in computational biology, bioinformatics, and/or cancer biology is required
- Demonstrated track record of strategic scientific leadership leveraging computational biology to drive discovery in the clinical and pre-clinical settings
- Strong understanding of relevant concepts in cancer biology, drug development, and current therapeutic landscape in oncology
- Knowledge of current best-practices for high-throughput genomics/molecular data analyses and familiarity of their underlying statistical principles
- Excellent communication and interpersonal skills
Additional Locations for the Position:
- South San Francisco, CA
- Alexandria Center, NY
Loxo@Lilly currently anticipates that the base salary for this position level could range from between $158,00 to $232,100 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus(depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands / Travel
The physical demands of this job are consistent with a lab.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment
This position’s work environment is in a lab.
The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- IT/Software Contracts Consultant (Drug Discovery & Development)
- Function:
- Business Operations
- Location:
- Remote
Position Summary
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
The IT/Software Contracts Consultant (Drug Discovery & Development) is responsible for negotiating contracts to support IT related to drug discovery and development projects.
Roles and Responsibilities of the Position:
- Work with information technology, discovery, legal, and finance teams to help draft, negotiate and manage contracts and amendments to support the business needs across drug discovery & early phase drug development
- Identify and mitigate business risks throughout the contracting process
- Provides guidance to Loxo’s discovery project managers related to ongoing IT/software licensing for drug discovery engagements
- May potentially support third party risk management process for IT/Software vendors
Required Qualifications and Preferred Background:
- Bachelor’s degree required along with 3+ years of contract management experience, including the drafting and negotiation of software licenses and professional services agreements in a Pharma/Biotech setting
- IT/Software vendor management experience is required
- Experience negotiating software licenses to support drug discovery and bioinformatics is strongly preferred
- Proven experience drafting contracts as well as applying review and analysis skills is required
- Ability to communicate and collaborate efficiently and effectively in a dynamic, cross-functional environment
- Ability to manage and meet strict deadlines, work independently, and multi-task
- Excellent attention to detail
- MS Office skills (Outlook, Word, Excel, PowerPoint)
Physical Demands/ Travel:
The physical demands of this job are consistent with light office duties.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in an office.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Lead Specialist (non-PhD), Proteomics
- Function:
- Molecular & Cellular Biology
- Location:
- South San Francisco, CA
Position Summary
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
This position is an opportunity to learn and grow within a dynamic discovery biology team dedicated to creating specific targeted therapeutics for genetically defined oncology targets. The ideal candidate is someone who enjoys technical challenges, has the protein handling and cell culture skills needed to drive basic oncology research forward, and will excel in a collaborative environment. Experience with cell culture and biochemical techniques will be critical. Direct experience with sample preparation and method development for mass spectrometry are desirable. The ideal candidate will be enthusiastic about cancer research and is not afraid to get their hands dirty by helping with core lab functions including cell culture, protein characterization, mass spectrometry, and laboratory automation. The qualified candidate will have experience with basic chemistry/biology laboratory practices and is passionate to learn additional techniques working in a growing and dynamic group focused on discovery research. The candidate will work as part of a collaborative team of scientists with expertise in protein characterization, cell culture, chemistry, biochemistry, structure, and biophysics, supporting hit-to-lead and lead-ID phases of our oncology drug programs. The candidate will have opportunities to learn cutting edge techniques and to learn and develop technical expertise in proteomics.
Required Qualifications and Preferred Background:
- BA/BS or MS in Chemistry, Biology, Biochemistry, or related field
- Ideal candidate will have hands-on 1+ years experience with cell culture, sample preparation, and sample handling within an industry or academic/research setting.
- Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels.
- Highly organized with excellent analytical, documentation and multi-tasking skills.
- Familiarity with Thermo Orbitrap and/or Bruker timsTOF Pro instrumentation is ideal.
- Experience in cell line generation is a plus.
- Experience with mass spectrometry/proteomics is a plus.
- Expertise in other methods of enzymology or biophysical characterization and structural biology is a plus.
Loxo@Lilly currently anticipates that the base salary for the Expert Specialist level position could range from between $52,500 to $77,000 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.
Physical Demands/ Travel:
The physical demands of this job are consistent with laboratory setting.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in a lab.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Lead Specialist/Scientist, Biophysics
- Function:
- Biophysics
- Location:
- Louisville, CO
Position Summary
About Loxo@Lilly:
Loxo@Lilly aims to create medicines that make life better for all those affected by cancer around the world. Bringing together the focus and spirit of a biotech with the scale, resources, and heritage of Lilly, our team is focused on rapidly delivering impactful new medicines for people with cancer. Our approach centers on creating oncology medicines that unequivocally show early signs of clinical activity and will matter to patients. We intend to curate a balanced pipeline of medicines, either internally or externally discovered, with the potential to treat cancer with dramatic effect. Loxo@Lilly was created in December 2019, combining the Lilly Oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. Loxo@Lilly is a global organization with team members in Louisville, Colorado; Indianapolis, Indiana; New York City, New York; San Diego, California; South San Francisco, California; Stamford, Connecticut; and Madrid, Spain.
Loxo@Lilly's newly formed Drug Discovery group in Louisville, Colorado has an immediate opening for a researcher in Biophysics. The Loxo Drug Discovery group’s mission is to invent life-changing targeted therapies for cancer patient populations that are poorly treated by existing therapies. To that end, we are building a multi-disciplinary team of dedicated drug discovery scientists who are passionate about driving the science forward to create highly selective drugs for known oncogenic drivers.
The ideal candidate is self-motivated, responsible, and a productive scientist who enjoys collaborating with biologists, chemists, and assay scientists. In this role, he/she will utilize a variety of assay technologies including mass spectrometry, fluorescence spectroscopy, surface plasmon resonance, and isothermal titration calorimetry to evaluate protein/ligand interactions. Experience in protein purification and characterization is a plus. This position requires excellent people skills, a positive can-do attitude, passion for lab work, attention to detail, and the ability to thrive in a highly interactive, fast-paced, team environment.
Roles and Responsibilities of the Position
- Prosecute biophysical assays to identify and characterize small-molecule modulators using a variety of techniques and detection methods, including chromogenic, MS, SPR, ITC, FP, FRET and TR-FRET
- Continuously expand our biochemical characterization repertoire by exploring and developing additional assay and technological instrumentation
- Calculate and report assay results to the project teams
- Document experiments and results in electronic notebook, and results database
Required Qualifications and Preferred Background
- A BS or MS with 0-3+ years relevant work experience. Level commensurate with education and experience
- Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels
- Highly organized and detail oriented with excellent analytical, documentation, and multi-tasking skills
- Committed continual learner, who is accustomed to staying current with the latest scientific breakthroughs in structure-based drug design and biophysics
- Expertise in other methods of enzymology or biophysical characterization and structural biology is a plus
- Protein Purification and characterization a plus
Loxo@Lilly currently anticipates that the base salary for the Lead Specialist level position could range from between $52,500 to $77,000 and that the base salary for the Scientist could range from between $61,500 to $90,200 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.
Loxo@Lilly currently anticipates that the base salary for the Lead Specialist level position could range from between $52,500 to $77,000 and that the base salary for the Scientist could range from between $61,500 to $90,200 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.
Physical Demands/Travel:
The physical demands of this position are consistent with working in a laboratory/ bench environment. Some lifting, and maneuvering of equipment may be required.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is based in a laboratory/ bench environment.
The work environment characteristics described here are representative of those an employee encounters while preforming the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Manager/Senior Manager, Bioconjugation Process Development & Manufacturing, CMC Biologics
- Function:
- CMC
- Location:
- Remote
Position Summary
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
The CMC Biologics team has an exciting opportunity for an innovative individual to join our organization and develop the growing oncology portfolio of antibody-drug conjugates. In this role, you will collaborate on phase appropriate bioconjugation process development and manufacturing efforts including optimization, characterization, and validation of the bioconjugation process for oncology programs.
Roles and Responsibilities of the Position:
- Work in a team environment to drive and manage bioconjugation development and manufacturing activities primarily at third-party partners for assigned projects.
- Partner with colleagues in discovery, process development and analytical to develop integrated clinical process and manufacturing solutions that achieve quality by design targets with robust control strategies.
- Develop the clinical stage/scale bioconjugation strategy and prepare to and/or enable registration/commercial stage/scale.
- Provide technical and scientific direction to third-party partners.
- Create written development instructions and work with third-party partners to perform desired experiments incorporating Quality by Design (QbD).
- Oversee the preparation of technical reports, data summaries and CMC related documents required for various regulatory submissions.
- Collaborate on product characterization/comparability and lot release studies.
- Write and review sections in regulatory submission documents (e.g., IND, IMPD, BLA).
- Key member of the interdisciplinary CMC project teams.
Required Qualifications and Preferred Background:
- BS degree required; MS or PhD preferred.
- Minimum of three (3) years of experience working in a Biotech or Pharmaceutical FDA regulated industry or an equivalent combination of education, training and/or experience from which comparable knowledge, skills and abilities have been attained.
- Strong background in hands on bioconjugation activities at lab and/or larger scale. Experience with antibody drug-conjugate (ADC) modalities is a plus.
- Experience with manufacturing including strong scientific and technical experience within relevant manufacturing process technologies and unit operations.
- Knowledge of structured methodologies for process design, scale-up/down models, process control strategies, and process validation.
- Knowledge of regulatory environment (ICH/FDA/EMA regulations) and experience with organizing and writing regulatory submissions.
- Experience writing and presenting clearly on CMC topics.
- Demonstrable ability to work proactively, independently, and tenaciously.
Loxo@Lilly currently anticipates that the base salary for Manger level position could range from between $90,000 to $132,000 and that the Senior Manager level position could range from between $99,000 to $145,000 will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus(depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands/ Travel:
The physical demands of this job are consistent with laboratory bench setting.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in a lab.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Manager/Senior Manager, Supply Chain Management, CMC
- Function:
- CMC
- Location:
- Remote
Position Summary
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
The Clinical Supply Management has responsibility for the strategy, specifications, on-time delivery, and management of the clinical trial (CT) material supply and related information from the initiation of study planning through approval of the final study report for assigned compounds in the Loxo oncology portfolio. For the assigned compounds, responsibilities include managing CT material supply-related activities for all associated studies, clinical sites, and contract manufacturing and distribution organizations.
Roles and Responsibilities for the Position
- Support Clinical Supply Management by contributing to various work streams with internal and external team members to ensure robust supply chain strategies for the on-time delivery of clinical supplies across the oncology portfolio.
- Communicate with CMC and clinical partners potential risks, limitations, and mitigation strategies (where appropriate) associated with the CT material supply for each compound and study supported.
- Develop compound/program and study level supply plans and manufacturing and packaging schedules. Identify and account for demand uncertainty.
- Advise the CMC team and clinical partners on strategic options for combination drug sourcing, packaging and label design and standardization, distribution, use of Interactive Response Systems, material pooling, retest dating management, and inventory/resupply management.
- Contribute to the development of clinical protocols which account for CT material supply limitations and risks and allow ease of use and compliance by subjects/patients and clinical site staff. Update and maintain study supply plans including CT material supply forecasts for manufacturing, packaging, and labeling operations.
- Provide technical oversight of packaging and distribution collaboration partners including, but not limited to document review of packaging specifications, master, and executed batch records, distribution instructions and order processing and delivery.
- Provide on-going monitoring of inventory and expiration dates for assigned program/study. Ensures alignment with supply forecast and study/program requirements.
- Manage global accountability tracking including destruction for assigned programs.
- Support clinical label development process including creation of master label text, translations, and label proofs.
- Write, review, and/or provide input to documents including, but not limited to: pharmacy manuals, INDs, IMPDs, request for proposals, and IRT/IWRS specifications.
- Participate on project teams and sub-teams as needed and assigned,
- Track progress versus timelines and goals.
- Ensure documents and records are kept in compliance with regulations and SOPs including the Trial Master File (TMF).
- Continuously assess business processes for inefficiencies and improvement opportunities, identify action plans, and implement improvements. Network with clinical partners to ensure efficient cross-functional processes. Identify capability gaps at existing Contract Manufacturing Organizations (CMOs), and identify CMOs with the needed capabilities.
Required Qualifications and Preferred Background
- BA/BS and a minimum of 5-10 years of experience working in a Biotech or Pharmaceutical FDA regulated industry in Clinical Supply Management or a related field or an equivalent combination of education, training and/or experience from which comparable knowledge, skills and abilities have been attained. Level will be commensurate with education and years of experience.
- Solid understanding of pharmaceutical development, manufacturing, packaging, and labeling.
- Eager to communicate and collaborate with team members across functions including but not limited to: clinical operations, CMC, regulatory affairs, and QA.
- Working knowledge of cGMP’s (CFR/ICH) and GCP and applicable international regulations/guidelines.
- Prefer experience working with third-party vendors and contractors, knowledge of QP requirements, and import/export.
- Global experience with phase 1-4 clinical trials.
- Experience writing and presenting clearly on clinical supply topics.
- Ability to work in a virtual environment.
Loxo@Lilly currently anticipates that the base salary for Manger level position could range from between $90,000 to $132,000 and that the Senior Manager level position could range from between $99,000 to $145,000 will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus(depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole
discretion
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Principal Scientist/Senior Principal Scientist (non-PhD), Large Molecule Biology
- Function:
- Large Molecule Biology & Discovery Technologies
- Location:
- New York, NY
Position Summary
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
As a scientist in the Large Molecule Biology group, you will be joining a large and dynamic group focused on executing experiments on the cutting edge of pharmaceutical sciences. You will execute experiments needed to support the various research programs for identified targets. You will oversee aspects of portfolio programs independently and with minimal direct oversight. You will be expected to demonstrate laboratory expertise with biologic assays aimed at drug development (mAb, ADC and CD3 platforms). In addition, assay development for specialized assays related to portfolio programs is required. You will also be encouraged to develop your own ideas and contribute these to the broader group. You are expected to be a dynamic and motivated scientist who can drive their own experiments and research activities, while collaborating extensively with the rest of the organization to execute on various research programs.
Roles and Responsibilities of the Position:
- Design and execute studies to select and deliver candidates
- Demonstrate laboratory expertise with biologic assays aimed at drug development (mAb, ADC and CD3 platforms)
- Perform functional mAb screening and profiling (tumor cell signaling assays, internalization, tumor cell killing assays, cytokine release assays)
- Conduct candidate evaluation in both in vitro (PK/PD, receptor occupancy, density, cytokine release), and ex vivo assays (tumor isolation, analysis of blood cells)
- Interrogate experimental conduct of third parties/vendors
- Work with the project leader and senior leader to design strategy for the development of the molecule
- Present your work to internal teams and summarize findings in preclinical reports
- Communicate results at project team meetings, be involved in the coordination and preparation of presentations
- Discuss results with technical as well as non-technical personnel
- Work in cross functional environments via extensive collaboration with other parts of the organization
Required Qualifications and Preferred Background:
- BS or MS in biological sciences with 8+ years of industry or academic/research experience; Level commensurate with education and experience
- Extensive expertise performing in vitro, and ex vivo assays
- Strong data analysis skills with attention to detail
- Ability to design comprehensive experimental plans and carry out in a timely fashion
- Deep expertise in cancer disease states (indications, mutational status, tumor cell drivers)
- Demonstrated experience in working collaboratively across various scientific disciplines to meet end goals of business
- Excellent communication and interpersonal skills
- Demonstrated ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines
Loxo@Lilly currently anticipates that the base salary for the Principal Scientist level could range from between $90,000 to $132,000 and that the base salary for the Senior Principal Scientist could range from between $109,500 and $160,600 but will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands/ Travel:
The physical demands of this job are consistent with a laboratory bench setting.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in a lab based.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Principal Scientist/Senior Principal Scientist, Biophysics
- Function:
- Biophysics
- Location:
- Louisville, CO
Position Summary
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
Loxo@Lilly Drug Discovery group in Louisville, Colorado has an immediate opening for a researcher in Biophysics. The Loxo@Lilly mission is to invent life-changing targeted therapies for cancer patient populations that are poorly treated by existing therapies. To that end, we are building a multi-disciplinary team of dedicated drug discovery scientists who are passionate about driving the science forward to create highly selective drugs for known oncogenic drivers.
The ideal candidate is self-motivated, responsible, and a productive scientist who enjoys collaborating with biologists, chemists, and assay scientists. In this role, he/she will utilize a variety of assay technologies including mass spectrometry, fluorescence spectroscopy, surface plasmon resonance, and isothermal titration calorimetry to evaluate protein/ligand interactions. Successful candidate will have a demonstratable history of developing, and executing, creative biophysical assays. Some experience in coding is a plus, including but not limited to Python, R, Go, and SAS. This position requires excellent people skills, a positive can-do attitude, passion for lab work, attention to detail, and the ability to thrive in a highly interactive, fast-paced, team environment.
Roles and Responsibilities of the Position
- Design and develop novel biophysical assays to identify and characterize small-molecule or biological modulators using a variety of techniques and detection methods including chromogenic, MS, SPR, ITC, FP, FRET and TR-FRET
- Experimentally explore biological consequence of mechanism of inhibition by coordinating experiments with our cell biology team.
- Creatively address biologic/biophysical questions across a wide variety of techniques and technologies
- Continuously expand our biochemical characterization repertoire by exploring and developing additional assay and technological instrumentation
- Calculate and report assay results to the project teams
- Document experiments and results in electronic notebook, and results database
- Software coding experience is a plus
Required Qualifications and Preferred Background
- BS, or MS, in a Life Sciences discipline required
- Training in molecular biology, enzymology or biochemistry, and a record of lab based independent research experience (minimum of 10 years for BS, or 5+ years for MS) in either an industrial or academic/research environment is required. Level commensurate with education and experience.
- Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels
- Highly organized and detail oriented with excellent analytical, documentation, and multi-tasking skills
- Committed continual learner, who is accustomed to staying current with the latest scientific breakthroughs in structure-based drug design and biophysics
Loxo@Lilly currently anticipates that the base salary for the Principal Scientist level position could range from between $90,000 to $132,000 and the base salary at the Senior Principal Scientist level could range between $109,500 and $160,600 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Process Improvement Manager (Contract)
- Function:
- Clinical Data Management
- Location:
- Remote
Position Summary
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
The Contract Process Improvement Manager is responsible for overseeing the project management activities of all assigned process improvement initiatives. This role ensures initiatives are appropriately tracked, resourced, and budgeted for successful completion, and ensures the project status is transparently disseminated throughout the organization. They maintain effective working relationships at all levels within and outside of Loxo@Lilly. The ideal candidate will have deep experience within the field of project management/process improvement, as well as a sufficient degree of knowledge of clinical development activities, including clinical data management, clinical operations, data collection software, and GxP best practices. The individual will be a self-starter with excellent leadership skills, strong focus on innovation, collaboration, and most importantly, project management and process improvement methodology and tools.
*Roles and Responsibilities of the Position:
- Facilitates the collection of lessons learned and the identification of process improvement opportunities
- Develops and finalizes project charters, timelines, and costing for assigned initiatives
- Establishes and leads brainstorming sessions, kick off meetings, and recurring project team meetings
- Responsible for robust stakeholder management and the maintenance of the project’s timelines, risks, actions, issues, and decisions (RAID) log, and various dashboards, throughout the life of the project
- Proactively identifies significant project risks, develops mitigation strategies, escalates to leadership, and implements approved mitigation steps
- Supports planning and execution statuses in recurring project review meetings
- Manages and maintains project scope through project completion
- Sustains and grows industry knowledge with regards to innovations in trial execution best practices, clinical tools and technology, and information delivery to key stakeholders
- Evaluates new software and technologies, as appropriate
Required Qualifications and Preferred Background:
- Bachelor’s degree preferred.
- Minimum of 5 years’ project management experience within pharmaceutical industry.
- Demonstrated leadership and project management skills, preferably in clinical development
- Project Management Professional (PMP) and/or Six Sigma certification is a strong plus
- Thorough and broad knowledge of clinical development processes and tools preferred.
- Knowledge of regulatory guidelines such as GCP, 21 CFR Part 11 etc.
- Must have excellent verbal, written and communication skills.
- Ability to work independently as well as in a team environment.
- Excellent time management skills and a proven ability to work on multiple projects at any given time in a fast-paced environment.
- Demonstrated ability to stay abreast of trends and new information in the profession.
Physical Demands/ Travel:
The physical demands of this job are consistent with light office duties. This position will travel rarely; the average travel for this position is less than 5% with some variation based upon the demands of the business imperatives.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in a home-based office setting.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Scientific Lead, Bioconjugation, Large Molecule Discovery
- Function:
- Large Molecule Discovery
- Location:
- South San Francisco, CA
Position Summary
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
Loxo@Lilly’s Large Molecule Discovery team is looking for a Scientific Lead with strong Chemistry/Biochemistry skills to support our growing biologics portfolio. This role will support Antibody-drug conjugates (ADCs) linker and payload design, conjugation chemistry, and downstream biochemical assays to enhance ADC biological and pharmacologic properties. We are looking for a strong scientist with good knowledge and hands-on experience in designing, preparing, and characterizing ADCs. This individual will be a self-motivated, responsible, and productive scientist who enjoys collaborating. This individual will be responsible for rigorous experimental design, data analysis, and data interpretation. This position requires excellent people skills, a positive can-do attitude, and the ability to thrive in a highly interactive, fast-paced, team environment.
Roles and Responsibilities of the Position:
- Work with the bioconjugate chemistry and cross-functional teams to prepare, analyze, and optimize the linker-payload and its bioconjugation chemistry.
- Apply organic and medicinal chemistry skills to explore new ADC payload and linker designs to enhance ADC biological and pharmacologic properties.
- Work on the ADCs-related structure-activity relationships (SAR) study design and development.
- Perform enzyme kinetic analyses and MOA studies to characterize biological enzymes in the lysosomal and subcellular fractions.
- Oversee outsourcing linker-payload and bioconjugation chemistry to external CROs and monitor results.
- Maintain scientific and technical expertise through familiarity with scientific literature and attending conferences.
- Document experiments and results in electronic notebook or database.
Required Qualifications and Preferred Background:
- Ph.D. in Chemistry/Biochemistry discipline along with 0-5 years in an industry or academic/research environment and a record of lab-based independent research experience is required.
- Strong foundation in chemical biology research and development.
- Hands-on experience with classic conjugation techniques for therapeutic proteins.
- Experience with protein purification systems is preferred
- Must be highly collaborative and able to effectively engage small-molecule research project teams to make rapid progress.
- Demonstrated ability to work well with other accomplished professionals within and across functions/teams.
- Ability to multi-task and shift priorities rapidly to meet tight deadlines.
- Excellent written and verbal communicator.
- Detail oriented and well organized.
- Enthusiastic, self-motivated, and keen to improve processes.
Loxo@Lilly currently anticipates that the base salary for the Scientific Lead could range from between $120,000 to $176,000 but will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands/Travel:
The physical demands of this position are consistent with working in a laboratory/ bench environment. Some light lifting, and maneuvering may be required.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is based in a laboratory/ bench environment.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Scientific Lead, Biophysics
- Function:
- Biophysics
- Location:
- Louisville, CO
Position Summary
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
Loxo's newly formed Drug Discovery group in Louisville, Colorado has an immediate opening for a researcher in Biophysics. The Loxo Drug Discovery group’s mission is to invent life-changing targeted therapies for cancer patient populations that are poorly treated by existing therapies. To that end, we are building a multi-disciplinary team of dedicated drug discovery scientists who are passionate about driving the science forward to create highly selective drugs for known oncogenic drivers.
The ideal candidate is self-motivated, responsible, and a productive scientist who enjoys collaborating with biologists, chemists, and assay scientists. In this role, he/she will utilize a variety of assay technologies including mass spectrometry, fluorescence spectroscopy, surface plasmon resonance, and isothermal titration calorimetry to evaluate protein/ligand interactions. Successful candidate will have a demonstratable history of developing, and executing, creative biophysical assays. Some experience in coding is a plus, including but not limited to Python, R, Go, and SAS. This position requires excellent people skills, a positive can-do attitude, passion for lab work, attention to detail, and the ability to thrive in a highly interactive, fast-paced, team environment.
Roles and Responsibilities of the Position:
- Design and develop novel biophysical assays to identify and characterize small-molecule or biological modulators using a variety of techniques and detection methods including chromogenic, MS, SPR, ITC, FP, FRET and TR-FRET
- Experimentally explore biological consequence of mechanism of inhibition by coordinating experiments with our cell biology team.
- Creatively address biologic/biophysical questions across a wide variety of techniques and technologies
- Continuously expand our biochemical characterization repertoire by exploring and developing additional assay and technological instrumentation
- Calculate and report assay results to the project teams
- Document experiments and results in electronic notebook, and results database
- Software coding experience is a plus
Required Qualifications and Preferred Background:
- A PhD in a Life Sciences discipline is required, along with training in molecular biology, enzymology or biochemistry, and 0-3+ years of lab based research experience, either in industrial or academic environment.
- Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels
- Highly organized and detail oriented with excellent analytical, documentation, and multi-tasking skills
- Committed continual learner, who is accustomed to staying current with the latest scientific breakthroughs in structure-based drug design and biophysics
Loxo@Lilly currently anticipates that the base salary for the Scientific Lead level position could range from between $120,00 to $176,000 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.
Physical Demands/Travel:
The physical demands of this position are consistent with working in a laboratory/ bench environment. Some lifting, and maneuvering of equipment may be required.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is based in a laboratory/ bench environment.
The work environment characteristics described here are representative of those an employee encounters while preforming the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Scientific Lead, Cell Line Generation
- Function:
- Large Molecule Biology & Discovery Technologies
- Location:
- New York, NY
Position Summary
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
We are looking for a highly capable and motivated laboratory-based scientist experienced in cell line generation and characterization. This individual will be a part of the cell line generation/cell biology team that generates engineered cell lines for our preclinical programs in oncology. The primary responsibilities will include engineering cell lines for use in in vitro mechanistic assays and studies. The right candidate is expected to work within a collaborative team environment, while being able to work independently to design, execute, and optimize experiments. Beyond performing experiments, the scientist will analyze the data from experiments, present the data in meetings and work with the rest of the team to determine the next steps. Position level will be commensurate with applicant’s experience.
Roles and Responsibilities of the Position:
- Construct knockout and expression vectors using mammalian plasmid and lentiviral, adenoviral, or retroviral systems. Viral titer measurement, and viral stock maintenance.
- Generate engineered stable cell lines using transfection, CRISPR/Cas9 tools, lentiviral transduction, etc.
- Optimize cell line development platforms to improve speed and reproducibility of cell line development
- Perform routine molecular and cell biology techniques like DNA/RNA/protein extraction, qPCR analysis, western blot analysis, fluorescent microscopy and so on.
- Maintain cultures of frequently used suspension and adherent cell lines.
- Deposit and archive cell lines in the company’s repository cell line bank.
- Keep detailed and accurate laboratory records, present results at group meetings and project team meetings
Required Qualifications and Preferred Background:
- A PhD in biology, cell biology, molecular biology or a related field required along with 0-3+ years recent experience working with mammalian cell culture in industry, academic or research setting
- Basic tissue culture techniques such as cell propagation, cryo- preservation, maintenance and so on
- Prior cell culture experience with immortalized cell lines, cancer cell lines and/or primary cells
- Experience creating stable cell lines, transient transfections, viral transductions
- Experience with performing qPCR, ELISA, western blot, flow cytometry, and cell sorting, all in the context of mammalian cells. Fluorescent microscopy experience would be a plus.
- Experience in RNAi, CRISPR, and chemical inhibition of cellular pathways
- Prior experience with various analytical reagents such as Calcein AM, Cell Titer Glo, Alamar Blue, Annexin, PI/7AAD, and immunofluorescent antibodies
- A high level of proficiency with many kinds of scientific software used to operate lab equipment and/or the ability to quickly master new software
- Experience and proficiency with data analysis using statistical software such as Excel, Prism, Spotfire or others
- Must be organized and efficient and able to work according to timelines.
- Pharma/biotech drug discovery experience a plus.
Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Scientific Lead level position could range from between $120,000 to $176,000 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.
Physical Demands/ Travel:
The physical demands of this job are consistent with laboratory bench setting and light office duties.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in a laboratory-based setting.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Scientific Lead, Enzymology
- Function:
- Small Molecule Discovery
- Location:
- San Diego, CA
Position Summary
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
The Enzymology Scientist or Sr. Scientist will be responsible for developing and performing enzyme and binding assays to support drug discovery and development in a team environment. The scientist fulfilling this position will be responsible for characterizing the effects of small molecules on specific protein targets and will provide enzymology expertise to the project teams. A strong background in experimental curve-fitting, statistics, and assay optimization and execution is required.
Roles and Responsibilities of the Position:
- Design, develop, and execute enzyme and binding assays in multiple formats
- Screen small molecule inhibitors in plate-based assays formats to drive internal structure-based drug design
- Operate, implement, and troubleshoot laboratory automation
- Actively engage in advancing small molecule drug discovery oncology programs
- Perform comprehensive data analysis
- Communicate experimental findings to team members
- Operate, implement, and troubleshoot laboratory automation
- Actively engaged in advancing drug discovery programs
- This is a “hands-on” laboratory, based position
Required Qualifications and Preferred Background:
- BS/MS/PhD in biochemistry, biophysics, or related fields is required. Level is commensurate on degree and years of experience.
- Required experience: BS/MS with 5+ years industry or academic research experience OR PhD with 2+ years’ experience in industry or academic/research setting . Level commensurate with education and experience.
- The successful candidate is expected to have expertise in biochemistry, enzymology, and assay development
- Experience with general biochemical and kinetic-based assay technologies (e.g. TR-FRET, AlphaLISA® FP, Luminescence)
- Experience with laboratory instrumentation and automation for medium to high-throughput screening
- Excellent oral and written communication skills including experimental documentation
- Works well with team members across functional areas
- Ability to multi-task and shift priorities rapidly to meet tight deadlines
- Highly organized with exceptional attention to detail.
- Good and thoughtful listener
- Enthusiastic, self-motivated and a continuous learner
- Proficient in Microsoft Office suite and applications
Loxo@Lilly currently anticipates that the base salary for the Principal Scientist level position could range from between $90,000 to $132,000 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands / Travel
The physical demands of this job are consistent with a lab.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment
This position’s work environment is in a lab.
The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Scientific Lead, Organoid Team, Discovery Technologies
- Function:
- Large Molecule Biology & Discovery Technologies
- Location:
- New York, NY
Position Summary
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
This right individual will be joining a large and dynamic group focused on executing experiments on the cutting edge of pharmaceutical sciences. The candidate will execute experiments to support various research programs for identified targets and will be expected to demonstrate expertise with various organoid and patient-derived models, to be able to troubleshoot technical difficulties encountered in organoid growth, and to interrogate the work of third parties and collaborators. The candidate will also be encouraged to develop their own ideas, contribute these to the broader organoid group as well as project teams, and is expected to be a dynamic and motivated scientist who can drive their own experiments and research activities, while collaborating extensively with the rest of the organization to execute on various research programs. The candidate will collaborate with project teams in NYC, Indianapolis, SSF, and Boulder for design and execution of studies, and will work closely with multi-disciplinary teams, providing expertise throughout all stages of the lifecycle of target modulation and validation to advance our portfolio.
Roles and Responsibilities of the Position:
- Scientific roles and responsibilities:
- Develop key capabilities for the generation of necessary patient-derived organoid models for detailed functional characterization
- Design and execute studies to profile candidate molecules in organoid systems
- Troubleshoot technical difficulties encountered in organoid establishment, growth and testing
- Test biologics or small molecules in organoid tumor models (dose response experiments, profiling, comparing to control compounds)
- Grow organoids of various types; have extensive knowledge of media and growth factors on organoid development
- Perform experiments that modulate target expression in organoid systems
- Interrogate experimental conduct of third parties/vendors
- Additional responsibilities:
- Communicate results at project team meetings, be involved in the coordination and preparation of presentations
- Discuss results with technical as well as non-technical personnel
- Lead, and work collaboratively across multiple laboratory-based functions to establish the mechanisms, phenotypes, and biology of new targets using modern approaches in molecular and cellular biology and biochemistry
- Work in cross functional environments via extensive collaboration with other parts of the organization
- Direct leadership of a junior scientist may be required
Required Qualifications and Preferred Background:
- PhD in biological sciences required along with 2-3 years of industry, academic or research experience
- Extensive expertise working with organoid models
- Deep expertise in cancer disease states (indications, mutational status, tumor cell drivers)
- Demonstrated experience in working collaboratively across various scientific disciplines to meet end goals of business
- Excellent communication and interpersonal skills
- Demonstrated ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines
- Excellent written and verbal communication skills
Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the level position could range from between $120,000 to $176,000
and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.
Physical Demands/ Travel:
The physical demands of this job are consistent with laboratory setting.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in a lab.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Scientific Lead, Protein Sciences
- Function:
- Protein Sciences
- Location:
- Louisville, CO
Position Summary
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
This position offers the opportunity to be part of Loxo@Lilly's discovery teams focused on creating novel, highly specific and selective drugs for genetically identified targets. The Protein Purification Scientist will support the internal and external discovery research efforts across multiple projects and project teams. This is an extremely important role where the right person will be able to have a real impact on cutting-edge science, making a real difference in patient’s lives.
Roles and Responsibilities of the Position:
- Provide recombinant protein expression and protein purification expertise to deliver proteins central to research activities for small molecule discovery
- Understand the quality of proteins required for functional and biophysical assays, and develop protocols to deliver well characterized proteins accordingly
- Execute projects in an efficient manner, working with aggressive timelines
- Values quality over quantity, with the ability to prioritize
- Rapidly communicate scientific results and insights to the team
- Prepare reports for internal and external purposes including regulatory submissions
- Participate and lead project-based and technical team meetings to identify and solve problems, guide work towards project goals, communicate on-going work and progress, and plan forward thinking strategies
- Continually advance your understanding of current methodology and emerging technologies by reading scientific literature
- Proactively investigate new or different technologies, methods, and service providers to ensure our work is being done in a scientifically sound, efficient, and reasonable way
Required Qualifications and Preferred Background:
- PhD in protein sciences, biology, biochemistry, molecular biology, or a related field is required along with 3+ years hands-on experience, working in a laboratory in a biotechnology/pharmaceutical setting (may also consider experience out of an academic/research setting)
- Strong team player who inspires colleagues to solve difficult problems and develop efficient workflows
- Experience designing expression constructions for functional assays and crystallography
- Proficient with molecular biology techniques including cloning
- Expertise with a variety of protein expression systems including E. coli and Baculovirus infected insect cells
- Expertise with protein purification techniques such as IMAC, SEC, IEX and affinity chromatography is required, ideally utilizing the AKTA FPLC systems
- Expertise with protein characterization techniques such as LCMS, western blotting, and thermal stability assays, is desirable.
- Familiarity with biophysical and functional techniques such as SPR, ASMS, fluorescent binding assays, and enzyme kinetic assays is beneficial
- The candidate must be self-motivated but always maintain focus on why we are here and who is important i.e. the patients and their families/caregivers
- Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels
- Desire and ability to flex between protein expression/purification/characterization is a must
- Highly organized with excellent analytical, documentation and multi-tasking skills
Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Scientific Lead level could range from between $120,000 to $176,000 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands/ Travel:
The physical demands of this job are consistent with light office duties.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in an office and the lab.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Scientific Lead, Proteomics
- Function:
- Molecular & Cellular Biology
- Location:
- South San Francisco, CA
Position Summary
About Loxo@Lilly:
Loxo@Lilly aims to create medicines that make life better for all those affected by cancer around the world. Bringing together the focus and spirit of a biotech with the scale, resources, and heritage of Lilly, our team is focused on rapidly delivering impactful new medicines for people with cancer. Our approach centers on creating oncology medicines that unequivocally show early signs of clinical activity and will matter to patients. We intend to curate a balanced pipeline of medicines, either internally or externally discovered, with the potential to treat cancer with dramatic effect. Loxo@Lilly was created in December 2019, combining the Lilly Oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. Loxo@Lilly is a global organization with team members in Louisville, Colorado; Indianapolis, Indiana; New York City, New York; San Diego, California; South San Francisco, California; Stamford, Connecticut; and Madrid, Spain.
The Scientific Lead will be responsible for design and execution of mass spectrometry experiments to explore protein interactions that drive cancer’s progression. The candidate will work on multiple drug discovery project teams to provide rapid and rigorous mechanistic characterizations to understand the activities of small molecule compounds, advance novel drug targeting strategies, develop novel assays for drug discovery project teams, understand drug resistance, and evaluate new targets. The candidate will work closely with other project team members across disciplines including structural biology, cell biology, in vitro pharmacology, and medicinal chemistry.This position is based in our South San Francisco site.
Roles and Responsibilities for the Position
- Collaborate with colleagues throughout the company to ensure timely delivery of data.
- Adapt to highly dynamic project priorities, with diligent and rapid communication of scientific results and insights to the team.
- Develop and continually advance one’s knowledge base on genetically targeted drugs and structure-based drug design.
- Enthusiasm for laboratory research, with demonstrated experience independently generating precise, reliable data
- Driven by a fundamental interest to learn, develop new technologies and contribute to drug discovery
- Experience with cell biology and/or biochemical methods used for expressing, detecting, enriching & characterizing proteins (e.g. sample preparation methods for bottom-up proteomics workflows)
Required Background and Preferred Qualifications
- PhD in Biochemistry, Chemistry, Molecular/Cellular Biology or related field Required along with 0-3+ years industry or academic/research experience with large, complex data set analysis as well as expertise in analytical mass spectrometry.
- Familiarity with Thermo Orbitrap and/or Bruker instrumentation preferred.
- Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels.
- Committed to staying current with the latest scientific breakthroughs in the targeted oncology field from target identification through human clinical trials.
- Good and thoughtful listener who values collaboration
Loxo@Lilly currently anticipates that the base salary for the Scientific Lead could range from between $120,000 to $176,000 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.
Physical Demands/Travel:
The physical demands of this job are consistent with light office duties.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in the employee’s home office.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Scientific Lead/Senior Principal Scientist, Medicinal Chemistry
- Function:
- Small Molecule Discovery
- Location:
- Louisville, CO
Position Summary
About Loxo@Lilly:
Loxo@Lilly aims to create medicines that make life better for all those affected by cancer around the world. Bringing together the focus and spirit of a biotech with the scale, resources, and heritage of Lilly, our team is focused on rapidly delivering impactful new medicines for people with cancer. Our approach centers on creating oncology medicines that unequivocally show early signs of clinical activity and will matter to patients. We intend to curate a balanced pipeline of medicines, either internally or externally discovered, with the potential to treat cancer with dramatic effect. Loxo@Lilly was created in December 2019, combining the Lilly Oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. Loxo@Lilly is a global organization with team members in Louisville, Colorado; Indianapolis, Indiana; New York City, New York; San Diego, California; South San Francisco, California; Stamford, Connecticut; and Madrid, Spain.
Loxo's Drug Discovery team has an immediate opening for a Medicinal Chemist. The Loxo team’s mission is to invent life-changing targeted therapies for cancer patient populations that are poorly treated by existing therapies. To that end, we have built a multi-disciplinary team of dedicated drug discovery scientists who are passionate about driving the science forward to create highly selective drugs for known oncogenic drivers. We are currently looking for medicinal chemists with a proven track records of success in synthetic organic chemistry. The ideal candidate will be passionate about using synthetic chemistry and data analysis skills to solve medicinal chemistry challenges and will excel at working closely with scientists across disciplines. The position requires excellent people skills, a positive can-do attitude, and the ability to thrive in a highly interactive, fast-paced, team environment.
Roles and Responsibilities for the Position:
- Drive the team forward with new medicinal chemistry analogs that consistently move the project toward the next breakthrough drug candidate.
- Optimize lead series for potency, selectivity, physiochemical properties, in vitro ADME, and PK by coupling multivariate SAR analysis with hypothesis-driven medicinal chemistry design principles.
- Work closely with structural biology and computational chemistry colleagues to design novel compounds and hypotheses that address key drug optimization goals.
- Reduce ideas to practice in the lab quickly by effectively employing a broad range of modern organic chemistry transformations, synthetic methods, purification and characterization techniques.
- Synergize with the broader team by communicating results, sharing insights, making plans, and setting goals in an open, honest way.
Required Qualifications and Preferred Background:
- B.S. with 5+ years, M.S. with 3+ years, or Ph.D. with 0-1 years’ experience with a focus on synthetic organic chemistry or experience in small molecule organic synthesis and/or drug discovery experience in a biotechnology or pharmaceutical setting.
- Proficiency in modern synthetic methodology and variable reaction scales.
- Ability to design feasible synthetic routes to target molecules and choose appropriate reaction conditions.
- Skilled user of synthetic chemistry instrumentation: HPLC, LC-MS, NMR, and purification systems.
- Experience in lead compound optimization for potency, selectivity, ADME and PK is preferred but not required.
- Experience in using common synthetic chemistry software: electronic notebook, ChemDraw, Excel, literature search engines.
- An excellent team player with ability to communicate synergistically with a multidisciplinary team. Highly organized with excellent analytical, documentation, time management, and multi-tasking skills.
Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Senior Principal Scientist level could range from between $109,500 to $160,600 and that the base salary for the Scientific Lead could range from between $78,000 to $114,498 will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands/Travel:
The physical demands of this position are consistent with working in a laboratory/ bench environment. Some light lifting and maneuvering may be required.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
The work environment of this position is consistent with a laboratory/ bench environment. Some light lifting and maneuvering may be required.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Scientist, Biophysical Chemistry (Contract)
- Function:
- Large Molecule Discovery
- Location:
- South San Francisco, CA
Position Summary
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
The Contract Scientist, Biophysical Chemistry will play a pivotal role in performing biophysical analysis of proteins and protein/protein interactions within the Protein Science & Engineering - Biophysical Chemistry group. The scientist in this role will frequently interact with the Biophysical Chemistry and Bioconjugation team leaders and other scientists in a dynamic, team-oriented environment. The role will be responsible for maintaining lab instrumentation, ordering and preparing reagents, and performing screening and characterization of antibodies and antibody-drug conjugate (ADC) candidate molecules using various biophysical platforms.
Roles and Responsibilities of the Position:
- Using surface plasmon resonance (SPR) and Biolayer Interferometry (BLI) to characterize the kinetics and affinity of antibody/antigen interactions
- Using SPR and/or BLI for epitope binning and receptor/ligand blocking studies
- Characterizing protein stability, purity and quality using a variety of techniques, such as dynamic light scattering (DLS), static light scattering (SLS), capillary isoelectric focusing (cIEF), size exclusion chromatography (SEC), ion exchange chromatography (IEX), CE-SDS, and SDS-PAGE.
- Clearly documenting experiments and results in electronic lab notebook entries
Required Qualifications and Preferred Background:
- A BS or MS with 0-3+ years relevant work experience. Level commensurate with education and experience.
- Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels.
- Highly organized and detail oriented with excellent analytical, documentation, and multi-tasking skills.
- Previous experience with therapeutic antibodies, antibody conjugates, bi and multi-specific molecules, and other modalities is a plus
Physical Demands/ Travel:
The physical demands of this job are consistent with laboratory bench setting.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in a lab.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Scientist/Senior Scientist (non-PhD), Cell Line Generation
- Function:
- Large Molecule Biology & Discovery Technologies
- Location:
- New York, NY
Position Summary
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
We are looking for a highly capable and motivated laboratory-based scientist experienced in cell line generation and characterization. This individual will be a part of the cell line generation/cell biology team that generates engineered cell lines for our preclinical programs in oncology. The primary responsibilities will include engineering cell lines for use in in vitro mechanistic assays and studies. The right candidate is expected to work within a collaborative team environment, while being able to work independently to design, execute, and optimize experiments. Beyond performing experiments, the scientist will analyze the data from experiments, present the data in meetings and work with the rest of the team to determine the next steps. Position level will be commensurate with applicant’s experience.
Roles and Responsibilities of the Position:
- Construct knockout and expression vectors using mammalian plasmid and lentiviral, adenoviral, or retroviral systems. Viral titer measurement, and viral stock maintenance.
- Generate engineered stable cell lines using transfection, CRISPR/Cas9 tools, lentiviral transduction, etc.
- Optimize cell line development platforms to improve speed and reproducibility of cell line development
- Perform routine molecular and cell biology techniques like DNA/RNA/protein extraction, qPCR analysis, western blot analysis, fluorescent microscopy and so on.
- Maintain cultures of frequently used suspension and adherent cell lines.
- Deposit and archive cell lines in the company’s repository cell line bank.
- Keep detailed and accurate laboratory records, present results at group meetings and project team meetings
Required Qualifications and Preferred Background:
- BA/BS or MS in biology, cell biology, molecular biology or a related field required along with 2-5+ years recent experience working with mammalian cell culture in industry, academic or research setting. Level commensurate with education and experience.
- Basic tissue culture techniques such as cell propagation, cryo- preservation, maintenance and so on
- Prior cell culture experience with immortalized cell lines, cancer cell lines and/or primary cells
- Experience creating stable cell lines, transient transfections, viral transductions
- Experience with performing qPCR, ELISA, western blot, flow cytometry, and cell sorting, all in the context of mammalian cells. Fluorescent microscopy experience would be a plus.
- Experience in RNAi, CRISPR, and chemical inhibition of cellular pathways
- Prior experience with various analytical reagents such as Calcein AM, Cell Titer Glo, Alamar Blue, Annexin, PI/7AAD, and immunofluorescent antibodies
- A high level of proficiency with many kinds of scientific software used to operate lab equipment and/or the ability to quickly master new software
- Experience and proficiency with data analysis using statistical software such as Excel, Prism, Spotfire or others
- Must be organized and efficient and able to work according to timelines.
- Pharma/biotech drug discovery experience a plus
Loxo@Lilly currently anticipates that the base salary for the Scientist level position could range from between $61,500 to $90,200 and that the base salary for the Senior Scientist level position could range from between $75,000 to to $110,000 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.
Physical Demands/ Travel:
The physical demands of this job are consistent with laboratory bench setting and light office duties.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in a laboratory-based setting.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Senior Associate, Accounting/Manager, Accounting
- Function:
- Finance
- Location:
- Indianapolis, IN
Position Summary
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
This position will support accounting within Loxo including clinical trial accruals, general ledger review, account analysis, etc. as well as support of SOX documentation, and maintain systems and procedures. This position will work directly with a wide range of individuals including senior management, finance team, vendors and other stakeholders. This individual must possess great attention to detail, meticulous organization skills and a strong desire and ability to work within a dynamic, fast-paced environment with the expectations of the role consistently expanding.
Roles and Responsibilities of the Position:
- Proven Clinical Trial and R&D accounting experience; Some reporting experience preferred
- Strong analytical and accounting skills with thorough understanding of U.S. GAAP accounting principles and internal control
- Ability to proactively identify and propose solutions to solve problems
- Ability to work both independently and part of a team to perform multiple tasks simultaneously
- Experience working in a SOX controlled environment
- Strong Excel Skills
- Cloud based ERP experience a plus
Required Qualifications and Preferred Background:
- Bachelor’s Degree in Accounting/Finance is required
- 1-4 years in accounting and/or relevant Finance experience within a SOX controlled environment.
- Biotech, startup, or pharmaceutical experience strongly preferred.
- Strong excel knowledge.
- Experience with any SaaS (cloud based) accounting systems a plus.
- Experience and ability to work in fast-paced environment.
- Excellent interpersonal and communication skills (written and oral).
- Strong organizational skills with amazing attention to detail.
- Strong IT acumen with ability to work across multiple platforms and paperless environments.
Additional Locations for this Position:
- Stamford, CT
- Possible Hybrid schedule
Loxo@Lilly currently anticipates that the base salary for the Senior Associate level could range from between $66,000 to $96,800 and that the base salary for the Manager level position could range from between $82,500 to $121,000 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.
Physical Demands/ Travel:
The physical demands of this job are consistent with light office duties.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in an office.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Senior Associate, Accounting/Manager, Accounting
- Function:
- Finance
- Location:
- Stamford, CT
Position Summary
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
This position will support accounting within Loxo including clinical trial accruals, general ledger review, account analysis, etc. as well as support of SOX documentation, and maintain systems and procedures. This position will work directly with a wide range of individuals including senior management, finance team, vendors and other stakeholders. This individual must possess great attention to detail, meticulous organization skills and a strong desire and ability to work within a dynamic, fast-paced environment with the expectations of the role consistently expanding.
Roles and Responsibilities of the Position:
- Clinical Trial and R&D accounting experience
- Some reporting experience
- Strong analytical and accounting skills with thorough understanding of U.S. GAAP accounting principles and internal control
- Ability to proactively identify and propose solutions to solve problems
- Ability to work both independently and part of a team to perform multiple tasks simultaneously
- Experience working in a SOX controlled environment
- Strong Excel Skills
- Cloud based ERP experience a plus
Required Qualifications and Preferred Background:
- Bachelor’s Degree in Accounting/Finance is required
- 1-4 years in accounting and/or relevant Finance experience within a SOX controlled environment.
- Biotech, startup, or pharmaceutical experience strongly preferred.
- Strong excel knowledge.
- Experience with any SaaS (cloud based) accounting systems a plus.
- Experience and ability to work in fast-paced environment.
- Excellent interpersonal and communication skills (written and oral).
- Strong organizational skills with amazing attention to detail.
- Strong IT acumen with ability to work across multiple platforms and paperless environments.
Additional Locations for this Position:
- Indianapolis, IN
- Possible Hybrid schedule
Loxo@Lilly currently anticipates that the base salary for the Senior Associate level could range from between $66,000 to $96,800 and that the base salary for the Manager level position could range from between $82,500 to $121,000 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.
Physical Demands/ Travel:
The physical demands of this job are consistent with light office duties.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in an office.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Senior Associate, Data Management
- Function:
- Clinical Data Management
- Location:
- South San Francisco, CA
Position Summary
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
The Senior Associate, Data Management is responsible for performing clinical data management tasks from study start-up through eTMF archiving as directed by the study Lead Data Manager. This individual collaborates with the cross-functional study team to develop sponsor clinical data review listings, perform Sponsor Data Manager data review/cleaning, post and QC data transfers to and from Loxo, generate and report on study data metrics, and draft the Sponsor Data Management Plans for review. This individual will also ensure all actions are in full compliance with Loxo standard operating procedures (SOP) and regulatory agency guidelines.
Roles and Responsibilities of the Position:
- Generates data metric reports and listings for study team review.
- Performs routine and critical data review as specified in the study Data Management documents.
- Performs review of Data Management documents such as: CRF completion guidelines, data management plan (DMP), data reconciliation plans, edit check specifications (ECS).
- Perform Sponsor user acceptance testing (UAT) of electronic data capture (EDC) database, edit checks, reports and listings, and interactive X response systems (IxRS) as needed.
- Performs any, and all, other tasks and activities as requested.
Required Qualifications and Preferred Background:
- Bachelor’s degree in life sciences, math, computer science or related field required.
- Minimum of 2 – 5 years’ clinical data management experience required.
- Demonstrated proficiency in executing independent UAT.
- Demonstrated proficiency in MS Office (Outlook, Word, Excel, PowerPoint)
- Experience with web-based Electronic Data Capture (EDC), clinical data management systems and industry wide thesauri, such as MedDRA and WHO Drug. Experience with Veeva EDC is preferred.
- Excellent time management skills and a proven ability to work on multiple projects at any given time in a fast-paced environment.
- Oncology research experience is preferred.
- Self-driven and high achieving while maintaining a focus on quality in all aspects of work.
Available Locations for this role:
- Remote- US Based
- South San Francisco, CA
- Stamford, CT
Loxo@Lilly currently anticipates that the base salary for the Senior Associate level could range from between $66,000 to $96,800 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.
Physical Demands/Travel:
The physical demands of this job are consistent with light office duties.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in the employee’s home office.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Senior Associate/Manager, Clinical Application Programmer
- Function:
- Clinical Data Management
- Location:
- Remote
Position Summary
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
The Clinical Application Programme
r
is responsible for configuration and script writing for in-house clinical database builds for studies conducted by Loxo@Lilly, while maintaining a high degree of quality in all work performed. This role ensures all assigned database builds are appropriately tracked, resourced, and budgeted for successful completion, and ensures the project status is transparently disseminated throughout the organization. They maintain effective working relationships at all levels within and outside of Loxo@Lilly.
The ideal candidate will have varied experience in electronic data collection technologies, such as Veeva EDC, Medidata Rave, and Oracle InForm, etc., as well as a sufficient knowledge of industry clinical data standards, the management of CRF library collections, developing CRFs, dynamics and rules, and the integration of third-party data. A general understanding of the requirements for GxP systems implementation and maintaining systems in a validated state, is a plus. The individual will be a self-starter with excellent leadership skills, strong focus on innovation, collaboration, and most importantly, application programming and tools.
*Roles and Responsibilities of the Position:
- Serve as a subject matter expert in the use of EDC platforms and their suite of products including Studio/Designer, EDC, Local Lab Module, Coder, Data Extract and Reporting, among others.
- Provide oversight, technical support, and guidance to the study teams in the efficient use of the EDC product suite in the study planning, execution, and close out activities of clinical studies.
- Contribute to the quality of the data management clinical database programming deliverables including specification development, eCRF development, edit checks programming, and Quality Testing.
- Expertise in the development, support, and optimal use of the CRF library collections (Veeva CDMS, et al) and other data environments.
- Ability to support business initiatives along with being an advocate for business stakeholders to various system owners
- Proactively identifies potential technical and operational issues/risks and recommends/ implements solutions.
- Engage in the governance and management of the CRF Library Standards; maintain and support Library documentation.
- Establish and implement programming standards and comply with regulatory requirements.
- Participate in the development of, and ensure compliance to, standard operating procedures (SOPs), policies, guidelines, and programming standards.
- Perform all other tasks and activities as requested
Required Qualifications and Preferred Background:
- Bachelor’s degree preferred.
- Minimum of 3 years’ experience in electronic data collection application programming within life sciences.
- Minimum 2 years’ oncology experience, preferred.
- Expertise in Clinical Programming, methods, and techniques
- Knowledge of regulatory guidelines such as GCP, 21 CFR Part 11 etc.
- Knowledge of industry standard clinical technologies including CTMS, EDC (Veeva CDMS preferred, Rave, InForm), eCOA, IxRS, Clinical Data Repositories, etc.
- Knowledge of CDISC and CDASH standards/standard terminology
- Ability to work independently as well as in a team environment.
- Excellent time management skills and a proven ability to work on multiple projects at any given time in a fast-paced environment.
- Demonstrated ability to stay abreast of trends and new information in the profession.
Loxo@Lilly currently anticipates that the base salary for the Senior Associate position level could range from between $75,000 to $110,000 and that the base salary for the Manager position level could range from $90,000 to $132,000 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands/Travel:
The physical demands of this job are consistent with light office duties. This position will travel occasionally; the average travel for this position is 10% with some variation based upon the demands of the business imperatives.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in a home-based office setting
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Senior Associate/Manager, Quality Assurance - GMP
- Function:
- Quality Assurance
- Location:
- Remote
Position Summary
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
This individual will work closely with Loxo@Lilly Regulatory, Drug Supply, CMC, and the associated contract organizations in support of activities associated with GMP manufacturing and release. Additionally, will provide Quality Systems support, as required.
Roles and Responsibilities of the Position:
- Work closely with Loxo@Lilly QA, CMC, Regulatory, Drug Supply, and CMO colleagues through all phases of drug development, particularly early phase to ensure compliance and timeliness of GMP work, including:
- Batch record review (Executed and Master) for all phases of manufacturing (drug substance, drug product, packaging, labeling, and associated intermediates)
- Final disposition of finished product for clinical use, including country-specific release and collaboration with Qualified Persons (QPs)
- Authoring and review of deviations, CAPAs, and change controls
- Investigation of product complaints
- Quality review of analytical documentation including: analytical methods; validation protocols and reports; specifications; and stability protocols, reports, and expiry extensions
- QC of IMPD/IND CMC sections
- Review and approval of clinical product labels
- Authoring/ revision of SOPs
- Implementation of process improvements
- Ensuring that GMP work at Loxo and contract organizations is done in compliance with applicable laws, regulations, guidelines, and SOPs.
- Participation on project teams and sub-teams as needed and assigned
- Additional tasks as required.
Required Qualifications and Preferred Background:
- BA/BS in science or engineering required along with experience in Quality Assurance in an FDA regulated Biotech or Pharmaceutical setting; a minimum of 5 years of experience at the Senior Associate level and a minimum of 8+ years at the Manager level
- Experience in Batch Review and Release for clinical phase products
- Experience authoring and reviewing Deviations, CAPAs, and Change Controls
- Experience working with solid oral dosage products and/or Biologics
- Working knowledge of cGMP’s (CFR/ICH) and applicable international regulations/guidelines
- Experience working with Contract Manufacturing Organizations
- Strong understanding of GMP requirements for early phase drug development
- Attention to detail and accuracy of work
- Ability to work in a fast-paced environment to meet tight deadlines
- Ability to problem solve and implement process improvements
- Ability to serve as an active participant and contributor in cross-functional meetings
- Ability to escalate issues when necessary
- Ability to work in a cross-functional environment
- Ability to work in a virtual manufacturing environment
- Demonstrated ability to work well with other accomplished professionals
- Willing collaborator
- Strong communication skills, both written and oral
Additional locations for this role:
- Remote Based
- Louisville, CO
- Stamford, CT
- South San Francisco, CA
Loxo@Lilly currently anticipates that the base salary for the Senior Associate position could range from between $75,000 to $110,000 and that the Manager level position could range from between $90,000 to $132,000 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.
Physical Demands/ Travel:
The physical demands of this job are consistent with light office duties
.
Domestic and International Travel 10-15%
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in an office, manufacturing facility.
The work environment characteristics described here are representative of those an employee encounters while performing the
essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Senior Director, CMC Biologics
- Function:
- CMC
- Location:
- Remote
Position Summary
About Loxo@Lilly:
Loxo@Lilly aims to create medicines that make life better for all those affected by cancer around the world. Bringing together the focus and spirit of a biotech with the scale, resources, and heritage of Lilly, our team is focused on rapidly delivering impactful new medicines for people with cancer. Our approach centers on creating oncology medicines that unequivocally show early signs of clinical activity and will matter to patients. We intend to curate a balanced pipeline of medicines, either internally or externally discovered, with the potential to treat cancer with dramatic effect. Loxo@Lilly was created in December 2019, combining the Lilly Oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. Loxo@Lilly is a global organization with team members in Louisville, Colorado; Indianapolis, Indiana; New York City, New York; San Diego, California; South San Francisco, California; Stamford, Connecticut; and Madrid, Spain.
The CMC Biologics team has an exciting opportunity for an innovative individual to join our organization and develop the growing oncology portfolio of therapeutic proteins of various modalities (mAbs, bispecifics, antibody-drug conjugates, etc.). The role will lead multi-disciplinary CMC teams through early phase process development, project level business operations, technical agenda creation and execution, and partnering efforts for registration and commercialization for oncology programs.
Roles and Responsibilities for the Position:
- Lead a multi-disciplinary CMC team to coordinate, drive and manage development and manufacturing activities primarily at third-party partners in collaboration with CMC colleagues for assigned projects.
- Partner with colleagues in discovery and CMC to develop integrated clinical process and manufacturing solutions that achieve quality by design targets with robust control strategies. Drive timelines to achieve development and business results.
- Provide technical and scientific direction to CMC team and third-party partners.
- Create clear project progress update system for management and cross-functional team members including clinical supply management.
- Collaborate closely with other functions including but not limited to Nonclinical development, Clinical Development, Quality and Regulatory.
- Ensure effective communication, collaboration, and documentation of all CMC aspects of the program, including preparation of reports and regulatory filings in collaboration with functional CMC leads.
- Identify CMC-related risks and facilitate mitigation planning.
- Review sections in regulatory submission documents (e.g., IND, IMPD, BLA).
- Key member of the interdisciplinary CMC project teams.
Required Qualifications and Preferred Background:
- BS degree required. Prefer candidates with a Master’s and/or PhD.
- Minimum of ten (10) years of experience working in a Biotech or Pharmaceutical FDA regulated industry or an equivalent combination of education, training and/or experience from which comparable knowledge, skills and abilities have been attained.
- ·Must have background in development of antibody-drug conjugates.
- Extensive experience with antibody-drug conjugate manufacturing including strong scientific and technical experience within relevant manufacturing process technologies and unit operations.
- Knowledge of structured methodologies for process design, scale-up/down models, process control strategies, and process validation.
- Direct experience with managing third-party partners for process development and manufacturing in support of CMC activities.
- Knowledge of regulatory environment (ICH/FDA/EMA regulations) and experience with organizing and writing regulatory submissions.
- Experience writing and presenting clearly on CMC topics.
- Demonstrable ability to work proactively, independently, and tenaciously.
Loxo@Lilly currently anticipates that the base salary for the Senior Director level position could range from between $144,000 to $211,200 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.
Physical Demands/Travel:
The physical demands of this job are consistent with light office duties.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in the employee’s home office.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Senior Director, Downstream Process Development and Manufacturing, CMC Biologics
- Function:
- CMC
- Location:
- Remote
Position Summary
About Loxo@Lilly:
Loxo@Lilly aims to create medicines that make life better for all those affected by cancer around the world. Bringing together the focus and spirit of a biotech with the scale, resources, and heritage of Lilly, our team is focused on rapidly delivering impactful new medicines for people with cancer. Our approach centers on creating oncology medicines that unequivocally show early signs of clinical activity and will matter to patients. We intend to curate a balanced pipeline of medicines, either internally or externally discovered, with the potential to treat cancer with dramatic effect. Loxo@Lilly was created in December 2019, combining the Lilly Oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. Loxo@Lilly is a global organization with team members in Louisville, Colorado; Indianapolis, Indiana; New York City, New York; San Diego, California; South San Francisco, California; Stamford, Connecticut; and Madrid, Spain.
The CMC Biologics team has an exciting opportunity for an innovative individual to join our organization and develop the growing oncology portfolio of therapeutic proteins of various modalities (mAbs, bispecifics, antibody-drug conjugates, etc.). In this role, you will lead phase appropriate downstream development and manufacturing efforts including optimization, characterization, and validation of purification process for early-stage programs. Initially, they will also lead the formulation development and manufacturing activities of liquid and lyophilized formulations for early-stage programs.
Roles and Responsibilities for the Position
- Work in a team environment to drive and manage downstream development and manufacturing activities primarily at third-party partners including formulation development for assigned projects.
- Partner with colleagues in discovery, upstream process development and analytical to develop integrated clinical process and manufacturing solutions that achieve quality by design targets with robust control strategies
- Develop and lead the downstream development strategy and execution enabling consistent high-yielding, high-purity, and scalable downstream purification.
- Oversee the design and scale-up activities of purification process and ADC conjugation.
- Provide technical and scientific direction to third-party partners.
- Create written development instructions and work with third-party partners to perform desired experiments incorporating Quality by Design (QbD).
- Oversee the preparation of technical reports, data summaries and CMC related documents required for various regulatory submissions.
- Collaborate with analytical team developing methods for characterization and early formulation screening.
- Collaborate on product characterization/comparability and lot release studies.
- Supervise non-GMP and GMP drug substance manufacturing activities at third-party partners.
- Supervise non-GMP and GMP drug product fill/finish activities at third-party partners (as required).
- Write and review sections in regulatory submission documents (e.g., IND, IMPD, BLA).
- Key member of the interdisciplinary CMC project teams.
Required Background and Preferred Qualifications
- BS degree required. Prefer candidates with a Master’s and/or PhD.
- Minimum of ten (10) years of experience working in a Biotech or Pharmaceutical FDA regulated industry or an equivalent combination of education, training and/or experience from which comparable knowledge, skills and abilities have been attained.
- Strong background in development of biologics (monoclonal antibodies preferred); additional experience with T-cell engagers and antibody-drug conjugates ideal.
- Extensive experience with biologics drug substance manufacturing including strong scientific and technical experience within relevant manufacturing process technologies and unit operations.
- Knowledge of structured methodologies for process design, scale-up/down models, process control strategies, and process validation.
- Direct experience with managing third-party partners for process development and manufacturing in support of CMC activities.
- Knowledgeable in chemical and physical characterization of biologic proteins and antibodies.
- Knowledge of regulatory environment (ICH/FDA/EMA regulations) and experience with organizing and writing regulatory submissions.
- Experience writing and presenting clearly on CMC topics.
- Demonstrable ability to work proactively, independently, and tenaciously.
Loxo@Lilly currently anticipates that the base salary for the Senior Director level position could range from between $144,000 to $211,200 $159,000 to $232,000 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.
Physical Demands/Travel:
The physical demands of this job are consistent with light office duties.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in the employee’s home office.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Senior Director, Drug Product Development and Manufacturing, CMC Biologics
- Function:
- CMC
- Location:
- Remote
Position Summary
About Loxo@Lilly:
Loxo@Lilly aims to create medicines that make life better for all those affected by cancer around the world. Bringing together the focus and spirit of a biotech with the scale, resources, and heritage of Lilly, our team is focused on rapidly delivering impactful new medicines for people with cancer. Our approach centers on creating oncology medicines that unequivocally show early signs of clinical activity and will matter to patients. We intend to curate a balanced pipeline of medicines, either internally or externally discovered, with the potential to treat cancer with dramatic effect. Loxo@Lilly was created in December 2019, combining the Lilly Oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. Loxo@Lilly is a global organization with team members in Louisville, Colorado; Indianapolis, Indiana; New York City, New York; San Diego, California; South San Francisco, California; Stamford, Connecticut; and Madrid, Spain.
The CMC Biologics team has an exciting opportunity for an innovative individual to join our organization and develop the growing oncology portfolio of therapeutic proteins of various modalities (mAbs, bispecifics, antibody-drug conjugates, etc.). In this role, you will lead phase appropriate drug product development and manufacturing efforts including formulation development and manufacturing activities of liquid and lyophilized formulations for oncology programs.
Roles and Responsibilities for the Position
- Work in a team environment to drive and manage drug product development and manufacturing activities primarily at third-party partners including formulation development for assigned projects.
- Partner with colleagues in discovery, upstream and downstream process development and analytical to develop integrated clinical process and manufacturing solutions that achieve quality by design targets with robust control strategies
- Provide technical and scientific direction to third-party partners.
- Create written development instructions and work with third-party partners to perform desired experiments incorporating Quality by Design (QbD).
- Oversee the preparation of technical reports, data summaries and CMC related documents required for various regulatory submissions.
- Collaborate with analytical team developing methods for early formulation screening.
- Collaborate on product characterization/comparability and lot release studies.
- Supervise non-GMP and GMP drug substance manufacturing activities at third-party partners (as required).
- Supervise non-GMP and GMP drug product fill/finish activities at third-party partners.
- Write and review sections in regulatory submission documents (e.g., IND, IMPD, BLA).
- Key member of the interdisciplinary CMC project teams.
Required Qualifications and Preferred Background
- BS degree required. Prefer candidates with a Master’s and/or PhD.
- Minimum of ten (10+) years of experience working in a Biotech or Pharmaceutical FDA regulated industry or an equivalent combination of education, training and/or experience from which comparable knowledge, skills and abilities have been attained.
- Strong background in development of biologics (monoclonal antibodies preferred); additional experience with T-cell engagers and antibody-drug conjugates ideal.
- Extensive experience with biologics drug substance manufacturing including strong scientific and technical experience within relevant manufacturing process technologies and unit operations.
- Knowledge of structured methodologies for process design, scale-up/down models, process control strategies, and process validation.
- Direct experience with managing third-party partners for process development and manufacturing in support of CMC activities.
- Knowledgeable in chemical and physical characterization of biologic proteins and antibodies.
- Knowledge of regulatory environment (ICH/FDA/EMA regulations) and experience with organizing and writing regulatory submissions.
- Experience writing and presenting clearly on CMC topics.
- Demonstrable ability to work proactively, independently, and tenaciously.
Loxo@Lilly currently anticipates that the base salary for the Senior Director Senior Director level position could range from between $144,000 to $211,200 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.
Physical Demands/Travel:
The physical demands of this job are consistent with light office duties.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in the employee’s home office.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Senior Director, Drug Safety Operations
- Function:
- Drug Safety Operations
- Location:
- Remote
Position Summary
About Loxo@Lilly:
Loxo@Lilly aims to create medicines that make life better for all those affected by cancer around the world. Bringing together the focus and spirit of a biotech with the scale, resources, and heritage of Lilly, our team is focused on rapidly delivering impactful new medicines for people with cancer. Our approach centers on creating oncology medicines that unequivocally show early signs of clinical activity and will matter to patients. We intend to curate a balanced pipeline of medicines, either internally or externally discovered, with the potential to treat cancer with dramatic effect. Loxo@Lilly was created in December 2019, combining the Lilly Oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. Loxo@Lilly is a global organization with team members in Louisville, Colorado; Indianapolis, Indiana; New York City, New York; San Diego, California; South San Francisco, California; Stamford, Connecticut; and Madrid, Spain.
The Senior Director, Drug Safety Operations is responsible for pharmacovigilance activities involving the Company's products and/or clinical trials. This individual will be responsible for managing individual adverse events (AE) cases, including review, processing and evaluation of safety reports. Additional duties include participating in the safety surveillance program for investigational products, providing line management to Drug Safety Operations team as well as managing technical functions at a cross functional level.
Roles and Responsibilities of the Position
- Oversee the proper and timely collection and reporting of AE information from all sources.
- Assist in the preparation and management of aggregate safety reports (e.g. IND safety reports, DSURs, PSLLs etc.).
- Perform medical review of AEs/SAEs from clinical trials, interfacing with reporters as needed.
- Provide support for safety sections of clinical documents, including the review and approval of the safety portion of protocols, ICFs, CSRs, IBs and other documents as needed.
- Review of protocols, case report forms, guidelines, CSRs and manuscripts as requested.
- Assist with the development and maintenance of pharmacovigilance related SOPs, policies and work instructions.
- Create and track case processing metrics for internal monthly safety reports.
- Contribute to regulatory authority submissions by reviewing safety data and assisting in the preparation of relevant sections.
- Participate in regulatory and inspections/audits as it relates to pharmacovigilance activities.
- Collaborate cross functionally with other departments including clinical, biostatistics, data management, clinical operations and regulatory affairs with respect to safety related issues.
- Liaise to provide drug safety oversight of processes overseen by vendors.
- Participate in addressing drug safety-related questions from Regulators or to support Company internally.
- Provide Management and oversight to direct reports.
Background Requirements and Preferred Qualifications
- Health science degree required: Nursing (RN, BSN, MSN or NP), PA, RPH, PharmD, or MD
- Minimum of 12+ years of experience required in the pharmaceutical industry or CRO, along with 5+ years in drug safety, pharmacovigilance and risk assessment (or relevant experience).
- Experience in the management of safety information originating from clinical trials and post-marketing sources.
- Experience in Hematology/Oncology desired.
- Experience and working knowledge of Good Pharmacovigilance Practices (GPvP) required.
- Knowledge of U.S. and International Regulatory Reporting Requirements for Product Safety, and of the clinical development process.
- Working knowledge of relevant regulations and guidance documents governing both safety reporting and processing for both clinical trial and post-marketing environments.
- Ability to interpret scientific and clinical trial data.
- Strong verbal and written communications and presentation skills.
- Proven problem solving, decision-making and interpersonal skills.
- Detailed knowledge of drug safety databases.
- Expertise working with MedDRA.
- Possess strong leadership skills and the ability to compile and disseminate information to others in a cohesive fashion to assure a clear understanding of project status and direction.
- Proficiency in MS Office Suite.
- Strong ability to prioritize tasks and keen attention to detail.
- Ability to be both enterprising and resourceful.
- Proven ability to work on multiple projects in a fast-paced environment.
Loxo@Lilly currently anticipates that the base salary for the Senior Director level position could range from between $144,000 to $211,200 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.
Physical Demands/Travel:
The physical demands of this job are consistent with light office duties.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in the employee’s home office.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Senior Principal Scientist (non-PhD), Protein Sciences
- Function:
- Protein Sciences
- Location:
- Louisville, CO
Position Summary
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
This position offers the opportunity to be part of Loxo@Lilly's discovery teams focused on creating novel, highly specific and selective drugs for genetically identified targets. The Protein Purification Scientist will support the internal and external discovery research efforts across multiple projects and project teams. This is an extremely important role where the right person will be able to have a real impact on cutting-edge science, making a real difference in patient’s lives.
Roles and Responsibilities of the Position:
- Provide recombinant protein expression and protein purification expertise to deliver proteins central to research activities for small molecule discovery
- Understand the quality of proteins required for functional and biophysical assays, and develop protocols to deliver well characterized proteins accordingly
- Execute projects in an efficient manner, working with aggressive timelines
- Values quality over quantity, with the ability to prioritize
- Rapidly communicate scientific results and insights to the team
- Prepare reports for internal and external purposes including regulatory submissions
- Participate and lead project-based and technical team meetings to identify and solve problems, guide work towards project goals, communicate on-going work and progress, and plan forward thinking strategies
- Continually advance your understanding of current methodology and emerging technologies by reading scientific literature
- Proactively investigate new or different technologies, methods, and service providers to ensure our work is being done in a scientifically sound, efficient, and reasonable way
Required Qualifications and Preferred Background:
- BA/BS/MS in protein sciences, biology, biochemistry, molecular biology, or a related field along with hands-on experience, working in a laboratory in a biotechnology/pharmaceutical setting
- 5+ years’ experience with an MS degree; 8+ years’ experience with BS/BA degree); may also consider experience out of an academic/research setting
- Strong team player who inspires colleagues to solve difficult problems and develop efficient workflows
- Experience designing expression constructions for functional assays and crystallography
- Proficient with molecular biology techniques including cloning
- Expertise with a variety of protein expression systems including E. coli and Baculovirus infected insect cells
- Expertise with protein purification techniques such as IMAC, SEC, IEX and affinity chromatography is required, ideally utilizing the AKTA FPLC systems
- Expertise with protein characterization techniques such as LCMS, western blotting, and thermal stability assays, is desirable.
- Familiarity with biophysical and functional techniques such as SPR, ASMS, fluorescent binding assays, and enzyme kinetic assays is beneficial
- The candidate must be self-motivated but always maintain focus on why we are here and who is important i.e. the patients and their families/caregivers
- Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels
- Desire and ability to flex between protein expression/purification/characterization is a must
- Highly organized with excellent analytical, documentation and multi-tasking skills
Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Senior Principal Scientist position level could range from between $109,500 to $160,600 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands/ Travel:
The physical demands of this job are consistent with light office duties.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in an office and the lab.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Senior Principal Scientist (non-PhD)/Scientific Lead, Bio-Analytical Chemistry, Large Molecule Discovery
- Function:
- Large Molecule Discovery
- Location:
- South San Francisco, CA
Position Summary
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
Loxo@Lilly’s Large Molecule Discovery team is looking for a strong scientist to support our growing biologics portfolio. This role will support enzymology studies on ADCs and to carry out mass-spec based quantitation of small molecules and ADCs, distributed across various tissues and biological matrices, for ADC Discovery Research. This individual will be a self-motivated, responsible, and productive scientist who enjoys collaborating. He/she will be responsible for rigorous experimental design, data analysis and data interpretation. This position requires excellent people skills, a positive can-do attitude, and the ability to thrive in a highly interactive, fast-paced, team environment.
Roles and Responsibilities of the Position:
- Design and develop novel biochemical assays to identify and characterize small-molecule modulators using a variety of techniques and detection methods, including chromogenic, FP, FRET, TR-FRET, BRET, and ALPHA.
- Perform enzyme kinetic analyses and MOA studies to characterize the effect of biological enzyme systems on ADCs.
- Prepare lysosomal and subcellular fractions from various cancer cell-lines
- Extraction of small molecules and ADCs from a variety of tissue samples and biological matrices for mass-spec quantitation
- Mass-spec based quantitation of small and large molecules extracted from various biological matrices
- LC method development for various characterization and bioanalytical applications
- Continuously expand on biochemical repertoire by exploring and developing additional assay and technological instrumentation.
- Oversee outsourcing of enzyme assays to external CROs and monitor results.
- Operate automated platforms for liquid handling.
- Calculate and report assay results to the project teams.
- Document experiments and results in electronic notebook or database.
- This position is a hands-on lab-based role
Required Qualifications and Preferred Background:
- BS, MS, or PhD in a Life Sciences discipline along with training in chemistry, analytical chemistry, biochemistry or related fields, and a record of lab based independent research experience is required. Senior Principal Scientist (non-PhD) requires a BS degree and a minimum of 10 years experience or MS degree and a minimum of 8 years experience in an industry or academic/research setting/Scientific Lead requires a PhD and a minimum of 5 years experience, in an industry or academic/research setting
- Hands-on experience in characterizing small molecules, antibodies and ADCs using state-of-the-art AB Sciex/Thermo/ Waters TOFs and Triple Quads is required.
- Hands-on experience in analyzing mass-spec data using various vendor provided software for small molecule and protein analysis is required.
- Hands-on experience in running various analytical techniques including, and not limited, to HPLCs and UPLCs for characterization and quantitation of small/large molecules is required.
- Familiarity with routine maintenance and troubleshooting of analytical and mass-spec instrumentation
- Must be highly collaborative and able to effectively engage small-molecule research project teams to make rapid progress.
- Demonstrated ability to work well with other accomplished professionals within and across functions/teams. Willing collaborator.
- Strong written and oral communication skills.
- Ability to multi-task and shift priorities rapidly to meet tight deadlines.
- Excellent written and verbal communicator.
- Detail oriented and well organized.
- Good and thoughtful listener.
- Enthusiastic, self-motivated, and keen to improve processes.
- Proficient in Microsoft Office suite and applications.
Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Senior Principal Scientist (non-PhD) could range from between $109,500 to $160,600 and that the base salary for the Scientific Lead could range from between $120,000 to $176,000 but will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands/Travel:
The physical demands of this position are consistent with working in a laboratory/ bench environment. Some light lifting, and maneuvering may be required.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is based in a laboratory/ bench environment.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Senior Scientific Lead, Bioassay, Mass Spectroscopist
- Function:
- Bioassay
- Location:
- Louisville, CO
Position Summary
About Loxo@Lilly:
Loxo@Lilly aims to create medicines that make life better for all those affected by cancer around the world. Bringing together the focus and spirit of a biotech with the scale, resources, and heritage of Lilly, our team is focused on rapidly delivering impactful new medicines for people with cancer. Our approach centers on creating oncology medicines that unequivocally show early signs of clinical activity and will matter to patients. We intend to curate a balanced pipeline of medicines, either internally or externally discovered, with the potential to treat cancer with dramatic effect. Loxo@Lilly was created in December 2019, combining the Lilly Oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. Loxo@Lilly is a global organization with team members in Louisville, Colorado; Indianapolis, Indiana; New York City, New York; San Diego, California; South San Francisco, California; Stamford, Connecticut; and Madrid, Spain.
The Bioassay Mass Spectroscopist will be responsible for performing analyses of covalent interactions between enzymes and irreversible inhibitors to support drug discovery in a team environment. The scientist fulfilling this position will be responsible for characterizing adducts formed between enzyme and irreversible inhibitor and determining the kinetics of this interaction. A strong background in experimental curve-fitting, statistics, and mass spectroscopic method develop and execution is required.
Roles and Responsibilities of the Position
- Design, develop, and execute mass spectroscopic analyses of the covalent interactions between enzymes and irreversible inhibitors.
- Actively engage in advancing small molecule drug discovery oncology programs.
- Perform comprehensive data analysis
- Communicate experimental findings to team members
- Actively engaged in advancing drug discovery programs
- This is a “hands-on” laboratory, based position.
Required Qualifications and Preferred Background
- BS/MS/Ph.D. in biochemistry, biophysics, analytical chemistry, or related fields
- Ph.D. with >5 years’ experience in industry and/or academia, or BS or MS with >10 years industrial experience.
- Experience with instrumentation and data analyses for quadropole time of flight mass spectroscopy
- Covalent small molecule screening experience
- Experience in determining intact mass of protein adducts
- Excellent oral and written communication skills including experimental documentation.
- Strong enzymology background with experience in data analysis of irreversible inhibition (i.e., determining Ki and kinact values).
- Works well with team members across functional areas.
- Ability to multi-task and shift priorities rapidly to meet tight deadlines.
- Highly organized with exceptional attention to detail.
- Good and thoughtful listener.
- Enthusiastic, self-motivated and a continuous learner
- Proficient in Microsoft Office suite and applications
Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Principal Scientist level position could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.
Physical Demands/Travel:
The physical demands of this job are consistent with light office duties.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in the employee’s home office.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Senior Scientific Lead, Computational Biology (multiple locations)
- Function:
- Target Discovery
- Location:
- South San Francisco, CA
Position Summary
About Loxo@Lilly:
Loxo@Lilly aims to create medicines that make life better for all those affected by cancer around the world. Bringing together the focus and spirit of a biotech with the scale, resources, and heritage of Lilly, our team is focused on rapidly delivering impactful new medicines for people with cancer. Our approach centers on creating oncology medicines that unequivocally show early signs of clinical activity and will matter to patients. We intend to curate a balanced pipeline of medicines, either internally or externally discovered, with the potential to treat cancer with dramatic effect. Loxo@Lilly was created in December 2019, combining the Lilly Oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. Loxo@Lilly is a global organization with team members in Louisville, Colorado; Indianapolis, Indiana; New York City, New York; San Diego, California; South San Francisco, California; Stamford, Connecticut; and Madrid, Spain.
We are seeking a talented and highly motivated experienced Computational Biologist to join our Discovery Bioinformatics group. The candidate will lead bioinformatics efforts across multi-disciplinary teams to rapidly advance small molecule drug development efforts. This position is expected to contribute in shaping the next generation of cancer therapies through data-driven approaches.
Roles and Responsibilities of the Position:
- The successful candidate will join a dynamic team and oversee computational biology efforts across multiple functions. They will be expected to lead a team, supervise and develop scientists, and help build a research strategy that leverages deep cancer biology knowledge and high-dimensional data. Success critically depends on the ability to effectively present complex analyses and results in a clear and concise manner to a diverse audience of scientists.
Required Qualifications and Preferred Background:
- PhD in Bioinformatics, Biostatistics, Computational Biology, or similar area of study required. Post-doctoral training or equivalent prior work experience (3-5+ years)
- Substantial publication record and/or similar achievements
- Demonstrated track record of strategic scientific leadership in the computational biology field with leading and developing scientists.
- Strong understanding of relevant concepts in cancer biology and molecular biology
- Experience in large-scale data analyses involving high-throughput molecular assays such as DNA/RNA-Seq, ATAC/CHiP-Seq, single-cell technologies, etc.
- Understanding of current best-practices for high-throughput genomics/molecular data analyses and familiarity of their underlying statistical principles
- Experience using programming languages such as R, Python, or similar for statistical analysis
Available Locations for this role:
- South South Francisco, CA
- New York City, NY
- US Based-Remote
Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Senior Scientific Lead could range from between $129,000 to $189,000 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands / Travel:
The physical demands of this job are consistent with light office duties.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in an office.
The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Senior Scientific Lead, Mass Spec, Large Molecule Discovery
- Function:
- Large Molecule Discovery
- Location:
- South San Francisco, CA
Position Summary
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
The Senior Scientific Lead, Mass Spec, Large Molecule Discovery will play an important role in the discovery and development of transformative therapeutics in the Loxo@Lilly Large Molecule Discovery team. The role requires a clear understanding of Large Molecule Discovery strategy. This role will potentially lead a team that will address challenges in characterization of antibodies, reagent proteins and ADCs with mass-spectrometry. This includes conducting and overseeing experiments for protein/ antibody peptide mapping, intact mass analysis, post-translational modification (PTM) analysis, ADC characterization, developability assessment, and pre-clinical in-vivo/pharmacokinetic studies utilizing bioanalytical techniques, mass-spectrometry, and other analytical characterization.
Roles and Responsibilities of the Position:
- Lead a team that will specialize in characterization of therapeutic proteins that include ADCs, bispecific and other format antibodies, with mass-spectrometry and analytical techniques
- Responsible for developing strategies that include identification of above listed therapeutic proteins and protein reagents by peptide mapping, intact mass analysis, and post-translational modification (PTM) analysis
- This role will be tasked with ADC characterization, and developability assessment, and pre-clinical in-vivo/pharmacokinetic studies utilizing bioanalytical techniques
- Present data at meetings that may include representatives from other departments and/or outside parties and participates in brainstorming and troubleshooting within team, offering, and implementing solutions to problems.
- Participate in designing, overseeing, and executing key experiments for analytical and mass-spectrometry based characterization of these large molecules from early discovery to early development stage.
- Interact and collaborate with other teams across the company to provide analytical and mass-spec solutions; analyze, collate, and disseminate data to teams in a timely manner
- Work cross-functionally as part of internal multi-disciplinary teams, as well as working with external partners and CROs.
Required Qualifications and Background:
- Required: PhD degree in Chemistry or Biological Science with 6-8+ years’ relevant biopharma industry experience OR MS/BSc degree in Chemistry, Biological or Analytical Sciences (or equivalent field) with at least 12 years of relevant job experience in the biopharma industry. Solid understanding of drug development process with emphasis on antibody-drug conjugates required
- Experience setting up and maintaining mass-spectrometry and analytical research lab is required.
- Demonstrate proven expertise in protein mass-spectrometry for antibodies including LC-MS intact protein analysis, peptide mapping, conjugate analysis, PTMs, de-novo sequencing, and chemical modifications
- Experience in small molecule and protein mass-spectrometry of antibody drug-conjugates (ADC) for characterization of conjugation site analysis, positional isomers, free drug, drug stability, and metabolite analysis
- Experienced in setting up studies for assessment of antibodies and ADCs for developability/CMC and assist in writing of technical reports, SOPs, and regulatory documents for IND
- Prior experience in participation of team efforts for antibody lead panel generation, lead optimization, and IND enabling studies
- Demonstrated can-do attitude and brings innovative ideas in challenging projects set up in a collaborative, cross-functional organization
- Excellent communication skills and with strong organizational abilities
Loxo@Lilly currently anticipates that the base salary for the Senior Scientific Lead could range from between $129,000 to $189,000 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus(depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands/ Travel:
The physical demands of this job are consistent with laboratory bench setting.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in a lab.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Senior Scientific Lead, Medicinal Chemistry
- Function:
- Small Molecule Discovery
- Location:
- Louisville, CO
Position Summary
About Loxo@Lilly:
Loxo@Lilly aims to create medicines that make life better for all those affected by cancer around the world. Bringing together the focus and spirit of a biotech with the scale, resources, and heritage of Lilly, our team is focused on rapidly delivering impactful new medicines for people with cancer. Our approach centers on creating oncology medicines that unequivocally show early signs of clinical activity and will matter to patients. We intend to curate a balanced pipeline of medicines, either internally or externally discovered, with the potential to treat cancer with dramatic effect. Loxo@Lilly was created in December 2019, combining the Lilly Oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. Loxo@Lilly is a global organization with team members in Louisville, Colorado; Indianapolis, Indiana; New York City, New York; San Diego, California; South San Francisco, California; Stamford, Connecticut; and Madrid, Spain.
Loxo@Lilly's Drug Discovery team has an immediate opening for an experienced medicinal chemist. The Loxo@Lilly's team’s mission is to invent life-changing targeted therapies for cancer patient populations that are poorly treated by existing therapies. To that end, we have built a multi-disciplinary team of dedicated drug discovery scientists who are passionate about driving the science forward to create highly selective drugs for known oncogenic drivers. We are currently looking for accomplished medicinal chemists with a proven track records of success in small molecule drug discovery. The ideal candidate will be passionate about leading from the bench to solve medicinal chemistry challenges and will excel at working closely with scientists across disciplines. The position requires excellent people skills, a positive can-do attitude, and the ability to thrive in a highly interactive, fast-paced, team environment.
Roles and Responsibilities for the Position:
- Drive the project toward the next breakthrough drug candidate by designing and synthesizing new medicinal chemistry analogs that directly address project goals.
- Optimize lead series for potency, selectivity, physiochemical properties, in vitro ADME, and PK by coupling multivariant SAR analysis with hypothesis driven medicinal chemistry design principles. Use sound scientific methods to propose hypotheses and determine next steps even with complex or ambiguous data.
- Work closely with structural biology and computational chemistry colleagues to design novel compounds and hypotheses that address key drug optimization goals.
- Reduce ideas to practice in the lab quickly by effectively employing a broad range of modern organic chemistry transformations, synthetic methods, purification and characterization techniques.
- Synergize with the broader team by communicating results, sharing insights, making plans, and setting goals in an open, honest way.
- Provide medicinal chemistry insight for new target and lead identification and evaluation initiatives in the oncology space.
- Proactively investigate new or different technologies to improve the effectiveness of the drug discovery process.
- Analyze complex data streams and conceptualize priority synthesis targets based on a holistic data approach.
Required Qualifications and Preferred Background:
- BS, MS, or PhD in chemistry with a focus on synthetic organic chemistry
- Experience in small molecule drug discovery in a biotechnology or pharmaceutical setting and a B.S. with 8+ years’ experience, M.S. with 5+ years’ experience or Ph.D. with 2+ years’ experience.
- Proven track record of success in advancing programs from leads to advanced candidates.
- Extensive experience in lead compound optimization for potency, selectivity, ADME and PK.
- Experienced in the use of synthetic chemistry instrumentation: HPLC, LC-MS, NMR, and purification systems.
- Expert in using common medicinal chemistry software: electronic notebook, ChemDraw, Excel; data visualization; structure viewing; literature, chemical and database searching.
- Committed to staying current with the latest scientific breakthroughs in the medicinal chemistry field through continued reading of the literature and attendance of scientific conferences.
- An excellent team player with ability to communicate synergistically with a multidisciplinary team and be accountable for the medicinal chemistry progress of the project. Highly organized with excellent analytical, documentation, time management, and multi-tasking skills.
Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for Senior Scientific Lead could range from between $129,000 to $189,200 but will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands/ Travel:
The physical demands of this job are consistent with a laboratory bench setting.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in a lab based.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Senior Scientific Lead, Structural Biology
- Function:
- Structural Biology
- Location:
- Louisville, CO
Position Summary
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
This position offers the opportunity to be part of Loxo@Lilly discovery teams focused on creating novel, highly specific and selective drugs for genetically identified targets. The ideal candidate will offer structural and mechanistic insights to a multi-disciplinary discovery team by providing high-resolution protein-ligand crystal structures. This role also provides the opportunity to work on larger, collaborative structural biology projects involving cryo-EM.
Roles and Responsibilities for the Position
- Generate protein-small molecule complex x-ray crystal structures with hands-on lab involvement throughout the entire gene to structure process including protein expression, purification, crystallization, and structure determination
- Coordinate protein construct design, expression, and purification with the project team to support biochemical and biophysical assays.
- Rapidly communicate scientific results and insights to the team
- Identify, evaluate, and manage vendors for outsourced services and studies
- Collaborate with colleagues throughout the company to ensure structural work meets the program needs and results are appropriately interpreted
- Participate and lead project-based and technical team meetings to identify and solve problems, guide work towards project goals, communicate on-going work and progress, and plan forward thinking strategies
- Develop and continually advance one’s knowledge base on genetically targeted drugs and structure-based drug design
- Proactively investigate new or different technologies, methods, and service providers to ensure our work is being done in a scientifically sound, efficient, and reasonable way
- In the future, this position’s responsibilities may include supervision of scientists and associates
Required Qualifications and Preferred Background
- PhD in Biochemistry, Biophysics, Chemistry, or related field required
- Ideal candidate will have with 3+ years hands-on gene to structure protein-small molecule crystallography experience in a biotech/pharma setting
- Experienced in crystallization of protein-small molecule complexes and high-resolution x-ray structure determination
- Extensive experience in protein construct design, expression, purification, and characterization
- Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels
- Highly organized with excellent analytical, documentation and multi-tasking skills
- Committed to staying current with the latest scientific breakthroughs in structure-based drug design and structural biology.
- Experience in other methods of biophysical and structural biology, such as Cryo-EM, is a plus
- A learners mindset
Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Scientific Lead level position could range from between $120,000 to $176,000 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands/ Travel:
The physical demands of this job are consistent with laboratory setting.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in a lab.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Senior Scientist/Principal Scientist (non-PhD), CMC Analytical Chemistry
- Function:
- CMC
- Location:
- Louisville, CO
Position Summary
About Loxo@Lilly:
Loxo@Lilly aims to create medicines that make life better for all those affected by cancer around the world. Bringing together the focus and spirit of a biotech with the scale, resources, and heritage of Lilly, our team is focused on rapidly delivering impactful new medicines for people with cancer. Our approach centers on creating oncology medicines that unequivocally show early signs of clinical activity and will matter to patients. We intend to curate a balanced pipeline of medicines, either internally or externally discovered, with the potential to treat cancer with dramatic effect. Loxo@Lilly was created in December 2019, combining the Lilly Oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. Loxo@Lilly is a global organization with team members in Louisville, Colorado; Indianapolis, Indiana; New York City, New York; San Diego, California; South San Francisco, California; Stamford, Connecticut; and Madrid, Spain.
The Loxo@Lilly chemical manufacturing controls (CMC) team has an immediate opening for an experienced analytical chemist in the CMC group. This individual will be responsible for analytical method development and testing primarily associated with on-site process chemistry and pharmaceutical development operations. Work will include the development of analytical methods in support of drug substance process research, as well as drug product formulation development. A strong working knowledge of analytical laboratory instrumentation and regulatory requirements is needed to successfully perform job functions. This individual will be responsible for developing and troubleshooting drug substance and drug product analytical methods, the preparation of method development and validation reports, and general laboratory and instrument maintenance.The position will require a physical presence in Louisville, CO.
Roles and Responsibilities of the Position
- Work collaboratively with process chemistry, pharmaceutics, and medicinal chemistry to develop drug substance (DS) and drug product (DP) analytical methods
- Develop stability indicating HPLC methods in support of candidate molecules and formulations
- Develop assay, related substance, dissolution, Karl Fischer, residual solvent and chiral purity methods for transfer to external laboratories
- Perform pre-validation studies to demonstrate the effectiveness of analytical methodology to accurately characterize drug substance and drug product physicochemical and performance characteristics
- Author and review technical documents including analytical development reports and CMC sections for IND, IMPD and global marketing applications
- Monitor and evaluate data from drug product and drug substance stability studies with respect to product performance and trending
- Perform laboratory activities including instrument trouble-shooting, instrument maintenance, and chemical inventory
- Manage multiple projects, set priorities, and work in a fast-paced environment
- Laboratory operations including ordering supplies, maintaining inventory of laboratory consumables and scheduling/performing instrument maintenance
- Design and implement studies to evaluate the physical and chemical stability of drug substance and prototype drug product formulations, including forced degradation, excipient compatibility and stress studies
- Other duties as assigned
Required Qualifications and Preferred Background
- BS in analytical chemistry or related discipline with 5+ years of experience, MS with 2+ years experience, or Ph.D. with 0+ years experience in the pharmaceutical industry. Level commensurate on education and experience.
- Requires a strong background in analytical method development, applying analytical techniques to solve challenging problems, and experience in stability study design and data management
- Demonstrated proficiency in both hands-on analytical work, as well as managing activities, reviewing and organizing analytical data and solving analytical challenges
- Instrument maintenance, including trouble shooting and repair, as well as managing instrument specific vendor support
- Instrument experience, including HPLC, GC, FTIR, KF, Mass Spectrometry, dissolution, particle size and other analytical instrumentation common to pharmaceutical laboratories
- Experience authoring and reviewing technical documents including, but not limited to, development reports, analytical test methods, specifications, and evaluation of stability data
- In-depth knowledge of USP/Ph. Eur, ICH and cGMP requirements
- Demonstrated ability to work well with other accomplished professionals within and across functions/teams
- Strong written and oral communication skills
- Ability to multi-task and shift priorities rapidly to meet tight deadlines
- Self-motivated, and keen to improve processes and overcome inefficiencies
- Proficient in Microsoft Office suite and applications
Loxo@Lilly currently anticipates that the base salary for the Senior Scientist level position could range from between $75,000 to $110,000 and the base salary at the Principal Scientist level could range between $90,000 and $132,000 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.
Physical Demands/Travel:
The physical demands of this job are consistent with light office duties.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in the employee’s home office.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Senior Scientist/Principal Scientist (non-PhD), Target Discovery (Functional Genomics)
- Function:
- Target Discovery
- Location:
- South San Francisco, CA
Position Summary
Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
We are seeking a highly motivated and experienced individual to join a dynamic and fast-paced biology team in Target Discovery. The Senior Associate Scientist/Scientist will be responsible for creating and executing strategies toward discovery and credentialing of oncology targets through close collaboration with other discovery and translational functions. The ideal candidate will have a strong understanding of oncogenic pathways and experience in designing experiments to evaluate molecular interactions and cellular pathways. The Senior Associate Scientist/Scientist Target Discovery will be part of a multi-disciplinary effort focused on bringing forward innovative cancer drug therapy.
Roles and Responsibilities of the Position:
- Conceive and execute functional genomics screens for target discovery, interrogating MOA of therapeutic modalities, and understanding mechanisms of resistance and/or sensitivity.
- Design and perform screen follow-up studies using a repertoire of gene editing and cellular/molecular biological tools.
- Analyze, interpret, and present the data to the team and/or organization.
- Troubleshoot experiments in a timely manner.
- Learn and apply new techniques to support ongoing efforts.
- Actively participate in group discussions and collaborate with colleagues throughout the organization.
- Contribute to a safe and efficient workplace.
Required Qualifications and Preferred Background:
- BS or MS in biology, cancer, molecular biology, cell biology, biochemistry, or related discipline, with 3+ years lab-based experience.
- Proficiency in mammalian cell culture. Level commensurate with education and years of experience.
- Experience with gene editing platforms (i.e. CRISPR, TALEN, etc)
- Experience with functional genomics (i.e. CRISPR screen) is a plus
- Experience with general molecular biological techniques including PCR, cloning, and Western Blot, etc
- Highly organized, detail-oriented, self-motivated, and strong presentation/documentation skills
- Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, scientific advisors, and staff at all levels and problem-solving skills
Loxo@Lilly currently anticipates that the base salary for the Senior Scientist level could range from between $75,000 to $110,000, and that the base salary for the Principal Scientist level could range from between $90,000 to $132,000 will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.
Physical Demands/ Travel:
The physical demands of this job are consistent with working in a laboratory/ bench environment. Some light lifting, and maneuvering may be required.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in a lab/bench environment.The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com
for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
- Position:
- Outstanding Team Member
- Reporting To:
- Dedicated, Knowledgeable Supervisor
- Location:
- United States and Beyond
Position Summary
Patients are at the heart of everything we do at Loxo@Lilly, and we continue to be motivated by that goal. We pursue this goal with a tenacity, focus and commitment to excellence that defines who we are and how we work.
We seek dedicated, passionate, hardworking intelligent, thoughtful and authentic individuals who thrive within a collaborative and fast-paced environment and will bring their experiences, unique perspectives and problem-solving skills to the team. In return, we cultivate an environment that rewards and recognizes hard work and provides opportunities for learning and growth as part of a team making a meaningful difference in the field of medicine and for individual patients.
If you share our passion, please let us know how you could contribute to our team. We don't want to pass up an opportunity for the right candidate to join us just because you found us before we found you.
Connect With Us
Submit your resume and your "Who", "What" and "Why" (see below) to careers@loxooncology.com.
Your "Who", "What" and "Why":
- Who are you?
- What will you bring to Loxo?
- Why do we need you on the team?
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
For more information about Loxo Oncology’s privacy practice, please view the Privacy Statement.