Senior Principal Scientist, Flow Cytometry Lead, Discovery Technologies
Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.
The leader of the Flow Cytometry Group, Discovery Technologies will be joining a dynamic group focused on executing experiments on the cutting edge of pharmaceutical sciences. This individual will be responsible for overseeing the flow cytometry core group where they will deliver flow data, and support the various research programs for identified targets. They will be expected to demonstrate expertise with flow cytometry experiments (multi color flow cytometry, cell sorting), as well provide flow cytometry training to other group members. The leader of the Flow Cytometry Group will be responsible for oversight of the flow cytometry facilities at Loxo including instrument maintenance and related upgrades. They will also be encouraged to develop their own ideas and contribute these to the broader group. The leader is expected to be a dynamic and motivated scientist who can drive their own experiments and research activities, while collaborating extensively with the rest of the organization to execute on various research programs.
Roles and Responsibilities of the Position
- Scientific roles and responsibilities:
- Oversee the flow cytometry facility and staff
- Design and execute studies using flow cytometry; oversee experimental designs and execution
- Undertake multi color flow cytometry and cell sorting experiments
- Provide flow cytometry training to other group members as needed and desired
- Work collaboratively with the clinical biomarker team to perform to support retrospective and exploratory efforts for clinical programs
- Oversee equipment in the flow cytometry group, including maintenance and upgrades as needed
- Provide scientific expertise on flow cytometry to rest of R&D organization
- Interrogate experimental conduct of third parties/vendors
- Train and oversee junior scientists in the flow cytometry core
- Additional responsibilities:
- Communicate results at project team meetings, be involved in the coordination and preparation of presentations
- Discuss results with technical as well as non-technical personnel
- Work in cross functional environments via extensive collaboration with other parts of the organization
- Report results in formal documents for internal and external submission
- Maintain meticulous and accurate laboratory notebooks with timely entries
Required Qualifications and Background
- PhD in biological sciences with 3-5 years of experience, preferably in a pharmaceutical company or biotech and/or leading a core flow cytometry facility
- Extensive expertise in flow cytometry work with at least 12 color panels
- Ability to establish flow panels to address portfolio programs (heme and solid tumor cell surface markers, intracellular protein staining)
- Strong expertise in data analysis (FlowJo, FACS Diva etc..)
- Deep expertise in cancer disease states (indications, mutational status, tumor cell drivers)
- Demonstrated experience in working collaboratively across various scientific disciplines to meet end goals of business
- Leadership experience in a flow cytometry lab
- Excellent communication and interpersonal skills
- Demonstrated ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines
- Excellent written and verbal communication skills
Physical Demands / Travel
TBD <5%. The physical demands of this job are consistent with working in a lab.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
This position’s work environment is in a lab.
The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.