Career Opportunities

Career Opportunities

Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by our goal of improving the lives of people living with cancer. We pursue this goal with a tenacity, focus, and commitment to excellence that defines who we are and how we work.

We seek dedicated, passionate, hardworking, intelligent, thoughtful, and authentic individuals who thrive within a collaborative and fast-paced environment and will bring their experiences, unique perspectives and problem-solving skills to the team. In return, we cultivate an environment that rewards and recognizes hard work and provides opportunities for learning and growth as part of a team making a meaningful difference in the lives of patients.

Cell Group Manager

Location: Indianapolis, IN

Reports To:

Director, In Vivo

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

The Cell Group Manager will lead a team that will perform and manage all tasks required to produce quality cell stocks, ranging from tissue dissociation, serial culture, maintenance and harvest of cells as well as characterization of the cells banked to ensure high quality. With their team, the Cell Group Manager will also perform cell expansions and generate high quality cell preparations for in vivo study implants. The Manager should possess knowledge and understanding of cell culture equipment and procedures including quality control, periodic and preventative maintenance of equipment and troubleshooting. The manager must be willing to be cross trained to work with small animals for xenograft implantation and other related tasks. The manager must be able to work independently and in close collaboration with scientific teams, multi-task effectively and operate under direct technical supervision from the department manager.

Roles and Responsibilities of the Position*

Cell Culture and In Vitro Work (80%)

  • Responsible for in vitro activities to support In Vivo Pharmacology
    • Deliver high-quality cell preps for xenograft implants
    • Expansion/cryopreservation of stocks for the Oncology Cell Bank
    • Development and establishment of new cell lines
  • Tasks may include laboratory management, authoring SOPs, triaging and managing scale up for implant requests, coordinating tasks with other team members, equipment acquisition and maintenance, and cross-functional collaboration.
  • Proficiently operate, maintain and troubleshoot equipment.  This includes but is not limited to microscope, CO2 incubators, laminar flow hoods, centrifuge, biosafety cabinets and Vi-Cell instrumentation.
  • Aseptic culture and cell propagation, maintenance, special manipulations, freezing and thawing of cell lines.
  • Assist in maintaining databases for inventory and cell culture technical information as well as characterization data packages for models under study
  • Presentation of data in informal and formal research settings
  • Active hands-on participation in laboratory work as necessary to accomplish laboratory goals
  • Ability to communicate with multiple laboratories to execute experiments
  • Adherence to good research practices, SOPs and notebook documentation standards

People Management (10%):

  • Supervision of cell culture team members
  • Training and direction of cell culture team members
  • Coordination with Director and other In Vivo team members to best manage cell culture team work product and deliverables

In Vivo Work (10%):

  • Xenograft implantation in small animals
  • Assisting team members with pharmacology activities including, but not limited to, dosing and necropsy

Required Qualifications and Background

  • Minimum BA/BS in biology/related discipline OR 5+ years in vitro cell culture experience
  • 3+ years aseptic cell culture/cell biology experience

Physical Demands / Travel

0-10% travel required

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position's work environment is in a lab.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.