Career Opportunities

Career Opportunities


Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by our goal of improving the lives of people living with cancer. We pursue this goal with a tenacity, focus, and commitment to excellence that defines who we are and how we work.

We seek dedicated, passionate, hardworking, intelligent, thoughtful, and authentic individuals who thrive within a collaborative and fast-paced environment and will bring their experiences, unique perspectives and problem-solving skills to the team. In return, we cultivate an environment that rewards and recognizes hard work and provides opportunities for learning and growth as part of a team making a meaningful difference in the lives of patients.

Group Leader, Discovery Biology

Location: South San Francisco, CA or New York, NY

Reports To:

Senior Director, Discovery Biology

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

The Discovery Biology Group Leader will be responsible for leading a research team identifying the next generation of molecular targets for cancer therapeutics. The Discovery Biology Group Leader will lead the discovery and early validation of oncology targets through close collaborations with other discovery and translational functions. Experience in molecular biology, cell engineering, and biochemistry through in vitro and in vivo model systems is required. In addition, candidates should be familiar with computational and data-driven tools mining large-scale datasets. The Discovery Biology team will be part of a multi-disciplinary effort focused on high-quality, truth-seeking science to bring forward innovative cancer drug therapy.

Roles and Responsibilities of the Position*
  • Lead cross-functional teams that will be responsible for novel target discovery and validation
  • Supervise and mentor cell biologists and biochemists engaged in target identification and validation to think deeply and work creatively while delivering excellent scientific results and insights to the project teams and their colleagues
  • Develop and continually advance internal drug development efforts through our discovery, clinical and research programs
  • Proactively investigate new or different technologies and methods to advance our discovery projects
  • Collaborate closely with leaders across Loxo Oncology at Lilly to identify, validate and advance new targets into portfolio
Required Qualifications and Background
  • PhD in Molecular/Cellular Biology, Biochemistry, or related field
  • Minimum of 5-8 years postdoctoral and/or research experience with prior experience in target discovery/validation and cancer biology in the biotech or pharma setting
  • Deep experience in areas of cancer biology, molecular biology, biochemistry, and cancer genomics
  • Outstanding communication, writing, and presentation skills is a must
Additional Preferred Qualifications
  • Demonstrated experience supervising scientists
  • Expertise in designing and commissioning studies using cancer cell line and patient-derived xenograft models, to test oncology compounds
  • Experience with cell engineering such as knock-in and knockdown cell lines with CRISPR and/or other technologies
  • Experience working with external CROs (for PDX models, target screening, etc.)
  • Experience with early clinical trial studies and the development and implementation of pharmacodynamic and patient selection biomarker assays
  • Highly organized with excellent analytical, documentation and multi-tasking skills
  • Provide strategic input to target identification and validation strategy to leadership team
  • Ability to collaborate, lead, and influence others
Physical Demands / Travel

The physical demands of this job are consistent with light office duties and some laboratory work. Some light lifting, and maneuvering may be required.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in an office and laboratory environment.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

For more information about Loxo Oncology’s privacy practice, please view the Privacy Statement.