Career Opportunities

Career Opportunities


Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by our goal of improving the lives of people living with cancer. We pursue this goal with a tenacity, focus, and commitment to excellence that defines who we are and how we work.

We seek dedicated, passionate, hardworking, intelligent, thoughtful, and authentic individuals who thrive within a collaborative and fast-paced environment and will bring their experiences, unique perspectives and problem-solving skills to the team. In return, we cultivate an environment that rewards and recognizes hard work and provides opportunities for learning and growth as part of a team making a meaningful difference in the lives of patients.


Reports To:

Associate Director, Accounting

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

Managing and overseeing the daily accounting operations of the finance department. Responsible for month close activities, analyzing accounting data, executing and maintaining policies and procedures. Work closely with a cross-functional team and effectively communicate to ensure completion of tasks.

Roles and Responsibilities of the Position*

  • Manage the month-end, quarter-end and year-end accounting close process and ensure close process is performed in a timely and accurate manner
  • Perform month-end close activities related to major balance sheet accounts such as Cash and Cash Equivalents, Investments, Payroll and Related Benefits, Accrued Expenses, including Clinical Trial Accruals, and Equity
  • Prepare and post journal entries and prepare accounts reconciliations
  • Work directly with HR and Payroll Service in reviewing and accurately entering
  • Record all payroll entries necessary and complete reconciliations
  • Responsible for recording accruals related to bonus and PTO along with reconciliations
  • Design and maintain clinical trial accrual models in MS Excel
  • Liaise with multiple departments, CROs, and vendors monthly regarding:
  • overall progress of clinical trials to budget,
  • completion of work at period end by CROs, labs, and other vendors, and
  • number of patient visits completed, and site costs incurred
  • Collaborate with clinical operations and contracts to gain an understanding of drafted contracts and work orders for planned projects
  • Analyze invoice data and compare to budget, contracts, and work orders to derive needed accruals or prepaid expenses at each period end
  • Update budgets and forecasts and provide budget vs actual analysis for areas of responsibility
  • Review posted vendor invoices for accuracy of input
  • Support internal and external audit requirements related to specific areas of responsibilities and prepare supporting documentation for SEC filings as needed.
  • Assist in the design and implementation of corporate accounting policies and procedures and assist in SOX implementation

Required Qualifications and Background

  • Bachelor's degree in Accounting or Finance
  • 4+ years relevant professional experience is required (mix of private and public experience preferred)
  • Pharmaceutical or biotechnology industry experience is required
  • Intercompany transactions experience a plus
  • Clinical trial activity, modeling and accrual process experience is a plus
  • CPA is preferred
  • Strong understanding of U.S. GAAP accounting and reporting and SOX requirements
  • Strong analytical, creative problem solving, organizational and project management skills
  • High degree of dedication to improvement and strong sense of ownership
  • Initiative to implement changers and curiosity to enhance knowledge and skills,
  • Team player, have the ability to work independently and willingness to take on challenges in a r and dynamic
  • environment
  • Excellent written and verbal communication skills, including ability to interact effectively with management,
  • team, peers, cross-functional teams and business partners
  • Extensive knowledge and use of Microsoft Excel
  • QuickBooks experience is preferred
  • Experience with ERP & Payroll System implementation

Physical Demands / Travel

The physical demands of this job are consistent with working in an office/lab. Travel expected to be around 25%.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in an office/lab.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.


Reports To:

Senior Director, Pharmacology and Bioassays

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

Loxo Oncology at Lilly is looking for associate director to help lead the Bioassay Screening group. This individual will lead a team responsible for identifying, developing and performing robust, reproducible biochemical, biophysical, and cellular assays to support small molecule drug discovery and development. This position requires knowledge of biological pathways and techniques related to establishing robust enzymatic and cellular screening cascades. This individual will join an established and highly collaborative Drug Discovery group that includes teams within both Biological and Medicinal Chemistry drug discovery. 

Roles and Responsibilities of the Position*

  • Lead a multidisciplinary biological assay team
  • Operationalize compound testing in biological assays and timely data analysis to support weekly discovery screening cascades
  • Proven expertise in characterizing small molecule effects on specific protein targets in enzymes and cells using methods such as ELISA, In-Cell Westerns, Mesoscale, HTRF, AlphaScreen, MALDI-TOF MS, Luminescence)
  • Strong background in experimental curve-fitting and statistics

Required Qualifications and Background

  • PhD with >8 years industry experience or MS degree with 10+ years industry experience in relevant Biological or Scientific Discipline.

Additional Preferred Qualifications

  • The ideal candidate is a scientific leader in the areas of discovery and development of molecularly targeted drugs with proven experience designing robust, reproducible bioassays and leading a team to consistently deliver high quality, timely assay screening results
  • Experience leading, mentoring, supervising and developing scientific staff
  • Strong troubleshooting, organization, and planning skills
  • Experience working on structure-driven projects is a plus
  • Excellent oral and written communication skills
  • Strong publication record
  • Demonstrate ability and willingness to work effectively in a highly collaborative research environment

Physical Demands / Travel

The physical demands of this job are consistent with a laboratory setting.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in an office and a lab.  

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.


Reports To:

Head, CMC

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

The Loxo Oncology chemical manufacturing controls (CMC) team has an immediate opening for an Associate Director of Analytical Chemistry. The individual will be responsible for all aspects of analytical testing and cGMP manufacturing operations, including oversight of laboratory development work and analytical testing at external research, development, and manufacturing organizations (CDMOs).

Loxo Oncology is looking for an independent self-starter to lead method development, method transfers, method qualifications/validations, and IND stage molecules into phase I/II clinical trials. This individual will be responsible for troubleshooting drug substance and drug product analytical issues that arise during development and the preparation of technical reports and drug product sections of CMC regulatory submissions.

Roles and Responsibilities of the Position*

  • Work collaboratively with process chemistry, pharmaceutics, medicinal chemistry, DMPK, toxicology, pharmacology, CMC regulatory, and clinical development to support the delivery and release of test articles for different phases of animal and human studies
  • Manage technology transfer and qualification/validation of analytical methods to support starting material, intermediate, drug substance and drug product testing at CMOs/CTOs
  • Author and review technical documents, analytical development reports, and drug product sections for IND, IMPD and global marketing applications
  • Proactively identify ways in which research and manufacturing objectives can be achieved on expedited timelines while advancing multiple risk mitigation strategies in parallel
  • Manage multiple projects, set priorities, and work in a fast-paced environment
  • Collaborate with CMC and regulatory colleagues to establish and justify specifications for drug substances, starting materials, intermediates and drug products
  • Review and approval of analytical results, protocols and reports
  • Support evaluation of packaging configurations of oral solid dosage forms
  • Collaborate with QA, CMC team and CMOs towards timely generation and approval of documents
  • Other duties as assigned

Required Qualifications and Background

  • Ph.D. in analytical chemistry or related discipline with 8-10 years experience, or Master’s with 10‑12 years of experience, or a Bachelor’s degree with 13-15+ years pharmaceutical industry experience and a minimum of 8 years in a pharmaceutics and formulation development organization
  • Requires a strong background in analytical method development, applying analytical techniques to solve challenging problems, experience in IND-enabling and clinical stability study design/management
  • Demonstrated proficiency in both hands-on analytical work, managing activities, reviewing and organizing analytical data and solving analytical challenges at third party pharmaceutical manufacturers
  • Experience authoring and reviewing technical documents including, but not limited to, development reports, master batch records, analytical testing methods, and specifications
  • Well-versed on global regulatory requirements for the manufacture, testing, and control of clinical and commercial drug substance and drug products and able to apply this knowledge to manufacturing strategy to control quality attributes of drug products   
  • Experience in drafting CMC sections of INDs, IMPDs, and marketing applications, and practiced in responding to inquiries from regulatory agency review
  • Experience with CROs, CMOs and CDMOs
  • Expert knowledge of the USP, regulatory, ICH and cGMP requirements
  • Experience in late stage drug development
  • Demonstrated ability to work well with other accomplished professionals within and across functions/teams.
  • Strong written and oral communication skills
  • Ability to multi-task and shift priorities rapidly to meet tight deadlines
  • Detail oriented and well organized
  • Good and thoughtful listener
  • Enthusiastic, self-motivated, and keen to improve processes and overcome inefficiencies
  • Proficient in Microsoft Office suite and applications

Physical Demands / Travel

The physical demands of this job are consistent with light office duties. This position requires occasional travel.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in an office with some traveling in the field.  

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.


Reports To:

Senior Biochemist

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

This position is an opportunity to learn and grow within a dynamic structural biology team dedicated to creating specific targeted therapeutics for genetically defined oncology targets. The Associate Protein Biochemist will provide highly purified protein reagents that aid in the evaluation of protein ligand complexes.

Roles and Responsibilities of the Position*

  • Rapidly express and highly purify recombinant proteins from a variety of cell sources to support protein structural and biophysical/biochemical studies
  • Collaborate with colleagues throughout the company to ensure reagents meet experimental demands
  • Adapt to highly dynamic project priorities, with diligent and rapid communication of scientific results and insights to the team
  • Participate in discussions with vendors for outsourced services and studies
  • Learn and develop technical expertise in protein biochemical and biophysical characterization
  • Develop and continually advance one’s knowledge base on genetically targeted drugs and structure-based drug design

Required Qualifications and Background

  • BA/BS, MS, PhD in Biochemistry, Chemistry, or related field
  • Ideal candidate will have 2+ years hands-on protein expression and purification experience in a biotech/pharma setting
  • Some experience in protein construct design, cloning, and basic molecular biology principles
  • Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels
  • Highly organized with excellent analytical, documentation and multi-tasking skills
  • Committed to staying current with the latest scientific breakthroughs in structure-based drug design and structural biology
  • Expertise in other methods of enzymology or biophysical characterization and structural biology is a plus

Physical Demands / Travel

The physical demands of this job are consistent with light office duties. 

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in an office / lab / traveling in the field.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.


Reports To:

Biospecimen Manager

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

The Biospecimen Coordinator will be responsible for tracking inventory and overseeing the downstream processing of oncology research and clinical biomarker samples. This individual collaborates with oncology clinical study teams and research teams including Clinical Trial Managers (CTMs), Data Managers, and a network of contract research labs. 

Roles and Responsibilities of the Position*

  • Utilize software tools to track inventory of oncology research and clinical biomarker samples
  • Maintain accurate and concise inventory of research and clinical/preclinical oncology biomarker samples across drug programs and third-party labs
  • Support clinical development teams to design biospecimen handling logistics with preferred vendors
  • Maintain regular metrics of biospecimen activities for studies
  • Track and resolve discrepancies with study team, sites, or CRO vendors within specified time frames
  • Assist in developing biospecimen collection plans with vendors by aligning with the clinical study protocol for sample collection requirements.
  • Use monitoring tools to proactively identify trends and provide feedback to internal departments
  • Oversee shipments of biomarker samples from sample repositories to third party labs for testing

Required Qualifications and Background

  • Bachelors’ degree in Life Sciences, health related field or equivalent experience
  • Minimum of 3 years sample management experience in pharmaceuticals, laboratory, or biorepository setting
  • Oncology experience required across all phases of clinical trials
  • Good working knowledge of ICH, FDA, and GCP regulations and guidelines
  • Excellent verbal/written and interpersonal skills required for working successfully in a cross-functional team environment
  • Able to communicate and collaborate effectively with cross-functional teams in face-to-face conversation, by telephone, and by email
  • Excellent organizational skills with high attention to detail is required
  • Strong computer skills (spreadsheets, word processing, etc.) is required
  • Experience using sample management database is preferred
  • Ability to manage, prioritize, and routinely report progress on multiple projects and tasks

Physical Demands / Travel

The physical demands of this job are consistent with light office duties.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in an office.  

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.


Reports To:

Senior Director, Biostatistics

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

This position will serve as study statistician for Phase 1-3 oncology studies to support NDA submissions as well as coordinating activities with other functional groups to ensure timeliness and quality of study deliverables. 

Roles and Responsibilities of the Position*

  • Assist data management staff in the design of case report forms; review of study database structures, data management plan, edit check specifications, and manual data review listing specifications; write additional data check specifications.
  • Develop and review statistical analysis plans, including the definitions of derived variables, structure and content of analysis datasets, statistical analyses, and the design of templates for statistical tables, figures, and listings for clinical study reports.
  • Direct and conduct statistical analyses and interprets results of analyses for assigned studies. Maintain consistent analytical approaches and reporting formats within and across studies.
  • Understand and utilize SAS as well as other statistical software packages. As needed, write programs to select/retrieve/manipulate/edit/analyze data.
  • Responsible for the accuracy and completeness of statistical analyses conducted for assigned studies. Research and apply new statistical procedures as needed.
  • Prepare statistical summary reports as needed. Write and/or review the statistical sections of protocols and clinical study reports. Review draft protocols and clinical study reports.
  • Document and archive analysis and programming work to ensure a complete audit trail. Create and maintain biostatistics files for each assigned study.
  • Establish and maintain effective working relationships with vendors and study teams, including data management personnel, statistical programmers, clinical research personnel and corporate partners.
  • Participate in study meetings as needed.

Required Qualifications and Background

  • MS or PhD in Statistics/Biostatistics or related field with 0-2 (with PhD) or 1-3 (with MS) years of experience in biotech/pharmaceutical industry or medical research setting as a statistician or statistical analyst
  • Oncology experience is highly preferred
  • Ability to work effectively in a cross-functional team setting
  • Able to collaborate effectively with internal and external study teams to meet project timelines.
  • Good interpersonal and project management skills are essential.
  • Excellent written and oral communication skills

Physical Demands / Travel

The physical demands of this job are consistent with light office duties.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in an office.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.


Reports To:

Senior Director, Bioassay Screening

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

The Cell Biologist will be responsible for identifying, developing, and performing robust, reproducible cell assays to support drug discovery and development in a team environment. The Cell Biologists will provide hands-on compound testing to support the small molecule drug discovery oncology pipeline. The scientist fulfilling this position will be responsible for characterizing the effects of small molecule compounds on specific protein targets in cells using multiple plate-based assay formats examples include HTRF, ELISA, In-Cell Western, Mesoscale, and proliferation. A strong background in experimental curve-fitting, statistics, and assay optimization and execution is required.

Roles and Responsibilities of the Position*

  • Cell Culture Expertise
  • Develop robust cell-based assays
  • Design, execute, and trouble-shoot experiments
  • Experience in the following assay formats: HTRF, ELISA, In-Cell Western, Mesoscale, and Chemiluminescence 
  • CRISPR and Cloning experience is a plus.
  • Perform comprehensive data analysis
  • Communicate experimental findings to team members
  • Operate, implement and troubleshoot laboratory automation
  • Actively engaged in advancing drug discovery programs 
  • This is a “hands-on” laboratory, based position.

Required Qualifications and Background

  • BS/MS in biology, biochemistry or related fields
  • 2+ years of experience culturing cells and performing cell assays
  • A scientific foundation in the understanding and implementation of a wide range of cell-based screening assays and readouts
  • Excellent oral and written communication skills including experimental documentation
  • Works well with team members daily across functional areas
  • Continual learner who works independently and possesses a can-do attitude
  • Ability to multi-task and shift priorities rapidly to meet tight deadlines
  • Highly organized with exceptional attention to detail
  • Proficient in Microsoft Office suite and applications

Additional Preferred Qualifications

  • Experience in biotech or pharma environment
  • A scientific foundation in the understanding and implementation of a wide range of cell-based screening assays and readouts
  • Excellent oral and written communication skills including experimental documentation
  • Works well with team members daily across functional areas
  • Continual learner who works independently and possesses a can-do attitude
  • Ability to multi-task and shift priorities rapidly to meet tight deadlines
  • Highly organized with exceptional attention to detail

Physical Demands / Travel

The physical demands of this job are consistent with a lab.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in a lab.  

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.


Reports To:

Director, Computational Chemistry

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

The Loxo Oncology at Lilly Discovery group’s mission is to invent and advance life-changing oncology drugs for cancer patient populations that are poorly treated by existing therapies. To that end, we are building a multi-disciplinary team of dedicated discovery scientists that are passionate about driving the science forward to create and advance highly selective drugs for known oncogenic drivers. We are currently looking for a computational chemist who enjoys tackling cutting edge drug discovery problems and is well versed in the effective use of all current computational techniques and tools. The ideal candidate will be passionate about working with scientists across disciplines to invent and advance novel approaches to drug discovery. The position requires excellent people skills, a positive can-do attitude and the ability to thrive in a highly interactive, fast-paced, team environment.

Roles and Responsibilities of the Position*

  • Work closely with our multidisciplinary group on structure-based and ligand-based design and optimization of small molecule oncology drugs
  • Enable team success by employing a range of modern computational techniques including Quantitative Structural Activity Relationship (QSAR) models, homology modeling, molecular dynamics simulations, multivariate analysis, and in silico predictive models
  • Provide computational chemistry insight for new target identification and evaluation initiatives in the oncology space across a range of target and binding mode types
  • Catalyze new hit and lead discovery leaning computation insight to selection of screening collections, database mining and interpretation of results and virtual screening techniques
  • Work with on-site IT staff to administer and maintain the necessary hardware, software and other computational infrastructure to enable state of the art computational impact on oncology research programs
  • Proactively investigate new or different technologies to improve the effectiveness of the team
  • Contribute to the overall strategic thinking for the discovery organization

Required Qualifications and Background

  • Ph.D. in Chemistry or related field
  • Experience in small molecule drug discovery across a range of target types, approaches, and drug discovery strategies in a biotechnology or pharmaceutical setting is preferred
  • Possess a working understanding of medicinal chemistry, in vitro and in vivo ADME, and couple that with modeling-driven approaches that extend to aspects of lead optimization beyond potency
  • Forward thinking in terms of applying modern computational approaches to current scientific challenges. Apprised of the latest scientific breakthroughs in computational chemistry and ability to apply those techniques to good effect
  • The ideal candidate will be a key thought leader on the team with a passion for bringing creative approaches to solve challenging problems.
  • Excellent interpersonal skills with ability to communicate effectively with a multidisciplinary team, the LOXO executive team, and outside collaborators. The ability to lead the team in prioritization of activities and programs
  • Ability to multi-task and shift priorities rapidly to meet tight deadlines
  • Proficient in Microsoft Office suite and applications

Physical Demands / Travel

The physical demands of this job are consistent with lab environment.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in a lab.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.


Reports To:

Senior Clinical Trial Manager

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

CRA/Field Site Monitor will coordinate clinical studies and be responsible for all major stages of study development, execution, monitoring, and close-out. This individual will also be responsible for clinical study site maintenance, data and source documentation collection, as well as field monitoring of clinical trials. Duties will include ensuring compliance to the study protocol, and Monitoring Plan by ensuring completeness and accuracy of data as well as compliance with domestic and international regulations, Good Clinical Practices, applicable regulatory standards, and Standard Operating Procedures.

Roles and Responsibilities of the Position*

  • Drafts materials including informed consents, case report forms (CRFs), CRF completion guidelines, and technical instructions.
  • Carries out clinical site qualification, IRB/ethical committee submissions, protocol initiation, site monitoring, and site close-out
  • Coordinates and manages the activities of investigative sites to ensure compliance with study protocol requirements
  • Ensures preparation, collection and distribution of trial master file (TMF) documents and maintenance of regulatory files at investigative site
  • Conducts clinical site and data monitoring and completes monitoring visit reports
  • Evaluates clinical data and coordinates data query resolutions
  • Supports internal departmental quality compliance
  • Prepares progress reports and performance metrics

Required Qualifications and Background

  • Minimum of 2 years field monitoring experience
  • Oncology experience highly preferred
  • Understands and can apply knowledge of clinical trial designs to trial execution
  • Advanced knowledge and experience with GCP/ICH and local regulations
  • Experience in web-based data collection applications, knowledge of key areas of Compliance
  • Strong communication skills as single point of contact for investigator
  • Strong skills in building and maintaining relationships with investigative sites
  • Excellent organizational skills with high attention to detail is required
  • Strong computer skills (spreadsheets, word processing, etc.) is required
  • Ability to manage, prioritize, and routinely report progress on multiple projects and tasks
  • Strong presentation skills to internal professionals and external collaborators

Physical Demands / Travel


<p><strong>This role can require up to 40% domestic and international travel</strong></p>

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

<p><strong>Physical Demands:</strong></p>

<p>The physical demands of this job are consistent with light office duties</p>

<p><em>The physical demands here are representative of those that must be met by an employee to</em><em> successfully perform the essential functions of this job.</em></p>

<p><strong>This role can require up to 40% domestic and international travel</strong></p>

<p>&nbsp;</p>

<p><strong>Work Environment:</strong></p>

<p>This position&rsquo;s work environment is in an office.&nbsp; &nbsp;</p>

<p><em>The</em> <em>work</em> <em>environment</em> <em>characteristics</em> <em>describ</em><em>ed</em> <em>here</em> <em>are</em> <em>representative</em><em> of those an employee encounters while performing the essential functions of this job.</em></p>

<p>No specific work demands.</p>

<p><em>*To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions</em></p>

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.


Reports To:

Senior Director, Medical Affairs

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

The Diagnostics Medical Science Liaison (DxMSL) is responsible for the identification and engagement of targeted groups of regional thought leaders within the pathology, laboratory, and oncology communities with specific responsibility for providing consistent delivery of educational and compliant scientific information surrounding clinical/scientific aspects of cancer diagnosis and biomarker/genomic testing.

Roles and Responsibilities of the Position*

  • Identify and develop relationships with clinical/community/academic thought leaders on a local and regional level.
  • Serve as Loxo Oncology’s scientific representative to the Pathology, Diagnostic and Medical communities and facilitate the appropriate exchange of scientific information.
  • Utilize approved resources to address inquiries, ensuring they are in compliance with all guidelines and regulations.
  • Communicate diagnostic and therapeutic market trends which may impact biomarker/genomic testing.  
  • Participate and support advisory boards and steering committees.
  • Lead and/or participate on committee/project teams which support Diagnostic MSL strategies as delegated by MSL leadership. 
  • Attend identified relevant national/regional/local education meetings and conferences, maximizing opportunities at these events.
  • Develop and implement educational speaker programs for the pathology/lab audience.
  • Educate on high quality comprehensive testing for relevant biomarkers in precision oncology and make ties to Loxo pipeline assets.

Required Qualifications and Background

  • Advanced doctoral degree strongly preferred (e.g. PharmD, MD, DO, or PhD). Candidates with a diagnostic laboratory and or clinical pathology background (e.g. MSN, PA) and extensive hematology/oncology MSL experience will also be considered.
  • 0-3+years’ MSL experience in Oncology or Oncology Diagnostics required
  • Ability to establish and maintain relationships with influential thought leaders.
  • Product launch experience a plus; Laboratory or Clinical Diagnostics experience beneficial.
  • Exceptional interpersonal skills.
  • Ability to excel in dynamic settings with short timelines.
  • Strong written/verbal communication and presentation skills.
  • Proficient in Microsoft Office suite and applications.

Physical Demands / Travel

Please note this role will require up to 50% travel, primarily within assigned region but also nationally and globally as required.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is remote based, with significant travel on a regional basis to various sites.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.


Reports To:

Head, CMC

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

Loxo Oncology at Lilly’s chemical manufacturing controls (CMC) team has an immediate opening for an Associate Director of CMC. The individual will be responsible for leading and coordinating research and manufacturing operations at external research, development, and manufacturing organizations (CDMOs). Responsibilities will include ensuring that current GMP standards are implemented for the production, testing and control of manufactured drug substance and/or drug products.

Loxo Oncology at Lilly is looking for an independent self-starter with experience designing successful drug substance routes and manufacturing under cGMP.  This individual will be responsible for the preparation of technical reports and drug substance sections of CMC regulatory submissions.

Roles and Responsibilities of the Position*

  • Manage activities at drug substance and/or drug product CDMOs. Interact with contract site management and staff (may include being on site)
  • Manage the manufacture of drug substance for toxicology studies, clinical trials, and commercial supply at CDMOs, including review and approval of GMP documentation:
    • Analytical, process development and stability protocols, methods and reports
    • Change documentation
    • Master and executed drug substance batch records
  • Proactively manage risks/capability and develops mitigation plans. Identify and communicate risks and issues that impact quality, compliance, project timelines, resource requirements, finances or the overall business relationship
  • Prepare RFPs and technical packages for the procurement of starting materials and GMP drug substance manufacturing campaigns
  • Oversee the development of appropriate analytical testing methods for drug substance
  • Author and review technical documents, development reports, and drug substance CMC sections for IND, IMPD and global marketing applications
  • Proactively identify ways in which research and manufacturing objectives can be achieved on expedited timelines while advancing multiple risk mitigation strategies in parallel
  • Work with QA to prepare drug substance release and stability specifications and provide technical guidance for on-site audits

Required Qualifications and Background

  • Ph.D. in organic chemistry or related discipline with 10+ years experience, or Master’s with 12 years of experience, or a Bachelor’s degree with 15+ years pharmaceutical industry experience and a minimum of 8 years in a process chemistry route development organization
  • Excellent scientific knowledge of process chemistry
  • A proven track record of developing and improving process routes for GLP and GMP manufacturing.
  • Prior manufacturing experience, including management of Contract Manufacturing Organizations.
  • Knowledgeable in good manufacturing practices for the preparation of drug substance for clinical studies and commercial supply
  • Experience in drafting drug substance CMC sections of INDs, IMPDs, and marketing applications, and practiced in responding to inquiries from regulatory agency review
  • Demonstrated ability to work well with other accomplished professionals within and across functions/teams
  • Willing collaborator
  • Strong written and oral communication skills
  • Ability to multi-task and shift priorities rapidly to meet tight deadlines
  • Detail oriented and well organized
  • Good and thoughtful listener
  • Enthusiastic, self-motivated, and keen to improve processes and overcome inefficiencies
  • Proficient in Microsoft Office suite and applications

Physical Demands / Travel

The physical demands of this job are consistent with light office duties. This position requires occasional travel.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in an office with some traveling in the field.  

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.


Reports To:

Senior Director, Drug Safety

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

The Drug Safety Specialist will be responsible for providing Drug Safety/Pharmacovigilance support for new and ongoing clinical trials including the collection, processing, and reporting of adverse events/endpoints while adhering to International Council for Harmonization (ICH) guidelines, Good Clinical Practices (GCP), applicable regulatory guidelines, data protection guidelines and study procedures. 

Roles and Responsibilities of the Position*

  • Perform triage of incoming Serious Adverse Event (SAE) reports and consider assessments of seriousness, listedness, and causality; coordinate triage review with medical monitor.   
  • Review case narratives, including identifying relevant information from source documents and write/review queries when additional information needed 
  • Review data entry of SAEs in safety database including MedDRA coding
  • Coordinate medical monitor case review
  • Assist with the management of case processing deadlines
  • Assist in reconciliation between the safety and clinical databases for serious adverse events.
  • Compile safety information for aggregate safety reports and other safety related reports.
  • Assist with ongoing safety surveillance
  • Assist with compilation and updating of safety related spreadsheets including metrics and SUSAR submissions
  • Review and update existing standard operating procedures (SOPs) and assist with creation of new SOPs for safety department as indicated  
  • May oversee work performed by a safety Contract Research Organization (CRO)

Physical Demands / Travel

The physical demands of this job are consistent with light office duties.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in an office.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.


Reports To:

Senior Director, Bioassay Screening

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

The Enzymology Scientist will be responsible for developing and performing robust, reproducible enzyme and binding assays to support drug discovery and development in a team environment. The scientist fulfilling this position will be responsible for characterizing the effects of small molecule compounds on specific protein targets. A strong background in experimental curve-fitting, statistics, and assay optimization and execution is required.

Roles and Responsibilities of the Position*

  • Design, develop, and execute enzyme and binding assays in multiple formats.
  • Screen small molecule inhibitors in plated based assay formats to drive internal structure-based drug design.
  • Perform comprehensive data analysis and communicate experimental findings to the project team members.
  • Operate, implement, and troubleshoot laboratory automation.
  • Actively engage in advancing small molecule drug discovery oncology programs. 
  • This is a “hands-on” laboratory, based position.

Required Qualifications and Background

  • BS or MS in biology, biochemistry or related field
  • 5+years of experience in biochemistry, enzymology and/or assay development
  • The successful candidate is expected to have expertise in biochemistry, enzymology, and assay development
  • Experience with general biochemical and kinetic-based assay technologies (e.g. FP, TR-FRET, AlphaScreen, Luminescence)
  • Experience with laboratory instrumentation and automation for medium to high-throughput screening
  • Excellent oral and written communication skills including experimental documentation
  • Works well with team members daily across functional areas
  • Ability to multi-task and shift priorities rapidly to meet tight deadlines
  • Highly organized with exceptional attention to detail
  • Good and thoughtful listener
  • Enthusiastic, self-motivated and a continuous learner
  • Proficient in Microsoft Office suite and applications

Additional Preferred Qualifications

  • Drug discovery experience in a biotechnology or pharmaceutical setting
  • The successful candidate is expected to have expertise in biochemistry, enzymology, and assay development.
  • Experience with general biochemical and kinetic-based assay technologies (e.g. FP, TR-FRET, AlphaScreen, Luminescence)
  • Experience with laboratory instrumentation and automation for medium to high-throughput screening.
  • Excellent oral and written communication skills including experimental documentation.
  • Works well with team members daily across functional areas.
  • Ability to multi-task and shift priorities rapidly to meet tight deadlines.
  • Highly organized with exceptional attention to detail.
  • Good and thoughtful listener.
  • Enthusiastic, self-motivated and a continuous learner

Physical Demands / Travel

The physical demands of this job are consistent with a lab.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in a lab. 

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.


Reports To:

Associate Medicinal Chemist

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

The Lab Operations Coordinator will support a robust Discovery Lab environment through sample preparation, sample organization and tracking, data entry, safety maintenance, and additional responsibilities as needed. The Lab Coordinator will possess excellent information management skills as well as the ability to communicate, explain, interpret, and share information in order to best support the Discovery team.

Roles and Responsibilities of the Position*

  • Implement and maintain an inventory system for laboratory samples and manage sample storage on-site.
  • Prepare samples for testing in biological assays and coordinate sample delivery between lab and external vendors both US and globally.
  • Implement and maintain an inventory system for chemical reagents.
  • Maintain complete, accurate, and organized file systems.
  • Routinely order commonly used chemicals and laboratory supplies.
  • Contribute to the upkeep and safety of the laboratory and assure a clean, safe, adequately supplied work area.

Required Qualifications and Background

  • Associates or Bachelor’s degree in the Life Sciences preferred, but will also consider high school diploma and relevant experience2+ years' direct industry experience in a lab or sample management related role.
  • Understanding of safe laboratory practices.
  • Proficient in Microsoft Office.
  • Strong attention to detail and communication skills.
  • Demonstrated ability to work well with other scientists within and across functions/teams.
  • Willing collaborator.
  • Enthusiastic, self-motivated and keen to improve process efficiencies.

Physical Demands / Travel

The physical demands of this job are consistent with working in a wet-laboratory setting.  Requires ability to lift up to 15 lbs.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in a lab.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.


Reports To:

Senior Director, Business Operations

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

The Manager of Business Operations is responsible for negotiating complex contracts to support drug development and related biomarker needs, including sponsored research, material transfer, and collaboration agreements.  This individual will also manage the projects and relationships with partners and academic institutions arising from such agreements. 

Roles and Responsibilities of the Position*

  • Work with discovery, translational medicine, clinical, biomarker operations, legal, and finance teams to help draft, negotiate and manage contracts to support drug development and related biomarker needs
  • Identify and mitigate business risks throughout the contracting process
  • Help manage projects resulting from these contracts, including working with partners and academic institutions to track data/results as well as financial and resource obligations
  • Act as alliance manager for certain relationships

Required Qualifications and Background

  • Bachelor’s degree (MBA a plus)
  • 3+ years of business development/contract negotiation experience, preferably in the Diagnostics or Biotech/ Pharmaceutical Industries
  • Strong contract drafting, review and analysis skills
  • Alliance Management experience (or equivalent demonstration of relationship management)
  • Ability to communicate efficiently and effectively
  • Ability to manage and meet strict deadlines, work independently, and multi-task
  • Excellent attention to detail
  • MS Office skills (Outlook, Word, Excel, PowerPoint)

Physical Demands / Travel

 The physical demands of this job are consistent with light office duties.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in an office.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.


Reports To:

Senior Director, Finance

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

The Manager, Finance and Procurement will support the needs of our growing Discovery organization based in Boulder, CO. The Manager, Finance and Procurement, working closely with Finance and Discovery Teams,  will  help to formalize and streamline the procurement function across all areas within Discovery.  This individual will  be responsible for the planning and execution of contracting and sourcing activities, and end-to-end procurement operations as determined by Discovery team business needs. They will further be responsible for developing, recommending and implementing strategies to strengthen contract compliance and completeness, while reducing costs for the company. Additionally, this individual will provide support to the Finance team focused on forecasting, budgeting, reporting, decision support, and accounting close activities.

Roles and Responsibilities of the Position*

Procurement:

  • Partner with Discovery team and Finance to understand needs and ensure appropriate support
  • Act as the Procurement contact engaging with internal stakeholders to develop and drive execution of contracting and sourcing activities
  • Purchase order placement activities including processing of daily purchase transactions, review of appropriate classifications, price verifications, accuracy of vendor data and completeness of executed contracts to support the purchase order, in a timely manner with a processing turnaround time of 24-48 hours after requisition approval
  • Identify key vendors and organizations utilized by the Boulder Discovery team and develop sourcing strategy, including negotiation & supplier selection, and sourcing implementation
  • Prioritize, process and monitor purchase requisition queue. Review purchase requisitions for proper documentation and authorization. Actively resolve problems with incorrect requisitions. Assist employees with purchasing/contract procure to pay process and facilitate ongoing training
  • Manage all interactions for external partners supplying goods and services including contract execution, relationship management, supply ordering/inventory/tracking, interface to Coupa procurement systems, procurement data review and tracking, and vendor performance management
  • Issue purchase orders and instructions to suppliers. Provide assistance to resolve order related issues which involves working with all departments within the Company as well as outside vendors

Finance:

  • Participates in the financial planning and budgeting process, including Income Statement, Balance Sheet, molecule forecasting
  • Ensure timely delivery and accuracy of monthly and quarterly financial reporting
  • Support the annual financial planning and budgeting process
  • Ensure timely delivery and accuracy of monthly and quarterly financial reporting
  • Support the annual financial planning and budgeting process

Required Qualifications and Background

  • BS/BA is required with a strong preference for a degree in a science-related discipline
  • A minimum of 5 years of related experience in a Procurement, Business Operations, or Finance environment
  • Pharmaceutical or Biotech setting is required
  • CPA or MBA preferred
  • Experience with Coupa or other similar Procurement System
  • Experience working in a SOX and FDA regulated environment
  • Demonstrated understanding of Accounting and Accounts Payable
  • Strong verbal and written communication skills with a successful track record of presenting complex information to senior leaders and various stakeholders in the organization

Physical Demands / Travel

The physical demands of this job are consistent with working in an office/lab.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in a office/lab. Travel about 30% of time.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.


Reports To:

Executive Director, Quality Assurance

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

The Manager, Quality Assurance is responsible for all aspects of Quality Assurance and GCP compliance. The Manager Quality Assurance will establish and execute quality plans, policies and quality system elements related to GCP activities. This position will support the design, implementation and maintenance of QA and compliance programs including, but not limited to an SOP system, CAPAs, and work closely with the Clinical Operations team. The Manager, Quality Assurance will establish, maintain, and ensure effectiveness of quality programs and documentation to assure compliance in a GCP international regulatory environment and provide GCP guidance in Quality related areas.

Roles and Responsibilities of the Position*

  • Liaise across departments to proactively identify opportunities to streamline and strengthen GCP process
  • Serves as GCP SME when SOPs are written or revised
  • Reviews and approves Quality Events and associated Corrective and Preventative Actions within a regulated Quality Management System
  • Represents GCP expertise and acts as the QA point person on cross-functional clinical study teams
  • Keeps current with global health authority laws and regulations and implements process improvements resulting from new/revised regulations or guidance
  • Reviews study team documentation as requested (e.g. Data Management, Operations, Safety, Regulatory, etc.)
  • Liaises audit requirements between clinical study teams and auditing group and follows up on audits with the auditee
  • Utilizes the Loxo Quality Systems to manage Quality system elements
  • Drives inspection readiness activities for project teams
  • Supports external Health Authority inspections

Required Qualifications and Background

  • Bachelor’s degree with 10 or more years’ experience working in either a clinical compliance or clinical Quality group
  • Demonstrated Quality Management System experience (GCP specific QMS experience preferred)
  • Demonstrated Issue Management and CAPA experience in a clinical environment
  • Experience with FDA or other Regulatory Inspections of Investigator sites, Sponsors or CROs
  • Self-motivated with the ability to work effectively in a dynamic environment
  • Strong leadership with demonstrated ability to interface with senior leaders and different levels of the organization
  • Good problem solving, written and verbal communication skill
  • Ability to effectively manage multiple priorities with a sense of urgency
  • Strong track record of project management, stakeholder management, collaboration skills and negotiation of complex situations
  • Attention to detail and accuracy of work
  • Demonstrated ability to work well with other accomplished professionals within and across functions/teams 
  • Willing collaborator
  • Strong communication skills both written and oral
  • Ability to multi-task and shift priorities rapidly to meet tight deadlines
  • Professional demeanor and appearance and an excellent written and verbal communicator
  • Detail oriented and well organized
  • Good and thoughtful listener
  • Critical thinker and solution oriented
  • Enthusiastic, self-motivated and self-starter

Physical Demands / Travel

The physical demands of this job are consistent with light office duties.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in an office / lab / traveling in the field.  

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.


Reports To:

Executive Director, Quality Assurance

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

The Manager, Quality Assurance, Diagnostics/Biomarkers is responsible for all aspects of Quality Assurance in the biomarker and diagnostics area. The Manager Quality Assurance will establish and execute quality plans, policies and quality system elements related to GXP activities. This position will support the vendor management program for biomarker and diagnostics operations from early phase through commercialization. The Manager, Quality Assurance will establish, maintain, and ensure effectiveness of quality programs and documentation to assure compliance with CAP/CLIA, GCP, GLP, and international requirements.

Roles and Responsibilities of the Position*

  • Act as liaison across departments to proactively identify opportunities to streamline and strengthen the vendor qualification process.
  • Facilitate the qualification process for biomarker, diagnostic, and clinical laboratory vendors and represent QA at the qualification forums.
  • Maintain detailed list of biomarker/diagnostic vendors and their current status.
  • Serve as QA SME when SOPs are written or revised in this area, as well as general GxP SOPs.
  • Perform QA review of technical and regulatory documents that support clinical trials.
  • Represent QA on cross-functional clinical study teams.
  • Keeps current with global health authority laws and regulations and implements process improvements resulting from new/revised regulations or guidance.
  • Utilizes the Loxo Quality Systems to manage Quality system elements.
  • Supports external Health Authority inspections, as needed.

Required Qualifications and Background

  • Bachelor’s degree with 10 or more years’ experience working in either a clinical compliance or clinical quality group.
  • Demonstrated knowledge in CAP/CLIA certifications, and working knowledge of GXPs.
  • Experience working with third parties, auditing, and vendor qualification.
  • Demonstrated Quality Management System experience (SOPs, training, document control, auditing, etc.).
  • Experience working in a regulated environment (e.g. FDA, EMA, etc.).
  • Self-motivated with the ability to work effectively in a dynamic environment.
  • Strong leadership with demonstrated ability to interface with senior leaders and different levels of the organization.
  • Good problem solving, written and verbal communication skill.
  • Ability to effectively manage multiple priorities with a sense of urgency.
  • Strong track record of project management, stakeholder management, collaboration skills and negotiation of complex situations.
  • Attention to detail and accuracy of work.
  • Demonstrated ability to work well with other accomplished professionals within and across functions/teams. Willing collaborator.

Physical Demands / Travel

The physical demands of this job are consistent with light office duties.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in an office. 

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.


Reports To:

Vice President, Small Molecule Biology

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

The Mechanistic Biology Group Leader will be responsible for guiding the research of a mechanistic biology team focused on understanding protein-protein and protein-small molecule interactions utilizing biochemical and biophysical methods and techniques.  The mechanistic biology team will work on multiple drug discovery project teams to provide rapid rigorous mechanistic characterizations to differentiate the activities of small molecule compounds, advance novel drug targeting strategies, develop specialized assays for drug discovery project teams, understand drug resistance, and evaluate new targets.  The mechanistic biology team will work closely with other project team members across disciplines including structural biology, cell biology, translational biology, in vitro pharmacology, and medicinal chemistry.

Roles and Responsibilities of the Position*

  • Supervise and mentor biochemists and biophysicists engaged in Loxo Oncology at Lilly discovery projects to think deeply and work creatively while delivering excellent scientific results and insights to the project teams and their colleagues
  • Participate and lead project-based and technical team meetings to identify and solve problems, guide work towards project goals, communicate on-going work and progress, and plan forward thinking strategies
  • Actively participate in the team’s research activities (i.e. hands-on experimental work, experimental design, advanced analysis, etc.)
  • Develop and continually advance one’s knowledge base on the molecular pathways being targeted by our discovery, clinical and research programs.
  • Proactively investigate new or different technologies and methods to advance our discovery projects

Required Qualifications and Background

  • PhD in Biochemistry, Chemistry, Molecular/Cellular Biology or related field with 8+ years hands-on biochemistry or biophysics experience in a biotech/pharma setting OR BS/MS in Biochemistry, Chemistry, Molecular/Cellular Biology or related field with 12+ years hands-on biochemistry or biophysics experience in a biotech/pharma setting
  • Demonstrated experience supervising 2 or more scientists
  • Strong background in enzymology and experimental curve-fitting and statistics
  • Proven track record in design and development of state-of-the-art biophysical methods including, but not limited to; Surface Plasmon Resonance (SPR), Isothermal Titration calorimetry (ITC), Protein small molecule binding/activity assays, mass spectrometry, and protein/protein interaction analysis
  • Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels
  • Highly organized with excellent analytical, documentation and multi-tasking skills
  • Committed to staying current with the latest scientific breakthroughs in the targeted oncology field from target identification through human clinical trials
  • Good and thoughtful listener who values collaboration
  • Enthusiastic, self-motivated and keen to improve processes and overcome inefficiencies
  • Proficient in Microsoft Office suite and applications

Physical Demands / Travel

The physical demands of this job are consistent with work in a laboratory setting.  Some light lifting, and maneuvering may be required.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in a lab.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.


Reports To:

Chief Medical Officer

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

The Medical Director will lead and support the expansion of clinical development programs (or one large, complex program) in support of the overall product development plan and serve as an ambassador and resource to various physicians and clinical trial sites, based on strong medical and scientific principles, knowledge of compliance and regulatory requirements, Loxo customers, markets, business operations, and emerging issues, and perform other responsibilities as requested.

Roles and Responsibilities of the Position*

  • Primary responsibility for and ownership of design, analysis, interpretation, and reporting of scientific content of protocols, Investigator Brochures, Clinical Study reports, regulatory submissions and responses, and other program documents.   
  • May participate in or lead clinical development contributions to due diligence or other business development activity.  As required by program needs, contributes in partnership with research colleagues to design and implement translational strategies.
  • Acts as clinical lead and actively solicits opinion leader interactions related to the disease area(s); partners with Medical Affairs, Commercial and other functions in these activities as required, consistent with corporate policies, to ensure that broad cross-functional perspectives are incorporated into Clinical Development Plans and protocols as appropriate.
  • Stays abreast of professional information and technology through conferences, medical literature, and other available training, to augment expertise in the therapeutic area. May represent Loxo at key external meetings.
  • Responsible for understanding the regulatory requirements related to the clinical studies and global drug development and accountable for complying with those requirements. Serves as a clinical representative for key regulatory discussions.
  • Ensures adherence to Good Clinical Practices, pharmacovigilance standards, standard operating procedures and to all other quality standards in conducting research. 

Required Qualifications and Background

  • MD, Board certification in Oncology or Hematology.
  • PhD would be an advantage.
  • Ability to exercise judgment and address complex problems and create solutions for one or more projects.
  • Ability to develop collaborative working relationships with physicians, expert consultants, and contracted vendors.
  • Strong analytical mind and problem-solving skills, attention to detail, strong organizational skills, and ability to work independently and as part of a team.
  • Proven leadership skills and ability to bring out the best in others on a cross-functional global team. Must be able to lead through influence.
  • Proven ability to interact externally and internally to support a global scientific and business strategy.
  • Excellent English written and verbal communication skills. Strong document management skills, including proficiency with MS Word, EndNote, PowerPoint and Excel.
  • Demonstrated ability to work well with other accomplished professionals within and across functions/teams. Willing collaborator.
  • Strong communication skills both written and oral.
  • Ability to multi-task and shift priorities rapidly to meet tight deadlines.
  • Professional demeanor and appearance and an excellent written and verbal communicator.
  • Good and thoughtful listener.
  • Enthusiastic, self-motivated and keen to improve processes and overcome inefficiencies.

Physical Demands / Travel

The physical demands of this job are consistent with light office duties. This role will require 50-60% travel.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in an office / traveling in the field to both US and International locations.  

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.


Reports To:

Associate Director, Drug Discovery

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

Loxo Oncology at Lilly’s Drug Discovery team in Boulder, Colorado has an immediate opening for Medicinal Chemistry Research Associate / Associate Medicinal Chemists.  The Loxo Oncology at Lilly Drug Discovery team’s mission is to invent life-changing targeted therapies for cancer patient populations that are poorly treated by existing therapies. To that end, we have built a multi-disciplinary team of dedicated drug discovery scientists who are passionate about driving the science forward to create highly selective drugs for known oncogenic drivers. We are currently looking for medicinal chemists with a proven track records of success in synthetic organic chemistry. The ideal candidate will be passionate about using synthetic chemistry and data analysis skills to solve medicinal chemistry challenges and will excel at working closely with scientists across disciplines.  The position requires excellent people skills, a positive can-do attitude, and the ability to thrive in a highly interactive, fast-paced, team environment.

Roles and Responsibilities of the Position*

  • Drive the team forward with new medicinal chemistry analogs that consistently move the project toward the next breakthrough drug candidate.
  • Optimize lead series for potency, selectivity, physiochemical properties, in vitro ADME, and PK by coupling multivariant SAR analysis with hypothesis-driven medicinal chemistry design principles. -
  • Work closely with structural biology and computational chemistry colleagues to design novel compounds and hypotheses that address key drug optimization goals.
  • Reduce ideas to practice in the lab quickly by effectively employing a broad range of modern organic chemistry transformations, synthetic methods, purification and characterization techniques.
  • Synergize with the broader team by communicating results, sharing insights, making plans, and setting goals in an open, honest way.

Required Qualifications and Background

  • B.S., M.S. or Ph.D. in Chemistry with a focus on synthetic organic chemistry.
  • 1-5 years of experience in small molecule organic synthesis and/or drug discovery experience in biotechnology or pharmaceutical setting.
  • Proficiency in modern synthetic methodology and variable reaction scales.
  • Ability to design feasible synthetic routes to target molecules and choose appropriate reaction conditions.
  • Skilled user of synthetic chemistry instrumentation: HPLC, LC-MS, NMR, and purification systems.
  • Experience in lead compound optimization for potency, selectivity, ADME and PK is preferred but not required.
  • Experience in using common synthetic chemistry software: electronic notebook, ChemDraw, Excel, literature search engines.
  • An excellent team player with ability to communicate synergistically with a multidisciplinary team. Highly organized with excellent analytical, documentation, time management, and multi-tasking skills.

Physical Demands / Travel

The physical demands of this position are consistent with working in a laboratory/ bench environment. Some light lifting and maneuvering may be required.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is based in a laboratory/ bench environment.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.


Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

The Senior Molecular Cell Biologist will be part of the Loxo Oncology’s Drug Discovery group in Boulder, Colorado.  The Drug Discovery group is responsible for identifying molecular targets for life-changing oncology drugs, creating and evaluating novel drug candidates with a focus on small molecule drugs, and providing forward-thinking approaches to advance our clinical portfolio.  The Senior/Principal Cell Biologist will be responsible for creating and evaluating cellular assays, execution strategies to quantitatively determine the potency and selectivity of small molecule compounds and interrogate signaling pathways. The Senior Cell Biologist will have a strong understanding of signal transduction pathways and experience in designing experiments to evaluate molecular interactions and pathways. The Senior/Principal Cell Biologist will be part of the team designing, managing and evaluating in vivo pre-clinical studies. This is a hands-on position for an experienced lab scientist who enjoys working in the lab. This scientist must have excellent people skills and be able to work with a positive, “can-do” attitude in a dynamic, fast-paced, team environment focused on high quality science to deliver innovative cancer drugs.

Roles and Responsibilities of the Position*

  • Create, develop and validate quantitative mammalian cellular assays to address the project team’s mechanistic and functional needs.
  • Establish robust screening assays to support medicinal chemistry lead optimization programs. Establish processes to efficiently and effectively communicate results to the project team. 
  • Design and manage in vivo pre-clinical studies.
  • Identify, evaluate, and manage vendors for outsourced services and studies.
  • Collaborate with colleagues throughout the company to ensure assays meet the program needs and results are appropriately interpreted.
  • Prepare reports for internal and external purposes including regulatory submissions.
  • Participate and lead project-based and technical team meetings to identify and solve problems, guide work towards project goals, communicate on-going work and progress, and plan forward thinking strategies. 
  • Develop and continually advance one’s knowledge base on the molecular pathways being targeted by our clinical and research programs.
  • Proactively investigate new or different technologies, methods, and service providers to ensure our work is being done in a scientifically sound, efficient, and reasonable way
  • In the future, this position’s responsibilities may include supervision of scientists and associates.

Required Qualifications and Background

Required:

  • PhD in Molecular/Cellular Biology, Biochemistry, or related field with 5+ years hands-on molecular biology and cell assay experience in a biotech/pharma setting OR BS/MS in Molecular/Cellular Biology or Biochemistry with 10+ hands-on molecular biology and cell assay experience in a biotech/pharma setting

Ideal candidate will also have:

  • Extensive experience in creating, developing, and running cellular assays; engineering cell lines to express or knock-down genes of interest, interrogating cellular signal transduction pathways, and characterizing kinase activity.
  • Experience with flow cytometry and general molecular biological techniques including q-PCR, ELISA, MSD and Western Blot etc.
  • Strong background in experimental curve-fitting and statistics.
  • Experience in designing in vivo animal studies.
  • Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels.
  • Highly organized with excellent analytical, documentation and multi-tasking skills.
  • Committed to staying current with the latest scientific breakthroughs in the targeted oncology field from target identification through human clinical trials.
  • Good and thoughtful listener who values collaboration.
  • Enthusiastic, self-motivated and keen to improve processes and overcome inefficiencies.
  • Proficient in Microsoft Office suite and applications.

Physical Demands / Travel

The physical demands of this position are consistent with working in a laboratory/bench environment. Some light lifting, and maneuvering may be required.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is based in a laboratory/bench environment.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.


Reports To:

Associate Director, Drug Discovery

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

Loxo Oncology at Lilly’s Drug Discovery team in Boulder, Colorado has an immediate opening for an experienced medicinal chemist. The Loxo Oncology at Lilly Drug Discovery team’s mission is to invent life-changing targeted therapies for cancer patient populations that are poorly treated by existing therapies. To that end, we have built a multi-disciplinary team of dedicated drug discovery scientists who are passionate about driving the science forward to create highly selective drugs for known oncogenic drivers. We are currently looking for accomplished medicinal chemists with a proven track records of success in small molecule drug discovery. The ideal candidate will be passionate about leading from the bench to solve medicinal chemistry challenges and will excel at working closely with scientists across disciplines.  The position requires excellent people skills, a positive can-do attitude, and the ability to thrive in a highly interactive, fast-paced, team environment.

Roles and Responsibilities of the Position*

  • Drive the team forward with new medicinal chemistry analogs that consistently move the project toward the next breakthrough drug candidate.
  • Optimize lead series for potency, selectivity, physiochemical properties, in vitro ADME, and PK by coupling multivariant SAR analysis with hypothesis-driven medicinal chemistry design principles. Use sound scientific methods to propose hypotheses and determine next steps even with complex or ambiguous data.
  • Work closely with structural biology and computational chemistry colleagues to design novel compounds and hypotheses that address key drug optimization goals.
  • Reduce ideas to practice in the lab quickly by effectively employing a broad range of modern organic chemistry transformations, synthetic methods, purification and characterization techniques.
  • Synergize with the broader team by communicating results, sharing insights, making plans, and setting goals in an open, honest way.
  • Provide medicinal chemistry insight for new target and lead identification and evaluation initiatives in the oncology space.
  • Proactively investigate new or different technologies to improve the effectiveness of the drug discovery process.

Required Qualifications and Background

  • B.S., M.S. or Ph.D. in Chemistry with a focus on synthetic organic chemistry.
  • 5+ years of experience in small molecule drug discovery in a biotechnology or pharmaceutical setting.
  • Proven track record of success in advancing programs from leads to advanced candidates.
  • Extensive experience in lead compound optimization for potency, selectivity, ADME and PK.  
  • Experienced in the use of synthetic chemistry instrumentation: HPLC, LC-MS, NMR, and purification systems.
  • Expert in using common medicinal chemistry software: electronic notebook, ChemDraw, Excel; data visualization; structure viewing; literature, chemical and database searching.
  • Committed to staying current with the latest scientific breakthroughs in the medicinal chemistry field through continued reading of the literature and attendance of scientific conferences. 
  • An excellent team player with ability to communicate synergistically with a multidisciplinary team and be accountable for the medicinal chemistry progress of the project. Highly organized with excellent analytical, documentation, time management, and multi-tasking skills.

Physical Demands / Travel

The physical demands of this position are consistent with working in a laboratory/ bench environment. Some light lifting and maneuvering may be required.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is based in a laboratory/ bench environment.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.


Reports To:

Senior Director, Pharmacology and Bioassays

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

The Enzymology Senior Scientist will be responsible for developing and performing robust enzyme and binding assays to support drug discovery and development in a team environment. The scientist fulfilling this position will be responsible for characterizing the effects of small molecule compounds on specific protein targets and will provide enzymology expertise to the project teams. A strong background in experimental curve-fitting, statistics, and assay optimization and execution is required.

Roles and Responsibilities of the Position*

  • Extensive knowledge in assay development, mechanism-of-action studies, enzyme characterization, kinetics, and protein biochemistry is required
  • Design, develop, and execute enzyme and binding assays in multiple formats
  • Screen small molecule inhibitors in plated based assays formats to drive internal structure-based drug design
  • Perform comprehensive data analysis and communicate experimental findings to the project team members
  • Operate, implement, and troubleshoot laboratory automation
  • Actively engaged in advancing small molecule drug discovery oncology programs
  • This is a “hands-on” laboratory, based position

Required Qualifications and Background

  • Ph.D. with >5 years industrial experience or BS or MS with >10 years industrial experience. Degree in Biochemistry, Biophysics, Biology or related field. Industrial experience must include drug discovery experience in a biotechnology or pharmaceutical setting

Additional Preferred Qualifications

  • The successful candidate is expected to have expertise in biochemistry, enzymology, and assay development
  • Experience with general biochemical and kinetic-based assay technologies (e.g. FP, TR-FRET, AlphaScreen, Luminescence)
  • Experience with laboratory instrumentation and automation for medium to high-throughput screening
  • QTOF experience is a plus
  • Excellent oral and written communication skills including experimental documentation
  • Strong publication record
  • Works well with team members daily across functional areas
  • Ability to multi-task and shift priorities rapidly to meet tight deadlines
  • Highly organized with exceptional attention to detail
  • Good and thoughtful listener
  • Enthusiastic, self-motivated and a continuous learner
  • Proficient in Microsoft Office suite and applications

Physical Demands / Travel

The physical demands of this job are consistent with a lab.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in a lab.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.


Reports To:

Director, Translational Medicine

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

With their background in cancer biology, the Senior Scientist, Translational Medicine will lead and support translational research projects associated with Loxo Oncology at Lilly’s  preclinical and early development programs. This entails formulating and executing plans aimed at characterizing our lead compounds, including their: (1) efficacy (in vitro and in vivo), (2) mechanism of action, (3) target patient populations, and (4) biomarkers predicting clinical response. It may also involve developing prototype clinical diagnostic tests for promising biomarkers. The successful candidate will achieve these objectives by collaborating with Loxo Oncology at Lilly’s discovery scientists, evaluating and initiating new collaborations with academic institutions, identifying & overseeing research at CROs and working closely with their clinical development colleagues at Loxo Oncology at Lilly.

Roles and Responsibilities of the Position*

  • Design and execution of cancer cell line and xenograft studies assessing compound efficacy
  • Engineering of knock-in & knockdown cell lines with CRISPR and/or other technologies
  • High throughput siRNA and/or CRISPR screens of cell lines
  • Extraction of DNA, RNA & proteins, particularly from FFPE samples
  • RT-PCR and NGS assays of RNA abundance, CNVs and/or SNVs
  • IHC, Western blot, ELISA and mass spectrometry assays of protein abundance
  • FISH assays of chromosomal abnormalities
  • Utilize animal models for immune-oncology, inflammation, or autoimmunity research
  • Immunology/auto-immunity assays, including immune cell isolation and characterization using flow cytometry
  • Design and execution of cross-assay validation studies
  • Management of internal and/or CRO-based bench scientists
  • Management of academic sponsored research
  • Organization and coordination of multiple projects in parallel
  • Preparing and presenting scientific results at congresses and in peer-reviewed journals

Required Qualifications and Background

  • Ph.D. in a biological discipline with  8+ years of bench experience. Post-doctoral research and/or industry experience preferred
  • Extensive research experience in solid tumor and/or heme oncology
  • Demonstrated ability to evaluate the mechanism of action of compounds, to identify biomarkers, and to translate findings to relevant assays for clinical research
  • Familiarity with clinical trial design and the implementation of biomarker strategies
  • Self-organized, self-directed, highly motivated with strong critical thinking and analytical skills
  • Willingness to work collaboratively and incorporate diverse perspectives into decision-making
  • Demonstrated ability to work successfully in a nimble, fast-paced matrixed environment

Physical Demands / Travel

The physical demands of this job are consistent with light office duties. Up to 15% travel required for this role.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in an office.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.


Reports To:

Director, Statistical Programming

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

The Statistical Programmer is responsible for providing Statistical Programming activities across in support of one or more clinical stage programs. Responsibilities will include: support of workflow in generation of study-specific and ad-hoc clinical data listings, summary tables and figures; performing data analysis, statistical analysis, generate safety and efficacy tables, listings and graphs using Base SAS, SAS Macros, SAS/STAT, SAS/Graph, SAS/SQL and SAS/ODS.

Roles and Responsibilities of the Position*

  • Perform data analysis using primarily the SAS programming language for the summary and interpretation of clinical trial data.
  • Create and review CDISC SDTM and ADaM files, SAS export files and Define.xml use for Electronic Submission from the data received in non-standard form from various sources.
  • Perform data analysis, statistical analysis, generate safety and efficacy tables, listings and graphs using Base SAS, SAS Macros, SAS/STAT, SAS/Graph, SAS/SQL and SAS/ODS.
  • Develop SAS coding and table templates for preparing, processing and analyzing clinical data.
  • Establish monitoring of data transfers for ongoing trials to identify study conduct or data quality issues.
  • Review Data Management Plan, Data Validation Plan and edit check specifications.
  • Interact cross functionally with Statisticians and other members of the clinical team to perform ad hoc analysis and generate outputs according to the requirements.
  • Implement and contribute to statistical analysis plans; provide additional expertise in the analysis of clinical trial as it relates to protocol development, case report form design and data collection. 
  • Recognize inconsistencies and initiate resolution of data problems
  • Act independently to determine methods and procedures on new assignments.

Required Qualifications and Background

  • Bachelor/Master’s degree in Statistics, Life Sciences, Computer Sciences, or Mathematics with a minimum 3-5 years Pharmaceutical/Biotech programming experience.
  • Experience in the analysis of complex oncology and/or hematology clinical trial data.
  • Solid knowledge of SAS Programming language.
  • Experience with integrated summaries (ISE/ISS) and Clinical Study Reports.
  • Proven ability to work both independently and in a team setting.
  • Strong well-rounded technical skills (EDC systems, MS Word, Excel, PowerPoint).
  • Excellent verbal/written and interpersonal skills.
  • Ability to communicate and collaborate effectively with cross-functional teams in face-to-face conversation, by telephone, and by email
  • Ability to work effectively in a fast-paced environment with a positive “can-do” proactive attitude.

Physical Demands / Travel

This position will travel occasionally based upon the demands of the business imperatives.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is based in a typical office setting.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.


Reports To:

Executive Director, Quality Assurance

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

Loxo Oncology is seeking a highly-motivated Specialist, Quality Systems who is an excellent influencer and enjoys a fast paced, dynamic work environment. The ideal candidate has demonstrated knowledge of GXP Quality Systems and possesses sound judgment, capable of obtaining tangible results in a short period of time. This individual must assist with managing Loxo Quality Systems and will work collaboratively with both internal and external colleagues to influence mindset and provide proactive compliance. 

Roles and Responsibilities of the Position*

  • Provides support to QA Program Manager in overseeing the Loxo GXP Quality systems such as document management, change control, deviations, CAPA’s, training, internal/external audits, etc.
  • Supports lifecycle management of Quality documentation (e.g. SOP’s, Deviations, CAPAs, training records, audit reports, etc.)
  • Tracks and trends Quality system element status and performs follow up as needed
  • Supports the Loxo training program which includes assisting in curricula development and approval and management of employee training files
  • Collaborates with IT and QA Program Manager to problem solve system related issues
  • Supports inspection readiness activities by accessing and providing Quality system documentation
  • Works with internal departments to ensure continuous improvement of processes/procedures and quality of work product

Required Qualifications and Background

  • Bachelor's Degree is required in science, health or related field 5-7+ years’ experience in the Biotech/Pharmaceutical industry
  • Working knowledge of IT Quality System solutions and associated compliance requirements, which includes but is not limited to; system implementation, execution and change management (Veeva systems a plus)
  • Working knowledge of global regulations and guidelines (e.g. FDA/EU and ICH)
  • Broad and direct experience supporting regulatory authority inspections
  • Flexible in the face of shifting needs and/or priorities
  • Able to interface well with all levels of personnel, including peers and other department heads such as: IT, Clinical Operations, Data Management, CMC, Clinical Science, Regulatory, Biostatistics, Drug Safety, Translational Research, Supply Chain and Project / Program Management
  • Capacity to produce high quality results across multiple projects and demands, through effective prioritization, while working under short deadlines associated with a fast-paced dynamic scientific environment
  • Excellent communications skills, both written and verbal
  • Excellent teamwork, interpersonal skills and negotiation skills, both internally and externally
  • Strategic thinker, open-minded and flexible to adopting new ideas
  • Motivated, committed and self-managed
  • Willingness to work in a dynamic and changing corporate environment
  • Requires a flexible work schedule to accommodate program priorities and international activities as needed

Physical Demands / Travel

There are no specific physical demands for this position. 

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

There are no specific work demands for this position. 

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.


Reports To:

TBD

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

This position offers the opportunity to be part of Loxo’s discovery teams focused on creating novel, highly specific and selective drugs for genetically identified targets.  The Structural Biologist will offer structural and mechanistic insights to a multi-disciplinary discovery team by delivering high quality protein, protein: small molecule complex crystals, and protein-ligand crystal structures.

Roles and Responsibilities of the Position*

  • Generate protein-small molecule complex x-ray crystal structures with hands-on lab involvement throughout the gene to structure process including protein expression, purification, crystallization, and structure determination.
  • Coordinate protein construct design, expression, and purification with the project team to support biochemical and biophysical assays.
  • Rapidly communicate scientific results and insights to the team.
  • Collaborate with colleagues throughout the company to ensure structural work meets the program needs and results are appropriately interpreted.
  • Prepare reports for internal and external purposes including regulatory submissions.
  • Participate and lead project-based and technical team meetings to identify and solve problems, guide work towards project goals, communicate on-going work and progress, and plan forward thinking strategies. 
  • Develop and continually advance one’s knowledge base on genetically targeted drugs and structure-based drug design.
  • Proactively investigate new or different technologies, methods, and service providers to ensure our work is being done in a scientifically sound, efficient, and reasonable way
  • In the future, this position’s responsibilities may include supervision of scientists and associates.

Required Qualifications and Background

  • BA/BS, MS in Biochemistry, Chemistry, or related field
  • Ideal candidate will have with 5+ years hands-on gene to structure protein-small molecule crystallography experience in a biotech/pharma setting.
  • Highly skilled in crystallization of protein-small molecule complexes.
  • Extensive experience in protein construct design, expression, purification, and characterization.
  • Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels.
  • Highly organized with excellent analytical, documentation and multi-tasking skills
  • Committed to staying current with the latest scientific breakthroughs in structure-based drug design and structural biology.
  • Expertise in other methods of biophysical and structural biology is a plus

Physical Demands / Travel

There are no physical/travel demands for this job.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is based equally in a wet lab and office environment. 

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.


Reports To:

VP, Small Molecule Biology

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

The Translational Biology Group Leader will be responsible for leading a research team focused on in-depth studies to provide clinically-focused research to guide discovery projects, biomarker strategies, and early clinical development. The translational biology team will work on multiple drug discovery projects and early clinical programs across solid tumors and hematological malignancies providing mechanism-based studies to characterize prototype, literature, and clinical compounds in clinically relevant in vitro and in vivo assays. In addition, the translational biology team will develop and characterize drug resistance mechanisms in in vitro and in vivo models, identify and test drug combinations based on molecular mechanism, and analyze clinical trial patient molecular characterization results to inform discovery, clinical, and diagnostic programs. The translational biology team will work closely with other project team members across disciplines including cell biology, in vivo pharmacology, medicinal chemistry, biochemistry, bioinformatics, and clinical leads.

Roles and Responsibilities of the Position*

  • Participate and lead project-based and technical team meetings to identify and solve problems, guide work towards project goals, communicate on-going work and progress, and plan forward thinking strategies.
  • Actively participate in their team’s research activities (i.e. experimental work, experimental design, advanced analysis, etc.)
  • Effectively communicate biomarker strategies and assays to clinical teams, while also ensuring that insights from the clinical studies   inform discovery projects.
  • Supervise and mentor cell biologists and biochemists engaged in Loxo Oncology at Lilly translational research projects to think deeply and work creatively while delivering excellent scientific results and insights to the project teams and their colleagues.
  • Develop and continually advance one’s knowledge base on the molecular pathways being targeted by our discovery, clinical and research programs.
  • Proactively investigate new or different technologies and methods to advance our discovery projects

Required Qualifications and Background

  • PhD in Molecular/Cellular Biology, Biochemistry, or related field with 8+ years hands-on cell biology experience in a biotech/pharma setting OR BS/MS in Molecular/Cellular Biology, Biochemistry, or related field with 12+ years hands-on cell biology experience in a biotech/pharma setting
  • 2+ years of experience working on hematological malignancies

Additional Preferred Qualifications

  • Demonstrated experience supervising 2 or more scientists.
  • Expertise in designing and commissioning in vivo efficacy studies using cancer cell line and patient-derived xenograft models, to test oncology compounds
  • Strong background in cancer cellular signaling pathway experimentation and experimental curve-fitting and statistics
  • Thorough understanding of engineering knock-in and knockdown cell lines with CRISPR and/or other technologies
  • Experience with early clinical trial studies and the development and implementation of pharmacodynamic and patient selection biomarker assays
  • Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels
  • Highly organized with excellent analytical, documentation and multi-tasking skills
  • Committed to staying current with the latest scientific breakthroughs in the targeted oncology field from target identification through human clinical trials
  • Good and thoughtful listener who values collaboration
  • Enthusiastic, self-motivated and keen to improve processes and overcome inefficiencies
  • Proficient in Microsoft Office suite and applications

Physical Demands / Travel

The physical demands of this job are consistent with light office duties and some laboratory work. Some light lifting, and maneuvering may be required.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in an office and laboratory environment.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.


Position

Outstanding Team Member

Location

Stamford, CT, South San Francisco, CA, or Boulder, CO (or another location to be determined)

Position Summary

Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by that goal. We pursue this goal with a tenacity, focus and commitment to excellence that defines who we are and how we work.

We seek dedicated, passionate, hardworking intelligent, thoughtful and authentic individuals who thrive within a collaborative and fast-paced environment and will bring their experiences, unique perspectives and problem-solving skills to the team. In return, we cultivate an environment that rewards and recognizes hard work and provides opportunities for learning and growth as part of a team making a meaningful difference in the field of medicine and for individual patients.

If you share our passion, please let us know how you could contribute to our team. We don't want to pass up an opportunity for the right candidate to join us just because you found us before we found you.

Connect With Us

Submit your resume and your "Who", "What" and "Why" (see below) to careers@loxooncology.com.

Your "Who", "What" and "Why":

  • Who are you?
  • What will you bring to Loxo?
  • Why do we need you on the team?

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.