Career Opportunities

Career Opportunities

Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by our goal of improving the lives of people living with cancer. We pursue this goal with a tenacity, focus, and commitment to excellence that defines who we are and how we work.

We seek dedicated, passionate, hardworking, intelligent, thoughtful, and authentic individuals who thrive within a collaborative and fast-paced environment and will bring their experiences, unique perspectives and problem-solving skills to the team. In return, we cultivate an environment that rewards and recognizes hard work and provides opportunities for learning and growth as part of a team making a meaningful difference in the lives of patients.

Pharmacology Principal Scientist

Location: Indianapolis, IN

Reports To:

Pharmacology Project Leader

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

The Pharmacology Principal Scientist will be responsible for identifying, developing, and performing robust, reproducible in vitro and in vivo assays to support tier 1-3 assays.  The Scientist will provide hands-on compound testing to support the small molecule drug discovery oncology pipeline and will be responsible for characterizing the effects of small molecule compounds on specific protein targets using multiple assay formats. A strong background in experimental curve-fitting, statistics, and assay optimization and execution is required.

Roles and Responsibilities of the Position*
  • Develop robust Tier 1 - 3 assays including biochemical (enzyme and binding), cell based (e.g. target inhibition, proliferation etc), tumor models (development and analysis)
  • Design, execute, and trouble-shoot experiments
  • Perform comprehensive data analysis
  • Communicate experimental findings to team members
  • Actively engage in advancing drug discovery
  • This is a “hands-on” laboratory based position
Required Qualifications and Background
  • BS/MS/PhD in oncology, biology, biochemistry or related fields with 8+ years of related experience
  • Ability to leverage multiple assay platforms to measure target engagement, pathway modulation and cell sensitivity in response to compounds
  • Strong understanding of oncology and signaling pathways
  • Continual learner and possesses a can-do attitude
  • Excellent oral and written communication skills including experimental documentation
  • Ability to multi-task and shift priorities rapidly to meet tight deadlines
  • Possess personal accountability for excellent and timely results
  • Highly organized with exceptional attention to detail
  • Demonstrate ability and willingness to work effectively in a highly collaborative research environment
  • Proficient in Microsoft Office suite and applications
  • Experience with biochemical and kinetic-based assay technologies (e.g. FP, TR-FRET, AlphaScreen, Luminescence)
  • Experience with laboratory instrumentation and automation
  • Cell culture expertise (cell lines and primary cells) including clonal cell isolation techniques. Solid and liquid tumor cell lines.
  • Hands-on experience in lentivirus production, titration, and transduction
  • Demonstrated experience in developing cell-based assay to monitor protein levels and modifications including the following methods:   ELISA, In-Cell Westerns, Mesoscale, HTRF, AlphaScreen, MALDI-TOF MS
  • Cell viability, proliferation and apoptosis assays
  • Experience with multiplexed antibody-based detection methods (e.g. Luminex, Mesoscale)
  • Tumor and/or tissue sample handling and processing for biomarker analysis
  • Ability to perform quantitative data analysis, curve fitting, statistics etc
  • Experience developing multi-channel flow cytometry based screening assays including sample preparation, staining, operating flow cytometers, and analyzing flow 
  • Tumor biology including cell line xenograft and/or PDX models in oncology setting
Additional Preferred Qualifications
  • Metabolite analysis in cells and tumors
  • Experience with small molecule compound testing
  • Proficient in CRISPR, shRNA and/or siRNA gene regulation
  • Organoid or 3D culture method development
  • Colony formation assay experience
  • High content cellular imaging skills
  • Expertise in running high-throughput and automated cancer cell proliferation panels
  • Experience in confocal microscopy
  • Gene expression profiling of tumor samples
  • Experience in the generation and analysis of mouse cancer models
  • Experience with tumor implantation techniques and dosing, tumor measurement, health monitoring, and data collection and analysis
  • In vitro and ex vivo experience analyzing biomarkers (examples include flow cytometry, IHC, ELISA, RT-PCR, Westerns, Luminex)
  • Experience with bioluminescent imaging studies
  • Understanding of PK, PD, and PK/PD relationship
Physical Demands / Travel

The physical demands of this job are consistent with a laboratory setting.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in an office and a lab. 

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

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