Career Opportunities

Career Opportunities


Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by our goal of improving the lives of people living with cancer. We pursue this goal with a tenacity, focus, and commitment to excellence that defines who we are and how we work.

We seek dedicated, passionate, hardworking, intelligent, thoughtful, and authentic individuals who thrive within a collaborative and fast-paced environment and will bring their experiences, unique perspectives and problem-solving skills to the team. In return, we cultivate an environment that rewards and recognizes hard work and provides opportunities for learning and growth as part of a team making a meaningful difference in the lives of patients.

Research Associate, Biophysics

Location: South San Francisco, CA

Reports To:

Scientist, Biophysics

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

This position is an opportunity to learn and grow within a dynamic mechanistic biology team dedicated to creating specific targeted therapeutics for genetically defined oncology targets.  The ideal candidate is someone who enjoys technical challenges and is not afraid to get their hands dirty by helping with core lab functions including cell culture, protein characterization, biophysical experiments, and laboratory automation. The qualified candidate will have experience with basic chemistry/biology laboratory practices and is passionate to learn additional techniques working in a growing dynamic group focused on discovery research. The successful candidate will work as part of a collaborative team of scientists with expertise in protein production, cell culture, chemistry, biochemistry, structure, and biophysics, supporting hit-to-lead and lead-ID phases of our oncology drug programs. The candidate will have opportunities to learn cutting edge techniques and to learn and develop technical expertise in protein biochemical and biophysical characterization.

Roles and Responsibilities of the Position*
  • Characterize protein-ligand interactions using a variety of methods including but not limited to; Intact protein and peptide base Mass Spectrometry, Fluorescence Spectroscopy, and Surface plasmon resonance.
  • Maintain and characterize various mammalian cell types in vitro.
  • Purification of recombinant proteins from a variety of cell sources to support biophysical/biochemical studies.
  • Collaborate with colleagues throughout the company to ensure timely delivery of assay data.
  • Adapt to highly dynamic project priorities, with diligent and rapid communication of scientific results and insights to the team.
  • Participate in discussions with vendors for outsourced services and studies.
  • Learn and develop technical expertise in protein biochemical and biophysical characterization.
  • Develop and continually advance one’s knowledge base on genetically targeted drugs and structure-based drug design.
Required Qualifications and Background
  • BA/BS or MS in Chemistry, Biology, Biochemistry, or related field.
  • Ideal candidate will have hands-on experience with protein characterization and cell culture.
  • Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels.
  • Highly organized with excellent analytical, documentation and multi-tasking skills.
  • Committed to staying current with the latest scientific breakthroughs in structure-based drug design and structural biology.
  • Expertise in other methods of enzymology or biophysical characterization and structural biology is a plus.
Physical Demands / Travel

The physical demands of this job are consistent with light office duties.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in an office / lab / traveling in the field.  

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

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