Career Opportunities

Career Opportunities

Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by our goal of improving the lives of people living with cancer. We pursue this goal with a tenacity, focus, and commitment to excellence that defines who we are and how we work.

We seek dedicated, passionate, hardworking, intelligent, thoughtful, and authentic individuals who thrive within a collaborative and fast-paced environment and will bring their experiences, unique perspectives and problem-solving skills to the team. In return, we cultivate an environment that rewards and recognizes hard work and provides opportunities for learning and growth as part of a team making a meaningful difference in the lives of patients.

Scientist, Translational Biology

Location: Indianapolis, IN

Reports To:

Translational Biology Group Leader

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

With their background in cell and molecular biology or related field, the scientific staff in Translational Biology will support translational research projects associated with Loxo Oncology at Lilly’s preclinical and early development programs. The successful candidate will achieve these objectives through exceptional attention to detail, scientific rigor and collaborations with Loxo’s discovery scientists.

Roles and Responsibilities of the Position*
  • Designing and executing in vitro and in vivo experiments aimed at understanding the mechanisms of action of our lead compounds and characterizing promising biomarkers for predicting clinical response.
  • Developing in vitro and in vivo models to characterize resistance mechanism of our lead clinical compounds.
  • Achieve these objectives through exceptional attention to detail, scientific rigor and collaborations with Loxo’s discovery scientists.
  • Work collaboratively and incorporate diverse perspectives into decision-making.
  • Work successfully in a nimble, fast-paced matrixed environment.
Required Qualifications and Background
  • BA/BS/MS/PhD in cellular and molecular biology or related disciplines with 1+ year of hands-on bench experience, preferably in an industry setting.
Additional Preferred Qualifications
  • Demonstrated expertise using molecular and biochemical assays toward mechanistic understanding of cellular and biological processes.
  • Extensive experience with aseptic mammalian cell culture and familiarity with solid tumor and/or hematologic cell lines is preferred.
  • Highly motivated and independent with strong critical thinking, analytical and excellent record keeping skills.
  • Continual learner and possesses a can-do attitude.
  • Excellent oral and written communication skills.
  • Ability to multi-task and shift priorities rapidly to meet tight deadlines.
  • Possess personal accountability for excellent and timely results.
  • Highly organized with exceptional attention to detail.
  • Demonstrate ability and willingness to work effectively in a highly collaborative research environment.

The ideal candidate will have experience with many of the following:

  • Gene expression in mammalian cells and engineering knock-in & knockdown cell lines using CRISPR, siRNA and/or other technologies.
  • Stable cell line generation
  • DNA and RNA extraction, including from FFPE samples.
  • PCR, qRT-PCR and NGS assays to evaluate DNA mutational status and RNA abundance.
  • IHC, Western blot, ELISA and mass spectrometry assays of protein abundance.
  • Mouse handling and experience with xenograft models is an advantage.
  • Experience with a variety of sample types, such as cancer cell lines, primary cells, organoids, whole blood, and FFPE tissue
  • Organization and coordination of multiple experiments in parallel.
  • Preparing and presenting scientific results internally and externally.
Physical Demands / Travel

It is expected that the successful candidate will spend ~15% of his/her time traveling on behalf of the company.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

There are no specific work demands. 

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.