Career Opportunities

Career Opportunities


Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by our goal of improving the lives of people living with cancer. We pursue this goal with a tenacity, focus, and commitment to excellence that defines who we are and how we work.

We seek dedicated, passionate, hardworking, intelligent, thoughtful, and authentic individuals who thrive within a collaborative and fast-paced environment and will bring their experiences, unique perspectives and problem-solving skills to the team. In return, we cultivate an environment that rewards and recognizes hard work and provides opportunities for learning and growth as part of a team making a meaningful difference in the lives of patients.

Senior Director, Cell Biology

Location: Boulder, CO or Indianapolis, IN

Reports To:

Vice President, Small Molecule Biology

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

The Senior Director, Cell Biology will be responsible for directing cell-based research across multiple programs with a focus on understanding cellular signaling and function at a molecular level including protein-protein and protein-small molecule interactions. The mechanistic studies will provide individual project teams with rigorous mechanistic characterizations to differentiate the activities of small molecules, advance novel drug targeting strategies, develop specialized assays for drug discovery project teams, understand drug resistance and feedback mechanisms, and identify novel compounds targeting specific proteins. The mechanistic biology teams work closely with other project team members across disciplines including structural biology, medicinal chemistry, in vitro pharmacology, and translational biology. This senior director will interact closely with their team scientists, company leaders, and other functional teams to identify, prioritize, and execute experiments leading to in-depth understanding of cellular molecular mechanisms and differential effects of small molecule compounds on cell-based readouts.

Roles and Responsibilities of the Position*

  • Manage and supervise the research activities of Loxo Oncology at Lilly cell biology groups in Indianapolis, IN and Boulder, CO.
  • Supervise and mentor group leaders, biochemists, and cell biologists engaged in each discovery project to think deeply and work creatively while delivering excellent scientific results and insights to the project teams and their colleagues.
  • Provide critical feedback and significant scientific mentorship to scientists.
  • Participate and lead project team meetings to identify and solve problems, guide work towards project goals, communicate on-going work and progress, and plan forward thinking strategies.
  • Proactively investigate new or different technologies and methods to advance our discovery projects.
  • Prioritize the allocation of resources and oversee the scientific infrastructure required to support the teams.

Required Qualifications and Background

  • PhD in Biochemistry, Molecular/Cellular Biology or related field with 15+ years hands-on cell biology experience in a biotech/pharma setting OR BS/MS in Biochemistry, Molecular/Cellular Biology or related field with 18+ years hands-on cell biology experience in a biotech/pharma setting.
  • Demonstrated experience in supervising a group of scientists required.
  • Demonstrated leadership capability in acting fast, identifying and solving issues quickly, and strong ability in implementing and executing a working plan/strategy.
  • Deep understanding of molecular oncology, cancer cell signaling and cell biology, and drug resistance mechanisms.
  • Previous experience working in oncogene, cancer cell signaling, oncology drug discovery and/or translational studies are desirable.
  • Proven track record in solving complex biology problems through mechanistic studies using biochemical, genetic, and/or cellular technologies.
  • Excellent interpersonal skills with ability to communicate and interact well with leadership, colleagues, vendors, contractors, scientific advisors, and staff at all levels.
  • Highly organized with excellent analytical, documentation and multi-tasking skills.
  • Committed to staying current with the latest scientific breakthroughs in the targeted oncology field from target identification through human clinical trials.
  • Good and thoughtful listener who values collaboration and teamwork.
  • Enthusiastic, self-motivated, and keen to solve problems and improve processes with a “can-do” attitude.

Physical Demands / Travel

The physical demands of this job are consistent with working in a lab.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in a lab.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.