Career Opportunities

Career Opportunities


Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by our goal of improving the lives of people living with cancer. We pursue this goal with a tenacity, focus, and commitment to excellence that defines who we are and how we work.

We seek dedicated, passionate, hardworking, intelligent, thoughtful, and authentic individuals who thrive within a collaborative and fast-paced environment and will bring their experiences, unique perspectives and problem-solving skills to the team. In return, we cultivate an environment that rewards and recognizes hard work and provides opportunities for learning and growth as part of a team making a meaningful difference in the lives of patients.

Senior/Principal Scientist, Discovery Biology

Location: South San Francisco, CA or New York, NY

Reports To:

Group Leader, Discovery Biology

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

The Senior/Principal Scientist, Discovery Biology will be part of the Loxo Oncology at Lilly’s Discovery group identifying the next generation of molecular targets for cancer therapeutics.  The Senior/Principal Scientist, Discovery Biology will be responsible for creating and executing strategies toward discovery and early validation of oncology targets through close collaboration with other discovery and translational functions. The Senior/Principal Scientist, Discovery Biology will have a strong understanding of oncogenic pathways and experience in designing experiments to evaluate molecular interactions and pathways. The Senior/Principal Scientist, Discovery Biology will be part of a multi-disciplinary effort focused on high-quality, truth-seeking science to bring forward innovative cancer drug therapy.

Roles and Responsibilities of the Position*
  • Create, develop and validate quantitative mammalian cellular assays to credential novel targets
  • Establish robust high-throughput screening assays
  • Design and manage in vivo pre-clinical studies.
  • Conceive and lead collaborative projects on biomarker-driven programs
  • Evaluate emerging technologies, methods, and service providers to ensure our work is being done in a scientifically sound, efficient, and reasonable way
  • Collaborate with colleagues throughout the company to ensure assays meet the program needs and results are appropriately interpreted.
  • Participate and thrive in an interactive, team-oriented culture
  • Directly manage and mentor lab-based staff
Required Qualifications and Background
  • PhD in Molecular/Cellular Biology or Biochemistry, or related field
  • Minimum of 3-6 years of postdoctoral and/or hand-on research experience, preferability in biotech/pharma setting
  • Experience in relevant areas of cancer and molecular biology
  • Outstanding communication, writing, and presentation skills is a must
Additional Preferred Qualifications
  • Experience with cell engineering such as knock-in and knockdown cell lines with CRISPR and/or other technologies
  • Experience with flow cytometry and general molecular biological techniques including q-PCR, signaling experiments, assays for protein-protein interactions and Western Blot etc.
  • Experience in designing and handling in vivo animal studies
  • Experience in building models (cell line, organoid or PDX) from patient samples and using them to test drug activities
  • Experience working with external CROs
  • Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels and problem solving skills
  • Ability to summarize complex experiment and results for non-specialists
  • Enthusiastic, self-motivated and keen to improve processes and overcome inefficiencies
Physical Demands / Travel

The physical demands of this job are consistent with working in a laboratory/ bench environment. Some light lifting, and maneuvering may be required.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in a lab/bench environment.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

For more information about Loxo Oncology’s privacy practice, please view the Privacy Statement.