Career Opportunities

Career Opportunities


Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by our goal of improving the lives of people living with cancer. We pursue this goal with a tenacity, focus, and commitment to excellence that defines who we are and how we work.

We seek dedicated, passionate, hardworking, intelligent, thoughtful, and authentic individuals who thrive within a collaborative and fast-paced environment and will bring their experiences, unique perspectives and problem-solving skills to the team. In return, we cultivate an environment that rewards and recognizes hard work and provides opportunities for learning and growth as part of a team making a meaningful difference in the lives of patients.

Senior Principal Scientist/Principal Scientist, Large Molecule Biology

Location: New York, NY

Reports To:

Research Fellow, Large Molecule Biology

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

The Senior Principal Scientist/Principal Scientist will lead a dynamic group of scientists (internal team as well as external CRO) conducting various research projects to identify large molecule/biologics which can effectively treat various forms of cancer.  This is a hands-on role where you will lead from the bench.  The Senior Principal Scientist/Principal Scientist will design and perform experiments that determine the efficacy of pipeline agents through a variety of techniques such as in vitro and ex vivo assays, target validation, and functional screening. Collaboration across functional areas within Loxo Oncology at Lilly is required including Large Molecule and Oncology Biologics senior leadership.  The Senior Principal Scientist/Principal Scientist will be a key member of the large molecule organization, where you will be responsible for maintaining the scientific quality and efficiency of your organization, as well as assist and contribute to the strategic direction of large molecule discovery.

Roles and Responsibilities of the Position*
  • Design and oversee the execution of key mechanistic and discovery biology experiments involving diverse oncogenic mechanisms (i.e., tumor indications, signaling, cancer targets, biologic mechanisms of tumor inhibitions).
  • Maintain focus on project deliverables and prioritize experiments and efforts accordingly.
  • Oversee/perform assays to identify the drug candidate evaluate the candidate for clinical testing.
  • Liaise with CROs and vendors to outsource activities, provide input to management team on vendor selection.
  • Provide scientific expertise when determining organizations to strategically partner with.
  • Interrogate experimental conduct of third parties/vendors.
  • Participate in target identification in collaboration with leadership.
  • Build, lead, and manage team of Scientists at various levels.  
  • Indirectly oversee work of third parties/vendors (e.g., CROs).
  • Manage resource allocation effectively.
  • Build roadmaps to execute on specific targets, and overall strategic projects.
Required Qualifications and Background
  • PhD in cellular biology, immunology, or allied disciplines with minimum 3+ years’ industry experience OR BS/MS with 10+ years of direct pharmaceutical/biotechnology experience.
  • Laboratory experience with ADC and CD3 platforms and biologic assays.
  • Knowledge on immune targets and myeloid biology/targets.
  • Strong attention to detail and highly goal oriented with demonstrated critical thinking capabilities.
  • Ability to trouble shoot effectively and think outside of the box.
  • Ability to collaborate with translational biology functions (PK/PD, toxicology, Ab discovery).
  • Proven success leading, managing, and coaching others (either directly or indirectly).
  • Demonstrated ability and track record in managing work overseen by third parties/vendors/strategic partners.
  • Demonstrated experience in working collaboratively across various scientific disciplines to meet end goals of business.
  • Demonstrated excellence in making key strategic decisions in support of broader business goals.
  • Excellent written and verbal communication skills.
Physical Demands / Travel

The physical demands of this job are consistent with laboratory/bench setting.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in a lab.  

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

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