Career Opportunities

Career Opportunities

Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by our goal of improving the lives of people living with cancer. We pursue this goal with a tenacity, focus, and commitment to excellence that defines who we are and how we work.

We seek dedicated, passionate, hardworking, intelligent, thoughtful, and authentic individuals who thrive within a collaborative and fast-paced environment and will bring their experiences, unique perspectives and problem-solving skills to the team. In return, we cultivate an environment that rewards and recognizes hard work and provides opportunities for learning and growth as part of a team making a meaningful difference in the lives of patients.

Senior Scientist, Translational Medicine

Location: South San Francisco, CA

Reports To:

Senior Principal Scientist, Translational Medicine

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

With a strong background in cancer biology, the Senior Scientist, Translational Medicine will support lab-based translational research projects associated with Loxo Oncology at Lilly’s preclinical and early development programs. This entails independently planning and executing experiments aimed at characterizing our lead compounds, including their: (1) efficacy (in vitro and in vivo), (2) mechanism of action, (3) target patient populations, and (4) biomarkers predicting clinical response. The successful candidate will achieve these objectives by developing and executing in vitro assays, collaborating with Loxo Oncology at Lilly’s discovery scientists, and overseeing research at CROs.

Roles and Responsibilities of the Position*
  • Establish robust assays including a variety of cell-based assays (cell lines and primary cells), lentiviral transduction, enzymatic assays, ELISA, MSD, TR-FRET, Western blot, immunoprecipitation, RT-qPCR, and NGS.
  • Engineer knock-in & knockout cell lines with CRISPR and/or other technologies.
  • Execute high throughput siRNA and/or CRISPR screens of cell lines. 
  • Establish heme-oncology assays including immune cell isolation, flow cytometry, colony formation assay, and stromal cell co-culture assay.
  • Design and execute cross-assay validation studies.
  • Analyze and interpret data, with ability to troubleshoot assays.
  • Organize and coordinate multiple projects in parallel.
  • Identify, evaluate, and manage vendors for outsourced services and studies.
  • Prepare and present scientific results at congresses and in peer-reviewed journals.
Required Qualifications and Background
  • BS/MS or PhD in a biological discipline with at least 8 years of bench experience, preferably with industry experience in small molecule drug discovery programs.
  • Research experience in oncology, preferably with some exposure to heme-oncology and/or immuno-oncology.
  • Extensive experience with culturing adherent and non-adherent mammalian cell lines and primary cells using excellent sterile technique.
  • Experience with modern cloning technologies, generation of CRISPR-engineered cell lines, development of PD biomarker assays.  
  • Self-organized, detail-oriented, self-directed, highly motivated with strong critical thinking and analytical skills.
  • Willingness to work collaboratively and incorporate diverse perspectives into decision-making.
  • Demonstrated ability to work successfully in a nimble, fast-paced matrixed environment.
Physical Demands / Travel

The physical demands of this job are consistent with working in a laboratory/ bench environment. Some light lifting, and maneuvering may be required.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in a laboratory/bench environment.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.