Career Opportunities

Career Opportunities

Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by our goal of improving the lives of people living with cancer. We pursue this goal with a tenacity, focus, and commitment to excellence that defines who we are and how we work.

We seek dedicated, passionate, hardworking, intelligent, thoughtful, and authentic individuals who thrive within a collaborative and fast-paced environment and will bring their experiences, unique perspectives and problem-solving skills to the team. In return, we cultivate an environment that rewards and recognizes hard work and provides opportunities for learning and growth as part of a team making a meaningful difference in the lives of patients.

Structural Biologist, Cryo-Electron Microscopy

Location: San Diego, CA or Boulder, CO

Reports To:


Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

This position offers the opportunity to be part of Loxo’s discovery teams focused on creating novel, highly specific and selective drugs for genetically identified targets.  The scientist will offer structural and mechanistic insights to a multi-disciplinary discovery team by delivering high quality protein structures to advance our knowledge of mechanistic biology.

Roles and Responsibilities of the Position*
  • Deliver cryo-EM protein:ligand structures to drug discovery teams utilizing their expertise in the cryo-EM process from construct design through structure refinement and analysis.
  • Coordinate cryo-EM data collection on multiple protein targets.
  • Optimize sample vitrification conditions and collect high magnification data.
  • Analyze cryo-EM data collections including contrast transfer function estimation, particle picking through neural network algorithms, frame alignment, 2D classification, 3D ab-initio reconstructions, 3D classification through heterogeneous refinement, homogeneous refinement, masked local refinement, particle polishing, and 3D variability.
  • Provide scientific expertise to cross-functional project teams  on recent advances and explore the feasibility of experiment proposals.
  • Train scientists in cryo-EM data processing using various state-of-the-art software for 3D reconstructions, atomic model building and in fundamentals of cryo-EM sample handling and preparation.
Required Qualifications and Background
  • Ph.D. or equivalent in structural biology, biophysics, or a related field with postdoctoral/industrial experience in structural biology and 2+ years of documented experience in cryo-EM of proteins.
  • Experience with cryo-EM sample preparation protocols including negative staining and sample vitrification.
  • Experience with operation of Krios microscopes or similar.
  • Experience with cryo-EM software packages for collecting and processing data such as RELION and EMAN2.
  • Experience with software for model building and refinement such as Phenix, CCP4-em, Chimera, Rosetta etc.
  • Experience with Micro-ED, protein crystallography, and protein:ligand mechanistic studies is desired.
  • A true team player with a track record of successful collaborations.
Physical Demands / Travel

The physical demands of this job are consistent with working in a lab.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in an office and the lab. 

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.