Career Opportunities

Career Opportunities

Patients are at the heart of everything we do at Loxo Oncology, and we continue to be motivated by our goal of improving the lives of people living with cancer. We pursue this goal with a tenacity, focus, and commitment to excellence that defines who we are and how we work.

We seek dedicated, passionate, hardworking, intelligent, thoughtful, and authentic individuals who thrive within a collaborative and fast-paced environment and will bring their experiences, unique perspectives and problem-solving skills to the team. In return, we cultivate an environment that rewards and recognizes hard work and provides opportunities for learning and growth as part of a team making a meaningful difference in the lives of patients.

Translational Biology Group Leader

Location: Indianapolis, IN

Reports To:

Vice President, Discovery and Applied Genomics

Position Summary

Loxo Oncology at Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo Oncology at Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Boulder, CO, Indianapolis, IN, New York City, South San Francisco, Stamford, CT, and Madrid, Spain.

The Translational Biology Group Leader will be responsible for leading a research team focused on in-depth studies to provide clinically-focused research to guide discovery projects, biomarker strategies, and early clinical development. The translational biology team will work on multiple drug discovery projects and early clinical programs across solid tumors and hematological malignancies providing mechanism-based studies to characterize prototype, literature, and clinical compounds in clinically relevant in vitro and in vivo assays. In addition, the translational biology team will develop and characterize drug resistance mechanisms in in vitro and in vivo models, identify and test drug combinations based on molecular mechanism, and analyze clinical trial patient molecular characterization results to inform discovery, clinical, and diagnostic programs. The translational biology team will work closely with other project team members across disciplines including cell biology, in vivo pharmacology, medicinal chemistry, biochemistry, bioinformatics, and clinical leads.

Roles and Responsibilities of the Position*

  • Participate and lead project-based and technical team meetings to identify and solve problems, guide work towards project goals, communicate on-going work and progress, and plan forward thinking strategies.
  • Actively participate in their team’s research activities (i.e. experimental work, experimental design, advanced analysis, etc.)
  • Effectively communicate biomarker strategies and assays to clinical teams, while also ensuring that insights from the clinical studies   inform discovery projects.
  • Supervise and mentor cell biologists and biochemists engaged in Loxo Oncology at Lilly translational research projects to think deeply and work creatively while delivering excellent scientific results and insights to the project teams and their colleagues.
  • Develop and continually advance one’s knowledge base on the molecular pathways being targeted by our discovery, clinical and research programs.
  • Proactively investigate new or different technologies and methods to advance our discovery projects

Required Qualifications and Background

  • PhD in Molecular/Cellular Biology, Biochemistry, or related field with 8+ years hands-on cell biology experience in a biotech/pharma setting OR BS/MS in Molecular/Cellular Biology, Biochemistry, or related field with 12+ years hands-on cell biology experience in a biotech/pharma setting
  • 2+ years of experience working on hematological malignancies

Additional Preferred Qualifications

  • Demonstrated experience supervising 2 or more scientists.
  • Expertise in designing and commissioning in vivo efficacy studies using cancer cell line and patient-derived xenograft models, to test oncology compounds
  • Strong background in cancer cellular signaling pathway experimentation and experimental curve-fitting and statistics
  • Thorough understanding of engineering knock-in and knockdown cell lines with CRISPR and/or other technologies
  • Experience with early clinical trial studies and the development and implementation of pharmacodynamic and patient selection biomarker assays
  • Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels
  • Highly organized with excellent analytical, documentation and multi-tasking skills
  • Committed to staying current with the latest scientific breakthroughs in the targeted oncology field from target identification through human clinical trials
  • Good and thoughtful listener who values collaboration
  • Enthusiastic, self-motivated and keen to improve processes and overcome inefficiencies
  • Proficient in Microsoft Office suite and applications

Physical Demands / Travel

The physical demands of this job are consistent with light office duties and some laboratory work. Some light lifting, and maneuvering may be required.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment

This position’s work environment is in an office and laboratory environment.

The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform each role and responsibility satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.