Genomically Defined Cancers

Understanding Targeted Therapies

Targeted therapies block cancer from growing and spreading by interfering with specific genes or proteins necessary for tumor growth. This approach differs greatly from the traditional weapons against cancer such as surgery, radiotherapy, and chemotherapy.

Scientists have long been working to better understand how a cancer cell becomes a cancer cell and how its vulnerabilities can be exploited to deliver better therapies with fewer side effects.


Loxo Oncology’s Approach

At Loxo Oncology, we are focused on developing medicines that selectively and potently inhibit a single cancer-driving molecular target. Through this approach we believe we can deliver medicines that have increased clinical benefit in targeted patient populations.

Designing selective drugs is the first important learning in the field of targeted therapies. The second important learning is that targeted therapies often deliver most clinical benefit when examined in the patients most likely to derive benefit. These learnings have been enabled by genomic testing.

In the past ten years alone, we’ve seen an incredible shift in cancer care – one that uses information about a person’s genes and proteins to better diagnose and treat.

Precision medicine has led us to the understanding that many types of cancer need to be treated at the genomic level – treatment chosen based on a patient’s specific genomic alteration. Increasingly, genomic testing is shaping the development and use of some of the newest cancer treatments, and Loxo Oncology’s programs are designed to leverage some of the most recent advances in genomic testing to find the patients most likely to derive benefit from our targeted therapies.