LY3484356 (Oral SERD)

LY3484356 is an investigational, oral selective estrogen receptor degrader (SERD) with pure antagonistic properties. The estrogen receptor (ER) is the key therapeutic target for patients with ER+/HER2- breast cancer.

Novel degraders of ER may overcome endocrine therapy resistance while providing consistent oral pharmacology and convenience of administration. LY3484356 was specifically designed to deliver continuous estrogen receptor target inhibition throughout the dosing period and regardless of ESR1 mutational status.

LY3484356 is currently being studied in clinical trials. Safety and efficacy have not been established for the uses being studied.

LY3484356 is currently being evaluated in the following clinical trials:

EMBER: a global, first-in-human, open-label Phase 1a/b trial evaluating LY3484356 alone or in combination with other anticancer therapies in participants with ER+ advanced breast cancer or endometrioid endometrial cancer.

EMBER-2: an open-label Phase 1 trial evaluating LY3484356 in preoperative, postmenopausal women with stage I-III, ER+/HER2- breast cancer.

For more information about the LY3484356 clinical trials, please refer to Interested patients and physicians can contact the Loxo Oncology at Lilly clinical trial team by e-mailing